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Hydrothermal pretreatment of poultry litter for biogas production
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Oliveira, Mayara P. de

; Paranhos, Aline G. de O.

; Adarme, Oscar F. H.

; Aquino, Sérgio F. de

Revista Brasileira de Engenharia Agrícola e Ambiental

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Nov 2023, Volume 27 Nº 11 Páginas 873 - 881

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Hydrothermal pretreatment (HPT) allows the solubilization of the hemicellulose, leading to increased biodegradability for microorganisms. This paper presents a study based on the evaluation of the variables time (12 to 60 min), temperature (80 to 200°C), and solid/liquid ratio (4 to 8 g mL-1) for the HPT (autohydrolysis) of synthetic poultry litter (rice straw: poultry manure 1:5) using the Doehlert matrix. Twelve HPT conditions followed by anaerobic digestion were evaluated with a focus on methane production. Firstly, tests were conducted to evaluate biogas production in a single stage in a single reactor, where both the acidogenic and methanogenic phases occur. Subsequently, tests were conducted to evaluate biogas production in a two-stage, consisting of separating hydrogen and methane production phases. The best performance of the biochemical potential of methane was the conditions 6 (24 min, 120 °C, and solid-liquid ratio = 4) in a single stage and 3 (48 min, 160 °C, and SLR = 8) in a two-stage, producing 255.6 and 277.6 NmL CH4gVS-1, respectively. Using the desirability criteria, two hydrothermal pretreatment (HPT) conditions were evidenced/ condition 1 in two stages (12 min, 80 °C, and SLR = 4)- (D1-2S) and condition two in two stages (12 min, 98 °C, and SLR = 4) - (D2-2S) showed high methane production, 248.9 and 249.3NmL CH4∙gVS-1, respectively.

RESUMO O pré-tratamento hidrotérmico permite a solubilização da hemicelulose, o que leva a um aumento da biodegradabilidade para microrganismos. Este trabalho apresenta um estudo baseado na avaliação das variáveis tempo (12 a 60 min), temperatura (80 a 200 °C) e relação sólido/líquido (4 a 8 g mL-1) para o pré-tratamento hidrotérmico (auto-hidrólise) de cama de frango sintética (palha de arroz: esterco de frango 1:5) utilizando a matriz Doehlert. Doze condições de pré-tratamento seguidas de digestão anaeróbica foram avaliadas com foco na produção de metano. Primeiramente, foram realizados testes para avaliar a produção de biogás em uma única etapa, realizada em um único reator, no qual ocorrem tanto a fase acidogênica quanto a metanogênica. Posteriormente, foram realizados testes para avaliar a produção de biogás em estágio duplo, consistindo na separação das fases de produção de hidrogênio e metano. O objetivo deste trabalho foi definir as melhores condições para a auto-hidrólise do resíduo, visando aproveitá-lo para a produção de metano. As condições experimentais com melhor desempenho do potencial bioquímico do metano foram as condições 6 (24 min, 120 °C e SLR = 4) em único estágio e 3 (48 min, 160 °C e SLR = 8) em duplo estágio que produziram 255,6 e 277,6 NmL CH4∙gVS-1, respectivamente. Usando o critério de desejabilidade, duas condições de pré-tratamento hidrotérmico (HPT), a condição 1 de desejabilidade em dois estágios (12 min, 80 °C e SLR = 4)- (D1-2S) e a condição dois de desejabilidade em dois estágios (12 min, 98 °C e SLR = 4) - (D2-2S) apresentaram alta produção de metano em dois estágios, 248,9 e 249,3 NmL CH4∙gVS-1, respectivamente.

https://doi.org/10.1590/1807-1929/agriambi.v27n11p873-881

Synthesis of 4-(4-chlorophenyl)thiazole compounds: in silico and in vitro evaluations as leishmanicidal and trypanocidal agents
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CRUZ FILHO, IRANILDO JOSÉ DA

; OLIVEIRA, JAMERSON F. DE

; SANTOS, ALINE CAROLINE S.

; PEREIRA, VALÉRIA R.A.

