Abstract The cryopreservation reduces ram sperm quality, decreasing the pregnancy rate of ewes inseminated with thawed sperm. Hence, we aimed to improve the post-thaw quality of ram sperm replacing egg yolk on Tris-Glucose extender with different concentrations of LDL (2 or 8%), associated with the addition of 10 mM non-enzymatic antioxidants (ascorbic acid, hydroxytoluene butylate, ascorbyl palmitate, and trehalose). Semen samples were collected from six rams, split into different treatments, and frozen. After thawing, kinematic (CASA), structural (propidium iodide and carboxyfluorescein diacetate) and functional (hypoosmotic test) sperm membrane integrity was assessed. Total motility, VCL, and LIN were also assessed in thawed samples during 3 h of incubation (38 °C). The results showed that hydroxytoluene butylate at 10 mM in Tris-Glucose extender with 8% LDL improved velocity parameters immediately post-thaw compared with Tris-Glucose egg yolk extender, as well as prevented the reduction of total motility and VCL after incubation. There was no benefit of adding ascorbic acid and trehalose. Moreover, for the first time, it was shown the motility impairment promoted by ascorbyl palmitate to ram sperm.

Abstract Doxorubicin (Dox) is a medication used in the treatment of cancerous tumors and hematologic malignancies with potentially serious side effects, including the risk of cardiotoxicity. Flavonoids are plant metabolites with antioxidant properties and can be extracted from Camellia sinensis (CS). The aim of this study is to evaluate the possible cardioprotective effect of CS against injuries induced by Dox in rats. A total of 32 animals were distributed into four groups: (1) control - intraperitoneal injection (I.P.) of 0.5 mL saline weekly and 1.0 mL water by gavage daily; (2) CS - 0.5 mL saline I.P. weekly and 200 mg/kg CS by gavage daily; (3) Dox - 5.0 mg/kg Dox I.P. weekly and 1.0 mL water by gavage daily; and (4) Dox+CS -5.0 mg/kg Dox I.P. weekly and 200 mg/kg CS by gavage daily. Clinical examinations, blood profiles, electrocardiograms, echocardiograms, and histological analyses of hearts were performed over 25 days. The animals in the Dox group showed changes in body weight and in erythrogram, leukogram, electrocardiography, and echocardiography readings. However, animals from the dox+CS group had significantly less change in body weight, improved cardiac function, and showed more preserved cardiac tissue. This study demonstrated that CS prevents dox-induced cardiotoxicity, despite enhancing the cytotoxic effect on blood cells.

RESUMO Objetivo: realizar a tradução e a adaptação transcultural do Risk assessment and management of exposure of healthcare workers in the context of COVID-19. Método: trata-se de estudo metodológico. Foram seguidas as etapas de tradução, retrotradução, síntese, avaliação por comitê de juízes e pré-teste. Os participantes foram convidados por meio eletrônico e responderam um formulário on-line. Os dados foram coletados entre junho e setembro de 2020. A validação de conteúdo pelo comitê de juízes foi verificada por meio do índice de validade de conteúdo. Os participantes do pré-teste avaliaram a aplicabilidade do instrumento por meio do questionário “Avaliação da Praticabilidade de Instrumentos”. Resultados: participaram do estudo quatro tradutores, oito avaliadores no comitê de juízes e 35 profissionais responderam ao pré-teste. As modificações sugeridas pelo comitê de juízes foram acatadas e o consenso atingido em duas avaliações, obtendo índice de validade de conteúdo superior a 0,80 para todos os itens do instrumento. A versão pré-teste apresentou boa aplicabilidade e confiabilidade satisfatória (0,76). Conclusão: o instrumento foi adaptado para uso no Brasil, o que permitirá a comparação internacional dos resultados e o uso dos dados obtidos para a avaliação e tomada de decisão em relação à saúde do trabalhador. Além disso, seu uso poderá ser ampliado para avaliar outras situações de exposição de profissionais de saúde ao risco de contaminação por agentes infecciosos.

