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ABSTRACT The coronavirus pandemic brought an unprecedented disruption to society, with this, the impacts fostered by the crisis also extended to educational institutions. The aim of this study was to investigate whether higher education activities can be considered a stressor in a pandemic context. The sample consisted of 136 students with remote academic activities and 131 with suspended academic activities, who answered a sociodemographic questionnaire and an open question about the factors that have raised the level of stress in the months of April, May, June and July 2020. The textual corpus was processed with the aid of the Interface de R pour les Analyses Multidimensionnelles de Textes et de Questionnaires software. As a result, there were several stressors related or not related to academic activities for both groups, although the performance of digital academic activities has been pointed out with great frequency. Thus, digital academic activities are related to the level of stress among students.

RESUMEN La pandemia de coronavirus trajo una disrupción sin precedentes a la sociedad. Los impactos propiciados por la crisis se extendieron también a las instituciones educativas. El objetivo de este estudio fue investigar si las actividades de educación superior pueden considerarse un factor de estrés en un contexto de pandemia. La muestra estuvo conformada por 136 estudiantes con actividades académicas remotas y 131 con actividades académicas suspendidas, quienes respondieron un cuestionario sociodemográfico y una pregunta abierta acerca de los factores que han elevado el nivel de estrés en los meses de abril, mayo, junio y julio de 2020. El corpus textual se procesó con la ayuda del software Iramuteq. Como resultado, se presentaron varios factores estresantes relacionados o no con las actividades académicas para ambos grupos, aunque se ha señalado con gran frecuencia el desempeño de las actividades académicas digitales. Así, las actividades académicas digitales están relacionadas con el nivel de estrés de los estudiantes.

RESUMO A pandemia do coronavírus trouxe uma ruptura sem precedentes à sociedade, com isso, os impactos fomentados pela crise também se estenderam para as instituições de ensino. O objetivo deste trabalho foi investigar se as atividades de ensino superior podem ser consideradas um fator estressor no contexto pandêmico. A amostra foi constituída por 136 alunos com atividades acadêmicas remotas e 131 com atividades acadêmicas suspensas, os quais responderam um questionário sociodemográfico e uma pergunta aberta sobre os fatores que têm elevado o seu nível de estresse nos meses de abril, maio, junho e julho de 2020. Os corpora textuais foram processados com o auxílio do software Interface de R pour les Analyses Multidimensionnelles de Textes et de Questionnaires. Como resultados, observaram-se diversos fatores estressores relacionados ou não com as atividades acadêmicas para ambos os grupos, embora a realização de atividades acadêmicas digitais tenha sido apontada com grande frequência. Assim, as atividades acadêmicas digitais estão relacionadas com o nível de estresse entre os alunos.

https://doi.org/10.1590/s1413-24782023280006

Post-acute COVID-19 in three doses vaccinated autoimmune rheumatic diseases patients: frequency and pattern of this condition
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Silva, Clovis Artur

; Kupa, Leonard de Vinci Kanda

; Medeiros-Ribeiro, Ana Cristina

; Pasoto, Sandra Gofinet

; Saad, Carla Gonçalves Schahin

; Yuki, Emily Figueiredo Neves

; Landim, Joaquim Ivo Vasques Dantas

; Léda, Victor Hugo Ferreira e

; Correia, Luisa Sacchi de Camargo

; Sartori, Artur Fonseca

; Martins, Carolina Campagnoli Machado Freire

; Ribeiro, Carolina Torres

; Waridel, Filipe

; Martins, Victor Adriano de Oliveira

; Shinjo, Samuel Katsuyuki

; Andrade, Danieli Castro Oliveira

; Sampaio-Barros, Percival Degrava

; Borba Neto, Eduardo Ferreira

; Aikawa, Nadia Emi

; Bonfa, Eloisa

Advances in Rheumatology

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2023, Volume 63 elocation 26

