Abstract Objective: To investigate the usefulness, reliability, quality, and content of Portuguese-language YouTube videos on COVID-19. Material and Methods: Three keywords selected on Google Trends were searched on YouTube, and the 60 first videos listed with each term were analyzed. Two calibrated researchers evaluated the reliability (DISCERN Modified Scale), the quality (Global Quality Score - GQS), and the usefulness of videos for the users (COVID-19 Specific Score - CSS). The number of views, likes, and engagement were also analyzed. The data were evaluated by the Mann-Whitney test and Spearman correlation (α=5%). Results: 59 videos were included. The average scores of quality, reliability, and usefulness were 3.0 (±1.1), 3.2 (± 0.8), and 1.5 (± 0.9), respectively. Two-thirds of the videos (64.4%) had low/moderate quality, and the majority (76.2%) were about signs and symptoms. The numbers of views (p=0.005), likes (p=0.006), and engagement (p=0.014) were significantly higher in moderate/good quality videos. The number of comments (p=0.007), duration of videos (p=0.004), and the DISCERN score (p<0.001) were significantly higher in videos made by health professionals. The general quality of the videos was positively correlated to the CSS scores, number of views, likes, and engagement (p<0.05). Conclusion: Most videos had moderate quality and reliability and low usefulness for the users.

Abstract The simulation process was applied to the industrial circuit of the Juruti Bauxite Mine using mathematical models calibrated for the equipment and based on information from industrial sampling. The sampling campaign, mass balance routines and quantification of the process efficiency were discussed in Part I of this study and the model calibration and simulations process were the Part II objective. Simulation scenarios were defined considering the possible particle size curves for feeding the plant. Based on the simulated results, it was possible to observe which operations may be impacted by the increase in production, impacting the percentage of contaminants in the final product, indicating the necessity of equipment interventions to support increases in capacity. Another group of scenarios were established with the objective to evaluate the possibility of increasing the mass recovery and improving the quality of the fine product, by variations in the opening diameters of the apex and vortex finder of the five cyclone stages. Considering the simulated scenarios, the points of attention identified in the simulations were: (a) the washing efficiency could be reduced, in view of a consequent reduction in residence time connected to the change in characteristics of the ore fed to the plant; (b) increase capacity of the primary and secondary screens need to be done; (c) to keep the classification efficiencies, it is necessary install more cyclone units; and (d) changes in the apex diameter and vortex finder could generate results in terms of mass recovery and product quality.

Resumo Fundamento: A pandemia da COVID-19 tem causado um impacto sobre a mortalidade por várias doenças em todo o mundo, especialmente por doenças cardiovasculares (DCVs). O Brasil é um país de dimensões continentais com diferenças significativas na estrutura de saúde entre seus estados. Objetivo: Analisar a mortalidade hospitalar por DCV no sistema público de saúde durante o primeiro ano da pandemia por COVID-19 (2020) no Brasil. Métodos: Este é um estudo ecológico analisando o número absoluto de mortes hospitalares e a taxa de mortalidade hospitalar no Brasil, suas macrorregiões, e unidades federativas. Os dados foram obtidos do Sistema de Informações Hospitalares (SIH) do Ministério da Saúde. O P-escore foi usado para analisar o excesso de mortalidade. O escore compara os eventos observados com os eventos esperados para um dado local e período. O escore-P foi corrigido por um modelo de regressão joinpoint, com um intervalo de confiança de 95% e nível de significância de 5%. Resultados: Houve 93.104 óbitos hospitalares por DCV no Brasil em 2020, o que representa 1495 menos óbitos (escore-P: -1,58) que o esperado. A região centro-oeste apresentou um escore-P positivo, com um aumento de 15,1% no número de mortes. Dez estados apresentaram um maior número de óbitos em 2020. Ainda, observou-se um excesso de 13,3% de mortalidade hospitalar no país como um todo, e um excesso de mortalidade hospitalar em todas as macrorregiões. Conclusões: Houve uma diminuição no número absoluto de óbitos hospitalares, bem como um aumento na taxa de mortalidade por DCV no Brasil em 2020, após o início da pandemia por COVID-19.

Abstract Background: The COVID-19 pandemic has had an impact on mortality from several diseases worldwide, especially cardiovascular diseases (CVD). Brazil is a continent-sized country with significant differences in the health care structure between its federative units. Objective: Analyze in-hospital mortality from CVDs in the Brazilian public health system during the first year of the COVID-19 pandemic (2020). Methods: This is an ecological study analyzing the absolute number of in-hospital deaths and the rate of in-hospital mortality in Brazil, its macro-regions, and federative units. Data were obtained from the Hospital Information System of the Brazilian Ministry of Health. To analyze excess mortality, the P-score was used. It compares the events observed with those expected for a given place and period. The P-score was corrected by the joinpoint regression model, with a 95% confidence interval and 5% significance level. Results: There were 93,104 in-hospital deaths due to CVD in Brazil in 2020, representing 1,495 fewer deaths (P score: −1.58) than expected. The central-west region had a positive P-score, with a 15.1% increase in the number of deaths. Ten federative units showed a greater number of deaths in 2020. There was also a 13.3% excess in-hospital mortality at the country level, and an excess in-hospital mortality in all macro-regions. Conclusions: There was a decrease in the absolute number of in-hospital deaths, as well as an increase in in-hospital mortality from CVD in Brazil, in 2020, after the COVID-19 pandemic onset.

