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Ecotoxicological characterization of end-of-life organic substrate
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Serrão, Joana

; Bouguerra, Sirine

; Nogueira, Verónica

; Sanchez-Hernandez, Juan C.

; Carvalho, Susana M.P.

; Pereira, Ruth

Revista de Ciências Agrárias

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Dez 2022, Volume 45 Nº 4 Páginas 581 - 590

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Nos últimos anos a utilização de substratos para a produção de frutos e hortícolas em estufa tem vindo a aumentar. Estes materiais apresentam várias vantagens, nomeadamente um uso mais eficiente da água e dos nutrientes e a redução da aplicação de produtos fitofarmacêuticos. No entanto, o destino destes substratos no fim da sua vida útil é um assunto controverso que necessita de aprofundamento científico. Devido ao alto teor de matéria orgânica, a incorporação de substratos orgânicos (OS) em solos agrícolas poderá representar uma mais-valia. Porém, a segurança ambiental desta prática necessita de ser avaliada devido ao risco de acumulação de contaminantes e moléculas bioativas durante os ciclos de produção. Assim, este trabalho teve como objetivo efetuar uma avaliação ecotoxicológica de um OS em fim de vida, proveniente da cultura de tomate, através da realização de ensaios padronizados. Três percentagens deste resíduo foram incorporadas num solo agrícola natural (2.5, 5 e 10%), tendo sido testados os efeitos na germinação de sementes, crescimento de plantas, reprodução de oligoquetas e atividade enzimática dos solos. Os resultados preliminares não revelaram impactos negativos preocupantes para as concentrações testadas. De futuro, são necessários estudos mais abrangentes, nomeadamente para avaliar os possíveis efeitos ecotoxicológicos em matrizes aquáticas.

Abstract In recent years the use of substrates in horticultural protected crops has been increasing. Their use presents several advantages including a more efficient use of water and nutrients and a reduction in the use of phytopharmaceutical products. However, at the end-of-life of these materials, their disposal is still a matter of continuous research and controversial discussion. Due to the high organic matter content of organic substrates (OS), the incorporation of these residues in agricultural fields could be advantageous. However, this practice requires a prior assessment of its environmental safety because of the risk of contamination and accumulation of bioactive molecules during cultivation cycles. The aim of this work was to make an ecotoxicological evaluation of one OS from soilless tomato production using standard protocols. A natural agricultural soil was amended with three increasing percentages of end-of-life OS (2.5, 5 and 10%). Effects of amended soils on seedling emergence and plant growth, earthworm reproduction rate and selected soil enzymatic activity were assessed. The preliminary results did not reveal major detrimental effects derived from the amendment of soil using end-of-life coconut substrate, at least for the percentages tested. In the future, more studies are necessary to evaluate possible impacts in freshwater resources.

https://doi.org/10.19084/rca.28548

Micobiota asociada con yerba mate comercializada en Paraguay
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Mendoza, Laura

; Peralta, Inocencia

; Ulke, Gabriela

; Gonzalez, Laura

; Avalos, Claudia

; Ferreira, Francisco

; Piris, Laura

; Grabowski, Cristhian

; Benitez, Alicia

; Pizarro, Fernando

; Sanchez, Susana

; Cazal, Cinthia

; Moura Mendes, Juliana

; Kohli, Man Mohan

; Fernández Rios, Danilo

; Arrua, Andrea Alejandra

Reportes científicos de la FACEN

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Dez 2022, Volume 13 Nº 2 Páginas 175 - 182

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen: La yerba mate (Ilex paraguariensis) es una hierba ampliamente consumida que se originó en Paraguay, pero que crece en la región entre el sur de Brasil, el norte de Argentina, Paraguay y Uruguay. Se informa que la planta posee múltiples propiedades medicinales que hacen que la yerba mate sea popular para el consumo en esta región. Actualmente también se considera un producto nutracéutico y un alimento funcional que es consumido en diferentes países del mundo. En medicina popular, se ha reportado científicamente que posee múltiples propiedades. Treinta y nueve marcas de muestras de yerba mate se analizaron mediante placas de dilución en serie y se incubaron a 25°C durante 5 días se determinó la incidencia fúngica. De las 39 muestras analizadas, el 15,4% estuvieron libres de la presencia de hongos y levaduras. El 84,6% restante presentó contaminación con incidencias variables de Aspergillus. Se observó la presencia de Aspergillus secciones nigri, flavi, circumdati, fumigati, wentii, usti, versicolor y Emericella nidulans, siendo la prevalente Aspergillus sección nigri, representando el 65,3%. Teniendo en cuenta los riesgos a la salud asociados con estos hongos, es importante considerar la formulación de regulaciones con respecto al tamaño de las partículas y la presencia de ocratoxinas y aflatoxinas en los productos comerciales de yerba mate.

