Pesquisa | SciELO

ABSTRACT Opioid consumption has increased greatly in recent years, creating a public health crisis that affects all types of population. The use of illegal opiates amongst pregnant women has also risen, causing a surge in the frequency in which adverse neonatal outcomes, such as Neonatal Abstinence Syndrome (NAS), are seen in clinical practice. Furthermore, children exposed prenatally to these substances have cognitive, motor and psychiatric adverse outcomes throughout their lifetime. This article's objective is to provide an updated literature review about opioid use during pregnancy and its consequences on children exposed in-utero.

RESUMEN El consumo de opioides ha venido incrementando en los últimos años, generando una crisis de salud pública que afecta a todo tipo de población. El uso de sustancias opiáceas ilegales en embarazadas también está en incremento, por lo que, en la práctica clínica se evidencian con mayor frecuencia resultados neonatales adversos como el síndrome de abstinencia neonatal (NAS). Adicionalmente, los niños expuestos prenatalmente a estas sustancias pueden sufrir alteraciones cognitivas, motoras o psiquiátricas durante el transcurso de su vida. Este artículo tiene como objetivo proporcionar una revisión de la literatura actualizada acerca del uso de opioides durante el embarazo y las consecuencias para los niños expuestos a estas sustancias.

Deep sea ecosystem exploration and ‘health check’: sampling strategy and methods applied during the iAtlantic_BR10_Petrobras cruise in the Santos Basin, Southwest Atlantic
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Perez, Jose Angel A.

; Barros Neto, Halésio M.C. de

; Arantes, Renata C.M.

; Gaurisas, Daniela Y.

; Silva, Camila F.

; Alves, Fernanda Maria M.

; Costa, Júlia A.

; Eloi, Paula D.C.

; Fonseca, Thayse S.

; Gavazzoni, Lucas

; Lonskis, Isabella da S.

; Nardi, Ricardo U.

; Nascimento, Pedro O.

; Rodrigues, João Vitor M.

; Santos, Ana Lara F. dos

; Santos, Edson C. dos

; Schroeder, Rafael

; Silva, Luis Carlos da

; Souza, Fernanda dos S.S. de

; Bernardino, Ângelo F.

; Cavalcanti, Guarani H.

; Lindner, Alberto

; Mahiques, Michel M. de

; Millo, Christian

; Reis, Priscila

; Sweetman, Andrew K.

; Roberts, J. Murray

Ocean and Coastal Research

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2023, Volume 71 elocation e23046

Resumo: En | Texto: En | PDF: En

Abstract The iAtlantic Project has established an international collaborative strategy to improve mapping and characterization of deep and open ocean ecosystems in understudied regions of the Atlantic and evaluate their health. In December 2022, the first iAtlantic expedition in the South Atlantic set off to map and explore seafloor ecosystems in the Santos Basin slope (200-1,000 m depths) in collaboration with the Petrobras ‘Santos Basin - Regional Characterization Project.’ The 17-day ‘iAtlantic_BR10-Petrobras’ cruise was conducted on board the research vessel NPqHOc Vital de Oliveira (Brazilian Navy) and performed (a) water column structure characterization, (b) seafloor morphology mapping, (c) description of benthic habitats and communities by seafloor imagery and biological/ geological sampling, and (d) ex-situ experiments to assess the functioning of sedimentary ecosystems and their responses to climate-related environmental changes. This study describes the rationale behind the iAtlantic_BR10-Petrobras cruise science plan, reports its sampling strategy and methods, and summarizes its collected data and preliminary results.

https://doi.org/10.1590/2675-2824071.23069jaap

Contribution of public oral pathology services to the diagnosis of oral and oropharyngeal cancer in Brazil
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LOUREDO, Brendo Vinicius Rodrigues

; CURADO, Maria Paula

; PENAFORT, Paulo Victor Mendes

; DE ARRUDA, José Alcides Almeida

; ABREU, Lucas Guimarães

; MESQUITA, Ricardo Alves

; PINTO-JÚNIOR, Décio dos Santos

; ABRAHÃO, Aline Corrêa

; ANDRADE, Bruno Augusto Benevenuto de

; AGOSTINI, Michelle

; MORAES, Renata Mendonça

; ANBINDER, Ana Lia

; DOURADO, Pedro Henrique Silva

; SANTOS, Teresa Cristina Ribeiro Bartholomeu dos

; PIRES, Fábio Ramoa

; BORDIGNON, Natalia Cristina Trentin

; GONDAK, Rogério Oliveira

; DE OLIVEIRA, Marcia Gaiger

; CARRARD, Vinicius Coelho

; MARTINS, Manoela Domingues

; SOUSA-NETO, Sebastião Silvério

; ARANTES, Diego Antônio Costa

; MENDONÇA, Elismauro Francisco

; CIESLAK-SANCHES, Silvia Roberta

; ANTUNES, Daniella Moraes

; AMARAL-SILVA, Gleyson Kleber do

; MANIERI, Patricia Rubia

; RAMALHO, Luciana Maria Pedreira

; DOS SANTOS, Jean Nunes

; LEONEL, Augusto César Leal da Silva

; PEREZ, Danyel Elias da Cruz

; VERHEUL, Hannah Carmem Carlos Ribeiro Silva

; BARROSO, Keila Martha Amorim

; RODRIGUES, Flávia Luiza Santos

; GONZAGA, Amanda Katarinny Goes

; FERNANDES, Romana Renery

; DE SOUZA, Lélia Batista

; SOUZA, Lucas Lacerda de

; PONTES, Flávia Sirotheau Corrêa

; PONTES, Hélder Antônio Rebelo

; SILVA, Caroline Alfaia

; CÂMARA, Jeconias

; LIBÓRIO-KIMURA, Tatiana Nayara

; SANTOS-SILVA, Alan Roger

; LOPES, Márcio Ajudarte

; ALMEIDA, Oslei Paes de

; ROMAÑACH, Mário José

; VARGAS, Pablo Agustin

Brazilian Oral Research

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2023, Volume 37 elocation e126