; LIMA, MARIA CARMO A. DE

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Nº 1 elocation e20220538

Resumo: En | Texto: En | PDF: En

Abstract Neglected tropical diseases are a diverse group of communicable pathologies that mainly prevail in tropical and subtropical regions. Thus, the objective of this work was to evaluate the biological potential of eight 4-(4-chlorophenyl)thiazole compounds. Tests were carried out in silico to evaluate the pharmacokinetic properties, the antioxidant, cytotoxic activities in animal cells and antiparasitic activities were evaluated against the different forms of Leishmania amazonensis and Trypanosoma cruzi in vitro. The in silico study showed that the evaluated compounds showed good oral availability. In a preliminary in vitro study, the compounds showed moderate to low antioxidant activity. Cytotoxicity assays show that the compounds showed moderate to low toxicity. In relation to leishmanicidal activity, the compounds presented IC50 values that ranged from 19.86 to 200 µM for the promastigote form, while for the amastigote forms, IC50 ranged from 101 to more than 200 µM. The compounds showed better results against the forms of T. cruzi with IC50 ranging from 1.67 to 100 µM for the trypomastigote form and 1.96 to values greater than 200 µM for the amastigote form. This study showed that thiazole compounds can be used as future antiparasitic agents.

https://doi.org/10.1590/0001-3765202320220538

Long-term hepatic damage in high-fructose-fed C57BL/6 mice: hepatic fibrogenesis, endoplasmic reticulum stress markers, and fibrosis
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OLIVEIRA-CORDEIRO, BRENDA

; FERNANDES-DA-SILVA, ALINE

; SILVA-VEIGA, FLAVIA MARIA

; MIRANDA, CAROLLINE S.

; MARTINS, FABIANE F.

; SOUZA-MELLO, VANESSA

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Supl. 2 elocation e20220784

Resumo: En | Texto: En | PDF: En

Abstract The rising fructose intake in sugar-sweetened beverages and ultra-processed foods relates to the high incidence of nonalcoholic fatty liver disease. This study aimed to examine the effects of long-term high-fructose diet intake (for 16 or 20 weeks) on progressive hepatic damage, focusing on the endoplasmic reticulum stress markers and fibrogenesis as possible triggers of liver fibrosis. Forty 3-month-old male C57BL/6J mice were randomly divided into four nutritional groups: C16 (control diet for 16 weeks), C20 (control diet for 20 weeks), HFRU16 (high-fructose diet for 16 weeks), and HFRU20 (high-fructose diet for 20 weeks). Both HFRU groups showed oral glucose intolerance and insulin resistance, but only the HFRU20 group exhibited increased inflammation. The increased lipogenic and endoplasmic reticulum stress markers triggered hepatic fibrogenesis. Hence, time-dependent perivascular fibrosis with positive immunostaining for alpha-smooth muscle actin and reelin in HFRU mice was observed, ensuring fibrosis development in this mouse model. Our study showed time-dependent and progressive damage on hepatic cytoarchitecture, with maximization of hepatic steatosis without overweight in HFRU20 mice. ER stress and liver inflammation could mediate hepatic stellate cell activation and fibrogenesis, emerging as targets to prevent NAFLD progression and fibrosis onset in this dietary model.

https://doi.org/10.1590/0001-3765202320220784

Antarctic environments as a source of bacterial and fungal therapeutic enzymes
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LIMA, IGOR G.O.

; BISPO, JAMES R.S.

; AGOSTINHO, ADSON Y.H.

; QUEIROZ, ALINE C. DE

; MOREIRA, MAGNA SUZANA A.

; PASSARINI, MICHEL RODRIGO Z.

; OLIVEIRA, VALÉRIA M. DE

; SETTE, LARA D.

; ROSA, LUIZ HENRIQUE

; DUARTE, ALYSSON WAGNER F.