Abstract: Yerba mate (Ilex paraguariensis) is a widely consumed herb which originated in Paraguay but grows widely in the region between Southern Brazil, Northern Argentina, Paraguay, and Uruguay. The plant is reported to possess multiple medicinal properties which makes yerba mate popular for consumption as tea in this region. It is also being considered as a nutraceutical product and a functional food consumed in different countries around the world. In popular medicine, and it has been scientifically reported to possess multiple properties. Thirty-nine brands of yerba mate samples were analyzed by serial dilution plates. and incubated at 25 ° C for 5 days. Based on their morphological characteristics, the fungal incidence and the number of colonies forming units were determined. Of the 39 samples analyzed, 15.4% were free from the presence of fungi and yeasts. The remaining 84.6% of the samples were contaminated with variable contents of the fungi Aspergillus. The presence of Aspergillus sections nigri, flavi, circumdati, fumigati, wentii, usti, versicolor and Emericella nidulans was observed the most prevalent among them was Aspergillus section nigri, representing 65.3%. Considering the health risks associated with these fungi, it is important to consider formulating regulations regarding the particle size and the presence of ochratoxins and aflatoxins in commercial yerba mate products.

https://doi.org/10.18004/rcfacen.2022.13.2.175

Recomendaciones de manejo de los anticoagulantes orales directos (DOACs) anti Xa y anti IIa
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Ceresetto, José M.

; Tajer, Carlos

; Duboscq, Cristina

; Bottaro, Federico

; Casais, Patricia

; Korin, Jorge

; Fondevila, Carlos

; Giumelli, Carla

; Scazziota, Alejandra

; Rossi, Andrea

; Botto, Fernando

; Ariscancela, Maria Ester

; Martinuzzo, Marta

; Zaidel, Ezequiel

; Fitz Maurice, Mario

; Bahit, Cecilia

; Vazquez, Fernando

; Molnar, Soledad

; Saizberg, Simón

; Negri Aranguren, Pedro

; Rosa, Claudio

; Fedele, José Luis

; Comignani, Pablo

; Pombo, Gonzalo

; Raña, Pablo

; Adamczuk, Yolanda

; Martí, Alejandra

; Charask, Adrián

; Penchasky, Diana

; Riveros, Dardo

; Mariani, Javier

; Puente, Dolores

; Celebrin, Lucia

; Bosio, Martín

; Brodsky, Andrés

; Sanchez Lucero, Analía

; Castillo Costa, Yanina

; Hirschson, Alfredo

; Arbesú, Guillermo

; Viñuales, Susana

; Kazelian, Lucía

; Maneyro, Alberto

; Gutierrez, Victoria

; Castro Rios, Miguel

; Gagliardi, Juan

; Lescano, Adrián

; Repetto, Fernanda

Medicina (Buenos Aires)

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Abr 2022, Volume 82 Supl. 2 Páginas 1 - 55

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Direct oral anticoagulants have emerged as the drugs that have changed the man agement of the antithrombotic treatment in the last 15 years. Their advantages, like a more friendly way of anticoagulation and their lower risk of bleeding, especially in the brain, have positioned these new anticoagu lants as the first drug of choice in the two most frequent indications of anticoagulation, atrial fibrillation, and the venous thromboembolic disease. However, not all the patients can receive these agents, not all the direct oral anticoagulants have the same characteristics, and most importantly, not all the diseases with an indication of an anticoagulant drug can be treated with them. Therefore, it is mandatory that all the faculties involved in the management of these drugs must know them in depth, to decide the best treatment for the patient. This position paper, from a group of experts in anticoagulation in Argentina, can help the general practitioner in the daily use of direct oral anticoagulants based on the new evidence and the experience of a wide group of professionals. The way we relate to the anticoagulant treatment has changed in the last years. The doctors who work with them must also do so.

Resumen Los anticoagulantes orales directos han surgido como una de las herramientas que ha cambiado el manejo de la enfermedad trombótica en los últimos 15 años. Sus ventajas, desde el punto de vista de la facilidad de uso y menor riesgo de sangrado, especialmente de sangrado cerebral, han posicionado a estos nuevos anticoagulantes como la primera alternativa de tratamiento en las dos indicaciones más frecuentes en que necesitamos estas drogas, la fibrilación auricular y la enfermedad tromboembólica venosa. Sin embargo, no todos los pacientes pueden recibir estos agentes, no todos los anticoagulantes directos tienen las mismas pro piedades y fundamentalmente, no todas las enfermedades con indicación de un anticoagulante pueden tratarse con ellos;con lo cual es necesario que todos los profesionales que están involucrados en el manejo de estos medicamentos estén obligados a conocerlos en profundidad, para poder decidir el mejor tratamiento en cada caso particular. Este documento de posición de expertos de diferentes especialidades de Argentina, presenta lineamientos para el uso correcto de los anticoagulantes directos en base a nueva evidencia y a la experiencia de uso de un amplio grupo de profesionales. La forma de relacionarnos con el tratamiento anticoagulante ha cambiado. Los médicos que trabajamos con ellos también debemos hacerlo.

810 downloads

Ensayo in vitro de extractos de Lippia graveolens y Lippia alba contra Aeromonas spp aisladas de tilapia (Oreochromis niloticus)
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García-Pérez, Josué

; Pérez-Sabino, Juan Francisco

; Moreira Sanchez, Yessenia Katerine

; Mendoza-Elvira, Susana

; Ribeiro da Silva, Antonio

; Ulloa-Rojas, Juan B.

