Pesquisa | SciELO

Abstract Spinal muscular atrophy (SMA) is considered one of the most common autosomal recessive disorders, with an estimated incidence of 1 in 10,000 live births. Testing for SMA has been recommended for inclusion in neonatal screening (NBS) panels since there are several therapies available and there is evidence of greater efficacy when introduced in the pre/early symptomatic phases. In Brazil, the National Neonatal Screening Program tests for six diseases, with a new law issued in 2021 stating that it should incorporate more diseases, including SMA. In the present study, dried blood spot (DBS) samples collected by the Reference Services of Neonatal Screening of RS and SP, to perform the conventional test were also screened for SMA, using real-time PCR, with SALSA MC002 technique. A total of 40,000 samples were analyzed, enabling the identification of four positive cases of SMA, that were confirmed by MLPA. Considering our sampling, Brazil seems to have an incidence comparable to the described in other regions. This work demonstrated that the use of the MC002 technique in samples routinely collected for the conventional NBS program is suitable to screen for SMA in our conditions and can be included in the expansion of the neonatal screening programs.

https://doi.org/10.1590/1678-4685-gmb-2023-0126

3D gravity modelling of areas under the aptian lakes in the Jatobá basin and Tucano Norte sub-basin – Negra and Tonã hills
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LIMA, RAFAEL P.

; CORREIA, PAULO B.

; OLIVEIRA, ROBERTO G.

; MORAES, ALEX S.

; NEUMANN, VIRGÍNIO HENRIQUE

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Nº 1 elocation e20210606

Resumo: En | Texto: En | PDF: En

Abstract Due to structural similarities and the possibility of connection between the two Aptian paleolakes in the Jatobá Basin and the Tucano Norte Sub-basin in North-eastern Brazil, the influence of the architecture of the crystalline basement under these lacustrine sedimentary rocks was analysed using gravimetric data near the faulted edges of the basins where the paleolakes are located. The Negra (Jatobá Basin) and Tonã (Tucano Norte Sub-basin) Hills are mainly sedimentary deposits of Aptian age and are linked to the post-rift I tectonic sequence. Aiming at the study of reservoirs analogous to pre-salt reservoirs, the gravimetric data were processed and interpreted to define the structural framework of the basin regions around these hills. Depth maps and density models were generated that could be analysed from various 3D perspectives, and the behaviour of the crystalline basement below these sedimentary sequences was investigated. In addition to the identification of horsts and semi-grabens that influenced the current relief pattern, the modelling showed that the Aptian paleolake sedimentary rocks of the Negra Hill are in the Ibimirim Low, which is approximately 2,900 m deep, while in the Tonã Hill, the sedimentary rocks are in the Salgado do Melão Low, which is approximately 5,100 m deep.

https://doi.org/10.1590/0001-3765202320210606

Predictive factors for the diagnosis of permanent congenital hypothyroidism and its temporal changes in Sergipe, Brazil – A real-life retrospective study
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Gumes-Felix, Hérika M.

; Ramalho, Roberto J. R.

; Melo, Enaldo V.

; Matos, Diana M.

; Menezes, Nelmo V.

; Oliveira, Carla R. P.

; Campos, Viviane C.

; Santos, Elenilde G.

; Marques, Daniela da S.

; Santos, Brenda Vaz dos

; Andrade, Bruna M. R. de

; Aguiar-Oliveira, Manuel H.

Archives of Endocrinology and Metabolism

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2023, Volume 67 Nº 2 Páginas 189 - 196