ABSTRACT Objective: to translate and transculturally adapt the Risk assessment and management of exposure of health care workers in the context of COVID-19 questionnaire. Method: this is a methodological study. The translation, back-translation, synthesis, evaluation by experts committee and pre-test stages were followed. The participants were invited by electronic means and answered an online questionnaire. The data were collected between June and September 2020. Content validation by the experts committee was verified using the Content Validity Index. The pre-test participants assessed the instrument's applicability by means of the “Assessment of Instruments' Feasibility” questionnaire. Results: the study participants were four translators, eight evaluators in the experts committee and 35 professionals who answered the pre-test. The changes suggested by the experts committee were accepted and consensus was reached in two evaluation rounds, obtaining a content validity index higher than 0.80 for all items of the instrument. The pre-test version presented good applicability and satisfactory reliability (0.76). Conclusion: the instrument was adapted for use in Brazil, which will allow international comparison of the results and using the data obtained for assessment and decision-making in relation to workers' health. In addition to that, its use may be expanded to assess other situations of health professionals' exposure to the risk of contamination by infectious agents.

RESUMEN Objetivo: realizar la traducción y adaptación transcultural del instrumento Risk assessment and management of exposure of healthcare workers in the context of COVID-19. Método: estudio metodológico en el que se desarrollaron las siguientes etapas: traducción, retrotraducción, síntesis, evaluación a cargo de un comité de expertos y prueba previa (pre-test). Se invitó a los participantes a través de medios electrónicos para que respondieran un formulario en línea. Los datos se recolectaron entre junio y septiembre de 2020. La validación del contenido a cargo del comité de expertos se verificó por medio del Índice de Validez del Contenido. Los participantes de la prueba previa evaluaron la aplicabilidad del instrumento por medio del cuestionario “Evaluación de la Viabilidad de Instrumentos”. Resultados: los participantes del estudio fueron cuatro traductores, ocho evaluadores en el comité de expertos y 35 profesionales que respondieron la prueba previa. Las modificaciones sugeridas por el comité de expertos fueron acatadas y se llegó a un consenso en dos evaluaciones, obteniéndose un Índice de Validez del Contenido superior a 0,80 para todos los ítems del instrumento. La versión de la prueba previa presentó buena aplicabilidad y confiabilidad satisfactoria (0,76). Conclusión: el instrumento fue adaptado para su uso en Brasil, lo que permitirá realizar una comparación internacional de los resultados y emplear los datos obtenidos con fines de evaluación y toma de decisiones en relación con la salud de los trabajadores. Además, se podrá expandir su utilización para evaluar otras situaciones de exposición de profesionales de la salud al riesgo de contaminación a raíz de agentes infecciosos.

RESUMO O objetivo deste trabalho foi avaliar a variabilidade espacial da resistência a penetração em solo sob diferentes condições de colheita de cana-de-açúcar na microrregião do Litoral Norte paraibano. O estudo foi realizado em Argissolo Acinzentado cultivado com cana-de-açúcar, nas fazendas Santa Emília II e Maria da Luz I, pertencentes à Usina Miriri e Bioenergia S/A, nos municípios de Rio Tinto e Capim, estado da Paraíba no Brasil. Selecionou-se três áreas: Colheita manual; Colheita mecanizada e; Colheita manual e mecanizada. As coletas se procederam em parcelas de 100 x 100 m, sob grid de amostragem de 20 x 20 m, contemplando linhas e entrelinhas de plantio, sendo cada ponto de cruzamento da malha amostral georreferenciado, e levantada a sua resistência mecânica à penetração com auxílio de um penetrômetro de impacto modelo IAA/Planausucar-Stolf na profundidade de 0-0,6 m. Foi procedida coleta de amostra deformadas e indeformadas nas profundidade de 0-0,1 e 0,1-0,2 m para análises das seguintes variáveis: Umidade do solo, Textura, Argila dispersa em água, Grau de floculação. Observou-se efeito pepita puro nas camadas de 0-0,1 e 0,4-0,5 m na linha da área de colheita manual e mecanizada. Na maioria das condições analisadas constatou-se o modelo esférico. Os alcances foram semelhantes para áreas, com amplitude de 25 a 49 m, indicando que o manejo de colheita, no período estudado, não exerceu influência para a resistência à penetração. Não foram observadas áreas compactadas e a dependência espacial da resistência à penetração foi caracterizada como moderada a forte.