Resumo: En | Texto: En | PDF: En

Abstract This study aimed to evaluate the contribution of oral and maxillofacial pathology laboratories (OMPLs) in Brazilian public universities to the diagnosis of lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC). A cross-sectional study was performed using biopsy records from a consortium of sixteen public OMPLs from all regions of Brazil (North, Northeast, Central-West, Southeast, and South). Clinical and demographic data of patients diagnosed with lip, oral cavity, and oropharyngeal SCC between 2010 and 2019 were collected from the patients’ histopathological records. Of the 120,010 oral and maxillofacial biopsies (2010-2019), 6.9% (8,321 cases) were diagnosed as lip (0.8%, 951 cases), oral cavity (4.9%, 5,971 cases), and oropharyngeal (1.2%, 1,399 cases) SCCs. Most cases were from Brazil’s Southeast (64.5%), where six of the OMPLs analyzed are located. The predominant profile of patients with lip and oral cavity SCC was Caucasian men, with a mean age over 60 years, low schooling level, and a previous history of heavy tobacco consumption. In the oropharyngeal group, the majority were non-Caucasian men, with a mean age under 60 years, had a low education level, and were former/current tobacco and alcohol users. According to data from the Brazilian National Cancer Institute, approximately 9.9% of the total lip, oral cavity, and oropharyngeal SCCs reported over the last decade in Brazil may have been diagnosed at the OMPLs included in the current study. Therefore, this data confirms the contribution of public OMPLs with respect to the important diagnostic support they provide to the oral healthcare services extended by the Brazilian Public Health System.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0126

A física e a música do fagote
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Grillo, Maria Lúcia Netto

; Baptista, Luiz Roberto Perez Lisbôa

; Silos, Matheus da Silva

; Chaves Júnior, José Gonçalves

; Barbosa, Caio Nabuco

; Souza, Matheus Brill e

; Corrêa, Elcio Antônio

Revista Brasileira de Ensino de Física

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2023, Volume 45 elocation e20230133

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

In the set of wind instruments (aerophones) there is one that, despite not being as popular as the flute or the saxophone, frequently figures in concert music; in orchestras and chamber performances: the bassoon. It has a distinctive, nasal and unmistakable sound. In this work we present some aspects of the physics and music of the bassoon. We selected some sites with songs that show the sound of the bassoon. Experiments were carried out to study sound waves, sound spectra, sound pressure levels, sound radiation as well as the psychoacoustics of the instrument. In the analysis of the experimental results, the programs Praat, dBTrait and dBInside were used. We observed that the bassoon can be considered a harmonic instrument and that the intensity relationship between the fundamental and the harmonics, including their presence or absence, depends on the emitted frequency, the measurement position, the time of emission of the note and how the sound was captured (including or not the attack and decay). The experimental processes used can be applied to the study of the physics of other musical instruments, allowing the observation of different types of sound sources and thus contributing to the motivation in physics and music teaching.

No conjunto dos instrumentos de sopro (aerofones) existe um que, apesar de não ser tão popular quanto a flauta ou o saxofone, figura frequentemente na música de concerto; em orquestras e apresentações de câmara: o fagote. Possui uma sonoridade distinta, anasalada e inconfundível. Neste trabalho apresentamos alguns aspectos da física e da música do fagote. Selecionamos alguns sites com músicas que evidenciam o som do fagote. Foram feitos experimentos para estudo das ondas sonoras, espectros sonoros, níveis de pressão sonora, radiação sonora bem como a psicoacústica do instrumento. Na análise dos resultados experimentais foram utilizados os programas Praat, dBTrait e dBInside. Observamos que o fagote pode ser considerado um instrumento harmônico e que a relação de intensidade entre a fundamental e os harmônicos, inclusive sua presença ou ausência, depende da frequência emitida, da posição de medida, do tempo de emissão da nota e de como o som foi captado (incluindo ou não o ataque e o decaimento). Os processos experimentais utilizados podem ser aplicados ao estudo da física de outros instrumentos musicais, permitindo a observação de diferentes tipos de fontes sonoras e assim contribuindo para a motivação no ensino de física e de música.

https://doi.org/10.1590/1806-9126-rbef-2023-0133

The SISBIOTA-Diptera Brazilian Network: A long-term survey of Diptera from unexplored Brazilian Western Arc of Amazon, Cerrado, and Pantanal
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Lamas, Carlos José Einicker