CES Medicina Veterinaria y Zootecnia

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Abr 2022, Volume 17 Nº 1 Páginas 28 - 46

Resumo: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract This study evaluated the antimicrobial activity of Lippia graveolens and Lippia alba extracts and essential oils against nine strains of Aeromonas spp., isolated from Oreochromis niloticus. The crude extracts were obtained by percolation technique and CO2 supercritical fluid extraction, while the essential oils by applying hydro-distillation technique using a Clevenger apparatus. The antimicrobial activity for each extract and essential oils was verified through the disc diffusion method at 24 hours. The essential oil of L. graveolens showed higher effectiveness to inhibit fish bacterial pathogens (100%) than the extracts, revealing an inhibition zone diameter that ranged from 25.20 - 36.94 mm. The extracts from supercritical fluid and from the percolation technique with ethyl acetate and cyclohexane presented the same effectiveness (77.78%). The crude extract obtained with ethanol 95% showed limited antimicrobial effect (22.22%), presenting the smallest inhibition zone (ranged from 8.34 to 9.57 mm). On the other hand, L. alba displayed a lower antibacterial activity, being the essential oil 66.67% effective, presenting an inhibition zone ranging between 10.68 to 16.29 mm. The result of this study indicates that essential oils from both L. graveolens and L. alba offer a promising alternative for the control of Aeromonas spp. growth.

Resumen El presente estudio evaluó la actividad antimicrobiana de extractos y aceites esenciales de Lippia graveolens y Lippia alba, frente a nueve cepas de Aeromonas spp., aisladas de Oreochromis niloticus. Los extractos crudos se obtuvieron por la técnica de percolación y a través de la extracción de CO2 supercrítico, mientras que los aceites esenciales se realizaron mediante la técnica de hidrodestilación empleando un equipo Clevenger. La actividad antimicrobiana para cada extracto y aceite esencial se verificó mediante el método de difusión en disco a las 24 horas. El aceite esencial de L. graveolens mostró mayor efectividad para inhibir patógenos bacterianos de peces (100%), en comparación con los extractos. Se obtuvo un diámetro de inhibición que osciló entre 25,20 a 36,94 mm. Los extractos de fluido supercrítico y de la técnica de percolación con acetato de etilo y ciclohexano presentaron la misma efectividad (77,78%). El extracto crudo obtenido con etanol al 95% mostró efecto antimicrobiano limitado (22,22%), presentando el menor halo de inhibición (8,34 y 9,57 mm). Por otro parte, L. alba mostró menor actividad antibacteriana. El aceite esencial inhibió únicamente el 66,67% de las bacterias patógenas, presentando un halo de inhibición que oscila entre 10,68 a 16,29 mm. El resultado de este estudio indica que los aceites esenciales de L. graveolens y L. alba son una alternativa prometedora para el control del crecimiento de Aeromonas spp.

Resumo Neste estudo avaliou-se a atividade antimicrobiana de extratos e óleos essenciais de Lippia graveolens e Lippia alba, contra nove cepas de Aeromonas spp., isoladas de Oreochromis niloticus. Os extratos brutos foram obtidos pela técnica de percolação e por extração supercrítica com CO2, enquanto os óleos essenciais foram obtidos por hidrodestilação em aparelho tipo Clevenger. A atividade antimicrobiana para cada extrato e óleo essencial foi verificada pelo método de disco-difusão em 24 horas. O óleo essencial de L. graveolens apresentou maior eficácia na inibição de patógenos bacterianos em peixes (100%), comparado aos extratos. Obteve-se um diâmetro de halo de inibição que variou entre 25,20 e 36,94 mm. Os extratos do fluido supercrítico e da percolação com acetato de etila e ciclohexano apresentaram a mesma eficácia (77,78%). O extrato bruto obtido com etanol 95% apresentou efeito antimicrobiano limitado (22,22%), apresentando o menor diámetro de halo de inibição (8,34 e 9,57 mm). Por outro lado, L. alba apresentou menor atividade antibacteriana. O óleo essencial inibiu apenas 66,67% das bactérias patogênicas, apresentando um halo de inibição que varia de 10,68 a 16,29 mm de diámetro. Os resultados deste estudo indica que os óleos essenciais de L. graveolens e L. alba são uma alternativa promissora para o controle do crescimento de Aeromonas spp.

https://doi.org/10.21615/cesmvz.6452 40 downloads

Anterolateral thigh versus radial forearm flap for cervical esophageal reconstruction in cancer patients: A retrospective cohort study in Colombia
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Moreno, Andrey

; Cabrera, Luis F.