Resumo: En | Texto: En | PDF: En

ABSTRACT Objectives: Congenital hypothyroidism (CH) can be permanent (PCH) or transient (TCH). While the importance of thyroxine in myelination of the brain is undisputed, the benefits to neurodevelopmental outcomes of TCH treatment are controversial. Our objectives were to determine predictive factors for PCH and verify its prevalence changes over time. Subjects and methods: A total of 165 children were evaluated at 3 years of age to verify the diagnosis of PCH. 130 were submitted to a two-step cluster analysis, with the aim of grouping them into homogeneous clusters. The mean incidence of PCH and TCH was calculated from 2004 to 2010 and 2011 to 2015. Results: Sixty-six children were diagnosed with PCH, and 99 were diagnosed with TCH. Eighty-one percent of PCH children and all TCH children with thyroid imaging had glands in situ. Eighty children (61.5%) were in Cluster 1, 8 children (6.2%) were in Cluster 2 and 42 children (32.3%) were in Cluster 3. No children had PCH in Cluster 1, while 87.5% of children in Cluster 2 and all children in Cluster 3 had PCH. The most important predictor for PCH was the initial serum TSH, which was marginally higher in importance than the blood spot TSH, followed by the initial serum free T4. The mean incidence of PCH (odds ratio: 1.95, 95% CI 1.36 to 2.95, p < 0.0001) and TCH (odds ratio 1.33, 95%, CI 1.02 to 1.77, p = 0,038) increased over time. Conclusions: The most important PCH predictors are the initial serum TSH and the blood spot TSH. The mean incidence of both PCH and TCH in our series increased.

https://doi.org/10.20945/2359-3997000000579

Diretriz Brasileira de Dispositivos Cardíacos Eletrônicos Implantáveis – 2023
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Teixeira, Ricardo Alkmim

; Fagundes, Alexsandro Alves

; Baggio Junior, José Mário

; Oliveira, Júlio César de

; Medeiros, Paulo de Tarso Jorge

; Valdigem, Bruno Pereira

; Teno, Luiz Antônio Castilho

; Silva, Rodrigo Tavares

; Melo, Celso Salgado de

; Elias Neto, Jorge

; Moraes Júnior, Antonio Vitor

; Pedrosa, Anisio Alexandre Andrade

; Porto, Fernando Mello

; Brito Júnior, Hélio Lima de

; Souza, Thiago Gonçalves Schroder e

; Mateos, José Carlos Pachón

; Moraes, Luis Gustavo Belo de

; Forno, Alexander Romeno Janner Dal

; D’Avila, Andre Luiz Buchele

; Cavaco, Diogo Alberto de Magalhães

; Kuniyoshi, Ricardo Ryoshim

; Pimentel, Mauricio

; Camanho, Luiz Eduardo Montenegro

; Saad, Eduardo Benchimol

; Zimerman, Leandro Ioschpe

; Oliveira, Eduardo Bartholomay

; Scanavacca, Mauricio Ibrahim

; Martinelli Filho, Martino

; Lima, Carlos Eduardo Batista de

; Peixoto, Giselle de Lima

; Darrieux, Francisco Carlos da Costa

; Duarte, Jussara de Oliveira Pinheiro

; Galvão Filho, Silas dos Santos

; Costa, Eduardo Rodrigues Bento

; Mateo, Enrique Indalécio Pachón

; Melo, Sissy Lara De

; Rodrigues, Thiago da Rocha

; Rocha, Eduardo Arrais

; Hachul, Denise Tessariol

; Lorga Filho, Adalberto Menezes

; Nishioka, Silvana Angelina D’Orio

; Gadelha, Eduardo Barreto

; Costa, Roberto

; Andrade, Veridiana Silva de

; Torres, Gustavo Gomes

; Oliveira Neto, Nestor Rodrigues de

; Lucchese, Fernando Antonio

; Murad, Henrique

; Wanderley Neto, José

; Brofman, Paulo Roberto Slud

; Almeida, Rui M. S.

; Leal, João Carlos Ferreira

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 Nº 1 elocation e20220892

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20220892

Guidelines from the Brazilian society of surgical oncology regarding indications and technical aspects of neck dissection in papillary, follicular, and medullary thyroid cancers
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Farias, Terence

; Kowalski, Luiz Paulo

; Dias, Fernando

; Barreira, Carlos S. Ritta

; Vartanian, José Guilherme

; Tavares, Marcos Roberto

; Vaisman, Fernanda

; Momesso, Denise

; Oliveira, Alexandre Ferreira

; Pinheiro, Rodrigo Nascimento

; Ribeiro, Heber Salvador de Castro

Archives of Endocrinology and Metabolism

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2023, Volume 67 Nº 4 elocation e000607

