Pesquisa | SciELO

Research to identify plant bioactive compounds led to the evolution of extraction methods. This study optimized ultrasound-assisted extraction (UAE) and microwave-assisted extraction (MAE) to extract the flavonoids of Croton grewioides Baill. species contributing to characterize the polar extract profile and understand the antioxidant potential of these plant constituents. The use of experimental design and statistical treatments enabled the determination of the ideal conditions for each technique. The extracts of five accessions of C. grewioides were obtained under the optimized extraction conditions and were analyzed using ultra high-resolution mass spectrometry (FT-Orbitrap MS) operating at negative ionization mode for flavonoids detection. The accurate experimental mass obtained to the main compounds was used to attribute the molecular formula. Chemical structures of the main compounds detected were proposed using structure data bases. Chemometric analysis were performed with two FT-Orbitrap MS spectra samples using the identified metabolites and, the antioxidant activity data, showing that for this species the MAE was most effective in extracting the antioxidant compounds. It was possible to propose the structures for forty compounds in the C. grewioides extracts, demonstrating the excellent performance of the FT-Orbitrap MS in providing information on the chemical profile of polar compounds in plant extracts. methods ultrasoundassisted ultrasound assisted UAE (UAE microwaveassisted microwave (MAE Baill constituents technique C highresolution high resolution FTOrbitrap FT Orbitrap detection formula bases

https://doi.org/10.21577/0103-5053.20230004

Ecological importance of lepidopteran defoliators on eucalyptus plantations based in faunistic and natural enemy analyses
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Ghiotto, T. C.

; Barbosa, M. C.

; Guerreiro, J. C.

; Prado, E. P.

; Masson, M. V.

; Tavares, W. S.

; Wilcken, C. F.

; Zanuncio, J. C.

; Ferreira-Filho, P. J.

Brazilian Journal of Biology

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2023, Volume 83 elocation e268747

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Areas planted with Eucalyptus urophylla S.T. Blake variety platyphylla F. Muell. (Myrtaceae) expand annually in most regions of Brazil. Many lepidopteran species defoliate this plant, but with damage varying per species. The objective of this study was to identify the pest status of lepidopteran defoliators based in the faunistic analysis of these insects and of their natural enemies on E. urophylla variety platyphylla plantations in a representative producing region of Brazil. Adult moths of lepidopterans and of their natural enemies were captured using a light trap, installed every two weeks, from September 2016 to August 2018. A total of 183, 10, three and 139 lepidopteran species was captured and classified as primary, secondary, without defined importance to eucalypt plants and non-identified with 1,419, seven, 465 and 876 individuals, respectively. Two primary pest species were constants, two accessories and six accidentals and all secondary ones were accidentals. Six primary pest species were common and dominant and four non-dominants. Faunistic indices indicated the main lepidopteran species that should be monitored in pest management programs. Seven hymenopteran species (65 individuals), three dipterans (49 individuals) and two hemipterans (four individuals) were the natural enemies collected using light traps. The monitoring of lepidopteran pests with light traps can contribute to the management and to reduce damage and control costs for these species, besides identifying natural enemies for biological control programs in Eucalyptus plantations.

Resumo Áreas plantadas com Eucalyptus urophylla S.T. Blake variedade platyphylla F. Muell. (Myrtaceae) se expandem anualmente na maioria das regiões do Brasil. Muitas espécies de lepidópteros desfolham esta planta, mas com danos que variam de acordo com a espécie. O objetivo deste estudo foi identificar o status de praga de lepidópteros desfolhadores com base na análise faunística desses insetos e de seus inimigos naturais em plantios de E. urophylla variedade platyphylla em uma região produtora representativa do Brasil. As mariposas e seus inimigos naturais foram capturadas com armadilha luminosa, instalada quinzenalmente, de setembro de 2016 a agosto de 2018. Um total de 183, 10, três e 139 espécies de lepidópteros foram capturadas e classificadas como primária, secundária, sem importância definida para eucaliptocultura e não identificadas com 1419, sete, 465 e 876 indivíduos, respectivamente. Duas espécies de pragas primárias foram constantes, duas acessórias e seis acidentais e todas as secundárias foram acidentais. Seis espécies de pragas primárias foram comuns e dominantes e quatro não dominantes. Os índices faunísticos indicaram as principais espécies de lepidópteras que devem ser monitoradas em programas de manejo de pragas. Sete espécies de himenópteros (65 indivíduos), três dípteros (49 indivíduos) e dois hemípteros (quatro indivíduos) foram os inimigos naturais coletados com armadilha luminosa. O monitoramento de lepidópteros-praga com armadilha luminosa pode contribuir para o manejo e redução de danos e custos de controle para essas espécies, além de identificar inimigos naturais para programas de controle biológico em cultivos de eucalipto.

https://doi.org/10.1590/1519-6984.268747

A Study on Different Attitude Strategies and Mission Parameters Based on Lightsail-2
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Meireles, L. G.