Anais da Academia Brasileira de Ciências

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2022, Volume 94 Supl. 1 elocation e20210452

Resumo: En | Texto: En | PDF: En

Abstract Microbial therapeutic enzymes are the protagonists in the pharmacological treatment of different human diseases. The intrinsic enzymatic characteristics, such as high affinity and specificity to the corresponding substrate, enable effective therapies, with minimal adverse effects and complete remission. However, immunogenicity, short half-life, low enzymatic yield, and low selectivity regarding available enzyme drugs are currently the main obstacles to their development and the broad adherence to therapeutic protocols. By harboring adapted and still unexplored microbial life, environments of extreme conditions, such as Antarctica, become especially important in the prospecting and development of new enzymatic compounds that present higher yields and the possibility of genetic improvement. Antarctic microorganisms have adaptation mechanisms, such as more fluid cell membranes, production of antifreeze proteins and enzymes with more malleable structures, more robust, stable, selective catalytic sites for their respective substrates, and high antioxidant capacity. In this context, this review aims to explore enzymes synthesized by bacteria and fungi from Antarctica as potential drug producers, capable of providing therapeutic efficacy, less adverse effects, and lower production costs with highlight to L-Asparaginase, collagenase, superoxide dismutase and ribonucleases. In addition, this review highlights the unique biotechnological profile of these Antarctic extremophile microorganisms.

https://doi.org/10.1590/0001-3765202220210452

Spotlight on latent tuberculosis infection screening for juvenile idiopathic arthritis in two countries, comparing high and low risk patients
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Piotto, Daniela

; Nicacio, Aline

; Neto, Agna

; Mourão, Ana Filipa

; Oliveira-Ramos, Filipa

; Campanilho-Marques, Raquel

; Guedes, Margarida

; Cabral, Marta

; Santos, Maria José

; Fonseca, João Eurico

; Canhão, Helena

; Aikawa, Nádia Emi

; Oliveira, Sheila K. F.

; Ferriani, Virginia P. L.

; Pileggi, Gecilmara C. S.

; Magalhães, Claudia S.

; Silva, Clovis Artur

; Terreri, Maria Teresa

Advances in Rheumatology

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2022, Volume 62 elocation 20

Resumo: En | Texto: En | PDF: En

Abstract Background: Rheumatic diseases are associated with an increase in overall risks of tuberculosis (TB). The aim of this study was to evaluate the frequency of TB and the frequency of latent TB infection (LTBI), in clinical practice, for juvenile idiopathic arthritis (JIA) patients from high and low risk of TB incidence endemic countries. Methods: This is an international, multicenter, cross-sectional, observational study of data collection from Brazil and Registry of Portugal at REUMA.PT. The inclusion criteria were patients with Juvenile Idiopathic Arthritis (JIA) with age ≤ 18 years who underwent screening for Mycobacterium tuberculosis infection [tuberculin skin test (TST) and/or interferon gamma release assay (IGRA)]. Chest X-rays and history of exposure to TB were also assessed. Results: 292 JIA patients were included; mean age 14.3 years, mean disease duration 7.5 years, 194 patients (66.4%) performed only TST, 14 (4.8%) only IGRA and 84 (28.8%) both. The frequency of LTBI (10.6%) and TB was similar between the two countries. The reasons for TB screening were different; in Brazil it was performed more often at JIA onset while in Portugal it was performed when starting Disease Modified Anti-Rheumatic Drugs (DMARD) treatment (p < 0.001). Isoniazid therapy was prescribed in 40 (13.7%) patients (31 with LTBI and 9 with epidemiologic risks and/or due to contact with sick people). Only three patients (1%) developed active TB. Conclusion: We found nearly 10% of patients with LTBI, a small percentage of patients with treatment due to epide-miologic risks and only 1% with active TB. Distinct reasons and screening methods for LTBI were observed between the two countries.

https://doi.org/10.1186/s42358-022-00251-6

Bioaccessibility Assessment of Cu, Fe, K, Mg, P, and Zn in Thermally Treated Lamb Meat
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Higuera, Julymar M. de

; Santos, Herick M

; Oliveira, Aline F. de

; Nogueira, Ana Rita A

Journal of the Brazilian Chemical Society

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Nov 2021, Volume 32 Nº 11 Páginas 2111 - 2119