ABSTRACT This study purposed to compare responses of segmented neutrophils, monocytes, lymphocytes, and T lymphocyte Clusters of Differentiation 4 and 8 to blood flow restriction training in HIV patients. Two HIV patients participated in the study, one patient had a sedentary lifestyle, and the other was physically active. HIV-infected female patients performed a blood flow restriction training session consisting of two exercises: flat bench press and knee extension. Blood (6 mL) was collected for analysis prior to training, immediately after training, and 30 minutes after. After blood flow restriction training, percentage changes in the number of leukocytes were observed in both patients. Monocytes showed different responses in the two patients: a decrease in monocyte count was seen in the physically active, and an increase was observed in the sedentary lifestyle. Lymphocytes showed a higher increase in the physically active than in the sedentary lifestyle. There was an increase in the CD4+ / CD8+ T lymphocyte ratio in both patients. It was concluded blood flow restriction promoted acute inflammation after training, shown by changes in immune cell counts. These changes did not promote immunosuppression; instead, an increase in CD4+ / CD8+ T lymphocyte ratio was observed; and HIV-infected came similar results.

Resumo Fundamentos As doenças isquêmicas do coração (DIC) são a primeira causa de mortes dentre as doenças cardiovasculares (DCV). Objetivo Descrever o perfil sociodemográfico e analisar tendência da taxa de mortalidade por DIC, segundo sexo e por faixa etária, nos estados da região Nordeste do Brasil, 1996-2016. Métodos Estudo ecológico envolvendo a mortalidade por DIC nos estados do Nordeste. Variáveis analisadas: sexo, idade, escolaridade, estado civil, categoria do CID-10 e estado de residências. Foram calculadas taxas brutas e padronizadas. Os dados de óbitos foram coletados do Sistema de Informações sobre Mortalidade; e os dados populacionais, do Instituto Brasileiro de Geografia e Estatística (IBGE). Nas análises temporais, utilizou-se o modelo de regressão por pontos de inflexão, com cálculo do percentual de variação anual (APC, Annual Percent Change) e do percentual de variação médio do período (AAPC, Average Annual Percent Change). Considerou-se intervalo de confiança de 95% e significância de 5%. Resultados Registrou-se 405.916 óbitos por DIC na região Nordeste durante o período estudado. O perfil de óbitos caracteriza-se por homens (n=229.006; 56,42%), idosos (n=301.379; 74,25%), raça/cor parda (n=197.936; 48,76%), fundamental ou <4 anos na escola (n=232.599; 57,30%) e casados (n=179.599; 44,25%). Houve destaque incomum para o aumento na taxa de incremento anual na faixa etária de adolescentes (AAPC: 5,2%, p<0,01). A taxa de mortalidade regional padronizada cresceu de 30,7/100 mil habitantes, em 1996, para 53,8/100 mil, em 2016 (AAPC:2,8%; p<0,01). Todos os nove estados apresentaram tendência estatisticamente significante de crescimento, com ênfases para o Maranhão (AAPC:7,6%; p<0,01) e o Piauí (AAPC:6,0%; p<0,01). Conclusão O perfil prevalente observado foi de homens, idosos, raça/cor parda, baixa escolaridade e casados. A mortalidade por DIC apresentou tendência de crescimento em todos os estados, ainda que com padrão desigual entre as unidades federadas.

Abstract Background Ischemic heart disease (IHD) is the leading cause of death among cardiovascular diseases (CVD). Objective To describe the sociodemographic profile and analyze the trend in the mortality rate due to IHD, according to sex and by age group, in the states of the Northeast region of Brazil, from 1996 to 2016. Methods Ecological study involving IHD mortality in the northeastern states. Variables analyzed: sex, age, education, marital status, ICD-10 category and state of residence. Crude and standardized rates were calculated. Death data were collected from the Mortality Information System (SIM) and population data from the Brazilian Institute of Geography and Statistics (IBGE). In temporal analyzes the regression model by inflection points was used, with the calculation of annual percent change (APC) and average annual percent change of the period (AAPC). A 95% confidence interval and a significance level of 5% were considered. Results 405916 deaths due to IHD were registered in the northeast region during the study period. The death profile is characterized by men (n=229006; 56,42%), elderly (n=301379; 74,25%), race/color brown (n=197936; 48,76%), elementary or <4 years at school (n=232599; 57,30%) and married (n=179599; 44,25%). There was an unusual highlight to the increase in the annual growth rate in the age group of adolescents (AAPC: 5,2%, p <0.01). The standardized regional mortality rate grew from 30,7 per 100,000 inhabitants in 1996 to 53.8 per 100,000 in 2016 (AAPC 2.8%; p<0.01). All nine states presented a statistically significant growth trend, with emphasis on Maranhão (AAPC 7,6%; p<0.01) and Piauí (AAPC 6,0%; p<0.01). Conclusion The prevalent observed profile was male, elderly, race/color brown, low education level and married. Mortality due to IHD presented an upward trend in all states, although with an uneven pattern among the federated units.

