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Fitting Structure-Data Files (.SDF) Libraries to Progenesis QI Identification Searches
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Sanches, Pedro H. G.

; Oliveira, Danilo C. de

; Reis, Ivan G. M. dos

; Fernandes, Anna M. A. P.

; Silva, Alex A. R.

; Eberlin, Marcos N.

; Carvalho, Patrícia O.

; Duarte, Gustavo H. B.

; Porcari, Andreia M.

Journal of the Brazilian Chemical Society

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Jul 2023, Volume 34 Nº 7 Páginas 1013 - 1019

Resumo: En | Texto: En | PDF: En

Progenesis QI (PQI) is a multiplatform bioinformatics tool that facilitates the identification workflow for metabolomics experiments. PQI uses fragmentation data provided by MassBank of North America (MoNA) libraries, among others, for metabolite annotation. However, PQI does not officially support MoNA libraries and other libraries based on structure-data files (.sdf). This paper describes the development and application of a software named MoNA to Progenesis QI Library Converter, allowing PQI and MoNA by correcting the fragmentation data of the library for Progenesis readability. We evaluated several public experimental datasets, including human plasma, plant extracts, cultured cells, bacteria, rat serum, and rat hippocampus. The results showed that it is mandatory to proceed with file conversion of each library to allow PQI to access fragmentation information from .msp (main spectra profile) files. This step is highly recommended to improve the identification level of the metabolites.

https://doi.org/10.21577/0103-5053.20230016

First record of Neoechinorhynchus buttnerae and Piscinoodinium pillulare infection in Colossoma macropomum in the state of Tocantins, Brazil
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Maciel-Honda, Patricia Oliveira

; Sousa Neto, Elias Mendes de

; Costa-Fernandes, Thaís de Oliveira

; Jesus, Fabiano Henrique Ribeiro de

; Chagas, Edsandra Campos

; Tavares-Dias, Marcos

Revista Brasileira de Parasitologia Veterinária

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2023, Volume 32 Nº 1 elocation e013622

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract This study aims to report the occurrence of two important parasites in farmed tambaqui Colossoma macropomum in the state of Tocantins, the acanthocephalan Neoechinorhynchus buttnerae and the dinoflagellate protozoan Piscinoodinium pillulare, also suggesting the main treatments to control them. The fish sampled for the study were infected by N. buttnerae, and P. pillulare, with prevalence from 100% and mean intensity from 51.4 to 354,264, respectively. This was the first report on the occurrence of such parasites in C. macropomum in the state of Tocantins. We emphasize the need to adopt good farm management and biosecurity practices to prevent pathogenic agents to enter or leave a property. Reported treatments with synthetic and natural products with positive results are also suggested to treat against those parasites in farmed C. macropomum.

Resumo Este estudo teve como objetivo relatar a ocorrência de dois importantes parasitos em tambaqui Colossoma macropomum cultivado no estado de Tocantins, o acantocéfalo Neoechinorhynchus buttnerae e o protozoário dinoflagelado Piscinoodinium pillulare e também destacar os principais tratamentos para controlá-los. Os peixes examinados estavam infectados por N. buttnerae e P. pillulare, com prevalência de 100% e intensidade média de 51,4 a 354.264,4, respectivamente. Este foi o primeiro relato da ocorrência desses parasitos para C. macropomum no estado de Tocantins. Destaca-se a necessidade da adoção de boas práticas de manejo na produção e de manejo sanitário, para evitar a contaminação da propriedade e a transmissão para pisciculturas vizinhas. Em relação ao controle dessas parasitoses são apresentados os tratamentos com resultados positivos para C. macropomum, com o uso de produtos sintéticos e naturais.

https://doi.org/10.1590/s1984-29612023001

Long-term Ecological Research: Chasing fashions or being prepared for fashion changes?
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BERGALLO, HELENA G.

; ROSA, CLARISSA

; OCHOA, ANA C.

; MANZATTO, ANGELO GILBERTO

; GUIMARAES, ARETHA F.

; BANHOS, AUREO

; CASTILHO, CAROLINA V.

; BARROS, CLAUDIA F.

; NORRIS, DARREN

; DRUCKER, DEBORA P.

; RODRIGUES, DOMINGOS J.

; BACCARO, FABRICIO B.

; LOURENÇO, IGOR H.

; ZUANON, JANSEN

; STEGMANN, LIS F.

; ANJOS, MARCELO R.

; SILVEIRA, MARCOS

; ARAÚJO, PATRICIA S.G.

; BOBROWIEC, PAULO E.D.

; FADINI, RODRIGO

; NECKEL-OLIVEIRA, SELVINO

; EMILIO, THAISE

; SANTORELLI JUNIOR, SERGIO

; MAGNUSSON, WILLIAM E.