Resumo: En | Texto: En | PDF: En

A bioaccessibility test with raw and cooked lamb meat samples was performed. The evaluated cooking devices were grill, microwave oven, air fryer, pressure cooker, and electric oven. Physicochemical parameters and the total mass fraction of Cu, Fe, K, Mg, P, and Zn were determined in raw and cooked samples by inductively coupled plasma optical emission spectrometry (ICP OES). The trueness was evaluated using certified reference materials, with recoveries from 87 to 101%. The pressure cooking presented the major changes, including the highest values of internal temperature, loss of inorganic elements after cooking, and the lowest values of moisture and analyte mass fractions. An in vitro gastrointestinal simulation was performed, and the method was validated by an addition and recovery test, in which the trueness varied from 87 to 115%. The bioaccessibility ranged between 28-56, 4-19, 68-76, 41-54, 48-57, and 1-21% for Cu, Fe, K, Mg, P, and Zn, respectively. The cooking methods promoted changes in the meat samples, thus affecting the bioaccessibility of the nutrients. Based on the recommended dietary intake (RDI) calculation, lamb meat can be considered a good Fe, P, and Zn source.

https://doi.org/10.21577/0103-5053.20210103 22 downloads

Synthesis of Antioxidant Additive from Safflower Seed Oil
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Vieira, Maríthiza G.

; Batista, Lilian R.

; Muniz, Aline S.

; Lichston, Juliana E.

; Oliveira, Angelo R. S.

; César-Oliveira, Maria A. F.

; Antoniosi Filho, Nelson R.

Journal of the Brazilian Chemical Society

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Jan 2021, Volume 32 Nº 1 Páginas 40 - 46

Resumo: En | Texto: En | PDF: En

Several published studies have evaluated the problems associated with the utilization of biodiesel obtained from safflower (Carthamus tinctorius L.) oil due to the low oxidative stability, caused by the high content of unsaturated fatty acids. Thus, this study aimed at the extraction of safflower seed oil and its use as an unsaturation source to obtain a synthetic antioxidant. The synthesis of this phenolic additive was done by modifying its structure through the addition of hydroquinone to the unsaturation of the oil, by electrophilic substitution. It was investigated and confirmed that this reaction is promising for obtaining phenolic products, with high yields (83.5%). The product obtained in this research was evaluated as an antioxidant in commercial biodiesel by the Rancimat method, using 5000 ppm of the synthesized additive the induction period increased from 8 to 17 h (2.12 times). Therefore, this paper brought a positive response to the improvement of biodiesel oxidation stability that creates a possibility to increase the use and expansion of this fuel in the market, as utilization of the safflower seed as raw material for additives, bringing a new market for these seeds.

https://doi.org/10.21577/0103-5053.20200151 294 downloads

Use and misuse of biomarkers and the role of D-dimer and C-reactive protein in the management of COVID-19: A post-hoc analysis of a prospective cohort study
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Gonçalves, Fabio Augusto Rodrigues

; Besen, Bruno Adler Maccagnan Pinheiro

; Lima, Clarice Antunes de

; Corá, Aline Pivetta

; Pereira, Antônio José Rodrigues

; Perazzio, Sandro Félix

; Gouvea, Christiane Pereira

; Fonseca, Luiz Augusto Marcondes

; Trindade, Evelinda Marramon

; Sumita, Nairo Massakazu

; Duarte, Alberto José da Silva

; Lichtenstein, Arnaldo

; Bonfa, Eloisa

; Utiyama, Edivaldo M.

; Segurado, Aluisio C.

; Perondi, Beatriz

; Miethke-Morais, Anna

; Montal, Amanda C.

; Harima, Leila

; Fusco, Solange R. G.

; Silva, Marjorie F.

; Rocha, Marcelo C.

; Marcilio, Izabel

; Rios, Izabel Cristina

; Kawano, Fabiane Yumi Ogihara

; Jesus, Maria Amélia de

; Kallas, Ésper George

; Carmo, Carolina

; Tanaka, Clarice

; Souza, Heraldo Possolo de

; Marchini, Julio F. M.

; Carvalho, Carlos

; Ferreira, Juliana C.

