Pesquisa | SciELO

ABSTRACT There is a need for greater knowledge about the medium- and long-term effects of prescribed fire management on soil in ecosystems prone to wildfires and more vulnerable to climate change. This study examined the short- and medium-term effects of prescribed fire on soil chemical properties and chemical fractions of soil organic matter (SOM) in two positions of the landscape in a high-elevation grassland environment. The ecosystem is located in the mountain peaks of southeastern Brazil associated with the Atlantic Forest biome. Prescribed fire was conducted in 2017 to reduce understory vegetation and thus prevent potential severe wildfires. Soil samples were collected at the layers of 0.00-0.10, 0.10-0.20, and 0.20-0.40 m, at eight composite sampling. The composite samples were collected on five different occasions: before the prescribed fire, and 10, 30, 90, and 240 days after the prescribed fire. Soil chemical properties, total organic carbon, labile C, and chemical fractionation of SOM were analyzed. All soil properties investigated were affected by the prescribed fire, with variations in landscape position, duration of effect, and soil layer. In the backslope area, the medium-term effect of fire was negative and induced soil degradation and induced soil degradation. In the footslope area, the system showed greater resilience to the effects of fire, as indicated by the recovery of the soil’s chemical properties. These results can help assess the suitability of controlled burning of vegetation for managing risks of fire in mountainous regions, such as high-elevation grasslands.

https://doi.org/10.36783/18069657rbcs20230009

Antileishmanial effects of γCdcPLI, a phospholipase A2 inhibitor from Crotalus durissus collilineatus snake serum, on Leishmania (Leishmania) amazonensis γCdcPLI A serum (Leishmania
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Gonçalves, Marina Neves

; Lopes, Daiana Silva

; Teixeira, Samuel Cota

; Teixeira, Thaise Lara

; de Freitas, Vitor

; Costa, Tássia Rafaella

; Gimenes, Sarah Natalie Cirilo

; de Camargo, Isabella Mitie

; de Souza, Guilherme

; da Silva, Marcelo Santos

; Azevedo, Fernanda Van Petten de Vasconcelos

; Grego, Kathleen Fernandes

; Santos, Luísa Carregosa

; Oliveira, Vinícius Queiroz

; da Silva, Claudio Vieira

; Rodrigues, Renata Santos

; Yoneyama, Kelly Aparecida Geraldo

; Clissa, Patricia Bianca

; Rodrigues, Veridiana de Melo

Memórias do Instituto Oswaldo Cruz

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2023, Volume 118 elocation e220225

Resumo: En | Texto: En | PDF: En

BACKGROUND Leishmaniasis, a neglected disease caused by the parasite Leishmania, is treated with drugs associated with high toxicity and limited efficacy, in addition to constant reports of the emergence of resistant parasites. In this context, snake serums emerge as good candidates since they are natural sources with the potential to yield novel drugs. OBJECTIVES We aimed to show the antileishmanial effects of γCdcPLI, a phospholipase A2 inhibitor from Crotalus durissus collilineatus snake serum, against Leishmania (Leishmania) amazonensis. METHODS Promastigotes forms were exposed to γCdcPLI, and we assessed the parasite viability and cell cycle, as well as invasion and proliferation assays. FINDINGS Despite the low cytotoxicity effect on macrophages, our data indicate that γCdcPLI has a direct effect on parasites promoting an arrest in the G1 phase and reduction in the G2/M phase at the highest dose tested. Moreover, this PLA2 inhibitor reduced the parasite infectivity when promastigotes were pre-treated. Also, we demonstrated that the γCdcPLI treatment modulated the host cell environment impairing early and late steps of the parasitism. MAIN CONCLUSIONS γCdcPLI is an interesting tool for the discovery of new essential targets on the parasite, as well as an alternative compound to improve the effectiveness of the leishmaniasis treatment. Leishmaniasis efficacy context A serum (Leishmania amazonensis cycle assays macrophages G G2M GM G2 M tested Moreover PLA pretreated. pretreated pre treated. pre-treated Also parasitism

https://doi.org/10.1590/0074-02760220225

Association between disease activity and quality of life among patients with rheumatoid arthritis
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Costa, Rômulo Lopes da