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: The purpose of these guidelines is to provide specific recommendations for the surgical treatment of neck metastases in patients with papillary, follicular, and medullary thyroid carcinomas. Materials and methods: Recommendations were developed based on research of scientific articles (preferentially meta-analyses) and guidelines issued by international medical specialty societies. The American College of Physicians’ Guideline Grading System was used to determine the levels of evidence and grades of recommendations. The following questions were answered: A) Is elective neck dissection indicated in the treatment of papillary, follicular, and medullary thyroid carcinoma? B) When should central, lateral, and modified radical neck dissection be performed? C) Could molecular tests guide the extent of the neck dissection? Results/conclusion: Recommendation 1: Elective central neck dissection is not indicated in patients with cN0 well-differentiated thyroid carcinoma or in those with noninvasive T1 and T2 tumors but may be considered in T3-T4 tumors or in the presence of metastases in the lateral neck compartments. Recommendation 2: Elective central neck dissection is recommended in medullary thyroid carcinoma. Recommendation 3: Selective neck dissection of levels II–V should be indicated to treat neck metastases in papillary thyroid cancer, an approach that decreases the risk of recurrence and mortality. Recommendation 4: Compartmental neck dissection is indicated in the treatment of lymph node recurrence after elective or therapeutic neck dissection; “berry node picking” is not recommended. Recommendation 5: There are currently no recommendations regarding the use of molecular tests in guiding the extent of neck dissection in thyroid cancer.

https://doi.org/10.20945/2359-3997000000607

Selaginella P.Beauv. (Selaginellaceae) in the state of Maranhão, northeastern, Brazil: A floristic survey and a new record for the Cerrado domain
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Fernandes, Rozijane Santos

; Silva Junior, Wagner Ribeiro da

; Ferreira, Alessandro Wagner Coelho

; Ottoni, Felipe Polivanov

; Oliveira, Sirlane Santos

; Pietrobom, Marcio Roberto

; Valdespino, Iván A.

Biota Neotropica

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2023, Volume 23 Nº 3 elocation e20231515

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract This work is a floristic study of Selaginella in Maranhão. The species survey is based on collections from fieldwork conducted between April 2006 and February 2023 and specimens from Maranhão deposited at the CCAA, HBRA, MG, and SLUI herbaria. Ten species were identified: Selaginella conduplicata, S. convoluta, S. erythropus, S. flagellata, S. gynostachya S. marginata, S. minima, S. radiata, S. simplex, and S. sulcata. We report the first record of S. gynostachya for Maranhão and the Cerrado domain in Brazil. Until now, this species was only known from areas of Amazonia. We provide a map with records, an identification key, and comments about the identification and geographic distribution of Selaginella species in Maranhão state. For the new record, we also provide photos.

Resumo O presente trabalho trata do estudo florístico de Selaginella no Maranhão. O levantamento de espécies foi realizado com base em coletas de campo realizadas entre abril de 2006 e fevereiro de 2023 e em análise de espécimes coletados no Maranhão e depositadas nos herbários CCAA, HBRA, MG e SLUI. Foram identificadas 10 espécies: Selaginella conduplicata, S. convoluta, S. erythropus, S. flagellata, S. gynostachya S. marginata, S. minima, S. radiata, S. simplex e S. sulcata. Relatamos a primeira ocorrência de S. gynostachya para o Maranhão e também para o domínio do Cerrado Brasileiro. Até então essa espécie era registrada somente em áreas amazônicas. Neste artigo apresentamos um mapa com pontos de coleta, uma chave de identificação e comentários sobre a identificação, ecologia e distribuição geográfica para as espécies de Selaginella do Maranhão. Para o novo registro apresentamos também fotos.

https://doi.org/10.1590/1676-0611-bn-2023-1515

Clinical and anatomopathological findings of lipid-related lesions in wild and pet birds from the State of Paraíba, Northeastern Brazil
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Oliveira-Filho, Hodias S.

; Duarte, José L.C.

; Paranhos, Gabriel F.

; Oliveira, Rafael L.

; Farias, Roberto C.