; Fachin, Diego Aguilar

; Falaschi, Rafaela Lopes

; Alcantara, Daniel Máximo Correa de

; Ale-Rocha, Rosaly

; Amorim, Dalton de Souza

; Araújo, Maíra Xavier

; Ascendino, Sharlene

; Baldassio, Letícia

; Bellodi, Carolina Ferraz

; Bravo, Freddy

; Calhau, Julia

; Capellari, Renato Soares

; Carmo-Neto, Antonio Marcelino do

; Cegolin, Bianca Melo

; Couri, Márcia Souto

; Carvalho, Claudio José Barros de

; Dios, Rodrigo de Vilhena Perez

; Falcon, Aida Vanessa Gomez

; Fusari, Livia Maria

; Garcia, Carolina de Almeida

; Gil-Azevedo, Leonardo Henrique

; Gomes, Marina Morim

; Graciolli, Gustavo

; Gudin, Filipe Macedo

; Henriques, Augusto Loureiro

; Krolow, Tiago Kütter

; Mendes, Luanna Layla

; Limeira-de-Oliveira, Francisco

; Maia, Valéria Cid

; Marinoni, Luciane

; Mello, Ramon Luciano

; Mello-Patiu, Cátia Antunes de

; Morales, Mírian Nunes

; Oliveira, Sarah Siqueira

; Patiu, Claudemir

; Proença, Barbara

; Pujol-Luz, Cristiane Vieira de Assis

; Pujol-Luz, José Roberto

; Rafael, José Albertino

; Riccardi, Paula Raile

; Rodrigues, João Paulo Vinicios

; Roque, Fabio de Oliveira

; Sallum, Maria Anice Mureb

; Santis, Marcelo Domingos de

; Santos, Charles Morphy Dias dos

; Santos, Josenilson Rodrigues dos

; Savaris, Marcoandre

; Shimabukuro, Paloma Helena Fernandes

; Silva, Vera Cristina

; Schelesky-Prado, Daniel de Castro

; Silva-Neto, Alberto Moreira da

; Camargo, Alexssandro

; Sousa, Viviane Rodrigues de

; Urso-Guimarães, Maria Virginia

; Wiedenbrug, Sofia

; Yamaguchi, Carolina

; Nihei, Silvio Shigueo

Revista Brasileira de Entomologia

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2023, Volume 67 Nº 4 elocation e20230051

Resumo: En | Texto: En | PDF: En

ABSTRACT The SISBIOTA-BRASIL was a three-year multimillion-dollar research program of the Brazilian government to document plants and animals in endangered/understudied areas and biomes in Brazil. Distributional patterns and the historical events that generated them are extensively unknown regarding Brazilian fauna and flora. This deficiency hinders the development of conservation policies and the understanding of evolutionary processes. Conservation decisions depend on precise knowledge of the taxonomy and geographic distribution of species. Given such a premise, we proposed to research the diversity of Diptera of the Brazilian western arc of Amazon, Cerrado, and Pantanal in the states of Mato Grosso, Mato Grosso do Sul, and Rondônia. Three important biomes of the South American continent characterize these Brazilian states: Amazon forest, Cerrado (Brazilian Savannah), and Pantanal. Besides their ecological relevance, these biomes historically lack intensive entomological surveys. Therefore, they are much underrepresented in the Brazilian natural history collections and in the scientific literature, which is further aggravated by the fact that these areas are being exponentially and rapidly converted to commercial lands. Our project involved over 90 collaborators from 24 different Brazilian institutions and one from Colombia among researchers, postdocs, graduate and undergraduate students, and technicians. We processed and analyzed nearly 300,000 specimens from ~60 families of Diptera collected with a large variety of methods in the sampled areas. Here, we provide a detailed overview of the genera and species diversity of 41 families treated. Our results point to a total of 2,130 species and 514 genera compiled and identified for the three states altogether, with an increase of 41% and 29% in the numbers of species and genera known for the three states combined, respectively. Overall, the 10 most species-rich families were Tachinidae, Cecidomyiidae, Tabanidae, Psychodidae, Sarcophagidae, Stratiomyidae, Bombyliidae, Syrphidae, Tephritidae, and Asilidae. The 10 most diverse in the number of genera were Tachinidae, Stratiomyidae, Asilidae, Mycetophilidae, Syrphidae, Tabanidae, Muscidae, Dolichopodidae, Sarcophagidae, and Chloropidae. So far, 111 scientific papers were published regarding taxonomic, phylogenetic, and biogeographical aspects of the studied families, with the description of 101 new species and three new genera. We expect that additional publications will result from this investigation because several specimens are now curated and being researched by specialists.

https://doi.org/10.1590/1806-9665-rbent-2023-0051

Vigilancia ambiental de la circulación de poliovirus en tres municipios considerados como punto transitorio de migrantes en Colombia 2017-2019
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González-De Schroeder, María Mercedes

; Gómez-Hincapie, Jose Fernando

; Celis-Castaño, Sara

; Fonseca, Magile C.

; Londoño-Buriticá, Diana Patricia

; Vila-Ortega, José Joaquín

; Giraldo-Garcia, Alejandra María

; Padilla-Sanabria, Leonardo

; Sarmiento-Perez, Luis

; Castaño-Osorio, Jhon Carlos

Infectio

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Jun 2022, Volume 26 Nº 2 Páginas 107 - 112

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Objetivo: Determinar la circulación de poliovirus en tres municipios considerados como punto transitorio de migrantes en Colombia. Material y método: Se colectaron muestras de aguas residuales (n=36) de municipios fronterizos, seleccionados por mayor tránsito de migrantes regulares como irregulares, en el periodo comprendido entre el 2017-2019. Las muestras fueron concentradas y cultivadas siguiendo el algoritmo de vigilancia ambiental para la circulación de poliovirus de la Organización Mundial de la Salud (OMS). La identificación molecular se realizo mediante reacción en cadena de la polimerasa empleando cebadores específicos de grupo, de serotipo y de cepa vacunal sabin. Resultados y Discusión: Se detectó la presencia de Enterovirus no polio (EVNP) en las muestras ambientales obtenidas y no se hallo circulación de poliovirus deriva dos de la vacuna ni de poliovirus salvaje en los tres municipos evaluados; sin embargo en dos estudios previos publicados por Gonzalez y col con una metodologia similar en el año 2005 y 2015 evaluando las aguas residuales de la ciudad de Armenia-Quindio; se logró identificar la presencia de virus derivado de vacuna, con resultados negativos para la identificación de poliovirus salvaje. Conclusiones: Los hallazgos indican que el sistema de monitoreo de aguas residuales con el fin de determinar la presencia de virus es una herramienta util para realizar vigilancia ambiental.