; Freitas Netto, Felício de

; Lima, Diogo von Gaevernitz

; Mansani, Fabiana Postiglione

; Schafranski, Marcelo Derbli

; Zardo, Bruno Queiroz

; Toledo Júnior, Alceu de Oliveira

; Calixto, Lorena de Freitas

; Vellosa, José Carlos Rebuglio

; Montes, Elisangela Gueiber

Brazilian Journal of Pharmaceutical Sciences

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2022, Volume 58 elocation e20626

Resumo: En | Texto: En | PDF: En

Abstract The aim of this study is the association between the scores of disease activity, functional capacity and quality of life among patients diagnosed with rheumatoid arthritis, under clinical treatment at the Regional University Hospital of Campos Gerais - Wallace Thadeu de Mello and Silva. The sample was composed by volunteer patients, who freely underwent 3 research questionnaires. With the results of the survey, the disease activity score was correlated to the functional capacity and the quality-of-life scores. A mean of 3.87 and 1.2 was observed for the disease activity and the functional capacity scores, respectively, yet not achieving a correlation between those two variables. A strong correlation between the disease activity and the “functional capacity”, “general health status” and “mental health” domains was found. The lowest average observed corresponded to “physical limitation”, from the quality-of-life questionnaire. There was no statistically significant correlation between disease activity and functional capacity, although disease activity seems to affect the mental health, general health status and functional capacity of patients.

https://doi.org/10.1590/s2175-97902022e20626

Relationship between corticotherapy and increased cardiac risk in patients with rheumatoid arthritis
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Montes, Elisangela Gueiber

; Mansani, Fabiana Postiglione

; Schafranski, Marcelo Derbli

; Toledo Júnior, Alceu de Oliveira

; Calixto, Lorena de Freitas

; Costa, Rômulo Lopes da

; Staichak, Rodrigo Luiz

; Pinto, Francine Marques

; Berso, Juliane de Lara

; Guimarães, Nicole

; Souza, Marcos Noris Bernardes de

; Zardo, Bruno Queiroz

; Vellosa, José Carlos Rebuglio

Brazilian Journal of Pharmaceutical Sciences

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2021, Volume 57 elocation e19156

Resumo: En | Texto: En | PDF: En

Rheumatoid arthritis is an autoimmune inflammatory joint disease with global prevalence of 0.4% to 1.0%. Extra-articular manifestations increase its morbidity and severity, and cardiovascular diseases present the greatest risk. Therapeutic approaches have been used to treat rheumatoid arthritis, often involving the use of multiple classes of drugs with different mechanisms and forms of action. Corticosteroid therapy is widely used in this therapeutic combination; however, its use has been widely questioned because of its high toxicity and some negative effects, including the possibility of increased cardiovascular risk, depending on the dosage. Some studies have provided important insights into how glucocorticoids have an impact on cardiac complications in patients with rheumatoid arthritis. Most of these studies have concluded that exposure to these drugs at high or cumulative doses is associated with increased risk of death, as well as possibly being associated with the presence of a positive rheumatoid factor.

https://doi.org/10.1590/s2175-97902020000419156 1 downloads

Using the No-Apnea score to screen for obstructive sleep apnea in adults referred to a sleep laboratory: comparative study of the performance of the instrument by gender
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Duarte, Ricardo Luiz de Menezes

; Silveira, Flavio José Magalhães da

; Sá, Tiago Soares de Oliveira e

; Rabahi, Marcelo Fouad

; Mello, Fernanda Carvalho de Queiroz

; Gozal, David

Jornal Brasileiro de Pneumologia

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2020, Volume 46 Nº 5 elocation e20190297

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar o desempenho do escore No-Apnea, um instrumento simplificado para a triagem da apneia obstrutiva do sono (AOS), relacionado ao gênero. Métodos: Estudo transversal incluindo indivíduos adultos submetidos à polissonografia completa. O No-Apnea é um modelo contendo dois itens (circunferência do pescoço e idade) com uma pontuação total de 0 a 9. A gravidade da AOS foi baseada no índice de apneia-hipopneia ≥ 5 eventos/h (qualquer AOS), ≥ 15 eventos/h (AOS moderada/grave) e ≥ 30 eventos/h (AOS grave). O desempenho do No-Apnea foi avaliado pela área sob a curva (ASC) ROC e tabelas de contingência. Resultados: No total, 6.606 adultos (53,8% homens) foram avaliados. No geral, para a triagem dos diferentes níveis de gravidade de AOS, o No-Apnea teve sensibilidade variando de 83,9% a 93,0% e especificidade variando de 57,3% a 35,2%. Em todos os níveis de gravidade da AOS, o No-Apnea exibiu maior sensibilidade e menor especificidade nos homens que nas mulheres. O No-Apnea mostrou ser um adequado modelo de triagem para os pacientes em geral ou quando separados por gênero ou gravidade da AOS (ASC > 0,7 para todos). A capacidade discriminatória do No-Apnea em predizer qualquer AOS, AOS moderada/grave e AOS grave foi semelhante entre os sexos (p = 0,109, p = 0,698 e p = 0,094, respectivamente). Conclusões: Em uma amostra de indivíduos adultos encaminhados para laboratório do sono, o No-Apnea apresentou discriminação similar para a triagem de AOS de acordo com sua gravidade em mulheres e homens.

