Abstract Objective: Intimal hyperplasia is associated with graft failure and vascular sutures in the first year after surgery and in postangioplasty restenosis. Allium sativum (common garlic) lowers cholesterol and has antioxidant effects; it also has antiplatelet and antitumor properties and, therefore, has great potential to reduce or inhibit intimal hyperplasia of the arteries. Our objective is to determine if the garlic has an efficacy to inhibit myointimal hyperplasia compared to cilostazol. Methods: Female New Zealand rabbits were divided into the following groups (n=10 each) according to treatment: group A, garlic, 800 µg×kg-1×day-1, orally; group C, cilostazol, 50 mg.day-1, orally; group PS, 10 ml of 0.9% physiological saline solution, orally. Our primary is the difference of the mean of myointimal hyperplasia. Statistical analysis was performed by using ANOVA and Tukey tests, as well as the Chi-square test. We calculated the 95% confidence interval for each point estimate, and the P value was set as < 0.05. Results: Group PS had a mean hyperplasia rate of 35.74% (95% CI, 31.76–39.71%); group C, 16.21% (95% CI, 13.36–19.05%); and group A, 21.12% (95% CI, 17.26–25.01%); P<0.0001. Conclusion: We conclude that Allium sativum had the same efficacy in inhibiting myointimal hyperplasia when compared to the positive control, cilostazol.

Objetivo: determinar a diferença da média de hiperplasia miointimal pós-angioplastia na artéria ilíaca de coelhos tratados e não tratados com extrato das folhas de Moringa oleifera. Métodos: ensaio aleatório em animais de laboratório por cinco semanas de seguimento, desenvolvido no Biotério do Laboratório de Tecnologia Farmacêutica da Universidade Federal da Paraíba. Foram utilizadas coelhas da raça Nova Zelândia, submetidas à dieta hipercolesterolêmica e angioplastia da artéria ilíaca externa, randomizadas em dois grupos: Grupo M200 (n=10), coelhas tratadas com 200mg/kg/dia de extrato de folhas de Moringa oleifera, por via oral; Grupo SF (n=10), coelhas tratadas com soro fisiológico 0,9%, por via oral. Após cinco semanas, os animais foram eutanaziados e as artérias ilíacas preparadas para histologia. Os cortes histológicos foram analisados por morfometria digital. A análise estatística foi realizada com o teste t de Student. O nível de significância foi 0,05. Resultados: comparando as artérias ilíacas submetidas à angioplastia do grupo M200 com as do grupo SF, não houve diferença significativa da hiperplasia miointimal Conclusão: não houve diferença da hiperplasia miointimal nos grupos tratados com soro fisiológico e Moringa oleifera após angioplastia.

Objective: to assess post-angioplasty myointimal hyperplasia in iliac artery of rabbits treated with extract of Moringa oleifera leaves. Methods : we conducted a randomized trial in laboratory animals for five weeks of follow-up, developed in the Vivarium of Pharmaceutical Technology Laboratory of the Universidade Federal da Paraíba. We used rabbits from the New Zealand breed, subjected to a hypercholesterolemic diet and angioplasty of the external iliac artery, randomized into two groups: M200 Group (n=10) - rabbits treated with 200mg/kg/day of Moringa oleifera leaves extract orally; SF group (n=10) - rabbits treated with 0.9% saline orally. After five weeks, the animals were euthanized and the iliac arteries prepared for histology. Histological sections were analyzed by digital morphometry. Statistical analysis was performed using the Student's t test. The significance level was 0.05. Results : there was no significant difference in myointimal hyperplasia between M200 and SF groups when comparing the iliac arteries submitted to angioplasty. Conclusion : there was no difference of myointimal hyperplasia between groups treated with saline and Moringa oleifera after angioplasty.

O presente trabalho teve como objetivo avaliar os efeitos de diferentes doses de N e K2O, aplicados em cobertura, no desenvolvimento e rendimento de colmos, açúcar e álcool da cana-soca (Saccharum spp, cultivar SP79 1011) cultivada com e sem irrigação, em área da Destilaria Miriri, município de Capim, PB. O arranjo experimental foi um fatorial 2 x 4 (com e sem irrigação, e quatro doses de adubação de cobertura de N e K2O) com três repetições. A lâmina de irrigação usada, 27,5 mm, foi aplicada em intervalos de irrigação de 12 dias. As adubações de cobertura foram compostas dos elementos N e K2 O aplicando-se respectivamente: AC1 = 44 e 41, AC2 = 86 e 81, AC3 = 157 e 148; e AC4 = 236 e 222 kg ha-1. As interações estudadas regime de irrigação x doses de adubação de cobertura foram não-significativas. Quando submetida à irrigação, a cultura apresentou melhores rendimentos em todas as variáveis avaliadas, exceto peso médio do colmo, quando comparada a não irrigada. Nas parcelas irrigadas, a dose de adubação influenciou significativamente, segundo um comportamento linear positivo, os rendimentos de colmos, açúcar e álcool, enquanto que nas parcelas não irrigadas esse efeito só foi evidenciado no rendimento dos colmos. A máxima dose de adubação de cobertura utilizada no presente trabalho não foi suficiente para se atingir picos máximos de rendimentos, seja no regime irrigado ou não.

This research had the objective of evaluating the effect of different manuring levels of N and K2O on the growth and yield of the sugar-cane (Saccharum spp, cultivate SP79 1011) first leaf, cultivated with and without irrigation. The experiment was conducted in the farm of the Miriri distillery, in the municipality of Capim, Paraíba state. The experimental scheme had a factorial type 2 x 4 (with and without irrigation and four levels of manuring of N and K2O) with three replications. The water irrigation depth used, 27.5 mm, was applied in intervals of 12 days. The manurings were composed of the elements N and K2O, in levels based on recommendations of the consultants of the Miriri distillery, equal to AC1 = 44 kg ha-1 of nitrogen and 41 kg ha-1 of potassium, AC2 = 86 kg ha-1 of nitrogen and 81 kg ha-1 of potassium, AC3 =157 kg ha-1 of nitrogen and 148 kg ha-1 of potassium, and AC4 =236 kg ha-1 of nitrogen and 222 kg ha-1 of potassium. When submitted to irrigation, the crop presented better yield in all appraised variables. In the irrigated parcels, the manuring affected significantly, through a positive linear behavior, the production of stems, sugar and alcohol, while in the non-irrigated parcels this effect was shown only for the production of stems. The maximum level of manurring in this work was not enough to get the maximum yield colm peak, using irrigation management or not.