ABSTRACT The objective of this work was to evaluate the spatial variability of resistance to penetration in soil under sugarcane crops subjected to different harvest methods in the North Coast microregion of the state of Paraiba, Brazil. The study was conducted in a Typic Hapludult under sugarcane crops, at the farms Santa Emília-II and Maria da Luz-I of the company Miriri Food and Bioenergy S/A, in the municipalities of Rio Tinto and Capim, respectively, state of Paraíba, Brazil. Three sugarcane areas with different harvest methods (manual, mechanized, and manual/mechanized) were selected. The sampling was done in plots of 100 × 100 m, using a grid of 20 × 20 m, covering planting rows and interrows; each intersection point of the grid was georeferenced, and the soil mechanic resistance to penetration was evaluated with the aid of an impact penetrometer (IAA/Planalsucar-Stolf) up to the depth of 0-0.6 m. Soil disturbed and undisturbed samples from the 0.0-0.1 and 0.1-0.2 m layers were collected for analyses of soil moisture, texture, clay dispersed in water, flocculation degree. A pure nugget effect was found in the 0.0-0.1 and 0.4-0.5 m soil layers in the rows of the areas with manual/mechanized harvest. The spherical model was found for most conditions evaluated. The results for the areas were similar, with amplitude of 25-49 m, indicating that the harvest management had no effect on the soil resistance to penetration. No compacted areas were found, and the spatial dependency of the resistance to penetration was characterized as moderate to strong.

Abstract The aim of this work was to investigate the effects of mercerization on the structure of castor oil cake (CC) and on the tensile properties of LDPE/PHB/CC composites. To achieve this goal, the fibers were treated with NaOH solutions (5 and 10 wt%). Characterization techniques such as: scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) were used to investigate the structure of modified fibers. The composites were processed in a Haake mixer. Tensile tests of the composites were performed according to ASTM D638 standard. The analyzes revealed that mercerization promoted a partial conversion of cellulose I into cellulose II. Mercerization performed with 5% NaOH solution improved the tensile properties of the LDPE/PHB/CC composites, which were superior to those obtained with the 10% NaOH solution. This result suggests that the higher concentration of NaOH compromises the integrity of the fibers, deteriorating the mechanical properties.

Abstract Background: The knowledge on the management of patients with acute coronary syndrome (ACS) is essential to reduce the gap between evidence and practice. Objective: To describe a simulation training strategy for emergency healthcare professionals and provide preliminary data on knowledge acquisition, learners' confidence and prescription of medications after training. Methods: The training was part of the implementation of two myocardial infarction systems of care. It comprehended lectures and simulation-based learning using high and low-fidelity mannequins and actors. It was tested in two phases: the first one in Belo Horizonte and the second one in Montes Claros, both in the state of Minas Gerais. A test was applied before and after training to assess knowledge acquisition. Confidence to perform thrombolysis in ST-elevation myocardial infarction (STEMI) patients was assessed using a questionnaire, and the impact on medication prescription analyzed STEMI patients admitted to hospitals in Montes Claros. Results: In the first phase, 156 professionals answered both tests: 70% of them improved their results and the median number of right answers increased (6, interquartile range [IQR] 5-7; vs 7 ([IQR] 6-9; p < 0.05). In the second phase, 242 professionals answered both tests: 58% of the physicians and 83% of the nurses obtained better test scores. Participants referred a positive impact on their clinical practice, 95% reported feeling very secure when perform fibrinolysis after the training, and there was also an impact on medication prescription. Conclusions: There was an impact on the learners' knowledge acquisition and confidence using our two-phase training model, with evidence of impact on performance.