; Levin, Anna Sara Shafferman

; Oliveira, Maura Salaroli

; Guimarães, Thaís

; Lázari, Carolina dos Santos

; Sabino, Ester

; Magri, Marcello M. C.

; Barros-Filho, Tarcisio E. P.

; Francisco, Maria Cristina Peres Braido

; Costa, Silvia F.

Clinics

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2021, Volume 76 elocation e3547

Resumo: En | Texto: En | PDF: En

OBJECTIVE: Coronavirus disease 2019 (COVID-19) is associated with high mortality among hospitalized patients and incurs high costs. Severe acute respiratory syndrome coronavirus 2 infection can trigger both inflammatory and thrombotic processes, and these complications can lead to a poorer prognosis. This study aimed to evaluate the association and temporal trends of D-dimer and C-reactive protein (CRP) levels with the incidence of venous thromboembolism (VTE), hospital mortality, and costs among inpatients with COVID-19. METHODS: Data were extracted from electronic patient records and laboratory databases. Crude and adjusted associations for age, sex, number of comorbidities, Sequential Organ Failure Assessment score at admission, and D-dimer or CRP logistic regression models were used to evaluate associations. RESULTS: Between March and June 2020, COVID-19 was documented in 3,254 inpatients. The D-dimer level ≥4,000 ng/mL fibrinogen equivalent unit (FEU) mortality odds ratio (OR) was 4.48 (adjusted OR: 1.97). The CRP level ≥220 mg/dL OR for death was 7.73 (adjusted OR: 3.93). The D-dimer level ≥4,000 ng/mL FEU VTE OR was 3.96 (adjusted OR: 3.26). The CRP level ≥220 mg/dL OR for VTE was 2.71 (adjusted OR: 1.92). All these analyses were statistically significant (p<0.001). Stratified hospital costs demonstrated a dose-response pattern. Adjusted D-dimer and CRP levels were associated with higher mortality and doubled hospital costs. In the first week, elevated D-dimer levels predicted VTE occurrence and systemic inflammatory harm, while CRP was a hospital mortality predictor. CONCLUSION: D-dimer and CRP levels were associated with higher hospital mortality and a higher incidence of VTE. D-dimer was more strongly associated with VTE, although its discriminative ability was poor, while CRP was a stronger predictor of hospital mortality. Their use outside the usual indications should not be modified and should be discouraged.

https://doi.org/10.6061/clinics/2021/e3547

Inclusion of industrial egg residue in the feed of laying hens to replace limestone: digestibility, productive performance and egg quality
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BARRETA, MAURICIO

; BOIAGO, MARCEL M.

; ZAMPAR, ALINE

; FORTUOSO, BRUNO F.

; GEBERT, ROGER R.

; ROSCAMP, EDUARDO

; OLIVEIRA, ROSILENE C.

; DALIANE, JÉSSICA D.

; KOLM, MARINDIA

; GALLI, GABRIELA M.

; SILVA, ALEKSANDRO S. DA

Anais da Academia Brasileira de Ciências

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2021, Volume 93 Nº 4 elocation e20190769

Resumo: En | Texto: En | PDF: En

Abstract Our objective was to determine whether inclusion of industrial egg residue (IER) in the diets of laying hens would replace calcitic limestone without interfering with productive efficiency, egg quality or digestibility. In a first study (Experiment I), we used 30% IER in the diets of laying hens and found that the apparent digestibility coefficients were 51.6%, 42.8%, 51.6% and 17.8% for dry matter, crude protein, calcium and phosphorus, respectively. In the second study (Experiment II), we compared a control diet containing calcitic limestone with four diets containing increasing levels of IER, in proportions of 25%, 50%, 75% and 100%. During the first cycle (day 1–28), there was no difference between treatments in terms of productive performance or egg quality. During the second production cycle (day 29–56), we observed less food consumption by birds that ingested the highest levels of IER (100% substitution) than in controls. During the third cycle (day 57–84), we found that the inclusion of IER negatively affected performance, particularly lower production numbers, lower egg mass and higher feed conversion. Finally, during the third cycle, chickens broke and ingested their eggs shortly after laying. We conclude that the use of industrial egg residue cannot replace limestone in the feed of commercial laying hens, because it reduces performance and affects egg quality.

https://doi.org/10.1590/0001-3765202120190769 93 downloads

10.