Resumo: En | Texto: En | PDF: En

Abstract Background Data on post-acute COVID-19 in autoimmune rheumatic diseases (ARD) are scarce, focusing on a single disease, with variable definitions of this condition and time of vaccination. The aim of this study was to evaluate the frequency and pattern of post-acute COVID-19 in vaccinated patients with ARD using established diagnosis criteria. Methods Retrospective evaluation of a prospective cohort of 108 ARD patients and 32 non-ARD controls, diagnosed with SARS-CoV-2 infection (RT-PCR/antigen test) after the third dose of the CoronaVac vaccine. Post-acute COVID-19 (≥ 4 weeks and > 12 weeks of SARS-CoV-2 symptoms) were registered according to the established international criteria. Results ARD patients and non-ARD controls, balanced for age and sex, had high and comparable frequencies of ≥ 4 weeks post-acute COVID-19 (58.3% vs. 53.1%, p = 0.6854) and > 12 weeks post-acute COVID-19 (39.8% vs. 46.9%, p = 0.5419). Regarding ≥ 4 weeks post-acute COVID-19, frequencies of ≥ 3 symptoms were similar in ARD and non-ARD controls (54% vs. 41.2%, p = 0.7886), and this was also similar in > 12 weeks post-acute COVID-19 (68.3% vs. 88.2%, p = 0.1322). Further analysis of the risk factors for ≥ 4 weeks post-acute COVID-19 in ARD patients revealed that age, sex, clinical severity of COVID-19, reinfection, and autoimmune diseases were not associated with this condition (p > 0.05). The clinical manifestations of post-acute COVID-19 were similar in both groups (p > 0.05), with fatigue and memory loss being the most frequent manifestations. Conclusion We provide novel data demonstrating that immune/inflammatory ARD disturbances after third dose vaccination do not seem to be a major determinant of post-acute COVID-19 since its pattern is very similar to that of the general population. Clinical Trials platform (NCT04754698).

https://doi.org/10.1186/s42358-023-00309-z

Análise de Redes Sociais dos Artigos sobre Educação de Jovens e Adultos Publicados nos Últimos Vinte Anos do Boletim de Educação Matemática
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Braga, Eduardo dos Santos de Oliveira

; Pereira, Marcus Vinicius

; Rôças, Giselle

Bolema: Boletim de Educação Matemática

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Dez 2022, Volume 36 Nº 74 Páginas 1023 - 1043

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Refletir sobre a Educação de Jovens e Adultos (EJA) na Educação Matemática é cada vez mais urgente como forma de luta e reivindicação dos direitos que historicamente foram negados aos sujeitos dessa modalidade de ensino. Este artigo tem por objetivo mapear as produções acadêmicas publicadas na Revista Boletim de Educação Matemática (Bolema) nas últimas duas décadas (2000-2020) sobre EJA. Para isso, respaldados na metodologia do tipo estado do conhecimento, foram construídas redes de palavras-chave e das referências utilizadas por cada artigo selecionado. Os dados foram organizados e inseridos no software NodeXL Basic para a construção de redes, cuja análise permitiu verificar, dentre outros aspectos, as relações exercidas pelas palavras-chave utilizadas nos 12 artigos catalogados, identificar os aspectos teóricos privilegiados pelas pesquisas e os autores que exercem maior relevância no fluxo de informações sobre o tema. A Etnomatemática e a Modelagem Matemática são ações que dinamizaram reflexões nas pesquisas e os autores que se destacaram são Freire e Skovsmose. Apesar de tímida a produção do tema no periódico analisado, foi possível traçar considerações a respeito de três categorias que emergiram de nossa análise: práticas de sala de aula na EJA, produção de materiais didáticos na/para a EJA e currículo de Matemática na EJA, o que também demonstra os assuntos de destaque das produções.

Abstract Reflection on Youth and Adult Education (YAE) in Mathematics Education is increasingly urgent as a struggle and claim for rights that have historically been denied to YEA students. Thus, this article aims to map the academic productions published in the Mathematics Education Bulletin (Bolema) in the last two decades (2000-2020) on YAE. With the support of the state of knowledge methodology, we built keywords and reference networks used by each cataloged article. Data were organized and entered into the basic NodeXL software for building networks. The analysis allowed us to verify, among other aspects, the relationships exerted by the keywords used in the 12 cataloged articles, in order to identify the theoretical aspects used by researchers and authors that exert greater relevance in the flow of information on the subject. Ethnomathematics and Mathematical Modeling are actions that stimulated research reflections and the authors who stood out are Freire and Skovsmose. Despite the small production of the topic in the analyzed periodical, it was possible to draw considerations on three categories that emerged from our analysis: classroom practices in the production of teaching materials in YAE and mathematics curriculum in YAE; which demonstrates the issues highlighted in the productions.