; Pedraza, Mauricio

; Rojas, Andres

; López, Paula

; Sanchez, Sebastián

; Gomez, María Angela

; Correa, Susana

Cirugía y cirujanos

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Ago 2021, Volume 89 Nº 4 Páginas 461 - 468

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Objective: This study aimed to describe clinical outcomes of anterolateral thigh (ALT) and radial forearm flap in hypopharyngeal and esophageal reconstruction in a fourth level hospital in Bogotá, Colombia. Methods: This retrospective study included 38 patients who esophageal functional reconstruction using radial forearm or ALT flap at our center between February 2010 and December 2017. Results: Mean age was 51 years. About 80% of the included patients were females. Laryngoesophageal defects were present in 80%. Total circumferential reconstruction was required in 60% of patients. Brachial-radial grafts were performed in 26% and anterolateral thigh flaps in 74%. Overall, early complication rate was 30%, which 20% were fistulae (brachial-radial, 2.8%; ALT free flap, 8.3%). Late complications (20%) included stenosis and distal graft lumen obstruction. Only 10% of patients were unable to tolerate oral feeding and 50% of this patient needed permanent gastrostomy. Regarding oncological follow-up during the 24-month post-operative, no tumor recurrence was observed. Conclusions: Functional outcomes of reconstruction with brachial-radial and ALT flap were satisfying. Our findings suggest that ALT has a lower incidence of post-operative complications than radial forearm flap. The choice of the type of flap will depend on the size and location of the defect. Small and partially covered defects benefit from the use of a radial flap, and for larger and circumferential pharyngeal reconstructions with possible radiotherapy requirements, they benefit from an ALT flap.

Resumen Objetivo: Este estudio tuvo como objetivo describir los resultados clínicos del colgajo anterolateral de muslo y radial de antebrazo, para la reconstrucción hipofaríngea y esofágica en un hospital de cuarto nivel en Bogotá, Colombia. Métodos: Estudio retrospectivo inlcuyo 38 pacientes a los que se les realizó reconstrucción funcional esofágica con colgajo de antebrazo radial o anterolateral de muslo (ALT) entre febrero de 2010 y diciembre de 2017. Resultados: Edad media fue de 51 años. El 80% genero femeninp. Los defectos laringoesofágicos estuvieron presentes en el 80%. Se requirió reconstrucción circunferencial total en el 60% de los pacientes. Se realizaron injertos braquio-radiales en el 26% y colgajos anterolaterales de muslo en el 74%. La tasa global de complicaciones tempranas fue del 30%, de las cuales el 20% fueron fístulas (braquio-radial, 2,8%; colgajo libre de ALT, 8,3%). Las complicaciones tardías (20%) incluyeron estenosis y obstrucción de la luz del injerto distal. Solo el 10% de los pacientes no pudieron tolerar la alimentación oral y el 50% de este paciente necesitó gastrostomía permanente. En cuanto al seguimiento oncológico durante el postoperatorio de 24 meses, no se observó recidiva tumoral. Conclusión: Los resultados funcionales de la reconstrucción con colgajo braquio-radial y ALT fueron satisfactorios. Nuestros hallazgos sugieren que la ALT tiene una menor incidencia de complicaciones posoperatorias que el colgajo radial de antebrazo. La elección del tipo de colgajo dependerá del tamaño y la ubicación del defecto. Los defectos pequeños y parcialmente cubiertos se benefician del uso de un colgajo radial, y para reconstrucciones faríngeas más grandes y circunferenciales con posibles requisitos de radioterapia, se benefician de un colgajo ALT.

https://doi.org/10.24875/ciru.20000546 14 downloads

OPTIMIZING THE STRUCTURE OF AMPHIPHILIC INVERTIBLE POLYMERS (AIPs) MADE OF PEGs AND FATTY COMPOUND SEGMENTS TO OBTAIN A SINGLE CRITICAL MICELLE CONCENTRATION
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Andrade-Acuña, Daniela

; Dahrouch, Mohamed

; Sanchez, Susana A.

; Díaz, Enzo

; Mazières, Stephane

Journal of the Chilean Chemical Society

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Dez 2020, Volume 65 Nº 4 Páginas 5011 - 5014

Resumo: En | Texto: En | PDF: En

ABSTRACT Amphiphilic biopolyesters containing hydrophilic segments (PEGs) and hydrophobic blocks (silicon fatty from a castor oil derivative) showed the ability to self-assembly in inverted micelles. Due to their capability to form also direct micelles, these biopolyesters could be classified as amphiphilic invertible polymers AIPs. The micellar concentrations CMC and ICMC corresponding to the direct and inverted micelles respectively precisely correlated with PEG length. The methodology used in this investigation allowed to determine the PEG length needed to obtain the adequate structural biopolyester able to self-assembly in direct and inverted micelles from a unique concentration. Inverted micelle diameters, determined by DLS analysis, increased as the molecular polarity of the biopolyesters decreased. No individual inverted micellar were observed by TEM technique due to the concentration change during the sample preparation, however micellar macromolecular aggregations were revealed.