ABSTRACT Objective: To evaluate the performance of the No-Apnea score, a simplified screening instrument for obstructive sleep apnea (OSA), by gender. Methods: This was a cross-sectional study including adults undergoing full polysomnography. The No-Apnea model comprises two items (neck circumference and age) with a total score of 0 to 9. The severity of OSA was categorized, on the basis of the apnea-hypopnea index, as any (≥ 5 events/h), moderate-to-severe (≥ 15 events/h), or severe (≥ 30 events/h). The performance of the No-Apnea instrument was assessed by determining the area under the (ROC) curve (AUC) and by constructing contingency tables. Results: We evaluated a total of 6,606 adults (53.8% men). For categorizing the level of OSA severity, the No-Apnea score had a sensitivity of 83.9-93.0% and a specificity of 57.3-35.2%. At all OSA severity levels, the No-Apnea score exhibited higher sensitivity and lower specificity in men than in women. The No-Apnea score proved to be an appropriate screening model for patients in general or when separated by gender or severity of OSA (AUC > 0.7 for all). The discriminatory power of the No-Apnea score to predict any, moderate-to-severe, and severe OSA was similar between genders (p = 0.109, p = 0.698, and p = 0.094, respectively). Conclusions: In a sample of adults referred to the sleep laboratory, there was no significant difference between men and women in terms of the discriminatory power of the No-Apnea instrument in for screening for OSA severity.

https://doi.org/10.36416/1806-3756/e20190297 521 downloads

Detection of Drug Resistant Mycobacterium Tuberculosis Strains Using Kit SIRE Nitratase®: a Multicenter Study
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Miranda, Silvana Spindola de

; Almeida, Isabela Neves de

; Mansur, Maria de Fátima Filardi Oliveira

; Figueredo, Lida Jouca de Assis

; Carvalho, Wânia da Silva

; Hadaad, João Paulo Amaral

; Diniz, Jaciara de Lourdes do Carmo Guimarães

; Groll, Andrea von

; Silva, Pedro Almeida da

; Lopes, Maria Luiza

; Santos, Marcelo Cordeiro dos

; Brito, Alexandra

; Mello, Fernanda Carvalho de Queiroz

; Malaquias, Thiago da Silva Santos

; Croda, Julio

; Pinhata, Juliana Maira Watanabe

; Oliveira, Rosângela Siqueira de

; Chimara, Erica

; Rossetti, Maria Lúcia

; Halon, Maria Laura

; Lourenço, Maria Cristina

; Medeiros, Reginalda Ferreira de Melo

; Montes, Fátima Cristina Onofre Fandinho

; Machado, Diana

; Viveiros, Miguel

; Kritski, Afrânio Lineu

Brazilian Archives of Biology and Technology

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2020, Volume 63 elocation e20190179

Resumo: En | Texto: En | PDF: En

Abstract (1) Background: The Commercial Kit SIRE Nitratase® PlastLabor, is a drug susceptibility test kit used to detect Mycobacterium tuberculosis resistance to first-line TB treatment drugs. The present study aimed at evaluating its performance in a multicenter study. (2) Methods: To determine its accuracy, the proportion methods in Lowenstein Jensen medium or the BACTECTMMGITTM960 system was used as a gold standard. (3) Results: The study revealed that the respective accuracies of the kit with 190 M. tuberculosis clinical isolates, using the proportion methods in Lowenstein Jensen medium or BACTECTMMGITTM960 system as a gold standard, were 93.9% and 94.6%, 96.9% and 94.6%, 98.0% and 97.8%, and 98.0% and 98.9%, for streptomycin, isoniazid, rifampicin, and ethambutol, respectively. (4) Conclusion: Thus, the kit can rapidly screen resistance to streptomycin, isoniazid, rifampicin, and ethambutol. Additionally, it does not require sophisticated equipment; hence, it can be easily used in the laboratories of low and middle income countries.