ABSTRACT Introduction: Schistosomiasis is an infectious parasitic disease caused by trematodes of the genus Schistosoma, which threatens at least 258 million people worldwide and its control is dependent on a single drug, praziquantel. The aim of this study was to evaluate the anti-Schistosoma mansoni activity in vitro of novel imidazolidine derivatives. Material and methods: We synthesized two novel imidazolidine derivatives: (LPSF/PTS10) (Z)-1-(2-chloro-6-fluorobenzyl)-4-(4-dimethylaminobenzylidene)-5-thioxoimidazolidin-2-one and (LPSF/PTS23) (Z)-1-(2-chloro-6-fluoro-benzyl)-5-thioxo-4-(2,4,6-trimethoxy-benzylidene)-imidazolidin-2-one. The structures of two compounds were determined by spectroscopic methods. During the biological assays, parameters such as motility, oviposition, mortality and analysis by Scanning Electron Microscopy were performed. Results: LPSF/PTS10 and LPSF/PTS23 were considered to be active in the separation of coupled pairs, mortality and to decrease the motor activity. In addition, LPSF/PTS23 induced ultrastructural alterations in worms, after 24 h of contact, causing extensive erosion over the entire body of the worms. Conclusion: The imidazolidine derivatives containing the trimetoxy and benzylidene halogens showed promising in vitro schistosomicidal activity.

OBJETIVO:verificar a existência de associação entre a presença e o grau de perda auditiva em adultos e idosos e o desempenho em teste de rastreio cognitivo, o sexo e a idade dos mesmos.MÉTODOS:participaram deste estudo sujeitos com idade entre 52 e 92 anos. Todos responderam a questionário sócio-demográfico, ao teste de Mini Exame do Estado Mental e à audiometria tonal liminar.RESULTADOS: dos 90 indivíduos avaliados, 22 (24,4%) eram do sexo masculino e 68 (75,6%) do sexo feminino. Constatou-se que apenas 11 orelhas direitas e 11 orelhas esquerdas apresentavam limiares auditivos normais. Constatou-se que a idade estava associada com o aumento dos limiares auditivos, evidenciando que os indivíduos mais velhos apresentam maior grau de perda auditiva (p<0,005). Não houve diferença estatística entre os limiares auditivos de homens e mulheres (p=0,1). Observou-se que 80% dos sujeitos cujo resultado do rastreio cognitivo foi normal apresentaram os limiares auditivos menos afetados. Já 60% dos indivíduos cujo resultado do rastreio cognitivo foi alterado apresentaram maior grau de perda auditiva. Pode-se constatar a relação dos achados audiológicos com os resultados do teste de rastreio cognitivo, evidenciando que os sujeitos com o resultado alterado do mini Exame do Estado mental apresentam os maiores graus de perda auditiva (p<0,001).CONCLUSÃO:verificou-se que houve associação entre a presença e grau da perda auditiva com o resultado do Mini Exame do Estado Mental. O aumento da idade mostrou-se proporcional ao aumento dos limiares auditivos. Não foi constatada associação entre gênero e audição na amostra.