; Prado, A. F. B. A.

; Melo, C. F. de

; Pereira, M. C.

Revista mexicana de astronomía y astrofísica

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2022, Volume 58 Nº 1 Páginas 23 - 35

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN La misión LightSail-2 de la Planetary Society validó con éxito la capacidad de maniobra orbital de una nave impulsada por la presión de la radiación solar (PRS). Presentamos un estudio sobre dos estrategias distintas para la orientación de una vela solar. El objetivo es aumentar el efecto de la aceleración por la PRS a lo largo de la trayectoria orbital de la nave, con la intención de mantener o incrementar con el tiempo la altitud. Además, una de las estrategias se usó para determinar la posibilidad de mantener la altitud promedio de la nave al variar algunos parámetros de la misión. Los resultados muestran que es posible aumentar con el tiempo la altitud promedio de la nave, mientras que se reduce el número de maniobras necesarias para cambiar la orientación de la nave. Con este resultado se ve que también es posible modificar algunos parámetros de la misión sin afectar el desempeño de la vela solar.

ABSTRACT The Planetary Society’s LightSail-2 mission successfully validated the orbital maneuvering capability of a solar radiation pressure (SRP) propelled spacecraft. This paper presents a study on two alternative attitude strategies for the orientation of a solar sail. The goal is to increase the effect of the SRP acceleration over the spacecraft’s orbital trajectory, with the intention of maintaining or even gaining altitude over time. Furthermore, one of these strategies was employed while varying a few of the mission’s parameters to determine if it would be viable to maintain the spacecraft’s average altitude. Results show that it is possible to increase the average altitude of the spacecraft over time while still reducing the number of maneuvers necessary to change the spacecraft’s attitude. With that result in hand, it is also possible to change some of the mission parameters without compromising the solar sailing performance.

https://doi.org/10.22201/ia.01851101p.2022.58.01.02

Cytotoxic effect of Vernonanthura polyanthes leaves aqueous extracts
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Almeida, L. M.

; Prado, A. D. L.

; Xavier-Silva, K. R.

; Firmino, M. T.

; Paula, M. I. M.

; Gomes, P. N.

; Paula, J. A. M.

; Bailão, E. F. L. C.

Brazilian Journal of Biology

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Set 2021, Volume 81 Nº 3 Páginas 575 - 583

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Vernonanthura polyanthes, popularmente conhecida como assa-peixe, é uma planta medicinal amplamente utilizada pela população brasileira do Cerrado para o tratamento doenças, sem uma avaliação detalhada de sua eficácia, toxicidade e dosagem adequada. Dessa forma, são necessários estudos para investigar a segurança do uso do extrato aquoso de V. polyanthes. O objetivo deste estudo foi avaliar a toxicidade, citotoxicidade e genotoxicidade do extrato aquoso de folhas de V. polyanthes utilizando os ensaios de Artemia salina e Allium cepa. Para o ensaio de A. salina, três grupos de 10 larvas foram expostos ao extrato aquoso de folhas de V. polyanthes nas concentrações de 5, 10, 20, 40 e 80 mg/ml. Para o ensaio de A. cepa, 5 bulbos de cebola foram expostas ao extrato aquoso de folhas de V. polyanthes nas concentrações de 10, 20 e 40 mg/ml, e então submetidos a análise macroscópica e microscópica. O ensaio de A. salina sugere que a concentração de 24 mg/ml do extrato de V. polyanthes é capaz de matar 50% dos náuplios; enquanto o ensaio de A. cepa sugere que o extrato aquoso das folhas de V. polyanthes é tóxico em concentrações superiores a 20 mg/ml. O efeito citotóxico nas células da raiz de A. cepa foi observado apenas na concentração de 40 mg/ml. É importante dizer que a concentração de extrato aquoso de folhas de V. polyanthes comumente usada na medicina popular é de 20 mg/ml. Assim, a concentração popular utilizada está muito próxima do limite de toxicidade no modelo de A. salina (24 mg/ml) e é a mesma concentração que apresentou efeito tóxico nas células da raiz de A. cepa (20 mg/ml). Não foi observada atividade genotóxica do extrato aquoso de folhas de V. polyantes nas condições utilizadas neste trabalho. Por causa da ação antiproliferativa e ausência de atividade genotóxica, o extrato aquoso de folhas de V. polyanthes pode ser uma boa fonte natural de compostos antitumorais e pode apresentar potencial para uso na medicina. No entanto, estudos mais detalhados precisam ser realizados para confirmar esse potencial.