RESUMO OBJETIVOS Avaliar a frequência da prescrição de inibidores da bomba de prótons (IBPs) e suas indicações em pacientes internados no Hospital de Clínicas da Universidade Federal de Uberlândia (HC-UFU). MÉTODOS Estudo observacional transversal quantitativo, análise de dados obtidos em prontuários sobre prescrições de IBPs para pacientes internados no HC-UFU, aplicação de questionário aos médicos assistentes sobre as indicações do medicamento em cada caso e avaliação dessas indicações com base em dados da literatura. RESULTADOS Em um dia predeterminado, de 462 pacientes internados, houve prescrição de IBP para 183 (39,3%), com maior frequência (73,5%) em Unidade de Terapia Intensiva (UTI), seguida das enfermarias e do pronto-socorro (PS). O médico assistente foi localizado em 116 casos, a principal motivação referida para prescrição foi a profilaxia de hemorragia digestiva (77%). Entretanto, após revisão de prontuários, percebeu-se que em 50,8% a prescrição não era respaldada por literatura. CONCLUSÃO A frequência de prescrição de IBP para pacientes internados no HC-UFU está entre as menores descritas na literatura, mas ainda há prescrições desnecessárias. Orientação e conscientização da equipe assistente podem minimizar esses números.

SUMMARY OBJECTIVES To evaluate the frequency of prescription of proton pump inhibitors (PPIs) and their indications in patients hospitalized at the Hospital de Clínicas of the Federal University of Uberlândia (HC-UFU). METHODS This is a quantitative cross-sectional observational study that analyzes data obtained from patient records on prescriptions of PPIs for patients hospitalized at the HC-UFU and from a questionnaire applied to assistant physicians on the indications of the drug in each case and evaluates the indication based on literature data. RESULTS On a pre-determined day, of a total of 462 inpatients, there was a prescription of PPI for 183 (39.3%), with a higher frequency (73.5%) in the Intensive Care Unit (ICU), followed by the infirmaries and the Emergency Room. The assistant physician was located in 116 cases, and the main motivation referred to prescription was prophylaxis of digestive hemorrhage (77%). However, after reviewing medical records, it was noticed that in 50.8% of the cases, the prescription was not supported by the literature. CONCLUSION The frequency of PPI prescriptions for inpatients in the HC-UFU is among the lowest described in the literature, but there are still unnecessary prescriptions. Instruction and awareness of the assisting team can minimize these numbers.

Este artigo tem como objetivo analisar a cultura organizacional da Polícia Civil do estado do Ceará, contribuir nas análises dessas entidades a partir da apresentação de evidências ilustrativas das características organizacionais em termos de cultura e melhorar a compreensão das peculiaridades próprias do serviço público, mais especificamente das instituições repressoras ao crime. Foi desenvolvida uma revisão de literatura e um estudo de campo, por método de estudo de caso. O objeto de análise foi a Polícia Civil do estado do Ceará e foram realizadas oito entrevistas semiestruturadas, transcritas e analisadas diante dos objetivos da pesquisa. A análise da fala dos respondentes indicou que prevalecem, na instituição analisada, posições fragmentadas, ambíguas e contraditórias, que podem surgir a partir das tensões entre estruturas mentais pré-constituídas (especialmente em relação ao papel da burocracia) e as práticas e processos oriundos da construção social dos atores organizacionais. As passagens dos relatos dos delegados ilustram que, mesmo considerando o nível de padronização exigido em uma organização policial, até mesmo os líderes das organizações de base (delegacias) são divergentes em diversos aspectos da atividade e da cultura organizacional.

This study aims to examine the organizational culture in police organizations, contribute in the analysis of these entities from the presentation of showing evidences the characteristics in terms of organizational culture and improve understanding of the own peculiarities of the public service, specifically the repressive institutions against crime. It developed a literature review and field study by case study method. The object of analysis was the Civil Police of Ceará's state and eight semi-structured interviews were conducted, transcribed and analyzed. The analysis of the speech of the respondents indicated that prevail in the analyzed institution, fragmentary, ambiguous and contradictory positions, that may arise from tensions between preformed mental structures (especially in relation to the role of the bureaucracy) and the practices and procedures from the social construction of organizational actors. The passages in the delegates' reports illustrate that, even considering the level of required standardization in a police organization, even the leaders of grass-roots organizations (police district) are different in any aspects of activity and the organizational culture.