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Nº 3 elocation e20230051

Resumo: En | Texto: En | PDF: En

Abstract Long-term-ecological-research (LTER) faces many challenges, including the difficulty of obtaining long-term funding, changes in research questions and sampling designs, keeping researchers collecting standardized data for many years, impediments to interactions with local people, and the difficulty of integrating the needs of local decision makers with “big science”. These issues result in a lack of universally accepted guidelines as to how research should be done and integrated among LTER sites. Here we discuss how the RAPELD (standardized field infrastructure system), can help deal with these issues as a complementary technique in LTER studies, allowing comparisons across landscapes and ecosystems and reducing sampling costs. RAPELD uses local surveys to understand broad spatial and temporal patterns while enhancing decision-making and training of researchers, local indigenous groups and traditional communities. Sampling of ecological data can be carried out by different researchers through standardized protocols, resulting in spatial data that can be used to answer temporal questions, and allow new questions to be investigated. Results can also be integrated into existing biodiversity networks. Integrated systems are the most efficient way to save resources, maximize results, and accumulate information that can be used in the face of the unknown unknowns upon which our future depends.

https://doi.org/10.1590/0001-3765202320230051

Hyperphagia and hyperleptinemia induced by low-protein, high-carbohydrate diet is reversed at a later stage of development in rats
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FROELICH, MENDALLI

; LEMES, SUELEM A.F.

; ELIAS, MAÍSA P.S.

; OLIVEIRA, ANA PAULA S.S

; LISBOA, PATRICIA C.

; SOUZA, JOSÉ RICARDO DE

; MOURA, EGBERTO G.

; ALMEIDA, FHELIPE J.S

; PEREIRA, MAYARA P.

; LATORRACA, MARCIA Q.

; KAWASHITA, NAIR H.

Anais da Academia Brasileira de Ciências

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2022, Volume 94 Nº 3 elocation e20210902

Resumo: En | Texto: En | PDF: En

Abstract This study investigated whether increased food intake after 15 days of low-protein, high-carbohydrate (LPHC) and its normalization in the later period of development change the content of key proteins related to leptin or adiponectin signaling in the hypothalamus. Male rats were divided into five groups: Control groups received a control diet (17% protein, 63% carbohydrate) for 15 (C15) or 45 (C45) days; LPHC groups received an LPHC diet (6% protein, 74% carbohydrate) for 15 (LPHC15) or 45 (LPHC45) days; and Reverse group (R): received LPHC diet for 15 days followed by control diet for another 30 days. The LPHC15 group showed increased adiposity index, leptin level, and adiponectin level, as well as decreased the leptin receptor (ObRb) and pro-opiomelanocortin (POMC) content in the hypothalamus compared with the C15 group. LPHC diet for 45 days or diet reversion (R group) rescued these alterations, except the adiponectin level in LPHC45 rats, which was higher. In summary, LPHC diet reduced hypothalamic leptin action by diminishing ObRb and POMC levels, leading to hyperphagia and adiposity body. Medium-term administration of LPHC diet or reverting to control diet restored the levels of these proteins, thereby improving body lipid mass rearrangement in adulthood.

https://doi.org/10.1590/0001-3765202220210902

Clinical characteristics and evolution of hematological patients and COVID-19 in Argentina: a report from the Argentine Society of Hematology
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Basquiera, Ana L.

; García, Mercedes J

; Martinez Rolón, Juliana

; Olmedo, Julieta

; Laviano, Julia

; Burgos, Rubén

; Caeiro, Gastón

; Remaggi, Guillermina

; Raña, Pablo

; Paoletti, Mariano

; González, Carlos M.

; Fernández, Isolda

; Pavlovsky, Astrid

; Perusini, Maria A.

; Rodriguez, Andrea

; Guanchiale, Luciana

; Carvani, Analia

; Mandrile, Laura

; Figueroa, Flavia

; Vicente Reparaz, Ángeles

; Fragapane Mathus, Patricia N.

; Garate, Gonzalo

; Fauque, María E.

; Kantor, Gustavo

; Cruset, Soledad

; Gonzalez Lorch, Jacqueline S.

; Szelagowski, Milagros

; Giarini, María P.

; Oliveira, Natalia

; García, María C.

; Ventriglia, María V.

; Pereyra, Patricio H.

; Gutierrez, Daniel R.

; Kusminsky, Gustavo

; Troccoli, Josefina

; Freitas, María J.

; Cranco, Santiago

; Del V.Sanchez, Natalia

; Rey, Irene

; Funes, María E.