PURPOSE:to verify whether the presence and level of hearing loss in adults and elderly as well as their performance in tests are linked to their gender, age and cognitive tracking.METHODS:subjects with ages between 52 and 92 years old took part in this study. They all answered a sociodemographic questionnaire and went through Mini-Mental State Examination as well as pure-tone threshold audiometry.RESULTS: out of the 90 individuals, 22 (24,4%) were male and 68 (75,6%) were female. It was seen that only 11 right ears and 11 left ears presented normal auditory thresholds. It was possible to verify that age was indeed linked to the auditory thresholds increase, making it clear that older individuals present higher levels of hearing loss (p<0,005). There was no statistical difference between the auditory thresholds of male and female (p=0,1). It was observed that 80% of the individuals whose cognitive tracking results were normal presented least affected auditory thresholds, while 60% of those whose cognitive tracking results were altered presented a higher level of hearing loss. It is possible to identify a relation between these audiological findings and the cognitive tracking test results, proving that the individuals with the altered Mini-Mental State Examination results present higher hearing loss (p<0,001).CONCLUSION:there was an association between the presence and degree of hearing loss with the result of the Mini-Mental State Examination. Increasing age was proportional to the increase in hearing thresholds. There was no association between gender and hearing in the sample.

OBJECTIVE: To establish whether alterations of brain structures in Alzheimer's disease are associated with executive dysfunction. METHODS: Nineteen patients with Alzheimer's disease and 22 older control subjects underwent a comprehensive evaluation. The clock drawing test, digit span test, executive motor function test, Behavioral Assessment of the Dysexecutive Syndrome battery (Rule Shift Cards test), and Stroop test were used to evaluate executive dysfunction. A multiparametric approach using the FreeSurfer image analysis suite provided a description of volumetric and geometric features of the gray matter structures. RESULTS: The cortical thickness maps showed a negative correlation between the Behavioral Assessment of the Dysexecutive Syndrome battery (Rule Shift Cards test) and the right middle frontal gyrus; a positive correlation between the executive motor function test and the left superior parietal gyrus, left middle temporal gyrus, bilateral supramarginal gyri, right middle frontal gyrus, and right precuneus; a negative correlation between the Stroop test (part III) and the right superior parietal gyrus; and a negative correlation between the Stroop test (part III) and the right middle temporal gyrus. CONCLUSION: Executive dysfunction in Alzheimer's disease is correlated with alterations not only in the frontal areas but also within many temporal and parietal regions.

O pai é a fonte de apoio materno mais importante durante a transição decorrente do nascimento de filhos. Este estudo objetiva descrever a percepção de 45 mulheres grávidas e 42 mães com bebês de até seis meses sobre a participação e apoio paterno, durante a gestação e nascimento de filhos. A coleta de dados consistiu da aplicação, às mães, de um questionário de caracterização do sistema familiar e de uma entrevista semiestruturada, visando obter informações sobre o pai "real" e o "ideal". Os resultados mostram que, apesar de os pais serem percebidos como pouco participativos, as mães estavam satisfeitas com o seu envolvimento. Os dados sugerem que é necessário estimular a participação do pai, por ocasião do nascimento de filhos.

The father is a major figure on mother's support network during childbirth transition. This study aims to report father's participation and support during the pregnancy and the birth of their children, according to the point of view of 45 pregnant women and 42 women with six-month-old children. Data was collected through the administration of a family questionnaire and a semi-structured interview answered by the mothers in order to get information about the "real" and the "ideal" father. The results show that, although the mothers were satisfied with the fathers' role in family life, they thought fathers were not as participative as they should be. Data suggest that it is necessary to stimulate father's participation during childbirth.

A rede social de apoio tem sido enfatizada como um dos aspectos mais importantes para o bem-estar materno durante a gestação e o nascimento dos filhos. Este estudo teve como objetivo verificar as alterações no apoio prestado por familiares e não familiares durante esse período, na perspectiva de 45 mulheres grávidas e de 42 com bebês de até seis meses. A coleta de dados consistiu na aplicação de um questionário de caracterização do sistema familiar e de uma entrevista semiestruturada, visando obter informações sobre a estrutura e o funcionamento da família e de sua rede social durante a gestação e o nascimento dos filhos. Os resultados apontaram mudanças na vida familiar, durante essa transição, quanto ao contato social e ao suporte emocional e material. Os dados sugerem a importância da elaboração de programas de educação familiar para a manutenção do equilíbrio familiar, nesse período.