https://doi.org/10.1590/1980-4415v36n74a04

Impact of the COVID-19 pandemic on compulsory notification of meningitis during the first wave of the pandemic in Brazil: an ecological study using P-score
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Rocha, Carlos Alberto de Oliveira

; Santana, Gibson Barros de Almeida

; Leal, Thiago Cavalcanti

; Paiva, João Paulo Silva de

; Silva, Leonardo Feitosa da

; Santos, Lucas Gomes

; Nunes, Bruno Eduardo Basto Rolim

; Carmo, Rodrigo Feliciano do

; Souza, Carlos Dornels Freire de

Sao Paulo Medical Journal

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Fev 2022, Volume 140 Nº 2 Páginas 305 - 309

Resumo: En | Texto: En | PDF: En

Abstract BACKGROUND: Meningitis is listed as one of the diseases requiring compulsory notification in Brazil. It can affect all age groups and also has no seasonality. Cases can be recorded in all months of the year and in all states of Brazil. Despite its importance, the obligation of immediate notification may have been compromised by the coronavirus disease 2019 (COVID-19) pandemic. OBJECTIVE: To analyze the immediate impact of the COVID-19 pandemic on compulsory notifications of meningitis in Brazil and its states during the first wave of the pandemic. DESIGN AND SETTING: This was an ecological study involving all confirmed cases of meningitis in Brazil, in its regions and in its states. METHODS: Data for the months from 2015 to 2020 were obtained from the database of the Notifiable Diseases Information System (Sistema de Informação de Agravos de Notificação, SINAN), in the Department of Informatics of the National Health System (Departamento de Informática do Sistema Único de Saúde, DATASUS). The P-score was used to obtain the percentage change in the numbers of cases reported in 2020. RESULTS: A 45.7% reduction in notifications of meningitis in Brazil was observed. Regarding the regions and the states, with the exception of Roraima, all of them showed a negative P-score, with decreasing curves each month. CONCLUSION: The pandemic caused a negative impact on meningitis notifications in Brazil.

https://doi.org/10.1590/1516-3180.2021.0732.15092021

Diretriz de Miocardites da Sociedade Brasileira de Cardiologia – 2022
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Montera, Marcelo Westerlund

; Marcondes-Braga, Fabiana G.

; Simões, Marcus Vinícius

; Moura, Lídia Ana Zytynski

; Fernandes, Fabio

; Mangine, Sandrigo

; Oliveira Júnior, Amarino Carvalho de

; Souza, Aurea Lucia Alves de Azevedo Grippa de

; Ianni, Bárbara Maria

; Rochitte, Carlos Eduardo

; Mesquita, Claudio Tinoco

; de Azevedo Filho, Clerio F.

; Freitas, Dhayn Cassi de Almeida

; Melo, Dirceu Thiago Pessoa de

; Bocchi, Edimar Alcides

; Horowitz, Estela Suzana Kleiman

; Mesquita, Evandro Tinoco

; Oliveira, Guilherme H.

; Villacorta, Humberto

; Rossi Neto, João Manoel

; Barbosa, João Marcos Bemfica

; Figueiredo Neto, José Albuquerque de

; Luiz, Louise Freire

; Hajjar, Ludhmila Abrahão

; Beck-da-Silva, Luis

; Campos, Luiz Antonio de Almeida

; Danzmann, Luiz Cláudio

; Bittencourt, Marcelo Imbroinise

; Garcia, Marcelo Iorio

; Avila, Monica Samuel

; Clausell, Nadine Oliveira

; Oliveira Jr, Nilson Araujo de

; Silvestre, Odilson Marcos

; Souza, Olga Ferreira de

; Mourilhe-Rocha, Ricardo

; Kalil Filho, Roberto

; Al-Kindi, Sadeer G.