Synthesis, Antileishmanial Activity and Spin Labeling EPR Studies of Novel β-Carboline-Oxazoline and β-Carboline-Dihydrooxazine Derivatives
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Baréa, Paula

; Paula, Jéssica C. de

; Alonso, Laís

; Oliveira, Aline R. de

; Costa, Willian F. da

; Alonso, Antonio

; Nakamura, Celso V.

; Sarragiotto, Maria H.

Journal of the Brazilian Chemical Society

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Jun 2020, Volume 31 Nº 6 Páginas 1170 - 1185

Resumo: En | Texto: En | PDF: En

A series of novel 1-(substituted-phenyl)-3-(4,5-dihydro-1,3-oxazol-2-yl)-9H-β-carboline (8a-8i) and 1-(substituted-phenyl)-3-(5,6-dihydro-4H-1,3-oxazin-2-yl)-9H-β-carboline (9a-9h) derivatives, as well as their respective N-(chloroalkyl)-1-(substituted-phenyl)-9H-β-carboline-3-carboxamide precursors (6a-6i and 7a-7h), were synthesized and evaluated for their in vitro antileishmanial activity against promastigote and intracellular amastigote forms of Leishmania amazonensis. Compounds 8d, 8i, 9e and 9h exhibited significant activity for both promastigote and amastigote forms, with IC50 (50% inhibitory concentration) values ranging from 2.9 to 23.0 µM. In addition, spin label electron paramagnetic resonance (EPR) spectroscopy studies were carried out for the most active compounds against L. amazonensis promastigotes. The studies indicated that the tested compounds cause strong stiffness in the parasite plasma membrane and are capable of inducing internal metalloproteins oxidation of the parasite, resulting in their cross-linking to skeletal proteins. Compounds 8d and 8i produced the largest effect, showing that the presence of oxazoline group at C-3 of β-carboline nucleus is important for antileishmanial activity.

https://doi.org/10.21577/0103-5053.20200003 257 downloads

11.

Topical hydrogel containing Achyrocline satureioides oily extract (free and nanocapsule) has anti-inflammatory effects and thereby minimizes irritant contact dermatitis
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MACHADO, VANESSA S.

; CAMPONOGARA, CAMILA

; OLIVEIRA, SARA M.

; BALDISSERA, MATHEUS D.

; SAGRILLO, MICHELE R.

; GUNDEL, SAMANTA DA S.

; SILVA, ANA PAULA T. DA

; OURIQUE, ALINE F.

; KLEIN, BRUNA

; WAGNER, ROGER

; SANTOS, ROBERTO C.V.

; SILVA, ALEKSANDRO S. DA

Anais da Academia Brasileira de Ciências

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2020, Volume 92 Nº 4 elocation e20191066

Resumo: En | Texto: En | PDF: En

Abstract Inflammatory dermatoses are prevalent worldwide, with impacts on the quality of life of patients and their families. The aim of this study was to determine the anti-inflammatory effects of Achyrocline satureioides oily extracts and nanocapsules on the skin using a mouse model of irritant contact dermatitis induced by croton oil, and a skin inflammation model induced by ultraviolet B (UVB) radiation. The mice were treated with 15 mg/ear oily extract (HG-OLAS) or nanocapsules (HG-NCAS) of A. satureioides incorporated into Carbopol® 940 hydrogels. We found that HG-OLAS and HG-NCAS formulations reduced ear edema in croton oil-induced lesions with maximum inhibitions of 54±7% and 74±3%, respectively. HG-OLAS and HG-NCAS formulations decreased ear edema induced by UVB radiation (0.5 J/cm2), with maximum inhibitions of 68±6% and 76±2% compared to the UVB radiation group, respectively. HG-OLAS and HG-NCAS modulated myeloperoxidase (MPO) activity after croton oil induction. Furthermore, croton oil and UVB radiation for 6 and 24 h, respectively, stimulated polymorphonuclear cells infiltration. The topical treatments reduced inflammatory processes, as shown by histological analysis. Together, the data suggest that topical application of A. satureioides oily extracts and nanocapsules produced antiedematogenic and anti-inflammatory effects. They constitute a compelling alternative for treatment of skin injuries.

https://doi.org/10.1590/0001-3765202020191066 768 downloads

12.