The social support network has been highlighted as one of the most important factors in maintaining the welfare of mothers during pregnancy and childbirth. The aim of this study is to ascertain the changes in support from family and others during this period, according to 45 pregnant women and 42 women with children under six months old. Data was collected by administering a family questionnaire and a semi-structured interview, focusing on information about the characterization of the family and the social support network during pregnancy and childbirth. The results show that the main changes occurred with social contact and psychological and material support. We suggest that family educational programs are fundamental in helping families during this period of transition.

A literatura especializada destaca que o manejo clínico da dor comporta dificuldades psicológicas, associadas à busca de alívio do sofrimento dos pacientes. Sendo assim, investigaram-se a percepção de estresse e as estratégias de enfrentamento de 31 profissionais de diferentes categorias, em um centro de atendimento a grandes queimados (dor aguda) e uma unidade de controle de dor e cuidados paliativos (dor crônica). Para tanto, aplicaram-se um questionário sociodemográfico, a Job Stress Scale (versão resumida) e o Inventário de Estratégias de Coping. Comparativamente às demais categorias, os técnicos de enfermagem indicaram mais fatores de estresse. Em compensação, informaram maior diversidade de estratégias de enfrentamento com diferenças significativas entre os serviços. Esses resultados corroboram estudos anteriores, os quais alertam sobre as condições adversas que interferem na atuação em enfermagem. Porém, também revelam disponibilidade de fatores de proteção, apontando perspectivas de intervenção preventiva, destinada à equipe de enfermagem.

The specialist literature highlights that the clinical management of pain involves psychological difficulties associated with the pursuit of the alleviation of the suffering of patients. Therefore, an investigation was conducted into the perception of stress and coping strategies of 31 professionals of different categories from a severe burns care center (acute pain) and a pain control and palliative care unit (chronic pain). For this, a sociodemographic questionnaire, the Job Stress Scale (short version) and the Coping Strategies Inventory were applied. Compared to other categories, the nursing technicians indicated more stress factors. In compensation, they reported a greater diversity of coping strategies with significant differences between the services. These results corroborate previous studies, which warn of the adverse conditions that interfere in nursing practice. However, they also reveal the availability of protective factors, indicating perspectives of preventive intervention for the nursing team.

La literatura especializada destaca que el manejo clínico del dolor produce dificultades psicológicas asociadas a las actividades realizadas para aliviar el sufrimiento de los pacientes. Siendo así, se investigaron la percepción del estrés y las estrategias para enfrentarlo en 31 profesionales de diferentes categorías en un centro de atención a quemaduras de gran tamaño (dolor agudo) y una unidad de control del dolor y cuidados paliativos (dolor crónico). Para esto, se aplicó un cuestionario sociodemográfico, la Job Stress Scale (versión resumida) y el Inventario de Estrategias de Coping. Comparado con las demás categorías, los técnicos de enfermería indicaron más factores de estrés. En compensación, informaron mayor diversidad de estrategias de enfrentamiento con diferencias significativas entre los servicios. Estos resultados corroboran estudios anteriores, los cuales alertan sobre las condiciones adversas que interfieren en la actuación en enfermería. Sin embargo, también revelan la disponibilidad de factores de protección, apuntando perspectivas de intervención preventiva destinadas al equipo de enfermería.

The specialist literature highlights that the clinical management of pain involves psychological difficulties associated with the pursuit of the alleviation of the suffering of patients. Therefore, an investigation was conducted into the perception of stress and coping strategies of 31 professionals of different categories from a severe burns care center (acute pain) and a pain control and palliative care unit (chronic pain). For this, a sociodemographic questionnaire, the Job Stress Scale (short version) and the Coping Strategies Inventory were applied. Compared to other categories, the nursing technicians indicated more stress factors. In compensation, they reported a greater diversity of coping strategies with significant differences between the services. These results corroborate previous studies, which warn of the adverse conditions that interfere in nursing practice. However, they also reveal the availability of protective factors, indicating perspectives of preventive intervention for the nursing team.