; Rassi, Salvador

; Alves, Silvia Marinho Martins

; Ferreira, Silvia Moreira Ayub

; Rizk, Stéphanie Itala

; Mattos, Tiago Azevedo Costa

; Barzilai, Vitor

; Martins, Wolney de Andrade

; Schultheiss, Heinz-Peter

Arquivos Brasileiros de Cardiologia

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2022, Volume 119 Nº 1 Páginas 143 - 211

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20220412

A single session of low-volume high-intensity interval and moderate-intensity continuous exercise elicits a transient reduction in ghrelin levels, but not in post-exercise energy intake in obese men
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Matos, Victor Araújo Ferreira

; Souza, Daniel Costa de

; Browne, Rodrigo Alberto Vieira

; Santos, Victor Oliveira Albuquerque dos

; Medeiros, Ítalo Freire

; Nascimento, Paulo Ricardo Porfírio do

; Costa, Eduardo Caldas

; Fayh, Ana Paula Trussardi

Archives of Endocrinology and Metabolism

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Fev 2021, Volume 65 Nº 1 Páginas 98 - 104

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: This study investigated the acute effects of high-intensity interval (HIIE) and moderate-intensity continuous (MICE) exercise on ghrelin levels in obese men. Subjects and methods: A total of 10 obese men (age 27.6 ± 1.8 years, body mass index 35.4 ± 4.5 kg/m², body fat 39.9 ± 2.1%) performed two exercise sessions in a randomized order: HIIE (10 × 1 min intervals at 90% of the maximal heart rate [HRmax] interspersed by 1 min of active recovery) and MICE (20 min at 70% of the HRmax). Ghrelin levels were assessed pre-, post- and 1h post-exercise, and energy intake was assessed 1h post-exercise through an ad libitum meal. Results: HIIE and MICE showed a trend to decrease ghrelin levels immediately post-exercise (-14.1 ± 21.6% and −9.6 ± 23.8%, respectively, p = 0.07) and decreased 1h post-exercise (-12.7 ± 31.8% and −13.8 ± 21.7%, respectively, p < 0.05). No changes were observed for post-exercise energy intake (p > 0.05). There was a positive correlation between the change in ghrelin levels and post-exercise energy intake only for HIIE (r = 0.63, p = 0.05). Conclusion: In summary, a single session of HIIE and MICE elicits a reduction on ghrelin levels without changing post-exercise energy intake in obese men.

https://doi.org/10.20945/2359-3997000000308 281 downloads

COVID-19 presenting as persistent hiccups: a case report
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Sene, Diogo Ribeiro de

; Watashi, Diego Moreno

; Bilitardo, Isabella de Oliveira

; Moreno, Carlos Eduardo Campos

; Moreno, Mariella Freire de Freitas

Revista do Instituto de Medicina Tropical de São Paulo

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2021, Volume 63 elocation e62

Resumo: En | Texto: En | PDF: En

ABSTRACT Hiccups are involuntary, spasmodic contractions of the diaphragm and intercostal muscles and can be classified as acute (< 48 h), persistent (48 h to a month) or intractable (> 1 month). A previously healthy 29-year-old man sought the Emergency Department with flu-like symptoms and a two-day history of persistent hiccups. His physical examination was otherwise unremarkable and vital signs were within normal limits. An unenhanced computed tomography scan of the chest showed small focal ground-glass opacities scattered throughout 25% of the lungs. A COVID-19 test was positive. Chlorpromazine was prescribed for the hiccups with improvement over 10 h. The patient was discharged home on the same day without hiccups and no other complications.

https://doi.org/10.1590/s1678-9946202163062 3 downloads

Justificativa e delineamento do estudo “Tocilizumabe em pacientes com COVID-19 moderado a grave: estudo aberto, multicêntrico, randomizado, controlado” (TOCIBRAS)
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Farias, Danielle Leão Cordeiro de

; Prats, João

; Cavalcanti, Alexandre Biasi

; Rosa, Regis Goulart

; Machado, Flávia Ribeiro

; Berwanger, Otávio

; Azevedo, Luciano César Pontes de

; Lopes, Renato Delascio

; Avezum, Álvaro

; Kawano-Dourado, Leticia

; Damiani, Lucas Petri

; Rojas, Salomón Soriano Ordinola

; Oliveira, Cleyton Zanardo de

; Andrade, Luis Eduardo Coelho

; Sandes, Alex Freire

; Pintão, Maria Carolina

; Castro Júnior, Claudio Galvão de

; Scheinberg, Phillip

; Veiga, Viviane Cordeiro

Revista Brasileira de Terapia Intensiva

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Set 2020, Volume 32 Nº 3 Páginas 337 - 347