; Araújo, Jeann Leal de

Pesquisa Veterinária Brasileira

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2023, Volume 43 elocation e07296

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT: Diseases related to lipid metabolism disorders are reported in several orders of birds, especially in psittacines, and include obesity, atherosclerosis, hepatic lipidosis, egg yolk coelomitis, lipomas, liposarcomas, xanthomas and xanthogranulomas. This study describes epidemiological, clinical and anatomopathological aspects of 28 cases involving lipid-related lesions in wild and pet birds from Northeastern Brazil. The cases were selected from 313 avian patients referred to the UFPB Veterinary Hospital from 2018 to 2022. Lipid-related tumors were the most frequent lesions, followed by obesity, hepatic steatosis, egg yolk coelomitis, atherosclerosis and lipemia. The Psittaciformes order was the most affected, and an erroneous diet (excess consumption of sunflower seeds, bread, crackers, rice, etc.) was identified as the main risk factor for the development of these lesions, which reinforces the need to warn bird owners and caretakers about the importance of adequate nutrition. Forty-nine percent of the reported tumors were in the pericloacal region, which makes lipomas and xanthomas an important differential diagnosis for nodules in this location of birds, especially psittacids.

RESUMO: Doenças relacionadas à desordens no metabolismo dos lipídeos são reportadas em diversas ordens de aves, especialmente em piscítacídeos e incluem obesidade, aterosclerose, lipidose hepática, celomite por gema de ovo, lipomas, lipossarcomas, xantomas e xantogranulomas. Este estudo descreve aspectos epidemiológicos, clínicos e anatomopatológicos de 28 casos envolvendo lesões relacionadas a lipídeos em aves silvestres e pet no Nordeste Brasileiro. Os casos foram selecionados de um total de 313 aves atendidas entre 2018 e 2022 no Hospital Veterinário da UFPB. Tumores relacionados a lipídeos foram as lesões mais relatadas, seguido por obesidade, esteatose hepática, celomite por gema de ovo, aterosclerose e lipemia. A ordem Piscitaciforme foi a mais acometida e dieta errônea (Excesso de sementes de girassol, pão, bolacha, arroz, etc.) foi identificado como o principal fator de risco para o desenvolvimento das lesões, o que reforça a necessidade de advertir os tutores quanto a importância da alimentação adequada. Quarenta e nove por cento dos tumores relatados estavam na região pericloacal, o que torna lipomas e xantomas um diagnóstico diferencial importante para nódulos nessa localização em aves, principalmente psitacídeos.

https://doi.org/10.1590/1678-5150-pvb-7296

Spatial and Scientometric study of the Brazilian scientific production on Antarctic soils and permafrost
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VIEIRA, ÍCARO S.

; OLIVEIRA, FÁBIO S. DE

; MICHEL, ROBERTO F.M.

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Supl. 3 elocation e20230823

Resumo: En | Texto: En | PDF: En

Abstract This article carried out the first scientometric and spatial analysis of Brazilian scientific production on Antarctic soils and permafrost, based on all publications available from the Scopus and Web of Science databases. Information on co-authorship, citation, research topics, and sampling sites was used to understand the social and theoretical structure as well as the spatial dynamics of this research field in Brazil over the last 25 years. We highlight that Brazil is presently, the main country to study the soils and permafrost of Maritime Antarctica, in addition to having an international robust and prolific production, with high impact on the literature, and widely distributed throughout the studied region. It was also possible to identify potential future international partners, new research locations and strategic research themes.

https://doi.org/10.1590/0001-3765202320230823

Different evaluation methods of Canchim cattle temperament
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Marcondes, Cintia Righetti

; Souza, Vanessa Aparecida Feijó de

; Bugner, Ana Luisa Paçó

; Oliveira, Fábio da Roza

; Maffei, Walsiara Estanislau

; Ribeiro, Andrea Roberto Bueno

Pesquisa Agropecuária Brasileira

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2023, Volume 58 elocation e03350