Abstract Vernonanthura polyanthes, popularly known as assa-peixe, is a medicinal plant that has been widely used by Brazilian Cerrado population for treatment of diseases without a detailed evaluation of their effectiveness, toxicity, and proper dosage. Thus, more studies investigating the safety of V. polyanthes aqueous extract before the use are needed. The purpose of this study was to evaluate the toxicity, cytotoxicity and genotoxicity of V. polyanthes leaves aqueous extract using the Artemia salina and Allium cepa assays. For the A. salina assay, three groups of 10 larvae were exposed to V. polyanthes leaves aqueous extract at the concentrations of 5, 10, 20, 40, and 80 mg/ml. For the A. cepa assay, 5 onion bulbs were exposed to V. polyanthes leaves aqueous extract at 10, 20, and 40 mg/ml, and then submitted to macroscopic and microscopic analysis. As result it was identified a toxicity and cytotoxicity of V. polyanthes dependent on the extract concentration. The A. salina assay suggests that the concentration of 24 mg/ml of the V. polyanthes extract is able to kill 50% of naupllis; while the A. cepa assay suggests that V. polyanthes leaves aqueous extract is toxic at concentrations higher than 20 mg/ml; however the cytotoxic effect in A. cepa root cells was observed at 40 mg/ml of the extract. It is important to say that the V. polyanthes leaves aqueous extract concentration commonly used in popular medicine is 20 mg/ml. Thus, the popular concentration used is very close to toxicity limit in A. salina model (24 mg/ml) and is the concentration which showed toxic effect in A. cepa root cells (20 mg/ml). No genotoxic activity of V. polyantes leaves aqueous extract was observed in the conditions used in this study. Because of the antiproliferative action and no genotoxic activity, V. polyanthes leaves aqueous extract may present compounds with potential use for human medicine. However more detailed studies need to be performed to confirm this potential.

https://doi.org/10.1590/1519-6984.225281 560 downloads

Evaluation of the Seasonality and Extraction Method on the Polar Extracts of Croton grewioides Baill. by Chromatogram Fingerprinting and Isolation of a New Triglycosylated Flavonoid
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Prado, Vilma M. J.

; Jesus, Raphael A. de

; Oliveira, Julio M. A.

; Pereira, Camila S. A.

; Blank, Arie F.

; Pereira-Filho, Edenir R.

; Cass, Quezia B.

; Lima, Juliana M. de

; Ferreira, Antonio G.

; Nogueira, Paulo C. L.

; Moraes, Valéria R. S.

Journal of the Brazilian Chemical Society

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Fev 2021, Volume 32 Nº 2 Páginas 385 - 394

Resumo: En | Texto: En | PDF: En

Croton grewioides Baill. popularly known as “canelinha” or “canelinha-de-cheiro” has been used for the treatment of influenza, antitussive, febrifuge and headache; however, the study of its phytochemical composition is limited. The aim of this study was to investigate the effect of the extraction method and seasonality through leaf extracts of four accessions of Croton grewioides by fingerprint chromatograms aided by principal component analysis to analyze the differences and similarities among the samples. We aimed also to provide chemical characterization of isolated secondary metabolites using semi-preparative liquid chromatography. The results showed that only the chemical profile of the methanolic extracts of accessions 101 and 113 were influenced by the seasonality. For the first time, four flavonoids were isolated through semi-preparative chromatography in this species, characterized as quercetin 3-O-β-D-galactopyranosyl-(1→2)-α-L-rhamnopyranoside-(1→6)-α-L-rhamnopyranoside (1), quercetin 3-O-β-D-galactopyranosyl-(1→2)-α-apiopyranoside-(1→6)-α-L-rhamnopyranoside (2), quercetin 3-O-glucopyranoside (3) and 3-O-methyl-quercetin (4), the flavonoid (2) has been recognized as a new triglycosylated derivative.

https://doi.org/10.21577/0103-5053.20200190 249 downloads

Presence of Complete or Incomplete Septa in Human Jugular Foramens
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Oliveira-Neto, O. B

; Haddad, J

; Prado, F. B

; Rossi, A. C

; Monte-Bispo, R. F

; Sousa-Rodrigues, C. F

; Olave, E

; Freire, A. R

International Journal of Morphology

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Fev 2021, Volume 39 Nº 1 Páginas 45 - 49

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

SUMMARY: The objective of this study was to determine the occurrence of anatomical variants in the exocranial surface of the jugular foramen, specifically, the presence of single or double and complete or incomplete septation. A cross-sectional anatomical study was performed using 96 Brazilian dry human skulls (53 male and 43 female). One examiner determined the number (single or double) and type (i.e. complete or incomplete) of osseous septation at the outer surface of jugular foramens. Data went through statistical analysis on GraphPad Prism 6.01. Our results shown that Male individuals where more likely to present normal jugular foramens (male = 71.69%, female = 34.88%; p = 0.003). However, one incomplete septation occurred more often on the right side of female individuals (1 incomplete septation, male = 16.98%; 1 incomplete septation, female = 34.88%; p = 0.044). Similarly, one complete septation (i.e. the presence of two fully divided jugular compartments) also occurred more often on the right side of female individuals (1 complete septation, male = 9.43%; 1 complete septation, female = 25.58%; p = 0.038). Anatomical variants of the jugular foramen regarding single or double complete or incomplete septations were more likely to be found on the right side of female individuals, whose also presented a higher rate of jugular foramens with any type of septation than regular non-altered jugular foramens.