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: Os marcadores pró-inflamatórios desempenham papel importante na severidade de pacientes com COVID-19. Assim, terapêuticas anti-inflamatórias são agentes interessantes para potencialmente combater a cascata inflamatória descontrolada em tais pacientes. Delineamos um ensaio para testar tocilizumabe em comparação com o tratamento padrão, tendo como objetivo melhorar os desfechos por meio da inibição da interleucina 6, um importante mediador inflamatório na COVID-19. Métodos e análises: Este será um estudo aberto multicêntrico, randomizado e controlado, que comparará os desfechos de pacientes tratados com tocilizumabe mais tratamento padrão com o tratamento padrão isoladamente em pacientes com COVID-19 moderada a grave. Como critérios de inclusão, serão exigidos dois dos quatro critérios a seguir: dosagens de dímero D acima de 1.000ng/mL, proteína C-reativa acima de 5mg/dL, ferritina acima de 300mg/dL e desidrogenase lática acima do limite superior do normal. O objetivo primário será comparar a condição clínica no dia 15, conforme avaliação por meio de escala ordinal de 7 pontos aplicada nos estudos de COVID-19 em todo o mundo. O desfecho primário será avaliado por regressão logística ordinal assumindo razões de propensão proporcionais ajustadas pelas variáveis de estratificação (idade e sexo). Ética e disseminação: O TOCIBRAS foi aprovado pelos comitês de ética locais e central (nacional) do Brasil em conformidade com as atuais diretrizes e orientações nacionais e internacionais. Cada centro participante obteve aprovação do estudo por parte de seu comitê de ética em pesquisa, antes de iniciar as inscrições no protocolo. Os dados derivados deste ensaio serão publicados independentemente de seus resultados. Se tiver sua efetividade comprovada, esta estratégia terapêutica poderá aliviar as consequências da resposta inflamatória na COVID-19 e melhorar os resultados clínicos.

ABSTRACT Introduction: Pro-inflammatory markers play a significant role in the disease severity of patients with COVID-19. Thus, anti-inflammatory therapies are attractive agents for potentially combating the uncontrolled inflammatory cascade in these patients. We designed a trial testing tocilizumab versus standard of care intending to improve the outcomes by inhibiting interleukin-6, an important inflammatory mediator in COVID-19. Methods and analysis: This open-label multicentre randomized controlled trial will compare clinical outcomes of tocilizumab plus standard of care versus standard of care alone in patients with moderate to severe COVID-19. Two of the following four criteria are required for protocol enrolment: D-dimer > 1,000ng/mL; C reactive protein > 5mg/dL, ferritin > 300mg/dL, and lactate dehydrogenase > upper limit of normal. The primary objective will be to compare the clinical status on day 15, as measured by a 7-point ordinal scale applied in COVID-19 trials worldwide. The primary endpoint will be assessed by an ordinal logistic regression assuming proportional odds ratios adjusted for stratification variables (age and sex). Ethics and dissemination: The TOCIBRAS protocol was approved by local and central (national) ethical committees in Brazil following current national and international guidelines/directives. Each participating center had the study protocol approved by their institutional review boards before initiating protocol enrolment. The data derived from this trial will be published regardless of the results. If proven active, this strategy could alleviate the consequences of the inflammatory response in COVID-19 patients and improve their clinical outcomes.

https://doi.org/10.5935/0103-507x.20200060 1910 downloads

Rabies in Callithrix sp. in the urban area of Niterói, Rio de Janeiro, Brazil
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Moutinho, Flavio Fernando Batista

; Andrade, Marcela Garcia Araújo de

; Nunes, Viviane Moura Azevedo

; Rubião, Eduardo Cárdenas Nogueira

; Batista, Helena Beatriz de Carvalho Ruthner

; Romijn, Phyllis Catharina

; Cattaneo, Carlos Alberto

; Oliveira, Fernando Guilherme de

; Oliveira, Rafael de Novaes

; Marcanth, Nairedisa

; Silvestre, Leilane Gorga Gaspar Ruas

; Borges, Fábio Villas Boas

; Bruno, Sávio Freire

Revista da Sociedade Brasileira de Medicina Tropical

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2020, Volume 53 elocation e20190402

Resumo: En | Texto: En | PDF: En

Abstract In Brazil, rabies occurs mainly within an urban cycle, in which dogs and bats are reservoirs. This paper aims to report the occurrence of rabies in Callithrix sp. in Niterói, Rio de Janeiro, Brazil. In June 2019 a hybrid specimen was referred for diagnosis. The Direct Fluorescent Antibody, Mouse Inoculation, and Polymerase Chain Reaction tests were positive. A phylogenetic analysis was compatible with antigenic variant 3, characteristic of Desmodus rotundus. New studies should be undertaken to elucidate the real role of callitrichids in the urban rabies cycle.

https://doi.org/10.1590/0037-8682-0402-2019 532 downloads

10.