Abstract Objective: To determine the circulation of poliovirus in three municipalities considered as transitory points for migrants in Colombia. Material and Method: Wastewater samples (n = 36) were collected from border municipalities, selected for greater transit of regular and irregular migrants, in the period between 2017-2019. The samples were concentrated and cultured following the World Health Organization (WHO) environmental surveillance algorithm for poliovirus circulation. Molecular identification was performed by polymerase chain reaction using group-specific, serotype and sabin vaccine strain primers. Results: The presence of non-polio Enterovirus (NPV) was detected in the environmental samples obtained and no circulation of poliovirus derived from the vaccine or wild poliovirus was found in the three evaluated municipalities; However, in two previous studies published by Gonzales et al with a similar methodology in 2005 and 2015 evaluating the wastewater of the city of Armenia-Quindío; It was possible to identify the presence of virus derived from vaccine, with negative results for the identification of wild poliovirus. Conclusions: The findings indicate that the wastewater monitoring system in order to determine the presence of viruses is a useful tool to carry out environmental surveillance.

https://doi.org/10.22354/in.v26i2.1008 64 downloads

Encapsulation technique efficiency in high zinc chloride concentration clayey soil with traditional agents
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Perez, Isabel Amado

; Ferreira, José Wilson dos Santos

; Malko, José Adriano Cardoso

; Silva, Maria Isabel Pais

; Casagrande, Michéle Dal Toé

Engenharia Sanitaria e Ambiental

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Jun 2022, Volume 27 Nº 3 Páginas 607 - 616

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Ainda que a técnica de encapsulamento seja usada na remediação ambiental há mais de três décadas, existem poucos estudos que avaliam sua eficácia para altas concentrações de contaminantes. Assim, este trabalho tem como objetivo avaliar a eficiência da técnica de encapsulamento de solo argiloso contaminado com 5 e 10% de cloreto de zinco, utilizando cal e cimento. Análises química, mecânica, mineralógica e microscópica foram realizadas para o solo puro, contaminado e encapsulado, com base em ensaios de fluorescência de raios X, resistência à compressão simples, espectrometria de absorção atômica, microscopia eletrônica de varredura e microtomografia de raios X. Ambos os agentes encapsulantes aumentaram a resistência ao longo dos períodos de cura de sete, 28 e 60 dias, embora as interações químicas entre zinco e cal tenham afetado negativamente os ganhos quando comparados ao do cimento. Os lixiviados apresentaram redução significativa na concentração de zinco, acima de 77% para condições experimentais críticas. O contaminante reduziu a presença de elementos químicos que compõem a matriz do solo, fazendo com que os vazios aumentassem; por outro lado, as reações pozolânicas promovidas pela adição de cal e cimento resultaram em distribuição de vazios mais homogênea, melhorando o comportamento mecânico e a capacidade de retenção de cloreto de zinco.

ABSTRACT Although the encapsulation technique has been used in environmental remediation for over three decades, there are few studies evaluating its efficacy for high contaminant concentrations. Therefore, this study aims to evaluate the encapsulation technique efficiency of clayey soil contaminated with 5% and 10% of zinc chloride, using lime and cement. Chemical, mechanical, mineralogical, and microscopic analyses were performed for pure, contaminated, and encapsulated soil, based on X-ray fluorescence (XRF/EDX), unconfined compression strength (UCS), atomic absorption spectrometry (AAS), scanning electron microscopy/energy dispersive X-ray spectrometer (SEM/EDS), and X-ray micro-computed tomography (micro-CT) tests. Although chemical interactions between zinc and lime negatively affected the gains when compared to cement, both encapsulating agents increased the strength over the curing periods of 7, 28, and 60 days. The leachates presented a significant reduction in the contaminant concentration, above 77% for critical experimental conditions. The contaminant reduced the presence of chemical elements that compose the soil matrix, consequently causing the voids to increase; in contrast, pozzolanic reactions promoted by the addition of lime and cement resulted in homogeneous voids distribution, enhancing the mechanical behavior and the capability of zinc chloride retention.

https://doi.org/10.1590/s1413-415220200241

Insuficiencia cardíaca crónica en Argentina. OFFICE IC AR, un registro conjunto de la Sociedad Argentina de Cardiología y de la Federación Argentina de Cardiología
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THIERER, JORGE

; PERNA, EDUARDO R.

; MARINO, JAVIER

; CORONEL, MARÍA LORENA

; BARISANI, JOSÉ LUIS

; GARCÍA BRASCA, DANIELA

; PEREZ TERNS, PAULA

; CÍMBARO CANELLA, JUAN PABLO

; PEREIRO GONZÁLEZ, STELLA MARIS

Revista argentina de cardiología

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Mar 2022, Volume 90 Nº 1 Páginas 15 - 24

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT Background: Several Argentine registries on chronic heart failure (CHF) have been generated over the past 25 years, either individually by the Argentine Society of Cardiology (SAC) or the Argentine Federation of Cardiology (FAC), with different representativeness. The last known data are from 2013. The OFFICE IC AR registry was jointly undertaken by the SAC and FAC to know the reality of CHF in Argentina. Objective: The aim of this registry was to extensively and comprehensively describe the outstanding characteristics of CHF in Argentina, including patient characteristics, use of diagnostic and therapeutic resources, adherence to practice guidelines and mid-and long-term prognosis. Methods: This was a prospective cohort study of patients with at least 6-month evolution CHF and not hospitalized for at least the past 3 months. Clinical and paraclinical data were collected. Patients were categorized according to left ventricular ejection fraction (LVEF), into HF with reduced EF, HFrEF (≤40 %), HF with midrange EF, now termed HF with mildly reduced EF, HFmrEF (41%-49%), and HF with preserved EF, HFpEF (≥50%). The incidence of hospitalization for HF (HHF), cardiovascular mortality (CVM) and all-cause mortality (ACM) was recorded for at least 1-year follow-up. Results: Between November 2017 and January 2020, 100 cardiologists from all over the country included 1004 patients with CHF. Mean age was 65.8 ± 12.4 years, 74.6% were men, and 93.8% had known LVEF. In 68.4% of cases, patients had HFrEF, 16% HFmrEF and 15.6% HFpEF. A high prevalence of comorbidities was found, including diabetes and anemia in 30% of cases, and chronic renal failure in 22%. There was high use of neurohormonal antagonists (NHA): 89.5% betablockers, 57.3% renin-angiotensin system inhibitors or antagonists, 28.9% sacubitril-valsartan and 78.6% aldosterone antagonists. Triple therapy was used in 69% of patients, with higher prescription in HFrEF, but elevated even on HFpEF. At a median follow-up of 1.7 years, the annual incidence of CVM/HHF was 12.8%, CVM 6.6% and ACM 8.4%, without statistical differences between the different LVEF categories. Conclusions: This first SAC-FAC joint CHF registry verified a high prevalence of HFrEF, a high prevalence of comorbidities, frequent use of NHA and prognosis according to international registries.