https://doi.org/10.1590/1678-4324-2020190179 905 downloads

A summary of the proceedings of a meeting on the treatment of latent tuberculosis infection in target populations in Brazil
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Rolla, Valeria

; Trajman, Anete

; Kawamura, Masae

; Cavalcante, Solange

; Soares, Elizabeth

; Perini, Filipe de Barros

; Carvalho, Anna Cristina Calçada

; Croda, Julio

; Silva, Jose Roberto Lapa e

; Schmaltz, Carolina Arana Stanis

; Sant’Anna, Flavia Marinho

; Bastos, Mayara

; Gomes, Adriano

; Durovni, Betina

; Saraceni, Valeria

; Silva, Elisangela

; Mello, Fernanda Carvalho de Queiroz

; Santos, Marcelo Cordeiro dos

; Pinto, Marcia

; Santos, Marisa

; Sanches, Fernando Augusto Dias e

; Oliveira, Sandra Maria do Valle Leone de

Jornal Brasileiro de Pneumologia

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2020, Volume 46 Nº 4 elocation e20200023

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36416/1806-3756/e20200023 296 downloads

Flora and Annual Distribution of Flowers and Fruits in the Ubajara National Park, Ceará, Brazil
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Silveira, Andréa Pereira

; Menezes, Bruno Sousa de

; Loiola, Maria Iracema Bezerra

; Lima-Verde, Luiz Wilson

; Zanina, Dalva Neta e

; Carvalho, Ellen Cristina Dantas de

; Souza, Bruno Cruz de

; Costa, Rafael Carvalho da

; Mantovani, Waldir

; Menezes, Marcelo Oliveira Teles de

; Flores, Lilian Maria Araújo

; Nogueira, Francisco Carlos Barboza

; Matias, Ligia Queiroz

; Barbosa, Lívia Silvia

; Gomes, Fernanda Melo

; Cordeiro, Luciana Silva

; Sampaio, Valéria da Silva

; Batista, Maria Edenilce Peixoto

; Soares Neto, Raimundo Luciano

; Silva, Maria Arlene Pessoa da

; Campos, Natália Barbosa

; Oliveira, Arycelle Alves de

; Araujo, Francisca Soares de

Floresta e Ambiente

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2020, Volume 27 Nº 2 elocation e20190058

Resumo: En | Texto: En | PDF: En

Abstract Although the conservation of tropical biodiversity depends on protected areas, there is still a very large ‘gap’ of knowledge on the flora of Brazilian reserves, especially in the Northeast region of Brazil. Field and herbarium surveys of the phanerogamic flora of the Ubajara National Park, located on the Brazilian Northeast, were made and analyses on phenology and dispersal syndromes were performed. 418 taxa (213 trees and shrubs, 100 terrestrial herbs, 68 climbing plants, 33 sub-shrubs, two epiphytes, one hemiparasite and one aquatic herb) were recorded. The most representative families were: Fabaceae, Malvaceae, Asteraceae, Rubiaceae and Euphorbiaceae. The annual flowering / fruiting peak hypothesis was not fully confirmed, therefore, the forest may be an important food resource for the fauna all year long (especially in the moister region). Zoochory was the predominant dispersal syndrome in the moister area, whereas, autochory and anemochory together, predominated in the drier area.

https://doi.org/10.1590/2179-8087.005819 1144 downloads

10.