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CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico,
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Salinas-Santander, Mauricio Andrés

; Cantu-Salinas, Cristina Susana

; Ocampo-Candiani, Jorge

; Suarez-Valencia, Victor de Jesus

; Ramirez-Guerrero, Jennifer Guadalupe

; Sanchez-Dominguez, Celia Nohemi

Anais Brasileiros de Dermatologia

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Jun 2020, Volume 95 Nº 3 Páginas 283 - 288

Resumo: En | Texto: En | PDF: En

Abstract Background: Alopecia areata is an autoimmune disease that produces non-scarring hair loss around the body. Gene variants of the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene, a negative regulator of T-cell response, have been associated with a predisposition to autoimmune diseases in different populations; however, the involvement of these genetic variants in the development of AA is controversial. Objective: The present study evaluated the potential association of two CTLA4 gene variants with alopecia areata in a Mexican population. Methods: We genotyped +49AG (rs231775) and CT60 (rs3087243) variants in 50 AA patients and 100 healthy control participants through PCR-RFLP. Results: No statistical difference was observed for either of the gene variants regarding allele or genotype frequencies between AA patients and the controls when the parameters of family/personal history of autoimmune diseases or gender were considered (p > 0.05). Study limitations: Small sample size of patients and the data were obtained from Northeast Mexico population. Conclusion: The genetic variants rs231775 and rs3087243 of the CTLA4 gene are not a risk factor for the development of alopecia areata in the analyzed Mexican population.

https://doi.org/10.1016/j.abd.2020.03.001 406 downloads

Flow enhancer influence on non-isothermal systems for heavy crude oil production
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Suarez-Dominguez, Edgardo J.

; Perez-Sanchez, Josue Fco.

; Palacio-Perez, Arturo

; Izquierdo-Kulich, Elena

; Gonzalez-Santana, Susana

Acta universitaria

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2020, Volume 30 elocation e2645

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Production of heavy and extra-heavy crude oils generally entails high costs, especially in the winter season, due to heat losses. This work studies the effect of a flow enhancer (a chemical formulation based on biodiesel and oxidized biodiesel of soy oil) on the viscosity of heavy crude oil from different wells in Northern Mexico. The observed results indicate a non-linear decreasing behavior of viscosity concerning temperature and volume fraction of the viscosity reducer. It is also presented a theoretical model that predicts the flow increase that can be achieved using the enhancer in systems in which crude oil temperature is higher than the temperature of the environment. Results showed adequate correspondence between experimental and predicted data. It was found that the enhancer increases the volume of crude oil that can be processed without varying pressure gradient.

Resumen La producción de crudo pesado conlleva, generalmente, altos costos asociados a la extracción y transporte, sobre todo en temporadas en las que existen pérdidas de calor en los sistemas empleados. En este trabajo, se estudia el efecto de un mejorador de flujo (formulación de biodiesel y biodiesel oxidado) en la viscosidad de crudo pesado del norte de México, y se desarrolla un modelo que predice el comportamiento del flujo en sistemas de temperatura variable. Los resultados muestran una buena correspondencia entre los datos predichos y los experimentales, observando un decremento no lineal de la viscosidad del crudo con respecto a la temperatura y la fracción en volumen del reductor. Se encontró, además, que el empleo del mejorador de flujo incrementa la producción de crudo sin aumentar el gradiente de presión en el sistema.

https://doi.org/10.15174/au.2020.2645 183 downloads

Frequency of family meals and risk of eating disorders in adolescents in Spain and Peru
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Valero-Solis, Susana

; Granero-Perez, Roser

; Sanchez-Carracedo, David

Revista Latinoamericana de Psicología

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Jun 2019, Volume 51 Nº 1 Páginas 48 - 57

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen La prevalencia de los trastornos de la conducta alimentaria en España se encuentra entre 0.27 % y 6.41% y en Perú entre el 7.3% y el 11.4%. Se dispone de numerosas investigaciones sobre los factores de riesgo para estos trastornos, pero escasos estudios han analizado posibles factores protectores, como las comidas familiares, en muestras jóvenes que incluyan participantes de diferentes países. Este artículo analiza la contribución de la frecuencia de las comidas familiares sobre el riesgo de trastornos de conducta alimentaria en una muestra de adolescentes (n = 916, edad media de 14.6 años, rango de edad 12 a 17 años) procedentes de España y Perú. Los principales resultados mostraron un doble parámetro de interacción entre el sexo y el origen de los participantes con la frecuencia de las comidas familiares: el riesgo de estos trastornos se modifica específicamente en mujeres y adolescentes nacidos en España. Estas evidencias empíricas sugieren que el sexo y las diferencias culturales podrían estar influyendo en los desórdenes alimentarios durante la etapa adolescente y podrían actuar moderando el impacto del riesgo y los factores protectores de la patología alimentaria. Se recomienda ampliar la investigación sobre la contribución de las comidas familiares en el riesgo de los trastornos de la conducta alimentaria en adolescentes considerando posibles diferencias culturales con el fin de diseñar programas de prevención e intervención más eficientes.