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract The objective of this work was to evaluate the temperament of Canchim calves using different methods, to compare these methods, and to determine the most suitable for commercial use. The temperament of 1,831 calves was evaluated at 15 days after weaning by visually analyzing movement, tension, breathing, vocalizing, and kicking. Measurements were taken at 10 and 20 s after the calf entered the scale. The reactivity score was determined electronically, and flight speed was measured after the calf left the scale. The results of the principal component analysis showed that the first component explained 40.27% of total variation. Positive correlations were found for tension at 10 and 20 s, movement at 10 and 20 s, and reactivity score, with correlation coefficients ranging from 0.60 to 0.88. Temperament and reactivity scores presented moderate correlations of 0.25 and 0.35, respectively, with flight speed. However, kicking had no correlation with any variable. No differences were observed for reactivity measured at 10 or 20 s. The visual evaluations of movement and tension or of reactivity through an electronic device can be used for temperament evaluation of Canchim calves.

Resumo O objetivo deste trabalho foi avaliar o temperamento de bezerros da raça Canchim por meio de diferentes métodos, comparar estes métodos e determinar o mais adequado para uso comercial. O temperamento de 1.831 bezerros foi avaliado 15 dias após a desmama, tendo-se analisado visualmente deslocamento, tensão, respiração, vocalização e coice. As medidas foram feitas aos 10 e 20 s após o bezerro entrar na balança. A reatividade foi determinada eletronicamente, e a velocidade de saída foi medida após o bezerro sair da balança. O resultado da análise de componentes principais indicou que o primeiro componente explicou 40,27% da variação total. Foram verificadas correlações positivas para tensão aos 10 e 20 s, deslocamento aos 10 e 20 s, e reatividade, com coeficientes de correlação de 0,60 a 0,88. Os escores de temperamento e reatividade apresentaram correlação moderada de 0,25 e 0,35, respectivamente, com velocidade de saída. No entanto, coice não se correlacionou com nenhuma variável. Não foi observada nenhuma diferença para reatividade medida aos 10 ou 20 s. As avaliações visuais de deslocamento e tensão ou da reatividade por dispositivo eletrônico podem ser utilizadas na avaliação de temperamento de bezerros Canchim.

https://doi.org/10.1590/s1678-3921.pab2023.v58.03350

10.

Proteomic characterization and biological activities of the mucus produced by the zoanthid Palythoa caribaeorum (Duchassaing & Michelotti, 1860)
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SILVA, MARLLYN M.

; CAMPOS, THIERS A.

; CAVALCANTI, ISABELLA M.F.

; OLIVEIRA, IDJANE S.

; PÉREZ, CARLOS DANIEL

; SILVA, ROBERTO AFONSO DA

; WANDERLEY, MARCELA S.O.

; SANTOS, NOEMIA P.S.

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Nº 4 elocation e20200325

Resumo: En | Texto: En | PDF: En

Abstract Mucus, produced by Palythoa caribaeorum has been popularly reported due to healing, anti-inflammatory, and analgesic effects. However, biochemical and pharmacological properties of this mucus remains unexplored. Therefore, the present study aimed to study its proteome profile by 2DE electrophoresis and MALDI-TOF. Furthermore, it was evaluated the cytotoxic, antibacterial, and antioxidant activities of the mucus and from its protein extract (PE). Proteomics study identified14 proteins including proteins involved in the process of tissue regeneration and death of tumor cells. The PE exhibited cell viability below 50% in the MCF-7 and S-180 strains. It showed IC50 of 6.9 μg/mL for the J774 lineage, and also, favored the cellular growth of fibroblasts. Furthermore, PE revealed activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Staphylococcus epidermidis (MIC of 250 μg/mL). These findings revealed the mucus produced by Palythoa caribaeorum with biological activities, offering alternative therapies for the treatment of cancer and as a potential antibacterial agent.

https://doi.org/10.1590/0001-3765202320200325

11.

Art and science: impact of semioccluded vocal tract exercises and choral singing on quality of life in subjects with congenital GH deficiency
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Andrade, Bruna M. R. de

; Valença, Eugenia H. O.

; Salvatori, Roberto

; Oliveira Neto, Luiz A.

; Souza, Anita H. O.

; Oliveira, Alaíde H. A.