Cover cropping system and mulching can shape soil microbial status in fruit orchards
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Cruz, Andre Freire

; Pires, Marcio de Carvalho

; Nascimento, Lennon Kaique Beda do

; Ramos, Maria Lucrecia Gerosa

; Oliveira, Sebastiao Alberto

; Blum, Luiz Eduardo Bassay

; Yamanishi, Osvaldo Kiyoshi

Scientia Agricola

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2020, Volume 77 Nº 4 elocation e20180316

Resumo: En | Texto: En | PDF: En

ABSTRACT The use of cover crop in agricultural fields has been well elucidated, especially regarding nitrogen fixation from legume crops and their function as weed protection. Furthermore, to cover crops can benefit the soil microbial community. This study aimed to evaluate and compare the benefits of mulching and cover cropping systems on soil microbial growth and activity, and their effects on plant mineral nutrition in pomelo (Citrus maxima ) and macadamia ( Macadamia integrifolia ) orchards. The treatments included: 1) control [Glyphosate herbicide (Roundup at 4 l per ha)], 2) manual weed control, 3) mulching with dead leaves from their respective trees (macadamia and pomelo), 4) millet, 5) faba bean, 6) millet + faba bean. All the treatments were applied for 120 days before soil and plant leaves were sampled for analyses. Plant mineral nutrition, soil microbial biomass C (MBC) and soil microbial biomass N (MBN); basal respiration (BRA), arbuscular mycorrhizal fungi (AMF) colonization (COL); number of AMF spores (SPO) in soil; total organic carbon (TOC) and total nitrogen (TN) were evaluated. Plant nutrition was not altered by the treatments; however, the MBC, COL and SPO markedly increased in response to mulching and faba bean + millet treatments. Especially in macadamia soils, these treatments had a great response to soil microbiology. Significant negative correlations were also detected for the COL, SPO, BRA and TOC with the Nutrient Balance Index (NBI). These results indicate that in short-term the cover cropping system is useful to improve the soil microbial growth and AMF formation in soils of pomelo and macadam orchards.

https://doi.org/10.1590/1678-992x-2018-0316 1413 downloads

11.

Nasal Polyposis: More than a Chronic Inflammatory Disorder-A Disease of Mechanical Dysfunction- The São Paulo Position
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Pezato, Rogerio

; Voegels, Richard Louis

; Pignatari, Shirley

; Gregório, Luiz Carlos

; Bezerra, Thiago Freire Pinto

; Gregorio, Luciano

; Balsalobre, Leonardo

; Tepedino, Miguel Soares

; Coronel, Nathália

; Pinna, Fabio de Rezende

; Mendes Neto, José

; Oliveira, Pedro

; Macoto, Eduardo

; Stefanini, Renato

; Figueiredo, Claudia

; Haddad, Fernanda

; Pilan, Renata

; Soter, Ana Bezerra

; Melo, Nelson Almeida

; Candido, Danilo Almeida

; Amaral, Jonatas do

; Santos, Rodrigo de Paula

; Zele, Thibaut Van

; Fujita, Reginaldo

; Dreyfuss, Juliana L.