Abstract The prevalence of eating disorders is between 0.27% and 6.41% in Spain and between 7.3% and 11.4% in Peru. Much research has been focused on the study of the main risk factors for eating disorders, but little is known about the potential protective factors (such as family meals) in samples of young people that include participants from different countries. This study estimates the contribution of the frequency of family meals on the risk for eating disorders in a large sample of adolescents recruited in Spain and Peru (n=916, with a mean age of 14.6 years old and age range of 12 to 17 years old). Results showed a double interaction parameter between the participants' sex and origin with the frequency of family meals: the risk for eating disorders is modified specifically for girls from both countries, and adolescents of both sexes born in Spain. This empirical evidence suggests that sex and cultural differences could be related to disordered eating patterns during adolescence and so could act as moderators for the impact of risk and protective factors for this clinical condition. The study of the contribution of the frequency of family meals on the risk of eating disorders in young people should take cultural differences into consideration with the aim of designing more targeted prevention and intervention programs.

https://doi.org/10.14349/rlp.2019.v51.n1.6 657 downloads

10.

Antimicrobial, Anti-Inflammatory and Antioxidant Activities of Polyoxygenated Chalcones
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Vásquez-Martínez, Yesseny A.

; Osorio, Mauricio E.

; San Martín, Diego A.

; Carvajal, Marcela A.

; Vergara, Alejandra P.

; Sanchez, Elizabeth

; Raimondi, Marcela

; Zacchino, Susana A.

; Mascayano, Carolina

; Torrent, Claudia

; Cabezas, Francisco

; Mejias, Sophia

; Montoya, Margarita

; Cortez-San Martín, Marcelo

Journal of the Brazilian Chemical Society

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Fev 2019, Volume 30 Nº 2 Páginas 286 - 304

Resumo: En | Texto: En | PDF: En

It was synthesized nine polyoxygenated chalcones with a potential and safe use as antioxidant, antimicrobial and anti-inflammatory therapies. Chalcones obtained by Claisen-Schmidt condensation were studied as antioxidant, inhibitors of human 5-lipoxygenase, antifungal, antibacterial and antibiotic resistance modifiers. Two chalcones with catecholic moieties were able to strongly decrease the minimum inhibitory concentration (MIC) of methicillin against methicillin-resistant Staphylococcus aureus, increase the antiradical activity and significantly inhibit the human 5-lipoxygenase. Only one of these chalcones was active synergistically with methicillin. Chalcones with methoxyl substituents at different positions displayed the best activities against Cryptococcus neoformans. Only one chalcone showed good activity against the plant pathogenic bacteria Pseudomonas syringae whose half maximal inhibitory concentration (IC50) value (2.5 µg mL-1) was similar to that observed with the antibiotic streptomycin (2.9 µg mL-1). These simple chalcones have safe potential uses in antioxidant, antimicrobial and anti-inflammatory therapies.

https://doi.org/10.21577/0103-5053.20180177 1776 downloads

11.

¿Podemos medir la cultura preventiva?: elaboración y validación de un cuestionario de cultura preventiva
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Subirats-Cid, Pilar

; Bretau-Viñas, Frederic

; Vilardell-Ynaraja, Miquel

; Carreras-Valls, Rosa

; Sanchez-Flores, Eugenia

; Guixeras-Campos, Assumpció

; Torrecillas Mota, Susana

; Serra Pujadas, Consol

; Colomés Figuera, Lluis

Medicina y Seguridad del Trabajo

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Mar 2018, Volume 64 Nº 250 Páginas 33 - 49

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT The aim of this study is to obtain a measuring tool for evaluating health promotion and safety culture in Catalan hospitals institutions. Once a wide bibliographic research was done/ provided, it was concluded that there is no useful validated tool for our purpose objective. In order to evaluate the different subjects related to health promotion and safety culture, it was decided to initiate the design and validation of a new questionnaire written in Catalan language. The initial stage / phase of the questionnaire was designed by an expert professional group in order to initiate the validation process and to obtain a tool easy to understand, with an exhaustive face and content validity which ensures psychometric properties.

RESUMEN El propósito de este proyecto es obtener un instrumento de medida para evaluar la cultura preventiva en las instituciones hospitalarias en Cataluña. Al realizar una amplia búsqueda bibliográfica se concluye que no disponemos de ningún instrumento validado que sea útil a este propósito por lo que se decide iniciar el diseño y la validación de un cuestionario en catalán, que permita medir los diferentes aspectos relacionados con la cultura preventiva que los centros aplican en su relación con los trabajadores. Se inicia la fase de diseño a cargo de un grupo de profesionales expertos en la materia hasta obtener un instrumento que cumpla las características de Fiabilidad y Validez que garanticen sus propiedades psicométricas, garantizando un exhaustivo proceso de validación.

1795 downloads

12.

