ABSTRACT We report an unusual case of fulminant endogenous Clostridium septicum panophthalmitis. A 74-year-old male patient presented with sudden amaurosis in the right eye, which in a few hours, evolved into an orbital cellulitis, endophthalmitis, anterior segment ischemia, and secondary perforation of the eye. A complete diagnostic study, which included cranial and orbital contrast-enhanced computed tomography scan, contrast-enhanced magnetic resonance imaging, blood cultures, and complete blood work, were performed. No causal agent was identified. Clostridium septicum infection caused fulminant gaseous panophthalmitis. Despite broad-spectrum antibiotic treatment, evisceration of the eyeball was necessary. The extension study showed a colon adenocarcinoma as the origin of the infection. Clostridium septicum panophthalmitis is a rare but aggressive orbital infection. This infection warrants the identification of a neoplastic process in the gastrointestinal tract in many cases not previously described.

RESUMO Este é o relato de um caso incomum de panoftalmite endógena fulminante por Clostridium septicum. Um paciente do sexo masculino, 74 anos, apresentou amaurose súbita no olho direito, que em poucas horas evoluiu para celulite orbitária, endoftalmite, isquemia do segmento anterior e perfuração secundária do olho. Foi realizado um estudo diagnóstico completo, que incluiu uma tomografia computadorizada com contraste cranial e orbital, um exame de ressonância magnética, hemocultura e hemograma completo. Nenhum agente causal foi identificado. A infecção por Clostridium septicum causou uma panoftalmite gasosa fulminante. Apesar do tratamento com antibióticos de amplo espectro, foi necessário eviscerar o globo ocular. O estudo de seguimento mostrou um adenocarcinoma de cólon como a origem da infecção. A panoftalmite por Clostridium septicum é um tipo raro, mas muito agressivo de infecção orbitária. Essa infecção deve sugerir a busca por um processo neoplásico no trato gastrointestinal, em muitos casos não diagnosticado anteriormente.

ABSTRACT Introduction: The confrontation to the epidemic of COVID-19 had a negative economic impact in the world, what generated an increment of the expenses and costs in the health sector of Santiago de Cuba province. Objective: To describe the economic impact of the COVID-19 in the sanitary sector of Santiago de Cuba during a year. Methods: A descriptive and prospective study was carried out in Santiago de Cuba province in the year 2021, for which the day-patient, budgetary expenses, average salary, total costs of a day-patient and unitary costs of a day-patient variables were analyzed. Results: The investigation revealed an increment in the expenses and its effect in the economy of the sanitary sector in 2021. When analyzing the expenses for departures, a higher significance was determined in those of medications, with 59.0 % of the total, what represented a growth of the unitary costs in comparison with the published standards. Conclusions: The expenses of the sanitary sector in this province contributed to control the propagation of COVID-19, to avoid the over expense for the introduction of vaccines, and allowed the decrease of the infection indexes. Also, the increment of the costs was evidenced in the different activity levels between 3 and 29 times more than the standardized costs of the country.

RESUMEN Introducción: El enfrentamiento a la epidemia de la COVID-19 tuvo un impacto económico negativo en el mundo, lo que generó un incremento de los gastos y costos en el sector de la salud en la provincia de Santiago de Cuba. Objetivo: Describir el impacto económico de la COVID-19 en el sector sanitario en Santiago de Cuba durante un año. Métodos: Se realizó un estudio descriptivo y prospectivo en la provincia de Santiago de Cuba en el año 2021, para lo cual se analizaron las variables días-pacientes, gastos presupuestarios, salario promedio del personal, costos totales de un día-paciente y costos unitarios de un día-paciente. Resultados: La investigación reveló un incremento en los gastos y su efecto en la economía del sector sanitario en el 2021. Al analizar los gastos por partidas, se determinó una mayor significación en los de medicamentos, con 59,0 % del total, lo que representó un crecimiento de los costos unitarios en comparación con los estándares publicados. Conclusiones: Los gastos del sector sanitario en esta provincia contribuyeron a controlar la propagación de la COVID-19, a evitar el sobregasto por la introducción de las vacunas, y permitieron la disminución de los índices de infección. Además, se evidenció el incremento de los costos en los diferentes niveles de actividad entre 3 y 29 veces más que los costos estandarizados del país.