; Jarchum, Sol

; Freue, Julian

; Miroli, Augusto

; Guerrero, Osvaldo

; López Ares, Lisa

; Campestri, Reinaldo

; Bove, Victor

; Salinas, Graciela N.

; Cabrejo, María

; Milone, Jorge H.

; Zabaljauregui, Soledad

; Gotta, Daniel

; Dupont, Juan Carlos

; Stemmelin, German

Medicina (Buenos Aires)

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Ago 2021, Volume 81 Nº 4 Páginas 536 - 545

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Individuals with malignancies and COVID-19 have a lower survival compared with the general population. However, the information about the impact of COVID-19 on the whole hematological population is scarce. We aimed to describe the 30th day overall survival (OS) after COVID-19 infection in pa tients with a hematological disease in Argentina. A completely anonymous survey from the Argentine Society of Hematology was delivered to all the hematologists in Argentina; it started in April 2020. A cut-off to analyze the data was performed in December 2020 and, finally, 419 patients were reported and suitable for the analysis (average age: 58 years, 90% with malignant diseases). After the COVID-19 diagnosis, the 30-day OS for the whole population was 80.2%. From the entire group (419), 101 (24.1%) individuals required intensive care unit admission, where the 30-day OS was 46.6%. Among allogeneic stem cell transplant recipients, the 30-day OS was 70.3%. Factors associated with a low OS were two or more comorbidities, an active hematological disease and history of chemotherapy. In individuals with the three factors, the 30-day OS was 49.6% while the 30-day OS in those without those factors was 100%. Patients with hematological diseases have a higher mortality than the general population. This group represents a challenge and requires careful decision-making of the treatment in order not to compromise the chances of cure.

Resumen El presente estudio tuvo por objetivo primario conocer la mortalidad de pacientes con enfermedad hematológica que presentaron infección por COVID-19 en Argentina. Para ello se difundió una encuesta desde la Sociedad Argentina de Hematología (SAH) entre los hematológos para informar sobre los pacientes con enfermedades hematológicas y diagnóstico de infección por SARS- CoV-2, entre el 19/4/2020, y el 7/12/2020. Se incluyeron individuos de todas las edades con diagnóstico de enfermedad hematológica benigna o maligna e infección por SARS-CoV-2 confirmada por técnica de RT-PCR. Se analizaron 419 pacientes (mediana 58 años; 90% enfermedades malignas). La supervivencia al día 30 fue de 80.2%. La supervivencia fue menor en aquellos que requirieron internación (74.2%), cuidados intensivos (46.6%) y asistencia respiratoria mecánica (36.8%). Entre los trasplantados alogénicos la supervivencia fue 70.3%. Los factores vinculados a la supervivencia global fueron las comorbilidades, el estado de la enfermedad al momento de la infección y el antecedente de quimioterapia. Se pudo establecer un score en el que aquellos que tuvieron un puntaje de 4 alcanzaron una supervivencia del 49.6% al día 30, mientras que la de los pacientes con score 0 fue del 100% a 30 días. En comparación con la población general, los pacientes con enfermedades hematológicas presentan una mayor mortalidad vinculada al COVID-19, motivo por el cual es primordial definir pautas destinadas a disminuir la exposición de los mismos sin comprometer las posibilidades de beneficiarse del tratamiento de la enfermedad de base.

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Efeitos do Exercício Aeróbico Tardio na Remodelação Cardíaca de Ratos com Infarto do Miocárdio Pequeno
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Souza, Lidiane M.

; Okoshi, Marina P.

; Gomes, Mariana J.

; Gatto, Mariana

; Rodrigues, Eder A.

; Pontes, Thierres H. D.

; Damatto, Felipe C.

; Oliveira, Leiliane R. S.

; Borim, Patrícia Aparecida

; Lima, Aline R. R.

; Zornoff, Leonardo A. M.

; Okoshi, Katashi

; Pagan, Luana U.

Arquivos Brasileiros de Cardiologia

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Abr 2021, Volume 116 Nº 4 Páginas 784 - 792