; Oliveira, Mario C.P.

; Melo, Enaldo V.

; Carvalho, Susana de

; Sales, Neuza J

; Monteiro, Gisane C.

; Lima, José Marcel de

; Annunziato, Marcos Felipe Harder

; Mannis, Guilherme Daniel Breternitz

; Souza, Lucas E. de A.

; Goes, Yasmin D.

; Carvalho, Thayza S.

; Farias, Celiane de

; Santos, Michela P. dos

; Cardoso, Gabriela P. F.

; Sousa, Carla S. Pereira

; Santana, Julia Rodrigues

; Sales, Ester Almeida

; d’Avila, Jeferson Sampaio

; Aguiar-Oliveira, Manuel H.

Archives of Endocrinology and Metabolism

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Abr 2022, Volume 66 Nº 2 Páginas 198 - 205

Resumo: En | Texto: En | PDF: En

ABSTRACT Objectives: Currently, not much is known about the interactions between voice and growth hormone (GH). We have described large kindred with isolated GH deficiency (IGHD) due to a GHRH receptor mutation, resulting in severe short stature and high-pitched voice. These IGHD individuals have little interest in GH treatment, as they consider themselves “short long-lived people”, rather than patients. Interestingly, they report normal general quality of life, but they rate their Voice-Related Quality of Life (V-RQOL) as low. Here, we assessed the social and auditory-perceptual impacts of artistic-intervention voice therapy with semioccluded vocal tract exercises (SOVTE) and choral singing, on their voices. Material and methods: Seventeen GH-naïve adult IGHD individuals were enrolled in a single-arm interventional pre-post study with 13 weekly sessions of choir singing over 90 days. Outcome measures were V-RQOL scores, self-assessment of voice, and auditory-perceptual analysis (GRBAS scale, G: grade of the severity of dysphonia; R: roughness; B: breathiness; A: asthenia; and S: strain). Results: Marked improvements in total (p = 0.0001), physical (p = 0.0002), and socioemotional (p = 0.0001) V-RQOL scores and in self-assessment of voice (p = 0.004) were found. The general grades of vocal deviation (p = 0.0001), roughness (p = 0.0001), breathiness (p = 0.0001) and strain (p = 0.0001) exhibited accentuated reductions. Conclusions: Voice therapy with semioccluded vocal tract exercises and choral training improved social impact and perceptual voice assessments in IGHD subjects and markedly improved their voice-related quality of life. This is particularly important in a setting where GH replacement therapy is not widely accepted.

https://doi.org/10.20945/2359-3997000000449

12.

Soil-chronosequence and Quaternary landscape evolution at the marine terraces of Harmony Point, Nelson Island, Maritime Antarctica
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RODRIGUES, WILLIAM F.

; MACHADO, MARIANA R.

; OLIVEIRA, FÁBIO S. DE

; SCHAEFER, CARLOS ERNESTO G.R.

; LEITE, MARIÂNGELA G.P.

; MICHEL, ROBERTO F.M.

; GAUZZI, TEODORO

Anais da Academia Brasileira de Ciências

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2022, Volume 94 Supl. 1 elocation e20201141

Resumo: En | Texto: En | PDF: En

Abstract This study characterized the physical, chemical, macro- and micromorphological soil properties from three successive marine terrace levels from Harmony Point (Nelson Island, Maritime Antarctica) in order to understand the pedological signatures of Quaternary coastal landscape evolution of Maritime Antarctica. Soils were sampled on the Late Holocene beach (current beach) and Mid Holocene marine terraces higher up, at 3, 8, and 12 m a.s.l. At the lower levels, the predominant soils were Gelorthents, whereas Haplogelepts dominate the higher terraces. Soil properties are mostly influenced by parent material and faunal activity, in which cryoclastic (thermal weathering) and phosphatization are the main soil-forming processes. Soils from the upper levels are more developed, deeper with reddish colors, granular structures and incipient formation B horizon. These horizonation features highlight that soils vary according with age of glacier-isostatic terrace uplift, representing a Quaternary soil chronosequence. All marine terrace levels are Ornithogenic soils, at varying degrees. However, the presence of old bird nesting sites for long periods led to formation of phosphatic horizons, stable Fe-phosphate minerals and abundant vegetation in the highest terraces of this part of Maritime Antarctica.

https://doi.org/10.1590/0001-3765202220201141

13.