RESUMEN: El objetivo de la presente investigación fue determinar la presencia de variaciones anatómicas en la superficie exocraneal del foramen yugular, especificamente, la presencia de septos únicos o dobles, completos o incompletos. El estudio fue realizado en 96 cráneos secos (53 masculinos y 43 femeninos) de indivíduos Brasileños. Se determinaron septos óseos completos o incompletos y número de ellos. Los resultados obtenidos fueron tratados estadísticamente con el programa GraphPad Prism 6.01. Los sujetos de sexo masculino fueron más propensos a presentar forámenes yugulares normales (sexo masculino: 71,69%; sexo femenino: 34,88%, p= 0,003). Sin embargo, se observaron septos incompletos con mayor frecuencia en el lado derecho y en el sexo femenino (sexo masculino: 16,98%; sexo femenino: 34,88%, p=0,044). Adicionalmente, una septación completa (presencia de dos compartimientos yugulares, divididos completamente), se presentaron más frecuentemente en el lado derecho de indivíduos femeninos (sexo masculino: 9,43%; sexo femenino: 25,58%, p= 0,038). Las variantes anatómicas del foramen yugular, en relación a septos simples o dobles, completos o incompletos, se encontraron con mayor frecuencia en el lado derecho de las mujeres, las que presentaron un alto rango de forámenes yugulares con algún tipo de septos respecto a los forámenes yugulares regulares no alterados.

390 downloads

La importancia de la laparoscopia como herramienta diagnóstica en la patología tumoral. A propósito de un caso
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González-Prado, Cristina

; Reoyo-Pascual, José F.

; Zanfaño-Palacios, Jesús

; Santos-González, Jorge F.

; Cabriada-García, Guillermo

; López-Rodríguez, Beatriz

; Muñoz-Plaza, Nerea

; Otero-Rondón, Michelle C.

Gaceta mexicana de oncología

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2021, Volume 20 Supl. 1 Páginas 106 - 108

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Oncology is a diverse field where anatomopathology has an important role. Many diagnostic tests can develop into adverse effects or increase hospital costs. It is important to remind how helpful laparoscopy is in those patients where there is no definitive diagnosis. Laparoscopy surgery is not only a therapeutic tool, but also a diagnostic one. In those cases where medicine has nothing more to say, minimal invasive surgery helps us to get histologic samples as biopsy or cytology to get the best treatment to our patient.

Resumen La patología tumoral es un campo muy extenso donde la anatomía patológica puede marcar el devenir del tratamiento. Las pruebas diagnósticas reiterativas para obtener dicho resultado pueden conllevar gastos humanos y hospitalarios innecesarios. Es en este marco donde encuadramos una herramienta principalmente terapéutica: la laparoscopia. La laparoscopia desempaña un papel olvidado, pero a la vez muy importante a la hora de diagnosticar. En aquellos pacientes donde la medicina no nos proporciona un diagnóstico definitivo, la cirugía mínimamente invasiva nos ayuda a obtener las muestras necesarias, como son las biopsias o las citologías, para proporcionar finalmente un tratamiento definitivo al paciente.

https://doi.org/10.24875/j.gamo.20000201 6 downloads

On the effects of solar radiation pressure on the deviation of asteroids
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Marchi, L. O.

; Sanchez, D. M.

; Venditti, F. C. F.

; Prado, A. F. B A.

; Misra, A. K.

Revista mexicana de astronomía y astrofísica

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2021, Volume 57 Nº 2 Páginas 279 - 295

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT In this work, we study the effects of solar radiation pressure (SRP) on the problem of changing the orbit of an asteroid to support planetary defense, scientific research, or exploitation of materials. This alternative considers a tethered reflective balloon (or a set of reflective balloons) attached to the asteroid, with a high area-tomass ratio, to use the SRP to deflect a potentially hazardous asteroid (PHA) or to approximate the target asteroid to Earth. The tether is assumed to be inextensible and massless, and the motion is described only in the orbital plane of the asteroid around the Sun. The model is then used to study the effects that the tether length, the reflectivity coefficient, and the area-to-mass ratio have on the deviation of the trajectory of the asteroid.