Abstract The teaching scenarios in the context of the health pandemic generated by COVID-19 have forced the development of a change in the academic paradigm in higher education that has not only had repercussions on the development of the contents of the subjects, but also on the way the different agents involved (teachers and students) interact with each other. This is a participatory research in context on a subject of the teaching degree at the University of Cadiz where the challenge of improving academic results from previous years and changing the attitude of students, very unfavourable due to low success rates, is faced. After the creation of the participatory scenario and a specific plan for the subject, the academic results and attitudes showed a change in the students’ formative conception, focusing on the main finding of the new methodological design. In this way, this research can be replicated in other contexts as it is considered a good educational practice that integrated the communicative, informational, interactive and collaborative potential of virtual environments to face the challenge of teaching a subject with low academic success rates in an emergency situation. Thus, the results show a change in the learning culture that aims to be institutionalised in normalised contexts.

Resumen Los escenarios docentes en contexto de la pandemia sanitaria generada por la COVID-19 han obligado a desarrollar en la educación superior un cambio en el paradigma académico que no solo ha repercutido en el desarrollo de los contenidos de las asignaturas, sino en la forma de interaccionarse los diferentes agentes implicados (docentes y estudiantes). Esta es una investigación participativa en contexto sobre una materia del grado de magisterio de la Universidad de Cádiz donde se afronta el reto de la mejora de resultados académicos de cursos anteriores y el cambio de actitud de los estudiantes, muy desfavorable por las bajas tasas de éxito. Tras la creación del escenario participativo y un plan específico de la asignatura, los resultados académicos y actitudes mostraron un cambio en la concepción formativa de los estudiantes, centrado en el principal hallazgo del nuevo diseño metodológico. De esta forma, esta investigación puede replicarse en otros contextos al considerarse una buena práctica educativa que integró el potencial comunicativo, informacional, interactivo y colaborativo que posibilitaban los entornos virtuales para afrontar el reto de la enseñanza de una asignatura con bajas tasas de éxito académico en una situación de emergencia. Así, los resultados evidencian un cambio en la cultura de aprendizaje que pretende institucionalizarse en contextos normalizados.

ABSTRACT Background: the development of Information and Communication Technologies in education becomes a didactic and pedagogical tool. Objective: to design an interactive alternative with the use of the Moodle platform for the teaching-learning of the Pedagogy subject of the Bachelor's degree in Health Technology. Methods: a development study was carried out using a qualitative and quantitative methodology at the Faculty of Medical Sciences of Sagua la Grande during the 2018-2019 academic year. Theoretical methods were used: analytical-synthetic, inductive-deductive, logical-practical, modeling; and empirical ones: documentary review, interview, and questionnaire and class observation. Results: the interactive alternative for the Pedagogy subject was designed with the application of the RUP (Rational Unified Process) methodology and the UML (Unified Modeling Language) language for the analysis, design, implementation and documentation of object-oriented systems and for visualize, specify, build and document the system. It was assembled on the Moodle platform with the didactic structure of the design, components and elements so that the student can carry out tasks to arrive at the desired knowledge. Conclusions: the teaching-learning process of the Pedagogy subject has shown the need to use the interactive platform by using developeing methods in students, used in face-to-face and blended organizational forms, which allow its generalization in undergraduate and postgraduate courses.