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento: O exercício físico tem sido considerado uma importante terapia não farmacológica para a prevenção e tratamento das doenças cardiovasculares. No entanto, seus efeitos na remodelação cardíaca leve não são claros. Objetivo: Avaliar a influência do exercício aeróbico sobre a capacidade funcional, estrutura cardíaca, função ventricular esquerda (VE) e expressão gênica das subunidades da NADPH oxidase em ratos com infarto do miocárdio pequeno (IM). Métodos: Três meses após a indução do IM, ratos Wistar foram divididos em três grupos: Sham; IM sedentário (IM-SED); e IM exercício aeróbico (IM-EA). Os ratos se exercitaram em uma esteira três vezes por semana durante 12 semanas. Um ecocardiograma foi realizado antes e após o treinamento. O tamanho do infarto foi avaliado por histologia e a expressão gênica por RT-PCR. O nível de significância para análise estatística foi estabelecido em 5%. Resultados: Ratos com IM menor que 30% da área total do VE foram incluídos no estudo. A capacidade funcional foi maior no IM-EA do que nos ratos Sham e IM-SED. O tamanho do infarto não diferiu entre os grupos. Ratos infartados apresentaram aumento do diâmetro diastólico e sistólico do VE, diâmetro do átrio esquerdo e massa do VE, com disfunção sistólica. A espessura relativa da parede foi menor no grupo IM-SED do que nos grupos IM-EA e Sham. A expressão gênica das subunidades NADPH oxidase NOX2, NOX4, p22phox e p47phox não diferiu entre os grupos. Conclusão: Infarto do miocárdio pequeno altera a estrutura cardíaca e a função sistólica do VE. O exercício aeróbico tardio pode melhorar a capacidade funcional e a remodelação cardíaca por meio da preservação da geometria ventricular esquerda. A expressão gênica das subunidades da NADPH oxidase não está envolvida na remodelação cardíaca, nem é modulada pelo exercício aeróbico em ratos com infarto do miocárdio pequeno.

Abstract Background: Physical exercise has been considered an important non-pharmacological therapy for the prevention and treatment of cardiovascular diseases. However, its effects on minor cardiac remodeling are not clear. Objective: To evaluate the influence of aerobic exercise on the functional capacity, cardiac structure, left ventricular (LV) function, and gene expression of NADPH oxidase subunits in rats with small-sized myocardial infarction (MI). Methods: Three months after MI induction, Wistar rats were divided into three groups: Sham; sedentary MI (MI-SED); and aerobic exercised MI (MI-AE). The rats exercised on a treadmill three times a week for 12 weeks. An echocardiogram was performed before and after training. The infarction size was evaluated by histology, and gene expression was assessed by RT-PCR. The significance level for statistical analysis was set at 5%. Results: Rats with MI lower than 30% of the LV total area were included in the study. Functional capacity was higher in MI-AE than in Sham and MI-SED rats. The infarction size did not differ between groups. Infarcted rats had increased LV diastolic and systolic diameter, left atrial diameter, and LV mass, with systolic dysfunction. Relative wall thickness was lower in MI-SED than in the MI-AE and Sham groups. Gene expression of the NADPH oxidase subunits NOX2, NOX4, p22phox, and p47phox did not differ between groups. Conclusion: Small-sized MI changes cardiac structure and LV systolic function. Late aerobic exercise is able to improve functional capacity and cardiac remodeling by preserving the left ventricular geometry. NADPH oxidase subunits gene expression is not involved in cardiac remodeling or modulated by aerobic exercise in rats with small-sized MI.

https://doi.org/10.36660/abc.20190813 362 downloads

Early liver function improvement following successful treatment of chronic hepatitis C in patients with decompensated cirrhosis: a real-life study
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Lourenço, Mariana Sandoval

; Zitelli, Patricia Momoyo Y.

; Cunha-Silva, Marlone

; Oliveira, Arthur Ivan N.

; Lima, Roque Gabriel Rezende de

; Souza, Evandro de Oliveira

; Oliveira, Claudia P.

; Sevá-Pereira, Tiago

; Carrilho, Flair J.

; Pessoa, Mario G.

; Mazo, Daniel F.

Clinics

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2021, Volume 76 elocation e3186

Resumo: En | Texto: En | PDF: En

OBJECTIVES: Despite higher rates of sustained virologic response (SVR), important concerns remain when patients with decompensated cirrhosis due to hepatitis C virus (HCV) are treated with direct-acting antiviral agents (DAA). Questions include efficacy, safety, and the magnitude of liver function improvement. Here, we aimed to evaluate HCV treatment data in this specific population in Brazil. METHODS: We included 85 patients with decompensated cirrhosis submitted to HCV therapy with DAA followed at two academic tertiary centers in the southeastern region of Brazil. RESULTS: Seventy-nine patients (92.9%) were Child-Pugh (CP) score B, and six (7.1%) were CP score C. The mean MELD score was 12.86. The most common treatment was sofosbuvir plus daclatasvir±ribavirin for 24 weeks. The overall intention-to-treat (ITT) SVR rate was 87.4% (74/85) and modified-ITT 96.1% (74/77). ITT SVR was associated with lower baseline INR values (p=0.029). Adverse events (AE) occurred in 57.9% (44/76) of patients. Serious AE were reported in 12.8% (10/78), and were related to the presence of hepatic encephalopathy (p=0.027). SVR was associated with improvement in CP (p<0.0001) and MELD scores (p=0.021). Among baseline CP score B patients with SVR, 46% (29/63) regressed to CP score A. Ascites was independently associated with no improvement in liver function in patients who achieved SVR (p=0.001; OR:39.285; 95% CI:4.301-258.832). CONCLUSIONS: Patients with decompensated HCV cirrhosis showed a high SVR rate with interferon-free therapy. Early liver function improvement occurred after successful HCV eradication. However, long-term follow-up of these patients after SVR remains strongly advised.