RESUMEN Estudiamos los efectos de la presión de la radiación solar (SRP) sobre el problema de la modificación de la órbita de un asteroide para propósitos de defensa planetaria, investigación científica o explotación de materiales. Consideramos un globo reflector (o un conjunto de ellos) sujeto con una correa al asteroide, con una relación área-masa grande, para utilizar la SRP para desviar a un asteroide potencialmente dañino (PHA), o para aproximar al asteroide a la Tierra. Suponemos que la correa es inextensible y de masa cero. El movimiento se describe sólo en el plano orbital del asteroide en torno al Sol. El modelo se usa para estudiar los efectos de la longitud de la correa, el coeficiente de reflectividad y el cociente área-masa sobre la desviación de la trayectoria del asteroide.

https://doi.org/10.22201/ia.01851101p.2021.57.02.03 121 downloads

A survey on extensions of the pure gravity swing-by maneuver
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Ferreira, A. F. S.

; Moraes, R. V. de

; Prado, A. F. B. A.

; Winter, O. C.

; Gomes, V. M.

Revista mexicana de astronomía y astrofísica

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2021, Volume 57 Nº 2 Páginas 445 - 457

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT The present paper surveys the more recent techniques related to the swing-by maneuver, where a spacecraft changes its energy and angular momentum by passing close to celestial bodies. It is focused on the literature related to extensions of this maneuver, with emphasis in the powered version, where an impulse is applied to the spacecraft near the closest approach. Several mathematical models are considered, including the patched-conics approximation for analytical studies, and the restricted three-body problem for the numerical simulations. The main goal is to show the models and the main conclusions available in the literature for those maneuvers. Some key results are shown to discuss important aspects of this maneuver, including the analysis of the energy variation of the spacecraft, the behavior of the trajectories and other applications.

RESUMEN Presentamos una resenã de los resultados recientes sobre la maniobra de columpio, en la cual una nave espacial cambia su energía y momento angular al pasar cerca de un cuerpo celeste. Nos concentramos en la literatura sobre las extensiones de esta maniobra, con énfasis en la versión con potencia aplicada, en la cual se le impone a la nave un impulso durante el máximo acercamiento. Se consideran varios modelos matemáticos, incluyendo la aproximación de la cónica parcial para estudios analíticos y el problema restringido de los tres cuerpos para las simulaciones numéricas. Nuestro objetivo principal es mostrar los modelos y las conclusiones disponibles en la literatura para estas maniobras. Con los principales resultados discutimos aspectos interesantes de la maniobra, incluyendo el análisis de la variación de la energía de la nave y el comportamiento de las trayectorias.

https://doi.org/10.22201/ia.01851101p.2021.57.02.16 114 downloads

10.

Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
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Fink, Thais T.

; Marques, Heloisa H.S.

; Gualano, Bruno

; Lindoso, Livia

; Bain, Vera

; Astley, Camilla

; Martins, Fernanda

; Matheus, Denise

; Matsuo, Olivia M.

; Suguita, Priscila

; Trindade, Vitor

; Paula, Camila S.Y.

; Farhat, Sylvia C.L.

; Palmeira, Patricia

; Leal, Gabriela N.

; Suzuki, Lisa

; Odone Filho, Vicente

; Carneiro-Sampaio, Magda

; Duarte, Alberto José S.

; Antonangelo, Leila

; Batisttella, Linamara R.

; Polanczyk, Guilherme V.

; Pereira, Rosa Maria R.

; Carvalho, Carlos Roberto R.

; Buchpiguel, Carlos A.

; Latronico, Ana Claudia

; Seelaender, Marilia

; Silva, Clovis Artur

; Pereira, Maria Fernanda B.

; Sallum, Adriana M. E.

; Brentani, Alexandra V. M.

; Neto, Álvaro José S.

; Ihara, Amanda

; Santos, Andrea R.

; Canton, Ana Pinheiro M.

; Watanabe, Andreia

; Santos, Angélica C. dos

; Pastorino, Antonio C.

; Franco, Bernadette D. G. M.

; Caruzo, Bruna

; Ceneviva, Carina

; Martins, Carolina C. M. F.

; Prado, Danilo

; Abellan, Deipara M.

; Benatti, Fabiana B.

; Smaria, Fabiana

; Gonçalves, Fernanda T.

; Penteado, Fernando D.

; Castro, Gabriela S. F. de

; Gonçalves, Guilherme S.

; Roschel, Hamilton

; Disi, Ilana R.

; Marques, Isabela G.

; Castro, Inar A.

; Buscatti, Izabel M.

; Faiad, Jaline Z.

; Fiamoncini, Jarlei

; Rodrigues, Joaquim C.

; Carneiro, Jorge D. A.

; Paz, Jose A.

; Ferreira, Juliana C.

; Ferreira, Juliana C. O.

; Silva, Katia R.

; Bastos, Karina L. M.

; Kozu, Katia

; Cristofani, Lilian M.

; Souza, Lucas V. B.

; Campos, Lucia M. A.

; Silva Filho, Luiz Vicente R. F.

; Sapienza, Marcelo T.

; Lima, Marcos S.

; Garanito, Marlene P.

; Santos, Márcia F. A.

; Dorna, Mayra B.

; Aikawa, Nadia E.

; Litvinov, Nadia

; Sakita, Neusa K.