The Impact of Lung Carcinoma Histology on the Frequency of Bone Metastases
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Oliveira, Marcelo Bragança dos Reis

; Souza, Larissa Costa

; Sampayo, Ermides Javier Garcia

; Carvalho, Gustavo Sobral de

; Mello, Fernanda Carvalho de Queiroz

; Paschoal, Marcos Eduardo Machado

Revista Brasileira de Ortopedia

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Out 2019, Volume 54 Nº 5 Páginas 524 - 530

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo O câncer de pulmão é a principal causa de morte por neoplasia, e os ossos são os principais locais de metástases desse tipo de câncer. O objetivo deste estudo foi avaliar a influência do tipo histológico do carcinoma de pulmão na frequência das metástases ósseas. Métodos Foram avaliados retrospectivamente os registros médicos de 407 pacientes diagnosticados com câncer de pulmão entre 2003 e 2012. A prevalência de metástases ósseas e suas associações com os subtipos histológicos foram avaliadas com o teste qui-quadrado, razão de probabilidade (RP), e intervalos de confiança (IC) de 95%. A sobrevida global foi avaliada com o método de Kaplan-Meier. Resultados A prevalência das metástases ósseas foi de 28,2% (n = 115), e a coluna vertebral foi o local mais frequente (98 metástases: 32,1%). O adenocarcinoma foi o subtipo histológico mais comum de carcinoma pulmonar (46,7%) e foi significativamente mais frequente entre os pacientes com metástases ósseas (13,0% versus 29,8%; p = 0,0004; OR = 0,35; 95% IC: 0,19–0,64). O tempo médio de sobrevida após o diagnóstico da primeira metástase óssea foi de 4 meses. Conclusão O adenocarcinoma foi o subtipo histológico mais comum de carcinoma pulmonar e foi significativamente associado a um maior risco de desenvolvimento de metástases ósseas.

Abstract Objective Lung cancer is the leading cause of death by cancer, and the bones are one of the most common sites of metastasis from this condition. This study aimed to evaluate the influence of lung carcinoma histology on the frequency of bone metastases. Methods This retrospective study evaluated the medical records of 407 patients diagnosed with lung cancer between 2003 and 2012. The prevalence of bone metastases and their association with histological subtypes were evaluated using chi-squared tests, odds ratios (ORs) and 95% confidence intervals (CIs). The overall survival was evaluated using the Kaplan-Meier method. Results The prevalence of bone metastases was 28.2% (n = 115), and the spine was the most frequently affected site (98 metastases; 32.1%). Adenocarcinoma was the most common histological subtype of lung carcinoma (46.7%), and it was significantly more frequent among patients with bone metastases (58.3% versus 42.1%; p = 0.003; OR = 1.92; 95% CI: 1.29–2.97). Squamous cell carcinoma was significantly less frequent among patients with bone metastases (13.0% versus 29.8%; p = 0.0004; OR = 0.35; 95% CI: 0.19–0.64). The median survival time after the first bone metastasis diagnosis was 4 months. Conclusion Adenocarcinoma was the most common histological subtype of lung carcinoma, and it was significantly associated with a higher risk of developing bone metastases.

https://doi.org/10.1016/j.rbo.2018.02.002 1450 downloads

11.

Hepatic changes after treatment with oxaliplatin
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Tenório, Leila Pereira

; Miranda, Michelle Ferraz Oliveira

; Andrade, Marcony Queiroz

; Araujo, Marcelo Antônio Nobrega

Radiologia Brasileira

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Out 2019, Volume 52 Nº 5 Páginas 343 - 344

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/0100-3984.2017.0173 1441 downloads

12.

Brazilian Society of Cardiology - The Women’s Letter
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Oliveira, Glaucia Maria Moraes de

; Negri, Fátima Elizabeth Fonseca de Oliveira

; Clausell, Nadine Oliveira

; Moreira, Maria da Consolação V.

; Souza, Olga Ferreira de

; Macedo, Ariane Vieira Scarlatelli

; Marino, Barbara Campos Abreu

; Polanczyk, Carisi Anne

; Lantieri, Carla Janice Baister

; Marques-Santos, Celi

; Freire, Cláudia Maria Vilas

; Nercolini, Deborah Christina

; Pedroti, Fatima Cristina Monteiro

; Barbosa, Imara Correia de Queiroz

; Santos, Magaly Arrais dos

; Braile, Maria Christiane Valéria Braga

; Paiva, Maria Sanali Moura de Oliveira

; Dracoulakis, Marianna Deway Andrade

; Holanda, Narriane Chaves

; Rolim, Patricia Toscano Rocha

; Teixeira, Roberta Tavares Barreto

; Mattos, Sandra

; Silva, Sheyla Cristina Tonheiro Ferro da

; Brandão, Simone Cristina Soares

; Lemke, Viviana de Mello Guzzo

; Lopes, Marcelo Antônio Cartaxo Queiroga

Arquivos Brasileiros de Cardiologia

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Jun 2019, Volume 112 Nº 6 Páginas 713 - 714

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.5935/abc.20190111 1001 downloads

13.