RESUMEN Introducción: Diferentes registros argentinos de insuficiencia cardíaca crónica (ICC) fueron generados en los últimos 25 años, en forma individual por la Sociedad Argentina de Cardiología (SAC) y la Federación Argentina de Cardiología (FAC), con diversa representatividad. Los últimos datos conocidos datan de 2013. El Registro OFFICE IC AR fue encarado en forma conjunta por la SAC y la FAC para conocer la realidad de la ICC en Argentina. Objetivos: Describir en forma amplia y comprensiva las características salientes de la ICC en Argentina, incluyendo las características de los pacientes, el uso de recursos diagnósticos y terapéuticos, la adherencia a las guías de práctica y el pronóstico a mediano y largo plazo. Material y Métodos: Estudio prospectivo de cohorte, de pacientes con ICC de al menos 6 meses de evolución, alejados de una internación por al menos 3 meses. Se recabaron datos clínicos y paraclínicos. Los pacientes fueron categorizados, de acuerdo a la fracción de eyección ventricular izquierda (FEVI), en IC con FE reducida, ICFER (≤40%); IC con FE en el rango medio, ICFErm, ahora denominada IC con FE levemente reducida, ICFElr (41%-49%), e IC con FE preservada, ICFEP (≥50%). En seguimiento de al menos 1 año se registró la incidencia de hospitalización por insuficiencia cardíaca (HIC), muerte cardiovascular (MCV) y muerte de todas las causas (MTC) Resultados: Entre noviembre de 2017 y enero de 2020, 100 cardiólogos de todo el país incluyeron 1004 pacientes con ICC; edad media 65,8 ± 12,4 años, 74,6% hombres, FEVI conocida en el 93,8%. El 68,4% tenía ICFER, el 16% ICFElr y el 15,6% ICFEP. Hubo alta prevalencia de comorbilidades, incluyendo diabetes y anemia en el 30%, e insuficiencia renal crónica en el 22%. Fue elevada la utilización de antagonistas neurohormonales (ANH): 89,5% betabloqueantes; 57,3% inhibidores o antagonistas del sistema renina angiotensina, 28,9% sacubitril valsartán y 78,6% antialdosterónicos. En 69% se utilizó triple terapia. Su empleo fue mayor en la ICFER, pero elevado incluso en la ICFEP. En una mediana de seguimiento de 1,7 años la incidencia anual de MCV/HIC fue 12,8%, la de MCV 6,6% y la de MTC 8,4%, sin diferencia entre las distintas categorías de FEVI. Conclusiones: En el primer registro conjunto de ICC SAC-FAC se verificó elevada prevalencia de ICFER, alta prevalencia de comorbilidades, uso frecuente de ANH y pronóstico acorde a los registros internacionales.

https://doi.org/10.7775/rac.es.v90.i1.20480 15 downloads

Adaptation of practical classes of clinical subjects in the COVID-19 era
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Zarzuelo, Maria Jose

; Valverde-Merino, Maria Isabel

; Lara, Laura Sanchez-Perez de

; Martinez-Martinez, Fernando

Brazilian Journal of Pharmaceutical Sciences

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2022, Volume 58 elocation e200987

Resumo: En | Texto: En | PDF: En

Abstract Pharmaceutical Care is a subject within the Pharmacy Degree that is taught using theoretical and practical classes. When COVID-19 appeared, Faculty of Pharmacy had to change its way of teaching and learning to online classes. Our aim is to assess the impact of COVID-19 situation on practical classes in Pharmaceutical Care. A prospective study was performed by undergraduate students from Pharmaceutical Care subject. Students attended to 2-day practical classes and were assessed through an evaluative workbook. Undergraduate students (n=390) obtained a score of 8.4±0.8 in practical classes, being higher in face-to-face sessions than online sessions, but not significant differences among both methodologies. The higher score was for the session of minor ailment services (9.3±1.3) and the lower for Personalized Medication Dosage (7.0±1.6) and similar in both scenarios. 59% of students obtained more than 8 score in the global punctuation, being higher in in-face-to-face practical classes. This study showed that learning in health care can be guided and evaluated through an online method. Adapt to new technologies, prevent vulnerable students from being left behind, as well as working on cross-cutting skills at a distance, are some of the challenges of higher education in times of COVID-19.

https://doi.org/10.1590/s2175-97902022e20987

10.

speciesLink: rich data and novel tools for digital assessments of biodiversity
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Canhos, Dora Ann Lange

; Almeida, Eduardo A. B.

; Assad, Ana Lucia

; Cunha Bustamante, Mercedes Maria da

; Canhos, Vanderlei Perez

; Chapman, Arthur David

; Giovanni, Renato De

; Imperatriz-Fonseca, Vera Lúcia

; Lohmann, Lúcia Garcez

; Maia, Leonor Costa

; Miller, Joseph T.