RESUMEN Fundamento: el desarrollo de las Tecnologías de la Información y las Comunicaciones en la educación se convierte en una herramienta didáctica y pedagógica. Objetivo: diseñar una alternativa interactiva con el empleo de la plataforma Moodle para la enseñanza-aprendizaje de la asignatura Pedagogía de la carrera Licenciatura en Tecnología de la Salud. Métodos: se realizó un estudio de desarrollo con el empleo de una metodología cualitativa y cuantitativa en la Facultad de Ciencias Médicas de Sagua la Grande durante el curso 2018-2019. Se emplearon los métodos teóricos: analítico-sintético, inductivo-deductivo, lógico-práctico, el modelado; y empíricos: la revisión documental, entrevista, cuestionario y la observación a clase. Resultados: se diseñó la alternativa interactiva para la asignatura de Pedagogía con la aplicación de la metodología RUP (Proceso Unificado Racional) y el lenguaje UML (Lenguaje Unificado de Modelado) para el análisis, diseño, implementación y documentación de sistemas orientados a objetos y para visualizar, especificar, construir y documentar el sistema. Se montó en la plataforma Moodle con la estructura didáctica del diseño, componentes y elementos de manera que el estudiante pueda ejecutar tareas para arribar al conocimiento deseado. Conclusiones: el proceso enseñanza aprendizaje de la asignatura Pedagogía ha demostrado la necesidad del uso de la plataforma interactiva al usar métodos desarrolladores en los educandos, utilizados en formas organizativas presenciales y semipresenciales, los que posibilitan su generalización en el pregrado y posgrado.

RESUMO Trata-se de relato crítico-reflexivo sobre a experiência de disciplina optativa voltada à formação de profissionais da saúde no combate ao racismo, oferecida aos estudantes de graduação da área de saúde na Universidade de São Paulo, durante a pandemia de Covid-19. A partir da descrição e da reflexão sobre as atividades de ensino e avaliação propostas, buscou-se reconhecer e apre(e)nder a contribuição da integração de saberes (interdisciplinaridade), de profissões (interprofissionalidade) e da diversidade racial no processo ensino-aprendizagem voltado ao combate ao racismo. São relatadas perspectivas de discentes, monitoras e docentes. A oferta da disciplina, com apoio de convidados, permitiu que o projeto abordasse o racismo e suas influências na saúde das pessoas negras e estimulou a produção cultural dos estudantes. A iniciativa mostrou-se uma possibilidade de introduzir mudanças na formação dos futuros profissionais de saúde em prol tanto da integralidade do cuidado quanto da colaboração interprofissional no combate ao racismo.

ABSTRACT This is a critical-reflective report on the experience of an elective course aimed at training health professionals in fighting racism. It was offered during the COVID-19 pandemic to undergraduate students from all the health subspecialties at the University of São Paulo. From the description and reflection on the proposed teaching and evaluation activities, we sought to recognize and learn/apprehend the contribution of the integration of knowledge (interdisciplinarity), professions (interprofessionality), and racial diversity in the teaching-learning process aimed at fighting racism. The perspectives of students, monitors, and teachers are reported. The support of guest teachers allowed this initiative to address racism and its influences on the health of black people, and the educational strategies encouraged students’ cultural production. The initiative proved to be a possibility for introducing changes in health education in favor of both comprehensive care and interprofessional collaboration in dismantling racism.

ABSTRACT This is a critical-reflective report on the experience of an elective course aimed at training health professionals in fighting racism. It was offered during the COVID-19 pandemic to undergraduate students from all the health subspecialties at the University of São Paulo. From the description and reflection on the proposed teaching and evaluation activities, we sought to recognize and learn/apprehend the contribution of the integration of knowledge (interdisciplinarity), professions (interprofessionality), and racial diversity in the teaching-learning process aimed at fighting racism. The perspectives of students, monitors, and teachers are reported. The support of guest teachers allowed this initiative to address racism and its influences on the health of black people, and the educational strategies encouraged students’ cultural production. The initiative proved to be a possibility for introducing changes in health education in favor of both comprehensive care and interprofessional collaboration in dismantling racism.