; Gaiolla, Paula V. V.

; Pasqualucci, Paula

; Toma, Ricardo K.

; Correa-Silva, Simone

; Sieczkowska, Sofia M.

; Imamura, Marta

; Forsait, Silvana

; Santos, Vera A.

; Zheng, Yingying

Clinics

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2021, Volume 76 elocation e3511

Resumo: En | Texto: En | PDF: En

OBJECTIVES: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19) METHODS: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed. RESULTS: The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p=0.030), lymphopenia (42% versus 18%, p=0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p=0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p=0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p=0.178) and cardiac alterations on echocardiogram (33% versus 22%, p=0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age (p=0.962), proportion of male sex (p=0.907), ethnicity (p=0.566), family minimum monthly wage (p=0.664), body mass index (p=0.601), and pediatric pre-existing chronic conditions (p=1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 [0-100] versus 81 [34-100], p=0.012), and school score (60 [15-100] versus 70 [15-95], p=0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls. CONCLUSIONS: Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19.

https://doi.org/10.6061/clinics/2021/e3511

11.

Search for Stable Orbits around the Binary Asteroid Systems 1999 KW4 and Didymos
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Oliveira, Thais C.

; Prado, Antonio F. B. A.

Revista mexicana de astronomía y astrofísica

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2020, Volume 56 Nº 1 Páginas 113 - 128

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT This work includes analytical and numerical studies of spacecrafts orbiting two binary asteroid systems: 1999 KW4 and Didymos. The binary systems aremodeled as full irregular bodies, such that the whole evolution of the results will show the impact of the irregular gravity field in the lifetime and dynamics of the spacecraft's orbit. The equations of motion of the binary system and the spacecraft are derived from Lagrange Equations. The solar radiation pressure is consired in the dynamics of the spacecraft. Two distinct methods are used to search for stable orbits around the binary systems. One is called the grid search method, which defines the main body as a point mass to estimate the initial state of the spacecraft based on a circular Keplerian orbit. The second method is the search for periodic orbits based on zero-velocity surfaces.

RESUMEN Este trabajo presenta estudios analíticos y numéricos sobre naves espaciales en órbita en torno a dos asteroides binarios: 1999 KW4 y Didymos. Se modelan los sistemas binarios como cuerpos irregulares, de modo que la evolución muestre el impacto del campo de gravedad irregular sobre los tiempos de vida y la dinámica de la órbita de la nave. Se derivan las ecuaciones de movimiento del sistema binario y de la nave a partir de las ecuaciones de Lagrange. Se considera la presión de radiación solar. Se buscan órbitas estables en torno a los sistemas binarios mediante dos métodos. El primero se conoce como el método de búsqueda en la malla, y considera al cuerpo principal como punto masa para estimar el estado inicial de la nave a partir de una órbita Kepleriana circular. El segundo busca órbitas periódicas mediante las superficies de cero velocidad.

https://doi.org/10.22201/ia.01851101p.2020.56.01.12 107 downloads

12.

Effect of diets with avocado meal on lipids in muscle, antioxidants and gene expression in finished pigs
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Lemus-Avalos, G.

; Lemus-Flores, C.

; Bugarín-Prado, J.O.

; Grageola-Núñez, F.

; Ayala-Valdovinos, M.A.

; Duifhuis-Rivera, T.

; Moo-Huchin, V. M.

; Dzib-Cauich, D.

Revista bio ciencias

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2020, Volume 7 elocation e968

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract: The aim of this investigation was to assess the effect level of inclusion of avocado meal (AM) at 0, 5 and 10% in pigs diet for 56 days before their slaughter, on effects in regard to proximal chemical composition, presence of antioxidants, lipid modulation in the Longissimus dorsi and gene expression in the Longissimus dorsi muscle and liver tissues. Eight male pigs of 55 ± 3 kg of initial weight were used in each diet group to compare them under a completely random design, with variance analysis and Tukey test. The gene expression in each tissue was analyzed with a mixedeffects model, comparing the values of change or fold change (FC) of diets with AM against diet control. Levels of γ-tocopherol, total phenolic compounds, antioxidant activity ABTS and DPPH are increased linearly with the inclusion of AM in the diet, decreasing intramuscular fat. In AM5 against AM0, the high expression of lipogenic genes (ACACA, ACP and FASN) in the Longissimus dorsi muscle was associated with the increase of arachidonic fatty acids (20:4-n6) and eicosapentaenoic (20:3-n3). Fatty acid esterification (SCD) was associated with decreased stearic acid (18:0) and increased higher 18:1/18:0 ratio. With AM10 against AM0, the expression of ACACA, SCD, ACP, and FASN were low in both tissues, decreasingin the muscle Longissimus dorsi palmitic acid (16:0); increased: arachidonic (20:0) and linoleic (18:2 n6) acids, PUFA, PUFA/SFA and PUFA/MUFA.