https://doi.org/10.6061/clinics/2021/e3186

Omega-3 and Omega-6 Determination in Nile Tilapia’s Fillet Based on MicroNIR Spectroscopy and Multivariate Calibration
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Santos, Dayane A. dos

; Coqueiro, Aline

; Gonçalves, Thays R.

; Carvalho, Jonathan C.

; Bezerra Jr., Jailton S.

; Matsushita, Makoto

; Oliveira, Carlos A. L. de

; Março, Paulo H.

; Valderrama, Patrícia

; Ribeiro, Ricardo P.

Journal of the Brazilian Chemical Society

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Set 2020, Volume 31 Nº 9 Páginas 1883 - 1890

Resumo: En | Texto: En | PDF: En

Tilapia (Oreochromis niloticus) is the most cultivated fish species in Brazil. Studies have shown that fish consumption is related to the prevention of cardiovascular diseases due to its high contents of polyunsaturated fatty acids, as omega-3 (n-3) and omega-6 (n-6). In this sense, a new method to determine omega-3 and omega-6 by near-infrared (NIR) spectroscopy and multivariate calibration based on partial least squares (PLS) was proposed. Spectra of fillets of Nile tilapias packed under vacuum were obtained and compared to the reference method (gas chromatography) used for quantification of fatty acids. The outliers were evaluated in the models that were validated by calculation of the parameters for model performance estimation, showing promising results. The appropriate values achieved for accuracy, limits of detection and quantification, indicate that the NIR/PLS models can be an alternative to chromatography in the determination of omega-3 and omega-6 in fillets of Nile tilapia. Furthermore, the spectra acquisition on the vacuum-packed fillet contributes to the NIR/PLS method in terms of cost and quickness.

https://doi.org/10.21577/0103-5053.20200082 510 downloads

Synthesis, Characterization and in vitro, in vivo and in silico Anti-Inflammatory Studies of the Novel Hybrid Based on Ibuprofen and 3-Hydroxy-Copalic Acid Isolated from Copaiba Oil (Copaifera multijuga)
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Souza, Fábio C. de

; Brito, Larissa F.

; Silva, Marcos T.

; Sugimoto, Michelle A.

; Pinto, Ana Cristina S.

; Almeida, Patrícia D. O. de

; Souza, Rodrigo O. S.

; Costa, Renyer A.

; Guilhon-Simplicio, Fernanda

; Wanderley, Almir G.

; Oliveira, Kelson M. T. de

; Sousa, Lirlândia P.

; Veiga-Junior, Valdir F. da

; Lima, Emerson S.

Journal of the Brazilian Chemical Society

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Jul 2020, Volume 31 Nº 7 Páginas 1335 - 1344

Resumo: En | Texto: En | PDF: En

A novel anti-inflammatory hybrid 3-ibuprofenyl-copalic acid (3-IbuCA) was synthesized from 3-hydroxy-copalic acid isolated from Amazonian copaiba oil (Copaifera multijuga Hayne), and the anti-inflammatory ibuprofen. After full characterization, several assays to verify its anti-inflammatory effects were performed in vitro, in vivo and in silico (molecular docking). Induced fit docking was performed to observe the interactions with the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). In vitro tests of cytotoxicity and tumor necrosis factor (TNF)-α inhibition, and in vivo tests of pleurisy, protein expression and gastrocytotoxicity were performed. Molecular docking studies with COX-1 and 2 showed binding free energies (ΔG) of -2.2 and -7.8 kcal mol-1, respectively, while for mofezolac and indomethacin, the binding free energies ΔG presented values of -8.5 and -10.1 kcal mol-1, which makes 3-IbuCA selective for COX-2 inhibition. This hybrid showed no toxicity against human macrophage at concentrations up to 2 µM, and inhibited TNF-α production in lipopolysaccharide (LPS)-stimulated macrophages. In the pleurisy assays, 3-IbuCA reduced the total leukocytes and mononuclear cells, which was followed by reduction of p-IKBα (phosphorylated nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha) protein expression. Compared with ibuprofen alone, the hybrid caused less gastric damage. Thus, the docking, together with in vitro and in vivo studies suggest that this novel hybrid has potential as a new anti-inflammatory agent.

https://doi.org/10.21577/0103-5053.20190266 429 downloads

10.