La literatura especializada destaca que el manejo clínico del dolor produce dificultades psicológicas asociadas a las actividades realizadas para aliviar el sufrimiento de los pacientes. Siendo así, se investigaron la percepción del estrés y las estrategias para enfrentarlo en 31 profesionales de diferentes categorías en un centro de atención a quemaduras de gran tamaño (dolor agudo) y una unidad de control del dolor y cuidados paliativos (dolor crónico). Para esto, se aplicó un cuestionario sociodemográfico, la Job Stress Scale (versión resumida) y el Inventario de Estrategias de Coping. Comparado con las demás categorías, los técnicos de enfermería indicaron más factores de estrés. En compensación, informaron mayor diversidad de estrategias de enfrentamiento con diferencias significativas entre los servicios. Estos resultados corroboran estudios anteriores, los cuales alertan sobre las condiciones adversas que interfieren en la actuación en enfermería. Sin embargo, también revelan la disponibilidad de factores de protección, apuntando perspectivas de intervención preventiva destinadas al equipo de enfermería.

A literatura especializada destaca que o manejo clínico da dor comporta dificuldades psicológicas, associadas à busca de alívio do sofrimento dos pacientes. Sendo assim, investigaram-se a percepção de estresse e as estratégias de enfrentamento de 31 profissionais de diferentes categorias, em um centro de atendimento a grandes queimados (dor aguda) e uma unidade de controle de dor e cuidados paliativos (dor crônica). Para tanto, aplicaram-se um questionário sociodemográfico, a Job Stress Scale (versão resumida) e o Inventário de Estratégias de Coping. Comparativamente às demais categorias, os técnicos de enfermagem indicaram mais fatores de estresse. Em compensação, informaram maior diversidade de estratégias de enfrentamento com diferenças significativas entre os serviços. Esses resultados corroboram estudos anteriores, os quais alertam sobre as condições adversas que interferem na atuação em enfermagem. Porém, também revelam disponibilidade de fatores de proteção, apontando perspectivas de intervenção preventiva, destinada à equipe de enfermagem.

INTRODUCTION: The role of structural brain changes and their correlations with neuropsychiatric symptoms and disability in Alzheimer's disease are still poorly understood. OBJECTIVE: To establish whether structural changes in grey matter volume in patients with mild Alzheimer's disease are associated with neuropsychiatric symptoms and disability METHODS: Nineteen Alzheimer's disease patients (9 females; total mean age =75.2 y old +4.7; total mean education level =8.5 y +4.9) underwent a magnetic resonance imaging (MRI) examination and voxel-based morphometry analysis. T1-weighted images were spatially normalized and segmented. Grey matter images were smoothed and analyzed using a multiple regression design. The results were corrected for multiple comparisons. The Neuropsychiatric Inventory was used to evaluate the neuropsychiatric symptoms, and the Functional Activities Questionnaire and Disability Assessment for Dementia were used for functional evaluation RESULTS: A significant negative correlation was found between the bilateral middle frontal gyri, left inferior temporal gyrus, right orbitofrontal gyrus, and Neuropsychiatric Inventory scores. A negative correlation was found between bilateral middle temporal gyri, left hippocampus, bilateral fusiform gyri, and the Functional Activities Questionnaire. There was a positive correlation between the right amygdala, bilateral fusiform gyri, right anterior insula, left inferior and middle temporal gyri, right superior temporal gyrus, and Disability Assessment for Dementia scores CONCLUSIONS: The results suggest that the neuropsychiatric symptoms observed in Alzheimer's disease patients could be mainly due to frontal structural abnormalities, whereas disability could be associated with reductions in temporal structures.