Mortality inequalities measured by socioeconomic indicators in Brazil: a scoping review
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Ichihara, Maria Yury

; Ferreira, Andrêa J.F.

; Teixeira, Camila S. S.

; Alves, Flávia Jôse O.

; Rocha, Aline Santos

; Diógenes, Victor Hugo Dias

; Ramos, Dandara Oliveira

; Pinto Júnior, Elzo Pereira

; Flores-Ortiz, Renzo

; Rameh, Leila

; Costa, Lilia Carolina C. da

; Gonzaga, Marcos Roberto

; Lima, Everton E. C.

; Dundas, Ruth

; Leyland, Alastair

; Barreto, Maurício L.

Revista de Saúde Pública

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2022, Volume 56 elocation 85

Resumo: En | Texto: En | PDF: En

ABSTRACT OBJECTIVE Summarize the literature on the relationship between composite socioeconomic indicators and mortality in different geographical areas of Brazil. METHODS This scoping review included articles published between January 1, 2000, and August 31, 2020, retrieved by means of a bibliographic search carried out in the Medline, Scopus, Web of Science, and Lilacs databases. Studies reporting on the association between composite socioeconomic indicators and all-cause, or specific cause of death in any age group in different geographical areas were selected. The review summarized the measures constructed, their associations with the outcomes, and potential study limitations. RESULTS Of the 77 full texts that met the inclusion criteria, the study reviewed 24. The area level of composite socioeconomic indicators analyzed comprised municipalities (n = 6), districts (n = 5), census tracts (n = 4), state (n = 2), country (n = 2), and other areas (n = 5). Six studies used composite socioeconomic indicators such as the Human Development Index, Gross Domestic Product, and the Gini Index; the remaining 18 papers created their own socioeconomic measures based on sociodemographic and health indicators. Socioeconomic status was inversely associated with higher rates of all-cause mortality, external cause mortality, suicide, homicide, fetal and infant mortality, respiratory and circulatory diseases, stroke, infectious and parasitic diseases, malnutrition, gastroenteritis, and oropharyngeal cancer. Higher mortality rates due to colorectal cancer, leukemia, a general group of neoplasms, traffic accident, and suicide, in turn, were observed in less deprived areas and/or those with more significant socioeconomic development. Underreporting of death and differences in mortality coverage in Brazilian areas were cited as the main limitation. CONCLUSIONS Studies analyzed mortality inequalities in different geographical areas by means of composite socioeconomic indicators, showing that the association directions vary according to the mortality outcome. But studies on all-cause mortality and at the census tract level remain scarce. The results may guide the development of new composite socioeconomic indicators for use in mortality inequality analysis.

https://doi.org/10.11606/s1518-8787.2022056004178

14.

Mortality inequalities measured by socioeconomic indicators in Brazil: a scoping review
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Ichihara, Maria Yury

; Ferreira, Andrêa J.F.

; Teixeira, Camila S. S.

; Alves, Flávia Jôse O.

; Rocha, Aline Santos

; Diógenes, Victor Hugo Dias

; Ramos, Dandara Oliveira

; Pinto Júnior, Elzo Pereira

; Flores-Ortiz, Renzo

; Rameh, Leila

; Costa, Lilia Carolina C. da

; Gonzaga, Marcos Roberto

; Lima, Everton E. C.

; Dundas, Ruth

; Leyland, Alastair

; Barreto, Maurício L.

Revista de Saúde Pública

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2022, Volume 56 elocation 85

Resumo: En | Texto: En | PDF: En

https://doi.org/10.11606/s1518-8787.2022056004178

15.

COVID-19 in the Perioperative Period of Cardiovascular Surgery: the Brazilian Experience
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Gomes, Walter J.

; Rocco, Isadora

; Pimentel, Wallace S.

; Pinheiro, Aislan H. B.