; Nelson, Gil

; Peterson, A. Townsend

; Pirani, José Rubens

; Souza, Sidnei de

; Stehmann, João Renato

; Thiers, Barbara

Biota Neotropica

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2022, Volume 22 Nº spe elocation e20221394

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo speciesLink é um portal de informações em larga escala sobre biodiversidade, que existe graças a uma ampla rede colaborativa de pessoas e instituições. O envolvimento do CRIA com a comunidade científica do Brasil e de outros países é responsável pelos resultados expressivos alcançados, atingindo atualmente mais de 15 milhões de registros de dados primários de biodiversidade, sendo 95% associados a espécimes preservados e cerca de 25% a imagens digitais de alta qualidade. A rede fornece dados sobre mais de 200.000 espécies, das quais mais de 110.000 ocorrem no Brasil. Este artigo descreve as redes temáticas do speciesLink, bem como algumas das ferramentas mais úteis desenvolvidas. A importância e as contribuições do speciesLink são destacadas, assim como as preocupações em garantir um apoio financeiro estável para e-infraestruturas de dados sobre biodiversidade. Aqui revisamos o valor do speciesLink como uma das principais fontes de informação sobre biodiversidade para pesquisa, educação, tomada de decisão, desenvolvimento de políticas e bioeconomia.

Abstract speciesLink is a large-scale biodiversity information portal that exists thanks to a broad collaborative network of people and institutions. CRIA’s involvement with the scientific community of Brazil and other countries is responsible for the significant results achieved, currently reaching more than 15 million primary biodiversity data records, 95% of which are associated with preserved specimens and about 25% with high-quality digital images. The network provides data on over 200,000 species, of which over 110,000 occur in Brazil. This article describes thematic networks within speciesLink, as well as some of the most useful tools developed. The importance and contributions of speciesLink are outlined, as are concerns about securing stable budgetary support for such biodiversity data e-infrastructures. Here we review the value of speciesLink as a major source of biodiversity information for research, education, informed decision-making, policy development, and bioeconomy.

https://doi.org/10.1590/1676-0611-bn-2022-1394

11.

Mood and Aﬀective Balance of Spaniards Conﬁned by COVID-19: A Cross-Sectional Study
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Perez-Fuentes, Maria del Carmen

; Molero Jurado, Maria del Mar

; Martos Martinez, Africa

; Simon Marquez, Maria del Mar

; Gazquez Linares, Jose Jesus

International Journal of Psychological Research

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Jun 2021, Volume 14 Nº 1 Páginas 55 - 65

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen. El objetivo de este trabajo fue analizar el estado de ánimo y el balance afectivo de los españoles en cuarentena y determinar el papel predictivo de las variables sociodemográﬁcas y de los estados anímicos, sobre el balance afectivo negativo. Se trata de un estudio transversal, con una muestra de 1014 adultos españoles, siendo el 67.2% mujeres y el 32.8% restante, hombres. El rango de edad estuvo entre 18 y 76 años. Los instrumentos empleados fueron la Escala de Evaluación del Estado de Ánimo y la Escala de Equilibrio Afectivo, empleando para su implementación una encuesta CAWI (Computer Aided Web Interviewing). Los resultados mostraron que la edad correlaciona negativamente con la Tristeza-Depresión, la Ansiedad y Alegría. Las mujeres presentan mayor nivel de Tristeza-Depresión, Ansiedad y afecto negativo, mientras que los hombres presentan más Alegría y mayor nivel de afecto positivo. Por lo tanto, el riesgo de presentar un balance afectivo negativo durante el conﬁnamiento es mayor entre mujeres y entre quienes maniﬁestan un estado emocional marcado por la tristeza-depresión y la ansiedad, mientras que tener mayor edad y mostrar puntuaciones elevadas en alegría se asocia con menor riesgo. En conclusión, conocer los grupos de riesgo en alteraciones emocionales y afectivas puede facilitar la detección y prevención de trastornos posteriores, como estrés agudo y trastorno de estrés postraumático, evitando la presencia generalizada, y que esto se convierta en un nuevo problema de Salud Pública derivado del COVID-19.

Abstract. The aim of this study was to analyze the mood and aﬀective balance of Spaniards in quarantine and determine the predictive role of sociodemographic variables and mood on the negative aﬀective balance. This cross-sectional study was carried out with a sample of 1014 Spanish adults, 67.2% were women and 32.8% men. The age ranged from 17 to 76. The instruments used were the Mood Assessment Scale and the Aﬀective Balance Scale, which were implemented as a CAWI survey (Computer Aided Web Interviewing). Results showed that age correlated negatively with Sadness-Depression, Anxiety, and Happiness. Women had more Sadness-Depression, Anxiety, and negative aﬀect, while men showed more Happiness and higher positive aﬀect. Thus, the risk of a negative aﬀective balance during conﬁnement was greater for women and those who showed an emotional state marked by sadness-depression and anxiety, while older age and higher scores in happiness were associated with lower risk. In conclusion, knowing which groups are at risk of emotional and aﬀective alteration can facilitate the detection and prevention of later disorders, such as severe stress and posttraumatic stress disorder, avoiding their generalized presence, and becoming a new public health problem derived from COVID-19.

https://doi.org/10.21500/20112084.4765 92 downloads

12.

Dynamics of neutralizing antibodies against Bovine respiratory syncytial virus in a dairy herd from Santa Fe Province, Argentina
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Ferella, Alejandra

; Aguirreburualde, María Sol Perez

; Sammarruco, Ayelen

; Parreno, Viviana

; Santos, María José Dus

; Mozgovoj, Marina

Revista argentina de microbiología

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Dez 2020, Volume 52 Nº 4 Páginas 111 - 120

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Bovine respiratory syncytial virus (BRSV) is one of the most relevant agents responsi-ble for respiratory disease in cattle from both dairy and beef farms. BRSV is spread by horizontalcontact causing a constant presence of seropositive animals that favors viral circulation throughout the year. Moreover, reinfections with BRSV are frequent between animals regardless of theirage as BRSV does not confer long-lasting protective immunity. Several studies have demonstrated the circulation of BRSV in cattle from different regions of the world; however, little isknown about the dynamics of BRSV infection in cows before and after they begin lactation. Theaim of this work was to study the dynamics of BRSV neutralizing antibodies from birth up to36 months of age in a closed dairy herd of Argentina specifically around the lactation period. Passive maternal antibodies against BRSV started to decrease monthly and became almost undetectable at 8 months of age. We detected two potential infection points at months 11 and 27after birth, in which 30% and 45% of the animals showed seroconversion, respectively. Specifically, an increase in the proportion of seropositive cows after the start of lactation suggests thatthey became reinfected around the time they began lactating. We demonstrate the importanceof understanding BRSV dynamics in a closed dairy herd to review the vaccination schedule ofthe animals to achieve protection against BRSV infection.