Biosorption Potential of the Aspergillus sp. and Insights into Secondary Metabolism in the Presence of Copper and Lead
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Alves, Maurício Augusto P. M. S.

; Silva, Sebastião C.

; Silva, Simone Y. S.

; Pereira Junior, João B.

; Marinho, Patrícia S. B.

; Dantas, Kelly das Graças F.

; Mota, Silvio Alex P. da

; Amaral, Jessica Cristina

; Silva, Maria Fátima das Graças F. da

; Oliveira, Marilene N.

Journal of the Brazilian Chemical Society

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Mar 2020, Volume 31 Nº 3 Páginas 574 - 579

Resumo: En | Texto: En | PDF: En

The fungus Aspergillus sp. was isolated from copper mining rejects and cultured in a liquid culture medium (potato dextrose, PD) enriched with CuSO4.5H2O and Pb(NO3)2 in different concentrations. By flame atomic absorption spectrometry (FAAS) it was observed that fungus absorbed 86% of both copper and lead, with initial concentrations of 100, 500 and 1000 mg L-1. The additional results provided by scanning electron microscopy, energy dispersive spectroscopy, and X-ray diffraction showed ability of the microorganism to act as a biosorbent as well as its capacity to transform the tested salts into other inorganic compounds. Chromatographic profile comparison of extracts obtained from the biotic, abiotic control and the cultivation enriched with the metals showed changes in the profile of the secondary metabolism. When the copper and lead salts were tested separately, there was an increase in the production of the compounds as function of the increase of the concentration and when associated promoted the decrease and disappearance of some substances produced by Aspergillus sp.

https://doi.org/10.21577/0103-5053.20190219 355 downloads

11.

Antiproliferative potential of solidagenone isolated of Solidago chilensis
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Gomes, Denise B.

; Zanchet, Barbara

; Locateli, Gelvani

; Benvenutti, Régis C.

; Vechia, Cristian A. Dalla

; Schönell, Amanda P.

; Diel, Kriptsan A.P.

; Zilli, Gabriela A.L.

; Miorando, Daniela

; Ernetti, Jackeline

; Oliveira, Bianca

; Zanotelli, Patrícia

; Santos, Maria F.C.

; Barisson, Andersson

; Banzato, Thais P.

; Ruiz, Ana L.T.G.

; Carvalho, João E.

; Cechinel Filho, Valdir

; García, Pablo A.G.

; Feliciano, Arturo San

; Roman Junior, Walter A.

Revista Brasileira de Farmacognosia

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Dez 2018, Volume 28 Nº 6 Páginas 703 - 709

Resumo: En | Texto: En | PDF: En

ABSTRACT Plants are considered among the main sources of biologically active chemicals. The species Solidago chilensis Meyen, Asteraceae, is native to the southern parts of South America, where the aerial parts of the plant are commonly used for the treatment of inflammatory conditions. However, the effects of S. chilensis on human cancer cells remain to be elucidated. In this study, we evaluated the antiproliferative effects of the hydroalcoholic and dichloromethane extracts of S. chilensis, as well as their chemical constituents quercitrin and solidagenone against the five human tumor cell lines in vitro. The dichloromethane extract showed a promisor antiproliferative effects in vitro, especially against glioma cell line. Besides, the hydroalcoholic extract and quercitrin were inactive. The diterpene solidagenone showed highly potent antiproliferative effects against breast (MCF-7), kidney (786-0), and prostate cancer (PC-3) cells (total growth inhibition: TGI < 6.25 µg/ml). Solidagenone meets the theoretical physico-chemical criteria for bioavailability of drugs, according to the "Rule of Five" and, by theorical studies, the observed biological effects were probably related to the interaction of the molecule with nuclear receptors and as an enzymatic inhibitor. This study contributes to chemical study and to the identification of antiproliferative molecules in S. chilensis.

https://doi.org/10.1016/j.bjp.2018.09.001 766 downloads

12.

Can combine headers and travel speeds affect the quality of soybean harvesting operations?
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Menezes, Patricia C. de

; Silva, Rouverson P. da

; Carneiro, Franciele M.

; Girio, Lucas A. da S.

; Oliveira, Mailson F. de

; Voltarelli, Murilo A.