RESUMO Trata-se de relato crítico-reflexivo sobre a experiência de disciplina optativa voltada à formação de profissionais da saúde no combate ao racismo, oferecida aos estudantes de graduação da área de saúde na Universidade de São Paulo, durante a pandemia de Covid-19. A partir da descrição e da reflexão sobre as atividades de ensino e avaliação propostas, buscou-se reconhecer e apre(e)nder a contribuição da integração de saberes (interdisciplinaridade), de profissões (interprofissionalidade) e da diversidade racial no processo ensino-aprendizagem voltado ao combate ao racismo. São relatadas perspectivas de discentes, monitoras e docentes. A oferta da disciplina, com apoio de convidados, permitiu que o projeto abordasse o racismo e suas influências na saúde das pessoas negras e estimulou a produção cultural dos estudantes. A iniciativa mostrou-se uma possibilidade de introduzir mudanças na formação dos futuros profissionais de saúde em prol tanto da integralidade do cuidado quanto da colaboração interprofissional no combate ao racismo.

ABSTRACT The main aim of this work was to evaluate the agronomic behavior and nutritional composition of ten varieties of improved pastures in the agroclimatic conditions of the Nuevo Olmal Annex in the Sonche district. For this, the experimental design of randomized complete blocks (DBCA) with 10 treatments and 3 blocks was used. The gramineous forage species studied were: Gramilla, ryegrass ecotype Cajamarquino, ryegrass tetraploid biannual Austral, ryegrass Hybrid Boxer, ryegrass tetraploid Magnum, Festulolium, Dactylis Glomerata Mammoth, ryegrass tetraploid annual Jumbo, Festuca Alta and ryegrass bi-annual tetraplioid Hercules. In our study, the variables studied were green forage yield per hectare, percentage of dry matter and nutritional content; the results of the analysis of variance indicated significant differences, (p < 0.05) for all the variables. The Bonferroni test at 5% determined that the highest yield achieved belongs to Ryegrass Biannual Tetraploide Hercules (26.631 /ha), the best percentage of dry matter was found with DG Mammoth (20.21%) and Festuca arundinaceae (19.39%), the highest amount of protein presents the local grass (25.52%), the highest percentage of crude fiber was found with D.G. Mammoth (17.68%) and local grass (17.28%), the highest relative value of in vitro digestibility of dry matter was found in T. Magnum (75.48%).

RESUMEN Esta investigación tuvo como objetivo evaluar el comportamiento agronómico y la composición nutricional de diez variedades de pastos mejorados, en las condiciones agroclimáticas del anexo de Nuevo Olmal en el distrito de Sonche. Para ello se utilizó el diseño experimental de bloques completos al azar (DBCA) con 10 tratamientos y 3 bloques. Las especies forrajeras gramíneas estudiadas fueron Gramilla, Raigrás ecotipo Cajamarquino, Raigrás tetraploide bianual Austral, Raigrás híbrido Boxer, Raigrás tetraploide Magnum, Festulolium, Dactylis glomerata Mammoth, Raigrás tetraploide anual Jumbo, Festuca Alta y Raigrás bianual tetraploide Hércules. Las variables evaluadas fueron rendimiento de forraje verde por hectárea, porcentaje de materia seca y con tenido nutricional. Los resultados del análisis de varianza indicaron diferencias significativas (p < 0.05) para todas las variables. La prueba de Bonferroni al 5% determina que el mayor rendimiento logrado pertenece a Raigrás bianual tetraploide Hércules (26,63 t/ha), el mejor porcentaje de materia seca se encontró con D.G. Mammoth (20,21%) y Festuca arundinaceae (19.39%), la mayor cantidad de proteína la presentó el pasto local (25,52%), el mayor porcentaje de fibra cruda se obtuvo con D.G. Mammoth (17,68%) y pasto local (17,28%), y el mayor valor relativo de digestibilidad in vitro de materia seca se halló en T. Magnum (75,48%).