Hypnea musciformis (Wulfen) J. V. Lamour. (Gigartinales, Rhodophyta) responses to gasoline short-term exposure: biochemical and cellular alterations
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Ramlov, Fernanda

; Carvalho, Tiago Jose Griebeler

; Costa, Giulia Burle

; Rodrigues, Eva Regina de Oliveira

; Bauer, Claudia Marlene

; Schmidt, Eder Carlos

; Kreusch, Marianne Gabi

; Moresco, Rodolfo

; Navarro, Bruno Bachiega

; Cabral, Debora Queiroz

; Bouzon, Zenilda Laurita

; Horta, Paulo Antunes

; Maraschin, Marcelo

Acta Botanica Brasilica

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Mar 2019, Volume 33 Nº 1 Páginas 116 - 127

Resumo: En | Texto: En | PDF: En

ABSTRACT Presence of toxic compounds in marine coastal waters has increased exponentially since Industrial Revolution. In this way, we aimed to evaluate biochemical and physiological changes occurring within Hypnea musciformis after short-term exposure to gasoline. Hypnea musciformis was cultivated without gasoline and then exposed to various concentrations of it (0.001 % - 1.0 %, v/v) for periods of 30 min, 1 h, 12 h and 24 h. A Pricncipal Compound Analysis of UV-vis spectral window (200-700 nm) was able to discriminate gasoline-exposed samples according to both exposure time and gasoline concentration. Changes in carotenoid profile composition were observed. Decreased carotenoid content was associated to gasoline exposure time, being lutein and trans-β-carotene the major compounds found. Higher gasoline concentrations negatively interfered with phenolic compounds accumulation. In addition, increased gasoline concentrations corresponded to decreased intracellular starch grains content as well as increased its deposition on cell wall external surface. Data obtained allow us to conclude that gasoline can damage Hypnea musciformis physiology and cell morphology. This is important, considering Hypnea musciformis carotenoids and phenolics are potential biomarkers of environmental stress investigated, as well as its increased cell wall thickness to avoid gasoline diffusion.

https://doi.org/10.1590/0102-33062018abb0379 699 downloads

14.

PATHOLOGICAL FRACTURES DUE TO BONE METASTASES FROM LUNG CANCER: RISK FACTORS AND SURVIVAL
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Oliveira, Marcelo Bragança dos Reis

; Marques, Bruno de Carvalho

; Matos, Rosa Aurílio

; Fontenelle, César Rubens da Costa

; Mello, Fernanda Carvalho de Queiroz

; Paschoal, Marcos Eduardo Machado

Acta Ortopédica Brasileira

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Dez 2018, Volume 26 Nº 6 Páginas 388 - 393

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: Fratura patológica é um evento esquelético frequente em pacientes com câncer de pulmão, resultando em alta morbidade e sobrevida global reduzida que torna a decisão de tratamento cirúrgico desafiadora. Objetivos: Identificar fatores de risco associados à ocorrência de fraturas patológicas em pacientes com câncer de pulmão e determinar a sobrevida. Métodos: Conduzimos um estudo retrospectivo de coorte com 407 pacientes diagnosticados com carcinoma pulmonar entre 2006 e 2015. A prevalência de metástase óssea e fratura patológica foi calculada. Análise estatística foi conduzida usando o teste X2, e razão de chances e o intervalo de confiança de 95% foi calculado. A sobrevida global foi determinada usando o método de Kaplan-Meier e as diferenças foram comparadas usando o teste do log-rank. Resultados: A prevalência de metástases ósseas e fraturas patológicas foi de 28,2% (n = 115) e 19,1% (n = 22), respectivamente. Fraturas patológicas foram mais frequentes em pacientes com metástases ósseas ao diagnóstico do câncer de pulmão (24,7 % [n = 20] vs. 5,9% [n = 2]; p < 0.05). A sobrevida global média após o diagnóstico do câncer de pulmão, da metástase óssea e da fratura patológica foram 6, 4 e 2 meses, respectivamente. Conclusão: Fratura patológica foi associada à metástase óssea sincrônica e a sobrevida global consideravelmente reduzida. Nível de Evidência IV. Série de Casos.