Revista Brasileira de Engenharia Agrícola e Ambiental

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Out 2018, Volume 22 Nº 10 Páginas 732 - 738

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO A qualidade da colheita mecanizada de soja é essencial para garantir que todo investimento realizado nas demais etapas do processo produtivo da cultura seja convertido em lucro para o produtor. Considerando que a qualidade dessa operação está relacionada com menores perdas e que a plataforma de corte utilizada e a velocidade de colheita podem influenciar nisso, objetivou-se avaliar a qualidade da colheita mecanizada da soja, no Cone Sul de Rondônia, em colhedoras com diferentes plataformas de corte e velocidades de deslocamento por meio do controle estatístico de processo. O experimento foi realizado na safra 2015/16 em uma área agrícola no município de Cabixi, RO, localizada nas coordenadas geográficas 13º 27’ S e 60º 41’ W. O delineamento experimental foi estabelecido de acordo com as premissas do controle estatístico de processo, sendo amostrados 80 pontos distanciados a cada 100 m. Avaliaram-se as perdas na plataforma, nos mecanismos internos e totais e a altura de corte. A melhor qualidade do processo de colheita foi obtida na plataforma de esteira, com pouca influência da velocidade de deslocamento. O nível de perdas na colheita foi acima do limite aceitável, indicando necessidade de melhorias do processo.

ABSTRACT Assuring the quality of mechanical soybean harvesting is crucial to ensure that investment in other stages of crop production is converted into profit for the farmer. Because the quality of this operation is related to decreased losses, which may be affected by the combine header used and by the harvesting speed, the aim of the present study was to assess the quality of mechanical soybean harvesting in the Southern Cone of Rondônia, using harvesters with different combine headers and travel speeds via statistical process control. The experiment was performed during the 2015/16 harvest in an agricultural area of the municipality of Cabixi, RO, located at the geographical coordinates 13° 27’ S and 60° 41’ W. The study was designed based on the premises of the statistical process control, sampling 80 points 100 m apart. Combine header, internal, total, and cutting height losses were assessed. Quality of the harvesting process was assessed using the draper header. Travel speed had little effect on process quality. Crop losses were higher than the acceptable limit, indicating the need to improve the process.

https://doi.org/10.1590/1807-1929/agriambi.v22n10p732-738 843 downloads

13.

Abortos, malformações congênitas e falhas reprodutivas espontâneas em caprinos causados na intoxicação pelas folhas da catingueira, Poincianella pyramidalis (sin. Caesalpinia pyramidalis)
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Souza, Maria de Fátima

; Bezerra, Isadora T.F.

; Barbosa, Francisca M.S.

; Rocha, Valdemar C.

; Sousa, Monica S.

; Oliveira Neto, Temístocles S.

; Lacerda-Lucena, Patrícia B.

; Lucena, Ricardo B.

Pesquisa Veterinária Brasileira

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Jun 2018, Volume 38 Nº 6 Páginas 1051 - 1057

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: O objetivo deste estudo foi investigar os efeitos de folhas da espécie arbórea Poincianella pyramidalis (Tul.) L.P. Queiroz como causa espontânea de abortos, malformações e falhas reprodutivas em rebanhos caprinos no semiárido brasileiro. Foram realizadas investigações epidemiológicas, avaliações clínicas de caprinos acometidos por malformações e necropsias de fetos abortados em 12 propriedades localizadas nos municípios de Gurjão e Soledade, na Paraíba, e no município de Pau dos Ferros, Rio Grande do Norte. O estudo considerou apenas as propriedades que tinham basicamente a presença de P. pyramidalis entre as plantas teratogênicas. Na propriedade localizada no município de Pau dos Ferros foi verificada a ocorrência de grande número de abortos e o nascimento de cabritos malformados, acometendo 90% das cabras gestantes. Nas 12 propriedades pertencentes aos municípios de Gurjão e Soledade na Paraíba os casos espontâneos de mortalidade embrionária, abortos e malformações acometeram 257 cabras (41,1% das cabras dos rebanhos). A artrogripose foi a principal malformação congênita observada. Exames de necropsia e histopatológico de quatro fetos acompanhados das placentas não constataram a presença de agentes infecciosos. Os casos de perda embrionária, abortos e malformações foram concentrados predominantemente nas épocas do ano em que a pastagem estava escassa, mas havia disponibilidade de P. pyramidalis nas propriedades, devido à ocorrência das chuvas da pré-estação, que não permitiu a germinação de pasto, mas a rebrotação de P. pyramidalis. Os achados desse estudo comprovam que esta planta interfere consideravelmente na eficiência reprodutiva dos rebanhos caprinos do Semiárido.