ABSTRACT Introduction: CIGB-258 is an immunomodulatory peptide with anti-inflammatory properties. Objectives: To establish the therapeutic schedule with CIGB-258 peptide for COVID-19 critically ill patients. In addition, to define the criteria for use and schedule of this peptide for COVID-19 seriously ill patients. Methods: 9 critically ill patients and 3 seriously ill patients were included in this study. Clinical, radiological and laboratory evaluations were recorded according to the established protocol. Serum samples were obtained before and after treatment with CIGB-258, for the determination of the inflammation biomarkers. Results: The therapeutic protocol was established with the CIGB-258 peptide, which consists of intravenous administration of 1 mg of peptide every 12 hours for critically ill patients. The dose should be increased to 2 mg every 12 hours, for patients who do not show clinical and radiological improvement in 24 hours. After extubation, patients should receive 1 mg of CIGB-258 daily, for another three days. Seriously ill patients should receive 1 mg of CIGB-258 every 12 hours, until their clinical condition resolves. Conclusions: CIGB-258 showed an excellent safety profile. The established therapeutic protocol contributed to all critically ill patients recovering from respiratory distress and being extubated. Seriously ill patients improved considerably. The levels of the biomarkers associated with hyperinflammation and cytokines decreased significantly during treatment.

RESUMEN Introducción: El CIGB-258 es un péptido inmunomodulador con propiedades antiinflamatorias. Objetivos: Establecer la frecuencia de dosis y el tiempo de tratamiento con el péptido CIGB-258, para pacientes críticos con COVID-19. Además, definir los criterios de uso y el esquema terapéutico del péptido, para pacientes graves con COVID-19. Métodos: Se incluyeron 9 pacientes críticos y 3 pacientes graves. Las evaluaciones clínicas, radiológicas y de laboratorio se registraron de acuerdo al protocolo establecido. Se obtuvieron muestras de suero antes y después del tratamiento con la CIGB-258, para la determinación de los biomarcadores de la inflamación. Resultados: Se estableció el protocolo de actuación con el péptido CIGB-258, el cual consiste en la administración intravenosa de 1 mg del péptido cada 12 horas a los pacientes críticos. La dosis debe aumentarse a 2 mg cada 12 horas, para los pacientes que no muestren mejoría clínica y radiológica en 24 horas. Después de la extubación, los pacientes deben recibir 1 mg de CIGB-258 al día, durante otros tres días. Los pacientes graves deben recibir 1 mg de CIGB-258 cada 12 horas, hasta que resuelvan su condición clínica. Conclusiones: CIGB-258 mostró un buen perfil de seguridad. El protocolo de actuación establecido contribuyó a que todos los pacientes críticos se recuperaran de la dificultad respiratoria y fueran extubados. Los pacientes graves mejoraron considerablemente. Los niveles de los biomarcadores asociados con hiperinflamación y las citocinas disminuyeron significativamente durante el tratamiento.

Qualea grandiflora Mart. (“pau-terra”) is a medicinal plant symbolic from Cerrado biome. Qualea species reportedly have antiparasitic properties, but their active compounds have yet to be identified. In this study, we investigated the antiplasmodial activity of Q. grandiflora fruit and stem extracts against Plasmodium falciparum. The polar extracts of both fruits and stems showed promising in vitro antiplasmodial activity against sensitive and resistant P. falciparum strains (half-maximal inhibitory concentration (IC50) = 1.2 and 4.2 ng mL-1, respectively), low cytotoxicity against human hepatic cells (IC50HepG2 ≥ 400 ng mL-1), and a noteworthy selectivity index (SI ≥ 322 and ≥ 96, respectively). The fruit ethanolic extract revealed significant oral efficacy at 100 mg kg-1 in a mouse model of P. berghei malaria (100% reduction in parasitemia on day 5 post-infection). To investigate the chemical composition of the extracts, we developed a method involving liquid chromatography-high resolution quadrupole-time of flight mass spectrometer. The chemical profiling of active extracts indicated 32 compounds, including gallotannins, ellagic acid derivatives and flavonoids. The common component in the active polar extracts was found to be ellagic acid (EA), which may contribute favorably to the in vitro and in vivo inhibitory activity observed in this study.