ABSTRACT Introduction: Pathological fractures are frequent skeletal-related events among lung cancer patients, which result in high morbidity and decreased overall survival and make operative treatment decisions challenging. Objectives: To identify risk factors associated with the occurrence of pathological fractures in patients with lung cancer and to determine survival. Methods: We conducted a retrospective cohort study with 407 lung carcinoma patients diagnosed between 2006 and 2015. The prevalence of bone metastases and pathological fractures was calculated. Statistical analysis was conducted using a chi-squared test, and the odds ratio and 95% confidence interval were calculated. Overall survival was determined using the Kaplan-Meier method and differences were compared using the log-rank test. Results: The prevalence of bone metastases and pathological fractures was 28.2% (n = 115) and 19.1% (n = 22), respectively. Pathological fractures were more frequent among patients with bone metastases at the time of diagnosis of lung cancer (24.7% [n = 20] vs. 5.9% [n = 2]; p < 0.05). The median overall survival following the diagnosis of lung cancer, bone metastases, and pathological fracture was 6, 4, and 2 months, respectively. Conclusions: Pathological fracture was associated with synchronous bone metastases and overall survival times were considerably reduced. Level of Evidence IV, Case Series.

https://doi.org/10.1590/1413-785220182606201669 1475 downloads

15.

Tendência dos gastos e das internações por condições sensíveis à Atenção Primária em menores de cinco anos na Bahia, Brasil
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Pinto Junior, Elzo Pereira

; Costa, Líllian de Queiroz

; Oliveira, Silvia Morgana Araujo de

; Medina, Maria Guadalupe

; Aquino, Rosana

; Silva, Marcelo Gurgel Carlos da

Ciência & Saúde Coletiva

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Dez 2018, Volume 23 Nº 12 Páginas 4331 - 4338

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Este estudo analisou a tendência dos gastos e das Internações por Condições Sensíveis à Atenção Primária (ICSAP) em crianças residentes na Bahia. Trata-se de um estudo ecológico de série temporal, na Bahia, de 2000 a 2012. Foram calculadas as taxas anuais de ICSAP em menores de cinco anos, dos gastos totais e dos gastos médios. Para a análise da tendência temporal foram construídos modelos de regressão linear. Foram notificadas 810.831 ICSAP em menores de cinco anos na Bahia de 2000 a 2012. A taxa de ICSAP decresceu 24,7% no período, passando de 44,6 para 33,6 hospitalizações/1.000 crianças. O gasto total foi estimado em 155,8 milhões de reais, sendo observada redução de 50,4%, comparando-se o primeiro com o último ano da série. A análise de regressão linear evidenciou tendência de redução das ICSAP (β = -1,20; p = 0,014), dos gastos médios (β = -3,45; p < 0,01) e gastos totais (β = -0,46; p < 0,01). Apesar do comportamento de queda, ainda há elevadas taxas de ICSAP, que repercutem em um grande volume de recursos gastos com tais hospitalizações. Nesse sentido, diminuir as ICSAP em menores de cinco anos é importante tanto para melhorar a saúde da população quanto para reduzir gastos hospitalares.

Abstract This study analyses expenditure trends in Hospitalizations for Ambulatory Care Sensitive Conditions (ACSCs) in children. It is an ecological time-series study, including hospitalizations of children under five in Bahia, between 2000 and 2012. We calculate the annual ACSC rates, as well as the total and average expenditure on these hospitalizations. We construct linear regression analysis models for the temporal trends. Between 2000 and 2012, 810,831 ACSC hospitalizations for the under-fives were recorded in Bahia. Hospitalization rates dropped 24.7% over this period, falling from 44.6 to 33.6 per 1,000 children. The total expenditure on such admissions is estimated to be 155.8 million Brazilian Reals. When we compare the first with the last year of the series, we note a reduction of 50.4% in total expenditure. The linear regression analysis demonstrates a reduction trend in average ACSC expenditure (β = -1.20, p = 0.014), (β = -3.45, p <0.01) and total expenditure (β = -0,46, p <0.01). Despite the reductions in these indicators, ACSC rates remain high, which has a significant impact on the volume of resources spent on avoidable hospitalizations. To this end, it is important to reduce ACSC expenditure, to both improve population health and reduce hospital costs.

https://doi.org/10.1590/1413-812320182312.32122016 1853 downloads

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