Expression of Hsp60 and its cell location in Paracoccidioides brasiliensis
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Fernandes, Fabrício Freitas

; Pitangui, Nayla S.

; Peron, Gabriela

; Valim, Clarissa X. R.

; Mazucato, Vívian M.

; Oliveira, Aline F.

; Silva, Thiago A. da

; Roque-Barreira, Maria-Cristina

; Panunto-Castelo, Ademilson

Revista do Instituto de Medicina Tropical de São Paulo

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2020, Volume 62 elocation e29

Resumo: En | Texto: En | PDF: En

ABSTRACT Paracoccidioides species cause paracoccidioidomycosis (PCM), a systemic mycosis highly prevalent in Brazil. Therapy of PCM has some issues that make studies for new therapeutic and vaccine targets relevant, such as the P. brasiliensis 60-kDa-heat-shock protein (PbHsp60), an immunogenic antigen that induces protection in experimental mice infection. Here, we investigated the relative expression of mRNA for PbHsp60 in P. brasiliensis in the different morphotypes of P. brasiliensis and in morphological transition phases. In addition, antibodies to rPbHsp60 were produced and used to analyze the location of PbHsp60 in yeast and hyphae by electron microscopy. The analyses showed a substantial increase in the relative amounts of HSP60 mRNA in yeast when compared to mycelium and an intermediate expression in transitional forms. Regarding the cell location, immunoelectron microscopy analysis revealed that PbHsp60 is within the cell wall. These observations suggest that this protein may be involved in the maintenance of the cell wall integrity and the interaction with the host for colonization, infection and pathogenesis.

https://doi.org/10.1590/s1678-9946202062029 431 downloads

13.

Concomitance of Aids and cysticercosis in autopsies
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Cavellani, Camila L.

; Favarato, Grace Kelly N. A.

; Silva, Aline Cristina S.

; Oliveira, Lívia F.

; Faleiros, Ana Carolina G.

; Corrêa, Rosana Rosa M.

; Lino-Júnior, Ruy S.

; Teixeira, Vicente de Paula A.

Jornal Brasileiro de Patologia e Medicina Laboratorial

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Jun 2019, Volume 55 Nº 3 Páginas 305 - 314

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO O objetivo do presente trabalho foi relatar a concomitância entre cisticercose e síndrome da imunodeficiência adquirida (Aids) em pacientes autopsiados em um hospital escola de Minas Gerais, Brasil. É possível associar cisticercose e pacientes com Aids, mas eles podem ou não apresentar os sintomas, dependendo do seu estado imunológico. Por isso, é necessário que a cisticercose entre no rol de infecções oportunistas e que mais estudos sejam feitos para melhor compreensão dessa coinfecção.

ABSTRACT The objective of the present study was to report the concomitance of cysticercosis and acquired immunodeficiency syndrome (Aids) in autopsied patients at a school hospital in Minas Gerais State, Brazil. Cysticercosis can be seen in patients with Aids, who may or may not present symptoms according to their immunological state. Therefore, it is necessary that cysticercosis be included in the list of opportunistic infections, and that more studies be carried out for a better understanding of this coinfection.

RESUMEN El objetivo del presente trabajo es reportar la concomitancia entre cisticercosis y el síndrome de inmunodeficiencia adquirida (Sida) en pacientes sometidos a autopsia en un hospital universitario de Minas Gerais, Brasil. Es posible asociar cisticercosis y pacientes con Sida, pero ellos pueden presentar síntomas o no, según su situación inmunitaria. Por eso, se recomienda incluir la cisticercosis en la lista de infecciones oportunistas y realizar más estudios para mejorar la comprensión de esa coinfección.

https://doi.org/10.5935/1676-2444.20190025 1039 downloads

14.