Modelos de regressão aplicados na caracterização de argamassas leves contendo agregados não convencionais de EVA e fibras de piaçava
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Santana, Marlesson Rodrigues Oliveira de

; Dominguez, Dany Sanchez

; Iglesias, Susana Marrero

; Pessôa, José Renato de Castro

; Dias, Leonardo Alves

Matéria (Rio de Janeiro)

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2018, Volume 23 Nº 3 elocation e12168

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO A indústria da construção civil tem um grande potencial para a reciclagem de resíduos mediante a incorporação desses materiais como agregados. O resíduo de EVA (Etileno-Acetato de Vinila) vem sendo utilizado como uma alterativa na produção de compósitos cimentícios leves em conjunto com fibras vegetais de Attalea funifera Martius (piaçava), como reforço. Neste trabalho, procurou-se modelar as propriedades mecânicas de resistência à compressão, resistência à tração e módulo de deformação de argamassas contendo agregados não convencionais como EVA e fibras de piaçava. Foi utilizado um modelo de regressão polinomial com três variáveis explicativas para modelar cada propriedade mecânica, utilizando como variáveis independentes as porcentagens de EVA e fibras presentes na mistura, e a relação água/cimento do material. A qualidade de ajuste dos modelos foi avaliada por meio de testes hipótese, e por critérios estatísticos, dentre deles Shapiro-Wilk, Durbin-Watson, Breusch-Pagan, coeficientes de determinação R2 e critério PRESS (Prediction Error Sum of Squares). Os resultados indicam que os modelos construídos reproduzem satisfatoriamente o comportamento do material. Por meio de simulações realizadas com os modelos propostos, constatou-se que a fibra de piaçava pode ser utilizada como reforço para melhorar as propriedades de resistência à tração e módulo de deformação para a argamassa, dessa forma, foi possível identificar uma proporção ótima entre os agregados.

ABSTRACT The civil construction has great potential for recycling other industries residues using these materials as aggregates. The EVA residue (Ethylene Vinyl Acetate) has been used in lightweight mortar production using piassava vegetable fibers (Attalea funifera Martius) as reinforcement. In this work, we build mathematical models to simulate the mechanical properties as compressive strength, tensile strength and modulus of elasticity for mortar with unconventional aggregates of EVA and piassava fibers. We used a polynomial regression model with three explanatory variables to describe each mechanical property, using as independent variables the EVA and fiber percentages in the mixture and also the water/cement ratio. The goodness of fit was measured through hypothesis tests, and statistical criteria’s as Shapiro-Wilk, Durbin-Watson, Breusch-Pagan, the coefficient of determination (R2), and the PRESS statistic. The results allow us to affirm the constructed models reproduce the material behavior. Using the proposed models and simulation techniques, it was found that the piassava fibers can be used as reinforcement elements in the tensile strength and modulus of elasticity for mortars. In addition, we calculate an optimum ratio between aggregates to obtain maximum resistance.

https://doi.org/10.1590/s1517-707620180003.0502 1189 downloads

13.

Metformin-related lactic acidosis: Case report
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Sanchez-Díaz, Jesus Salvador

; Monares-Zepeda, Enrique

; Martinez-Rodríguez, Enrique Antonio

; Cortes-Román, Jorge Samuel

; Torres-Aguilar, Oscar

; Peniche-Moguel, Karla Gabriela

; Diaz-Gutierrez, Susana Patricia

; Pin-Gutierrez, Eusebio

; Rivera-Solís, Gerardo

; García-Méndez, Rosalba Carolina

; Huanca-Pacaje, Juan Marcelo

; Calyeca-Sánchez, Maria Veronica

Colombian Journal of Anestesiology

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Dez 2017, Volume 45 Nº 4 Páginas 353 - 359

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Definimos acidosis láctica en presencia de pH<7,35, lactato en sangre >2,0 mmol/ly PaCO2 <42 mmHg. Por otro lado, la definición de acidosis láctica grave es controvertida. La causa principal de acidosis láctica grave es el estado de choque. La acidosis láctica pormetformina es rara, pero alcanza una mortalidad del 50%. La acidosis metabólica, incluyendo a la acidosis láctica, puede recibir tratamiento específico o tratamiento general con bicarbonato de sodio, trihidroxiaminometano, carbicarb o hemodiafiltracion continua. El éxito del tratamiento de la acidosis láctica yace en el control de la fuente etiológica; la terapia de reemplazo renal intermitente o continua está perfectamente justificada, y el argumento para decidir cuál utilizar es el estado de choque. Presentamos el informe de un caso de un paciente masculino con intoxicación por metformina como intento suicida, quien desarrolló acidosis láctica y falla orgánica múltiple; la base para el éxito del caso fue el tratamiento con hemodiafiltración continua.

Abstract Lactic acidosis is defined as the presence of pH <7.35, blood lactate >2.0 mmol/L and PaCO2 <42 mmHg. However, the definition of severe lactic acidosis is controversial. The primary cause of severe lactic acidosis is shock. Although rare, metformin-related lactic acidosis is associated with a mortality as high as 50%. The treatment for metabolic acidosis, including lactic acidosis, may be specific or general, using sodium bicarbonate, trihydroxyaminomethane, carbicarb or continuous haemodiafiltration. The successful treatment of lactic acidosis depends on the control of the aetiological source. Intermittent or continuous renal replacement therapy is perfectly justified, shock being the argument for deciding which modality to use. We report a case of a male patient presenting with metformin poisoning as a result of attempted suicide, who developed lactic acidosis and multiple organ failure. The critical success factor was treatment with continuous haemodiafiltration.

1626 downloads

14.