; Chamon, Wallace

; Alencar, Adriano Mesquita

; Perez-Novo, Claudina

; Stamm, Aldo Cassol

International Archives of Otorhinolaryngology

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Jun 2019, Volume 23 Nº 2 Páginas 241 - 249

Resumo: En | Texto: En | PDF: En

Abstract Introduction The importance of our study lies in the fact that we have demonstrated the occurrence ofmechanical dysfunction within polypoid tissues, which promotes the development of polyps in the nasal cavity. Objective To change the paradigm of nasal polyposis (NP). In this new conception, the chronic nasal inflammatory process that occurs in response to allergies, to pollution, to changes in the epithelial barrier, or to other factors is merely the trigger of the development of the disease in individuals with a genetic predisposition to an abnormal tissue remodeling process, which leads to a derangement of the mechanical properties of the nasal mucosa and, consequently, allows it to grow unchecked. Data Synthesis We propose a fundamentally new approach to intervening in the pathological process of NP, addressing biomechanical properties, fluid dynamics, and the concept of surface tension. Conclusion The incorporation of biomechanical knowledge into our understanding of NP provides a new perspective to help elucidate the physiology and the pathology of nasal polyps, and new avenues for the treatment and cure of NP.

https://doi.org/10.1055/s-0038-1676659 601 downloads

12.

A Saúde bucal está associada à presença de sintomas depressivos em idosos?
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Silva, Alexandre Emidio Ribeiro

; Kunrath, Isabelle

; Danigno, Julia Freire

; Cascaes, Andreia Morales

; Castilhos, Eduardo Dickie de

; Langlois, Caroline de Oliveira

; Demarco, Flavio Fernando

Ciência & Saúde Coletiva

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Jan 2019, Volume 24 Nº 1 Páginas 181 - 188

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O objetivo do estudo foi descrever a prevalência de sintomas depressivos medidos por meio da Escala de Depressão Geriátrica–EDG - 15 e testar a associação de variáveis de saúde bucal com sintomas depressivos em uma população de idosos vinculados a onze unidades de saúde da família do Sul do Brasil. Estudo transversal com 439 idosos. Foi utilizado questionário padronizado para a obtenção das variáveis socioeconômicas e de saúde bucal. As variáveis clínicas de saúde bucal foram obtidas por um dentista treinado. Os sintomas depressivos desfecho do estudo foram obtidos por meio da Escala de Depressão Geriátrica–EDG - 15. A prevalência dos sintomas depressivos foi de 18,3% (IC95% 14,6-21,8). Analisando as variáveis de exposição e os sintomas depressivos, por meio da análise regressão de Poisson ajustada, os indivíduos com 1 a 9 dentes (RP = 1,68; IC95%1,06-2,64, p = 0,012), com percepção de boca seca (RP = 2,23; IC95%1,52-3,28, p < 0,001) e de dor na boca (RP = 2,11; IC95% 1,10-4,07, p = 0,036) tiveram maiores prevalências de sintomas depressivos. O estudo identificou uma prevalência importante de sintomas depressivos e que as variáveis de saúde bucal estão associadas à presença dos mesmos na população idosa.

Abstract The scope of this study was to describe the prevalence of depressive symptoms measured by the Geriatric Depression Scale–EDG - 15 and test the association of oral health variables and depressive symptoms in a population of the elderly linked to eleven Family Health Units in the south of Brazil. It involved a cross-sectional study with 439 elderly individuals. A standardized questionnaire was used to obtain socio-economic and oral health variables of the study. The clinical variables of oral health were obtained by a qualified dentist. The symptoms of depression, which was the scope of the study, were obtained by the Geriatric Depression Scale–EDG −15. The prevalence of depressive symptoms was 18.3% (CI95% 14.6-21.8). Analyzing the exposure variables and depressive symptoms through adjusted Poisson regression analysis, individuals with 1 to 9 teeth (PR = 1.68; CI95% 1.06-2.64, p = 0.012), with a perception of dry mouth (PR = 2.23; CI95% 1.52-3.28, p < 0.001) and perception of pain in the mouth (PR = 2.11; CI95% 1.10-4.07, p = 0.036) have a higher prevalence of depressive symptoms. The study identified a significant prevalence of depressive symptoms and that oral health variables are associated with the presence of depressive symptoms in the elderly population.

https://doi.org/10.1590/1413-81232018241.12662017 2637 downloads

13.