Resumen El virus respiratorio sincitial bovino (Bovine respiratory syncytial virus, [BRSV]) es uno de los principales agentes responsables de la enfermedad respiratoria en bovinos, tanto de tambos como de cría. El virus se transmite horizontalmente y causa la presencia constante de animales seropositivos, lo cual favorece la circulación viral a lo largo del ano. A su vez, las reinfecciones por BRSV son frecuentes entre animales independientemente de su edad, dado que el virus no confiere inmunidad protectora a largo plazo. Numerosos estudios han demostrado la circulación de BRSV en bovinos de diferentes regiones del mundo, sin embargo, poco se conoce acerca de la dinámica de infección en vacas antes y después del inicio de la fase de lactancia. El objetivo de este trabajo fue estudiar la dinámica de anticuerpos neutralizantes anti- BRSV en vacas lecheras desde el nacimiento hasta los 36 meses de vida en un tambo cerrado de Argentina, específicamente, en el período de lactancia. Los anticuerpos pasivos específicos para BRSV comenzaron a declinar mensualmente hasta ser casi indetectables a los 6 meses. Detectamos dos potenciales puntos de infección a los meses 11 y 27 luego del nacimiento, momentos en los que el 30 y el 45% de los animales mostraron seroconversión, respectivamente. El incremento en la proporción de vacas seropositivas luego del comienzo de la lactancia sugiere que estas se reinfectaron en el inicio de dicha etapa. Demostramos la importancia de entender la dinámica de circulación del BRSV en un tambo cerrado, a fin de revisar el esquema de vacunación de los animales para que estén protegidos frente a la posible infección por este virus.

65 downloads

13.

The Beneficial Effect of Anticoagulation in Aortic Bioprosthesis is Associated with its Size
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Dayan, Victor

; Farachio, Paula

; Arocena, Maria Jose

; Fernandez, Amparo

; Perez, Diego

; Soca, Gerardo

Brazilian Journal of Cardiovascular Surgery

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Jun 2020, Volume 35 Nº 3 Páginas 307 - 313

Resumo: En | Texto: En | PDF: En

Abstract Objective: To evaluate the clinical and echocardiographic outcomes in aortic valve replacement (AVR) patients with aortic bioprosthesis under oral anticoagulation (OA). Methods: Patients who underwent AVR with bioprosthesiswere prospectively enrolled. They were classified based on postoperative use of OA. Clinical and operative variables were collected. Echocardiographic and clinical follow-ups were performed two years after surgery. The primary outcome evaluated was change in transprosthetic gradient. Secondary outcomes analyzed were change in New York Heart Association (NYHA) class, major bleeding episodes, hospitalization, stroke, and transient ischemic attack. Results: We included 103 patients (61 without OA and 42 with OA). Clinical characteristics were similar among groups, except for younger age (76±6.3 vs. 72.4±8.1 years, P=0.016) and higher prevalence of atrial fibrillation (0% vs. 23.8%, P<0.001) in the OA group. Mean (21.4±10 mmHg vs. 16.8±7.7 mmHg, P=0.037) and maximum (33.4±13.7 mmHg vs. 28.4±10.2 mmHg, P=0.05) transprosthetic gradients were higher in patients without OA. Improvement in NYHA class was more frequent in patients with OA (73% vs. 45.3%, P=0.032). Major bleeding, stroke, and hospitalization were similar among groups. OA was the only independent predictor for improvement of NYHA class after multivariate logistic regression analysis (odds ratio [OR]: 5.9, 95% confidence interval [CI]: 1.2-29.4; P=0.028). Stratification by prosthesis size showed that patients with ≤ 21 mm prosthesis benefited from OA. Conclusion: Early anticoagulation after AVR with bioprosthesis was associated with significant decrease of transprosthesis gradient and improvement in NYHA class. These associations were seen mainly in patients with ≤ 21 mm prosthesis.

https://doi.org/10.21470/1678-9741-2019-0144 240 downloads

14.

Antibacterial, antifungal, and antiviral activities of chalcone-bearing tetrahydropyranyl and 2,4-dihydroxyl moieties
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Lima, William Gustavo

; Tauany Andrade, Jéssica

; Rocha da Silva Santos, Felipe

; Campos Palumbo, Juliana Maria

; Silva Herrera, Karina Marjorie

; de Castro, Laurieny Eloína

; de Morais, Fernanda Bárbara

; Prates da Silva, Mayra Karla

; Ferreira Perez Villar, José Augusto

; Siqueira Ferreira, Jaqueline Maria

Revista Colombiana de Ciencias Químico - Farmacéuticas

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Abr 2020, Volume 49 Nº 1 Páginas 218 - 233