A combined phytochemical, crystallographic and biological study of Worsleya procera roots was performed. Fifteen alkaloids were identified by gas chromatography mass spectrometry (GC-MS) and seven of them were isolated. The structures of the alkaloids were elucidated by spectroscopic methods, and a detailed crystallographic study of tazettine was carried out. The isolated alkaloids and the obtained extracts were tested in vitro against Plasmodium falciparum (3D7 and K1 strains) and human hepatocarcinoma cells (HepG2) to assess their antiplasmodial and cytotoxic effects, respectively. One of the isolated alkaloid derivatives, lycorine, exhibited antiplasmodial activity against both sensitive (3D7) and resistant (K1) parasite strains in the low micromolar range (half-maximal sample inhibitory concentration (IC50) values of 2.5 and 3.1 µM, respectively) and displayed a low cytotoxicity profile, with a selectivity index greater than 100. Our findings indicate that lycorine is a hit for antimalarial drug discovery.

Existe controvérsia acerca da variabilidade da orientação do eixo tibio-talar durante os movimentos de dorsiflexão e flexão plantar do pé em relação à perna. Actualmente pensa-se que existe um eixo variável durante estes dois movimentos. Foi feita uma revisão bibliográfica sobre este tema e testada a aplicação do conceito de eixo variável na colocação dos fixadores externos do tornozelo, com a intenção de diminuir a rigidez resultante da sua utilização. Foi feita uma pesquisa no Pubmed usando os termos “ankle axis” e “tibio-talar axis”, tendo sido selecionados os estudos da biomecânica do tornozelo com foco no eixo tibio-talar. Os estudos de Inman são os que mais suportam a existência de um eixo de rotação único. Actualmente, a literatura aponta mais para a existência de um eixo variável para os movimentos de dorsiflexão e flexão plantar. Estudos como o de Barnett e Napier ou, mais recentemente, de Lundberg, suportam a ideia de um eixo variável. Tendo por base as teorias que defendem um eixo variável e apoiados no conceito (de Hicks) de que não podem existir movimentos simultaneamente nos dois eixos, foi feita a tentativa de aplicação deste conceito na colocação de fixadores externos trans-articulares no tornozelo. Colocando o pino do calcâneo na direcção do eixo que privilegia a dorsiflexão pode-se minimizar a tendência para equino do pé com menor necessidade de pinos adicionais no médio-pé.

There is still controversy about the variability of the talo crural axis during plantar and dorsiflexion of the ankle. Currrently, it is thought that there is a variable axis forthese two movements. A literature revision was conducted and we tested the application of the variable axis concept to the external fixation of the ankle, with the main goal of reducing the stiffness of the joint. Pubmed was searched using the key words “ankle axis” and “tibio-talar axis”, and the papers about ankle biomechanics were selected. Inman studies supports the idea of a single axis. Currently, the literature points more to the existence of a variable axis for the plantar and dorsiflexion movements. Studies such as that of Barnett and Napier or, more recently, of Lundberg, support this idea of a variable axis. Based on theories that advocate a variable axis and based on the Hicks concept that there cannot exist movements simultaneously in these two axis, an attempt was made to apply this concept in the placement of trans-articular external fixators in the ankle. By placing the calcaneus pin in the direction of the axis that favors dorsiflexion, the tendency for the foot to fall into equine position can be minimized, without the need for additional pins in the midfoot.

Introduction: suicidal behavior constitutes a serious health problem in the Cooperative Republic of Guyana with an average annual rate of 44 suicides per 100 000 inhabitants. Objective: to describe suicide attempts occurred at a Guyanese hospital. Method: a case series study based on emergency service charge sheets and medical records of 28 suicide attempts, attended at the Mahaicony Hospital, Guyana, from January to June, 2015. Results: the age group from 10 to 29 was the most affected with 67.86%, without significant differences between women and men 53.57% and 46.43% each. Indians descendants represented 71.43%; followed by Africans with 21.43% and mixtures showed a 7.14%. Literacy was the predominant level of education up to 64.29% and the ingestion of toxic substances up to 92.86% was the leading method, followed by the ingestion of tablets with 7.14%. Conclusions: suicide attempt is a health problem in this region, so strategies to identify and control the risk factors are the key for reducing its incidence.