Fibrosis: a distinguishing feature in the pathology of neural leprosy
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Antunes, Sérgio Luiz Gomes

; Jardim, Márcia Rodrigues

; Vital, Robson Teixeira

; Pascarelli, Bernardo Miguel de Oliveira

; Nery, José Augusto da Costa

; Amadeu, Thaís Porto

; Sales, Anna Maria

; da Costa, Eduardo Alves Freire

; Sarno, Euzenir Nunes

Memórias do Instituto Oswaldo Cruz

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2019, Volume 114 elocation e190056

Resumo: En | Texto: En | PDF: En

BACKGROUND Fibrosis in the peripheral nerve is the end stage of leprous neuropathy and the cause of the resulting permanent neural function impairments. Preventive measures to avoid this irreversible pathological state are a relief strategy for leprosy sufferers. OBJECTIVES The present study describes the frequency of fibrosis along with its characterisation and pathogenic development. METHODS Six-hundred-and-thirteen nerve samples were sorted from 278 neural leprosy (NL) and 335 non-leprosy neuropathy patients (ON). The total number of samples was histologically examined by routine staining methods (haematoxylin-eosin, Wade staining and Gomori’s trichrome) and fibrosis was evaluated via semi-quantitative estimation. FINDINGS Fibrosis was most frequent in the NL group (33% against 0.4% in ON) while fibrosis in association with endoneurial microfasciculation was found in 38 (41.3%) of the NL samples in the examination of semithin sections. Pericytic activation in the perivascular environment was confirmed to be the source of the fibroblasts and perineurial cells delimiting microfascicles. End-stage fibrosis in leprosy displays an arrangement of microfascicles devoid of neural components (i.e., Schwann cells and axons) lined by an intermediate phenotype of fibroblastic-perineurial cells filled with bundles of collagen fibres. MAIN CONCLUSIONS The present study underscores that fibrosis is frequently the severe end stage of neural leprosy NL pathogeny after analysing the notably distinct development of fibrosis within the neural environment.

https://doi.org/10.1590/0074-02760190056 957 downloads

14.

A Saúde bucal está associada à presença de sintomas depressivos em idosos?
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Silva, Alexandre Emidio Ribeiro

; Kunrath, Isabelle

; Danigno, Julia Freire

; Cascaes, Andreia Morales

; Castilhos, Eduardo Dickie de

; Langlois, Caroline de Oliveira

; Demarco, Flavio Fernando

Ciência & Saúde Coletiva

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2019, Volume 24 Nº 1 Páginas 181 - 188

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232018241.12662017 4 downloads

15.

Study the spatial variability of the noise levels inside two commercial poultry housing with different adiabatic evaporative cooling systems
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Alves Damasceno, Flavio

; Araújo e Silva Ferraz, Gabriel

; Alves Oliveira, Carlos Eduardo

; Osorio-Saraz, Jairo Alexander

; Freire Brandão, Leidimar

DYNA

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Dez 2018, Volume 85 Nº 207 Páginas 9 - 15

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen El objetivo del presente trabajo fue determinar la distribución espacial de los niveles de ruido en el interior de dos instalaciones avicolas comerciales que tienen diferentes sistemas de enfriamiento evaporativo adiabatico, durante el ciclo de vida de las aves. El nivel de ruido se evaluó mediante un medidor de nivel de sonido digital. Los datos fueron medidos manualmente en cada punto en seis secciones predeterminadas, para un total de 36 puntos. Los mapas de distribución espacial de ruido fueron generados para el interior de cada instalación animal, utilizando la técnica geoestadística a través de análisis de semi variograma e interpolación por "kriging" ordinario. Se concluyó de manera general que las aves estuvieron sometidas a niveles de ruido por encima de 62,0 dBA, y durante el período de limpieza y desinfección (período de descontaminación) las instalaciones estuvieron aproximadamente a 35,0 dBA. El perfil espacial de losniveles de ruido en el entorno productivo logra proporcionar una información más detallada acerca del sistema estudiado.

Abstract The objective of the present work was to determinate the map the spatial distribution of noise levels inside two commercial poultry housing having different adiabatic evaporative cooling systems, during the life cycle of birds. The noise level was assessed by a digital sound level meter. The data were measured manually at each point in six predetermined sections, totaling 36 points. Spatial distribution maps of noise were generated for the inside of each animal facility, using geostatistics technique through semivariogram analysis and interpolation by ordinary kriging. It concludes that the birds were, in general, subjected to noise levels above 62.0 dBA and during clean and disinfect (decontamination period) the sheds were at approximately 35.0 dBA. The spatial profile of the noise level to the productive environment provide for the attainment of more detailed information about the studied system.

https://doi.org/10.15446/dyna.v85n207.59724 232 downloads

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