Resumo: Es En Pt | Texto: Es En Pt | PDF: Es | PDF: En | PDF: Pt

RESUMEN Las chalconas se destacan como una estructura importante en la química médica y, por lo tanto, se ha empleado como prototipo para el desarrollo de nuevos fármacos. En este estudio, nuestro objetivo fue determinar el potencial antibacteriano, anti Candida y anti-Dengue de las nuevas chalconas que poseen los grupos 2,4-dihidroxilo y tetrahidropiranilo. El ensayo de actividad antimicrobiana mostró que las bacterias del género Staphylococcus (incluidas las cepas resistentes a la meticilina) fueron sensibles a las 2,4-dihidroxicalconas estudiadas, con concentraciones inhibitorias mínimas (CIM) que oscilan entre 19,5 y 125 µg.mL-1. El compuesto 4e, que tuvo el mejor efecto bacteriostático, también mostró un efecto bactericida a partir de la concentración de 80 µg.mL-1. El crecimiento de los aislamientos orales de Candida albicans también se inhibió eficientemente con el compuesto 4e (CIM: 15.6-32.3 µg.mL-1), que fue fungicida a una concentración de 15.6 µg.mL-1. Sin embargo, la presencia del grupo tetrahidropiranilo perjudicó la actividad antibacteriana y anti-fúngica de los análogos de la chalcona. Además, ninguno de los compuestos evaluados mostró un efecto contra el virus del dengue serotipo 2. En conclusión, el compuesto 4e muestra una buena actividad anti-estafilocócica y anti-Candida y puede ser un prototipo prometedor para el desarrollo de nuevos agentes antimicrobianos.

SUMMARY Chalcones highlights as an important structure in medicinal chemistry and thus has been widely used as a template in the development of new drugs. In this study, we aim to determine the antibacterial, anti-Candida, and anti-Dengue potential of new chalcone-bearing 2,4-dihydroxyl and tetrahydropyranyl moieties. Antimicrobial activity assays showed that microorganism of the Staphylococcus genus (including methicillin-resistant strains) were susceptible to 2,4-dihydroxychalcones, with minimum inhibitory concentrations (MICs) ranging of 19.5 to 125 µg.mL-1. Compound 4e, which showed the highest bacteriostatic effect, also has bactericidal activity from of 80 µg.mL-1. The growth of oral isolates of Candida albicans was also efficiently inhibited with compound 4e (MIC: 15.6-32.3 µg.mL-1), which was fungicidal at 15.6 µg.mL-1. However, the presence of the tetrahydropyranyl moiety impaired both the antibacterial and antifungal effects. None of the chalcones tested were actives against Dengue virus serotype 2. In conclusion, the compound 4e showed good anti-Staphylococci and anti-Candida activity and may be a promising prototype for the development of new antimicrobial agents.

RESUMO As chalconas se destacam como uma importante estrutura na química medicinal e dessa forma tem sido empregada como um protótipo para o desenvolvimento de novos fármacos. Nesse estudo, nós objetivamos determinar o potencial antibacteriano, anti-Candida, e anti-Dengue de novas chalconas que possuem os grupos 2,4-dihidroxil e tetrahidropiranil. O ensaio de atividade antimicrobiana mostrou que bactérias do gênero Staphylococcus (incluindo linhagens resistentes a meticilina) foram sensíveis para as 2,4-dihidroxichalconas estudadas, com concentrações inibitórias mínimas (CIM) variando de 19,5 para 125 Dengue potential of new chalcone µg.mL-1. O composto 4e, o qual apresentou o melhor efeito bacteriostático, também mostrou efeito bactericida a partir da concentração de 80 µg.mL-1. O crescimento de isolados orais de Candida albicans foi também eficientemente inibido com o composto 4e (CIM: 15.6-32.3 µg.mL-1), o qual foi fungicida a concentração de 15,6 µg.mL-1. Entretanto, a presença do grupo tetrahidropiranil prejudicou a atividade antibacteriana e antifúngica dos análogos de chalcona. Adicionalmente, nenhum dos compostos avaliados mostrou efeito contra o vírus da dengue sorotipo 2. Em conclusão, o composto 4e apresenta boa atividade anti-estafilocóccica e anti-Candida, e pode ser um promissor protótipo para o desenvolvimento de novos agentes antimicrobianos.

https://doi.org/10.15446/rcciquifa.v49n1.87036 345 downloads

15.

Efecto de los probióticos como tratamiento alternativo para la mastitis humana
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Aguilar-Cordero, María José

; Leon-Rios, Ximena Alejandra

; Luque-Ortega, Alvaro

; Perez-Castillo, Iñigo

; Rivero-Blanco, Tania

; Mur-Villar, Norma

Journal of Negative and No Positive Results

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2020, Volume 5 Nº 10 Páginas 1179 - 1194

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen El objetivo de este estudio es determinar el efecto del uso de los probióticos en relación a la mastitis, así como conocer la dosis adecuada de los probióticos y la semana ideal de gestación para que surja el efecto deseado. Para ello se ha realizado una revisión sistemática, con una cadena de búsqueda y unos filtros de acuerdo a cada una de las distintas bases. También, se realizó una búsqueda inversa a raíz de los resultados obtenidos. Se han aplicado criterios de inclusión y exclusión en la selección de los artículos. En cuanto a los resultados y según la evidencia actual se puede decir que el uso de probióticos como tratamiento alternativo a la mastitis humana podría resultar eficaz ya que existe diferencia estadísticamente significativa en la reducción de la carga bacteriana. En lo referente a la dosis y semana ideal de gestación para la administración de probióticos, se ha podido comprobar distintas dosis y semanas que han surtido efecto; pero sin poder concretar cuáles son las más efectivas e ideales.

Abstract The aim of this study is to determine the effect of the use of probiotics in relation to mastitis, as well as to know the adequate dose of probiotic and the ideal week of gestation so that the desired effect appears. For this, a systematic review has been carried out, with a search string and filters according to each of the different bases. Also, an inverse search was performed to the root of the results obtained. Inclusion and exclusion criteria have been applied in the selection of articles. Regarding the results and according to current evidence, it can be said that the use of probiotics as an alternative treatment to human mastitis could be effective since there is a statistically significant difference in the reduction of bacterial load. Regarding the dose and the ideal week of gestation for the administration of probiotics, different doses and weeks have been determined that have taken effect; but without being able to specify problems they are the most effective and ideal.

https://doi.org/10.19230/jonnpr.3801

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