Resumen: El objetivo de esta investigación fue valorar el nivel de inclusión de harina de aguacate (AM) al 0, 5 y 10 % en la alimentación de cerdos por 56 días antes del sacrificio, sobre efectos en composición química proximal, presencia de antioxidantes, modulación de los lípidos en el músculo Longissimus dorsi y expresión de genes en los tejidos Longissimus dorsi e hígado. Se emplearon en cada dieta ocho cerdos machos de 55 ± 3 kg de peso inicial, para compararlas bajo un diseño completamente al azar, con análisis de varianza y prueba de Tukey. La expresión de genes en cada tejido fue analizada con un modelo de efectos mixtos, comparando los valores de cambio o fold change (FC) de las dietas con AM contra la dieta control. Los niveles de γ-tocoferol, compuestos fenólicos totales, actividad antioxidante ABTS y DPPH se incrementan linealmente con inclusión de AM en la dieta, disminuyendo grasa intramuscular. En AM5 contra H0, la alta expresión de genes lipogénicos (ACACA, ACP y FASN) en el músculo Longissimus dorsi, se asoció al aumento de los ácidos grasos araquidónico (20:4-n6) y eicosapentaenoico (20:3-n3). La esterificación de ácidos grasos (SCD) se asoció a la disminución del ácido esteárico (18:0) y aumento de mayor relación 18:1/18:0. Con AM10 contra AM0, la expresión de ACACA, SCD, ACP y FASN fue baja en ambos tejidos, disminuyendo en el músculo Longissimus dorsi el ácido palmítico (16:0); aumentando: los ácidos araquídico (20:0) y linoleico (18:2 n6), PUFA, PUFA/SFA y PUFA/MUFA.

https://doi.org/10.15741/revbio.07.e968 290 downloads

13.

EVALUACIÓN DE LA ACTIVIDAD ANTIVIRULENCIA DE ACEITES ESENCIALES CONTRA Pseudomonas aeruginosa
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Blanco-Hernández, Araceli

; García-Contreras, Rodolfo

; Sánchez-Fernández, Rosa E.

; Palma-Tenango, Mariana

; Cibrián-Tovar, Juan

; Muñoz-Cazares, Naybi

; Soto-Hernández, R. Marcos

; Padilla-Chacon, Daniel

; Prado-Galbarro, F. Javier

; Castillo-Juárez, Israel

Revista fitotecnia mexicana

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Set 2019, Volume 42 Nº 3 Páginas 215 - 225

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Essential oils (EO) have been described as bactericidal agents; however, in vitro studies indicate that some of their volatile constituents at sublethal concentrations may inhibit or promote quorum sensing (QS) systems in Pseudomonas aeruginosa. It is necessary to explore the role that volatile mixtures can play on virulence and in the establishment of bacteria on in vivo systems. The study was carried out to evaluate the bactericidal and antivirulence properties of EO obtained from Thymus vulgaris L., Cymbopogon citratus (DC.) Stapf and Tagetes lucida (Cav) against P. aeruginosa. Anti- virulence activity was assessed by the inhibition of factors regulated by QS, such as pyocyanin production and protease and elastase activity; in addition, the composition of volatiles and their ability to prevent the establishment of the infection in model of lesion in mice were determined. In vitro tests showed that T. vulgaris EO (TVEO) only exhibited bactericidal activity, and T. lucida EO (TLEO) reduced pyocyanin production by 58 % at a sublethal concentration of 200 µg mL-1. In the case of the EO of C. citratus no bactericidal effect was registered at the maximum concentration evaluated (1000 μg mL-1), although it slightly reduced the pyocyanin production (30 %). In the in vivo studies only the TLEO and Neosporin® (positive control) interfered in the establishment of the bacteria, while the TVEO, contrary to the expected, favored the establishment of the bacterium, mainly in areas adjacent to the lesions. A positive correlation was observed between the establishment of the bacteria and the number of constituents present in the EO. These results support the use of the EO evaluated to combat P. aeruginosa and their possible application in anti-virulence therapies.