Synthesis, Physicochemical and Photophysical Characterization of 4-(1-Pyrenyl)-butyl-α-D-mannopyranoside
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Sandoval, Catalina

; Arriagada, Franco S.

; Fuente, Julio R. De la

; Sanchez, Susana A.

; Morales, Javier

; Pizarro, Nancy

; Nonell, Santi

; Gunther, German

Journal of the Brazilian Chemical Society

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Fev 2016, Volume 27 Nº 2 Páginas 402 - 410

Resumo: En | Texto: En | PDF: En

Glycolipids are biomolecules composed of a lipid chain (lipophilic) and a monosaccharide or oligosaccharide as hydrophilic group. Their chemical structure and biological role make them undoubtedly good candidates for a large and continuously growing number of biotechnological applications. Mannose is a carbohydrate present on membrane glycolipids of a wide number of pathogenic microorganisms (bacteria, fungi, protozoa, and viruses) and specifically recognized by several lectins. We synthesized a mannose derivative linked through a short methylene chain to a pyrene moiety which behaves as a surfactant, able to aggregate, and retains the photophysical properties of pyrene: showing comparable absorption and emission spectra, having lower fluorescence quantum yield and the ability to form excimer, and finally the ability to produce O2(1Δg) with high quantum yields. Thus, this novel molecule would open future applications for detection (fluorescence) or inactivation (singlet oxygen) of bacterial pathogens, viruses, tumor cells, or particular cells.

https://doi.org/10.5935/0103-5053.20150306 53817 downloads

15.

Estimación de crecidas extraordinarias en el arroyo Tegua (Córdoba), a partir de evidencias geomorfológicas, sedimentológicas y modelación hidráulica
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Doffo, Nelso C

; Olthoff, Leandro

; De Giovanni, Susana

; Origlia, Daniel

; Sanchez, María L

Revista de la Asociación Geológica Argentina

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Mar 2014, Volume 71 Nº 1 Páginas 48 - 55

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

The Tegua stream drains a 160,000 ha basin in the center-west of Córdoba. Its is born in Comechingones ranges (Pampeanas ranges) and develops its middle and lower basin in the Pampean plain. The regional climate is temperate subhumid (AAR = 800-930 mm). Despite the long history of damages to infrastructure and productive land, there are no gauging records, which makes difficult the assessment of historical floods, therefore, geomorphological-sedimentological techniques and hydraulic modeling are useful methodology for estimating extraordinary floods. It is proposed to recognize geomorphologicalsedimentological flood evidences, to determine stream sections for the hydraulic modeling, and to estimate peak flows and their relation to flood disasters. To estimate the discharge, the program HEC-RAS 4.0 was used. A 700 m long channel segment was chosen in the middle basin, with a subrectilinear pattern, steady section, and a slope of 0.0025. Sedimentary and non-sedimentary evidences of flooding were found and 17 cross sections were surveyed. Two values roughness of Manning "n" roughness coefficient were calculated, one for the channel bed (0,0204), and the other for the banks (0,06), according to tables. Flow rates of 55, 115, 140 and 200 m3/s were determined; their flood sheets are consistent with the surveyed evidence. The incision of the channel in cemented sediments has significantly stabilized the channel, making possible its hydraulic modeling. A highest flood with serious consequences (2007) was related to the non-sedimentary evidence and to an estimated stream flow of 200 m³/s.

El arroyo Tegua drena una cuenca de 160.000 ha en el centro-oeste de la provincia de Córdoba, nace en las Sierras de Comechingones (Sierras Pampeanas) y desarrolla su cuenca media y baja en la llanura Pampeana. El clima regional es templado subhúmedo (PMA=800-930 mm). Con un largo historial de afectaciones a infraestructuras y tierras productivas, el curso carece de registros de aforos, lo que dificulta la evaluación de crecidas históricas. Por ello las técnicas geomorfológicas-sedimentológicas y la modelización geomorfológicas, constituyen una metodología útil para estimar crecidas extraordinarias. Se propone reconocer evidencias geomorfológicos-sedimentológicas de crecidas, determinar tramos del arroyo para la modelización hidráulica y estimar caudales máximos y su relación con desastres aluviales. Para la estimación de la descarga se utilizó el programa HEC-RAS 4.0. Se seleccionó un segmento del canal de 700 m de longitud, en la cuenca media, con un patrón subrectilíneo, estable y con una pendiente de 0,0025. Se encontraron evidencias sedimentarias y no sedimentarias de crecida y se relevaron 17 perfiles transversales. Se determinó un coeficiente de rugosidad "n" de Manning para el fondo del canal de 0,0204 en forma analítica y otro para las márgenes de 0,06 extraído de tablas. Se determinaron caudales de 55, 115, 140 y 200 m3/s, cuyas láminas de crecida son coincidentes con las evidencias relevadas. La incisión del cauce en sedimentos cementados ha estabilizado notablemente el canal, posibilitando su modelización hidráulica. Una crecida importante (2007) fue asociada con las evidencias no sedimentarias relevadas y un caudal estimado de 200 m³/s.

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