Introducción: en la República Cooperativa de Guyana, la conducta suicida constituye un serio problema de salud, con una tasa anual de 44 suicidios por 100 000 habitantes, especialmente en la Región 5. Objetivo: describir el comportamiento del intento suicida en pacientes atendidos en un hospital guyanés. Método: se realizó un estudio de serie de casos, mediante el análisis de las hojas de cargo del servicio de emergencias y de las historias clínicas de 28 pacientes con intentos suicidas, atendidos en el Hospital Mahaicony, Guyana, durante el período enero-junio del 2015. Resultados: el grupo etario más afectado fue entre 10 y 29 años para un 67,86%, sin diferencias significativas entre mujeres y hombres con 53,57% vs. 46,43% respectivamente. Los individuos de ascendencia india incidieron hasta un 71,43%; seguido por la africana con 21,43%; y los mixtos con 7,14%. El grado de escolaridad predominante el alfabetizado con un 64,29% y el método de ingestión de sustancias tóxicas alcanzó un 92,86%, seguido por la toma de tabletas con 7,14%. Conclusiones: en esta región, el intento suicida es un problema de salud, por lo que se deben adoptar estrategias encaminadas a reducirlo, mediante la identificación y el control de los factores de riesgo. .

Abstract Analysis of the effect between the use of Facebook, perceived stress and alcohol consumption among young people. A descriptive, correlative and cross-sectional study was carried out. The sample of 1110 young university students from Nuevo León, Mexico, was selected by probability sample. Personal Data and Prevalence of Alcohol Consumption Inventory, Alcohol Use Disorders Identification Test (AUDIT), Facebook Use Identification Test, Perceived Stress Scale were used. The Research Ethics Committee approved it. We observed 6.4% of young people have mentioned that the use of Facebook affected the alcohol consumption. Seeing adds with alcohol on Facebook was related to alcohol consumption (rs = 0,204, p < 0,05). At the time Facebook was used, it was related to the perceived stress (rs = 0,189, p < 0,05). Finally, it was observed that there is a significant impact between the hours and days of use of Facebook, the stress perceived by young people, the age and gender regarding the harmful alcohol consumption among university students (R2 = 30,9%, p = 0,003). Therefore, it is crucial and necessary to consider social networks an important variable to be included in future interventions regarding mental health.

Resumen Analizar el efecto entre el uso de Facebook, el estrés percibido y el consumo de alcohol en jóvenes. Fue realizado un estudio descriptivo, correlacional y transversal. La muestra fue de 110 jóvenes universitarios jóvenes universitarios de Nuevo León, México. Muestreo probabilístico. Se utilizó una Cedula de Datos Personales y Prevalencias del Consumo de Alcohol, Cuestionario de Identificación de Trastornos por Uso del Alcohol (AUDIT), Cuestionario de Uso de Facebook y la Escala de Estrés Percibido. Se contó con la aprobación del Comité de Ética en Investigación. Se encontró que el 6,4% de los jóvenes mencionaron que el uso de Facebook ha afectado su consumo de alcohol. El visualizar anuncios con contenido de alcohol en Facebook se relacionó con el consumo de alcohol (rs = 0,204, p < 0,05). Las horas que se utiliza Facebook se relacionó con el estrés percibido (rs = 0,189, p < 0,05). Finalmente se observó que existe un efecto significativo entre las horas y días de uso de Facebook, el estrés percibido por los jóvenes, la edad y el sexo sobre el consumo de alcohol perjudicial en los jóvenes universitarios (R2= 30,9%, p = 0,003). Por lo tanto es importante y necesario el considerar las redes sociales como una variable importante para ser incluida en futuras intervenciones en salud mental.