Molecular detection of albinism gene in Brazilian buffalo herds (Bubalus bubalis)
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Bernardino, Pedro N.

; Martins, Aline F.A.

; Barbosa, José D.

; Schild, Ana L.

; Damé, Maria Cecília F.

; Borges, Alexandre S.

; Oliveira-Filho, José P.

Pesquisa Veterinária Brasileira

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Mar 2019, Volume 39 Nº 3 Páginas 175 - 178

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: O Albinismo é uma doença genética caracterizada pela deficiência na produção de melanina, o que torna os animais afetados mais susceptíveis a problemas cutâneos e influencia negativamente a criação destes animais. A mutação nonsense (c.1431G>A) no gene da tyrosinase já foi descrita como responsável pelo albinismo oculocutâneo em búfalos, entretanto estudos prévios sobre a prevalência dessa mutação ainda não foram realizados no Brasil. Portanto, o objetivo deste estudo foi avaliar a presença desta mutação em uma população de búfalos brasileiros. Foram genotipados 315 búfalos clinicamente normais, ou seja, sem o fenótipo albino evidente. Desses, 11 (3,5%) eram heterozigotos para a mutação (N/TYR) e os demais eram homozigotos selvagens (N/N). Este resultado demonstra que o alelo mutado para o albinismo em búfalo está presente no rebanho brasileiro e aponta a importância de estudos de prevalência de enfermidades hereditárias com o objetivo de prevenir a disseminação desses alelos mutados, minimizando os prejuízos.

ABSTRACT: Albinism is a genetic disease characterized by deficient melanin production making affected animals more susceptible to skin problems, negatively influencing production systems of the same. In buffalo, a nonsense mutation (c.1431G>A) in the tyrosinase gene was already described, which is responsible for the oculocutaneous albinism buffalo phenotype. However, prevalence studies have never been performed for this anomaly in Brazil. Therefore, the objective of this study was to investigate this mutation in buffalo herd in Brazil. Of the 315 buffalo tested with no albinism phenotype evident, 11 (3.5%) were heterozygous for the mutation and none were mutated homozygous, showing the existence of the albinism gene in buffalo production herds and proving the importance of prevalence studies for hereditary diseases in order to prevent the dissemination of these same genes and their negative productivity consequences.

https://doi.org/10.1590/1678-5150-pvb-6185 1578 downloads

15.

Robust volumetric models for supporting the management of secondary forest stands in the Southern Brazilian Atlantic Forest
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OLIVEIRA, LAIO Z.

; KLITZKE, ALINE R.

; FANTINI, ALFREDO C.

; ULLER, HEITOR F.

; CORREIA, JEAN

; VIBRANS, ALEXANDER C.

Anais da Academia Brasileira de Ciências

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Dez 2018, Volume 90 Nº 4 Páginas 3729 - 3744

Resumo: En | Texto: En | PDF: En

Abstract The majority of Atlantic Forest fragments in Southern Brazil are second-growth forests dominated by fast-growing species with considerable market-value timber. Nevertheless, volume prediction models are scarce, especially to estimate tree total volume (i.e., stem plus branches). This study approached the issue through the following aims: to fit and select stem and total volume models (generic and species-specific) using data from 288 harvested trees in a management operation, and to fit generic and species-specific bark factors. The power model embedding diameter at breast height (D) and tree stem or total height (H) presented the greatest prediction strength for both stem and total tree volume. Models including only D to predict total tree volume were similar to double-entry models regarding goodness-of-fit. Therefore, they may be useful in the context of subtropical closed-canopy forests, where the difficulty and uncertainty in H measurements are not trivial. Species-specific models fitted for Miconia cinnamomifolia (DC) Naudin. and Hyeronima alchorneoides Allemão surpassed generic models only for the former species. Nevertheless, the prediction improvement should offset the eventual extra efforts implied in the collection of reliable samples of these species. Finally, bark factors stood as a satisfactory tool for inside bark mean volume estimation.

https://doi.org/10.1590/0001-3765201820180111 852 downloads

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