Resumen Los aceites esenciales (AE) se han descrito como agentes bactericidas; sin embargo, estudios in vitro indican que algunos de sus constituyentes volátiles a concentraciones subletales pueden inhibir o promover los sistemas de percepción de quórum (PQ) en Pseudomonas aeruginosa. Es necesario explorar el papel que pueden tener las mezclas de volátiles sobre la virulencia y el establecimiento de la bacteria en sistemas in vivo. Este estudio se llevó a cabo para evaluar las propiedades bactericidas y antivirulencia de AE obtenidos de Thymus vulgaris L., Cymbopogon citratus (DC.) Stapf y Tagetes lucida (Cav) contra P. aeruginosa. La actividad antivirulencia se evaluó mediante la inhibición de factores regulados por PQ, como son la producción de piocianina y la actividad de proteasa y elastasa; además, se determinó la composición de volátiles y su capacidad para evitar el establecimiento de la infección en un modelo de lesión en ratones. Los ensayos in vitro mostraron que el AE de T. vulgaris (AETV) únicamente exhibió actividad bactericida y el AE de T. lucida (AETL) redujo la producción de piocianina en 58 % a concentración subletal de 200 µg mL-1. Para el caso del AE de C. citratus no se registró un efecto bactericida a la máxima concentración evaluada (1000 µg mL-1), aunque redujo ligeramente la producción de piocianina (30 %). En los estudios in vivo únicamente el AETL y el Neosporin® (control positivo) interfirieron en el establecimiento de la bacteria, mientras que el AETV, contrario a lo esperado, lo favoreció, principalmente en zonas adyacentes a las lesiones. Se observó una correlación positiva entre el establecimiento de la bacteria y el número de constituyentes presentes en los AE. Estos resultados apoyan el uso de los AE evaluados para combatir P. aeruginosa y su posible aplicación en terapias antivirulencia.

408 downloads

14.

Silicon mitigates ammonium toxicity in yellow passionfruit seedlings
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Silva Júnior, Gabriel B. da

; Prado, Renato M.

; Campos, Cid. N.S.

; Agostinho, Flávia B.

; Silva, Sylvia L. O.

; Santos, Luiz C.N.

; González, Leónides C.

Chilean journal of agricultural research

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Set 2019, Volume 79 Nº 3 Páginas 425 - 434

Resumo: En | Texto: En | PDF: En

ABSTRACT Ammonium (NH4 +) toxicity in yellow passionfruit (Passiflora edulis Sims f. flavicarpa O. Deg.) may be mitigated by Si application. This study aimed to evaluate the interaction effect of Si and high level of NH4 + on yellow passionfruit seedlings nutrition, physiology, growth, and DM production. Pots were filled with pinus bark and nutrition solution was applied. Treatments were arranged in a completely randomized design, with five replicates, in a 2 × 2 factorial scheme: two ratios of NH4 + and nitrate, NO3 + (40/60%, without high level of NH4 +; and 75/25%, with high level of NH4 +) at N concentration of 13 mmol N L-1, in the absence and presence of Si (2.0 mmol L-1). Sixty days after seedling transplant it was evaluated: N, Si, K, Ca and Mg root and shoots accumulation, leaf green color index (GCI), electrolyte leakage index (ELI), intracellular CO2 concentration (Ci), transpiration rate (Tr), stomatal conductance (gs), net photosynthesis rate (Pn), stem diameter, leaf area, root length, N use efficiency (NUE) and root and shoot DM content. Plants cultivated with Si had 19.1% and 16.3% lower Tr and gs, respectively, regardless NH4 + concentration. Moreover, Ci and Pn were 13.2% and 16.4%, respectively, higher in plants that received Si. Plants cultivated under high NH4 + concentrations, with Si application had 17% bigger stem diameter and 15.4% bigger root length than plants without Si application. Si application in yellow passionfruit seedlings cultivated with high level of NH4 + increased accumulation and NUE, root length, root DM, and GCI. In addition, Si application reduced ELI, which resulted in higher stem diameter. These results prove that Si application mitigates NH4 + toxicity in yellow passionfruit seedlings

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15.

Application of LC-DAD Metabolic Fingerprinting in Combination with PCA for Evaluation of Seasonality and Extraction Method on the Chemical Composition of Accessions from Lippia alba (Mill) N. E. Brown and Biological Activities
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Jesus, Raphael A. de

; Prado, Vilma M. J.

; Pinto, Vanderson S.

; Silva, Valdenizia R.

; Santos, Luciano S.

; Nogueira, Paulo C. L.

; Navickiene, Sandro

; Pereira-Filho, Edenir R.

; Blank, Arie F.

; Bezerra, Daniel P.

; Soares, Milena B. P.

; Seidl, Claudia

; Cardoso, Carmen L.

; Moraes, Valéria R. S.

Journal of the Brazilian Chemical Society

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Mai 2019, Volume 30 Nº 5 Páginas 978 - 987

Resumo: En | Texto: En | PDF: En

The methodology developed in this study through the acquisition of fingerprint chromatograms by liquid chromatography-diode array detector (LC-DAD), aided by principal component analysis, made it possible to assess, in a rational way, the chemical differences between six accessions of Lippia alba and to verify the influence of the method of extraction, the seasonality and the individuality of each accession on chemical composition of its extracts. Among all extracts analyzed against cancer cell lines, eight of them showed to be more promising against a human leukemia cell line (HL-60), displaying cell growth inhibition percentage ranging between 40.0 and 52.0%. In the inhibitory activity assays against acetylcholinesterase enzyme, all extracts showed weak inhibitory effect, with highlight only for six of them, which displayed inhibition ranging between 27.0 and 32.0%.

https://doi.org/10.21577/0103-5053.20180244 666 downloads

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