O segmento dos quadrinhos, inserido no contexto das indústrias criativas, tem assumido relevância econômica e cultural. Sendo assim, esta pesquisa tem como objetivo principal analisar fatores importantes do processo de contratação dos profissionais dessa área. O foco será na relação contratual entre os dois principais protagonistas das indústrias criativas, o artista e o agente, sendo que as análises serão baseadas na percepção dos artistas a respeito, principalmente, dos custos de transação, direitos autorais, assimetria de informações e agentes de mercado. O estudo de caráter descritivo e exploratório fez uso de métodos qualitativos também nas entrevistas realizadas no trabalho empírico. Os respondentes fazem parte da indústria criativa cearense e atuam no setor de quadrinhos. Os principais resultados encontrados pela análise de conteúdo das entrevistas diz respeito, basicamente, a falta de profissionalismo ainda existente no setor de quadrinhos da indústria criativa cearense. Há ainda, conforme indícios desta pesquisa, falta de visão mercadológica e de mentalidade profissional dos artistas, ausência de agentes especializados para interferir comercialmente, e a ausência de proteção aos direitos autorais e conexos. Acredita-se que os resultados aqui disponibilizados podem gerar informações relevantes para a melhor compreensão do mercado tido como objeto de estudo, e com isso colaborar na profissionalização deste importante segmento cultural para a atual economia.

The comics segment, in the context of creative industries, has achieved economic and cultural importance. Thus, this study aims to examine the important factors in the recruitment process of professionals in this areas.The focus will be on contractual relationship between the two main protagonists of the creative industries, the artist and the agent, and the analysis will be based on the perception of the artists with the area. primarily concerning transaction costs, copyright, asymmetry of information and agents of the market. The study is descriptive and exploratory nature, using the qualitative methods also the interviews in empirical work. The respondents are part of the creative industry sector in Ceará and work with comics. The main results found by the content analysis of the interviews is concerned, basically, with the lack of professionalism even in the comics sector of the creative industry of Ceará. There is, as evidence of this research, a lack of vision and marketing mindset of professional artists, a shortage of specialist agents to interfere commercially, and the lack of protection of copyright and related rights. It is believed that the results displayed here can generate information for better understanding of the market as its object of study, and to assist in the professionalism of this important segment of the current cultural economy.

No contexto da cooperação entre universidade, empresa e governo sobressaem-se os conceitos complementares de "universidade empreendedora" e "empreendedorismo acadêmico", nos quais uma instituição acadêmica vai além da formação, desempenhando um papel no Sistema de Inovação e no desenvolvimento do país. Considerando essa discussão, este estudo tem como objetivo abordar a questão da capacitação da universidade para promover a cooperação, tendo como base as seguintes questões de pesquisa: Como ocorre a cooperação da universidade com as empresas e o governo e desses com a universidade? Quais as barreiras e vantagens para os entes participantes? Que contratos e arranjos são articulados para a concretização dessa interação? A metodologia de natureza qualitativa faz uso do caso Parque de Desenvolvimento Tecnológico (PADETEC) ligado a uma universidade federal, enquanto instituição situada na fronteira dessas relações. A análise dos dados baseou-se na técnica da análise temática que se insere no conjunto das técnicas da Análise de Conteúdo. A análise evidenciou que há atuação de uma universidade empreendedora, mas, sobretudo, o empreendedorismo acadêmico dá sinais de existência; porém, é preciso ainda percorrer um longo caminho para se consolidar estes conceitos e, em consequência, a complementaridade entre suas respectivas práticas.

In the context of cooperation between university, company and government, the complementary concepts of "enterprising university" and "academic enterprising" stand out. This occurs when an academic institution is going beyond the formation, playing a part in the System of Innovation and in the development of the country. Considering this discussion, the aim of this study is to approach the subject of training at the university to promote cooperation, based on the following research subjects: How does the cooperation of the university with companies and government and of these with the university occur? What are the barriers and advantages for those participating in these processes? What contracts and arrangements are articulated for the materialization of this interaction? The qualitative methodology makes use of the case of the Technological Development Park (PADETEC) linked to a federal university as an institution located on the border of these relationships. The analysis of the data was based on the thematic analysis technique that is inserted in the group of Content Analysis techniques. The analysis showed that there is evidence of an enterprising university and that, above all, there are signs of academic enterprising. However, there is a long way to go in order to consolidate these concepts and, therefore, before they can complement one another in their respective practices.