; Souza, Paulo M. S.

; Costa, Luiz A. A.

; Teixeira, Marjory M. P.

; Ohashi, Leonardo P.

; Bublitz, Caroline

; Begot, Isis

; Moreira, Rita Simone L

; Hossne Jr, Nelson A.

; Vargas, Guilherme F.

; Branco, João Nelson R.

; Teles, Carlos A.

; Medeiros, Eduardo A. S.

; Sáfadi, Camila

; Rampinelli, Amândio

; Moratelli Neto, Leopoldo

; Rosado, Anderson Rosa

; Mesacasa, Franciele Kuhn

; Capriata, Ismael Escobar

; Segalote, Rodrigo Coelho

; Palmieri, Deborah Louize da Rocha Vianna

; Jardim, Amanda Cristina Mendes

; Vianna, Diego Sarty

; Coutinho, Joaquim Henrique de Souza Aguiar

; Jazbik, João Carlos

; Coutinho, Henrique Madureira da Rocha

; Kikuta, Gustavo

; Almeida, Zely Sant'Anna Marotti de

; Feguri, Gibran Roder

; Lima, Paulo Ruiz Lucio de

; Franco, Anna Carolina

; Borges, Danilo de Cerqueira

; Cruz, Felipe Ramos Honorato De La

; Croti, Ulisses Alexandre

; Borim, Bruna Cury

; Marchi, Carlos Henrique De

; Goraieb, Lilian

; Postigo, Karolyne Barroca Sanches

; Jucá, Fabiano Gonçalves

; Oliveira, Fátima Rosane de Almeida

; Souza, Rafael Bezerra de

; Zilli, Alexandre Cabral

; Mas, Raul Gaston Sanchez

; Bettiati Junior, Luiz Carlos

; Tranchesi, Ricardo

; Bertini Jr, Ayrton

; Franco, Leandro Vieira

; Fernandes, Priscila

; Oliveira, Fabiana

; Moraes Jr, Roberto

; Araújo, Thiago Cavalcanti Vila Nova de

; Braga, Otávio Penna

; Pedrosa Sobrinho, Antônio Cavalcanti

; Teixeira, Roberta Tavares Barreto

; Camboim, Irla Lavor Lucena

; Gomes, Eduardo Nascimento

; Reis, Pedro Horigushi

; Garcia, Luara Piovan

; Scorsioni, Nelson Henrique Goes

; Lago, Roberto

; Guizilini, Solange

Brazilian Journal of Cardiovascular Surgery

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Dez 2021, Volume 36 Nº 6 Páginas 725 - 735

Resumo: En | Texto: En | PDF: En

Abstract Introduction: We investigated the clinical course and outcomes of patients submitted to cardiovascular surgery in Brazil and who had developed symptoms/signs of coronavirus disease 2019 (COVID-19) in the perioperative period. Methods: A retrospective multicenter study including 104 patients who were allocated in three groups according to time of positive real time reverse transcriptase-polymerase chain reaction (RT-PCR) for the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2): group 1, patients who underwent cardiac surgery > 10 days after positive RT-PCR; group 2, patients with a positive RT-PCR within 10 days before or after surgery; group 3, patients who presented positive RT-PCR > 10 days after surgery. The primary outcome was mortality and secondary outcomes were postoperative complications, intensive care unit (ICU) length of stay, and postoperative days of hospitalization. Results: The three groups were similar with respect to age, the European System of Cardiac Operative Risk Evaluation score, and comorbidities, except hypertension. Postoperative complications and death were significantly higher in groups 2 and 3 than in group 1, and no significant difference between groups 2 and 3 was seen. Group 2 showed a high prevalence of surgery performed as an urgent procedure. Although no significant differences were observed in ICU length of stay, total postoperative hospitalization time was significantly higher in group 3 than in groups 1 and 2. Conclusion: COVID-19 affecting the postoperative period of patients who underwent cardiovascular surgery is associated with a higher rate of morbidity and mortality. Delaying procedures in RT-PCR-positive patients may help reduce risks of perioperative complications and death.

https://doi.org/10.21470/1678-9741-2021-0960

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