ABSTRACT: The aim of this study was to investigate the effects of the leaves of the tree Poincianella pyramidalis (Tul.) L.P. Queiroz as a spontaneous cause of abortion, malformation and reproductive failure in goat herds in the Brazilian semiarid region. Epidemiological investigations, clinical evaluation of goats affected by malformation and necropsy of aborted fetuses was carried out on 12 farms located in the municipalities of Gurjão and Soledade, state of Paraíba, and on a farm located at the municipality of Pau dos Ferros, state of Rio Grande do Norte. The study considered only the farms where occurred predominantly P. pyramidalis among teratogenic plants. On the farm located in the municipality of Pau dos Ferros the occurrence of frequent abortion and birth of malformed goats, affecting 90% of pregnant goats, was observed. On the 12 farms belonging to the municipalities of Gurjão and Soledade, spontaneous cases of embryonic mortality, abortion and malformation occurred in 257 goats (41.1% of goats). Arthrogryposis was the main congenital malformation observed. Necropsy and histopathological exams of four fetuses and their placentas did not detect the presence of infectious agents. The cases of embryonic mortality, abortion and malformation were predominantly concentrated during the seasons of the year when pasture was scarce, but P. pyramidalis was available, due to the occurrence of pre-seasonal rains, which did not allow the pasture to germinate but P. pyramidalis to regrowth. The findings of this study confirm that this plant significantly interferes in the reproductive efficiency of semi-arid goat herds.

https://doi.org/10.1590/1678-5150-pvb-5243 2455 downloads

14.

SYNTHESIS, LARVICIDAL AND ACETYLCHOLINESTERASE INHIBITORY ACTIVITIES OF CARVACROL/THYMOL AND DERIVATIVES
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Mesquita, Bruna M. de

; Nascimento, Patricia G. G. do

; Souza, Luciana G. S.

; Farias, Iolanda F. de

; Silva, Romézio A. C. da

; Lemos, Telma L. G. de

; Monte, Francisco J. Q.

; Oliveira, Irvila R.

; Trevisan, Maria T. S.

; Silva, Horlando C. da

; Santiago, Gilvandete M. P.

Química Nova

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Abr 2018, Volume 41 Nº 4 Páginas 412 - 416

Resumo: En | Texto: En | PDF: En

In order to produce bioactive derivatives of carvacrol and thymol, nine derivatives of each compound were prepared through modifications the phenolic hydroxyl group. The structures of compounds were confirmed by spectral data from MS, IR and NMR. Carvacrol, thymol and derivatives were submitted to the evaluation of the inhibition of the enzyme acetylcholinesterase, using a colorimetric method in which the inhibition of the enzyme is measured by coloration, and larvicidal activity against Aedes aegypti. Derivatives carvacryl acetate-1b and thymyl hexanoate-2b showed the best results for the inhibition of the acetylcholinesterase enzyme, and for the larvicidal activity the derivatives 1a, 1b, 1c, 3h, 2a, 2b, 2c and 4h showed positive results, emphasizing compound thymyl 4-methoxybenzoate-4h which showed LC50 values of 23.60 ppm, considered a very good result.

https://doi.org/10.21577/0100-4042.20170189 946 downloads

15.

Oral pigmentations in Laugier-Hunziker syndrome: a case report and review of diagnostic criteria
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Silva, Luiz Arthur B.

; Mafra, Rodrigo P.

; Oliveira, Patrícia T.

; Medeiros, Ana Miryam C.

; Pinto, Leão P.

; Silveira, Éricka Janine D.

Jornal Brasileiro de Patologia e Medicina Laboratorial

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Fev 2018, Volume 54 Nº 1 Páginas 52 - 56

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO A síndrome de Laugier-Hunziker (SLH) é uma rara desordem mucocutânea, de etiologia indeterminada, caracterizada por múltiplas máculas hiperpigmentadas, dispersas principalmente na mucosa oral, por vezes associadas a estrias longitudinais nas unhas. O diagnóstico requer exclusão de condições como doença de Addison e síndrome de Peutz-Jeghers. Descrevemos o caso de um paciente do sexo masculino, 34 anos, com presença de máculas hiperpigmentadas em lábios, mucosa jugal e palato, além de discretas estrias enegrecidas nas unhas dos pés. Após minuciosa investigação clínica e laboratorial, foi estabelecido o diagnóstico de SLH. Dada a ausência de queixas estéticas e sintomatologia, nenhum tratamento foi necessário.

ABSTRACT Laugier-Hunziker syndrome (LHS) is a rare mucocutaneous disorder, of unknown etiology, characterized by multiple hyperpigmented macules, dispersed mostly on the oral mucosa, occasionally associated with longitudinal ridging of the nails. The diagnosis requires exclusion of other conditions, such as Addison's disease and Peutz-Jeghers syndrome. We report a case of a 34-year-old male patient, presenting with hyperpigmented macules on the lips, buccal mucosa and palate, as well as mild dark striations on toenails. After careful clinical and laboratorial investigations, the diagnosis of LHS was established. Given the lack of aesthetic complaints and symptoms, no treatment was necessary.

https://doi.org/10.5935/1676-2444.20180011 2565 downloads

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