Pesquisa | SciELO

Abstract Background: Patients using immunosuppressive drugs may have unfavorable results after infections. However, there is a lack of information regarding COVID 19 in these patients, especially in patients with rheumatoid arthritis (RA). Therefore, the aim of this study was to evaluate the risk factors associated with COVID 19 hospitalizations in patients with RA. Methods: This multicenter, prospective cohort study is within the ReumaCoV Brazil registry and included 489 patients with RA. In this context, 269 patients who tested positive for COVID 19 were compared to 220 patients who tested negative for COVID 19 (control group). All patient data were collected from the Research Electronic Data Capture database. Results: The participants were predominantly female (90.6%) with a mean age of 53 ±12 years. Of the patients with COVID 19, 54 (20.1%) required hospitalization. After multiple adjustments, the final regression model showed that heart disease (OR =4.61, 95% CI 1.06–20.02. P < 0.001) and current use of glucocorticoids (OR =20.66, 95% CI 3.09–138. P < 0.002) were the risk factors associated with hospitalization. In addition, anosmia was associated with a lower chance of hospitalization (OR =0.26; 95% CI 0.10–0.67, P < 0.005). Conclusion: Our results demonstrated that heart disease and the use of glucocorticoids were associated with a higher number of hospital admissions for COVID 19 in patients with RA. Trial registration: Brazilian Registry of Clinical Trials RBR 33YTQC.

https://doi.org/10.1186/s42358-022-00244-5

Characterization of primary direct-acting antiviral (DAA) drugs resistance mutations in NS5A/NS5B regions of hepatitis C virus with genotype 1a and 1b from patients with chronic hepatitis
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Santos, Ana Paula de Torres

; Silva, Vanessa Cristina Martins

; Mendes-Corrêa, Maria Cássia

; Lemos, Marcilio Figueiredo

; Malta, Fernanda de Mello

; Santana, Rúbia Anita Ferraz

; Dastoli, Gregório Tadeu Fernando

; Castro, Vanessa Fusco Duarte de

; Pinho, João Renato Rebello

; Moreira, Regina Célia

Revista do Instituto de Medicina Tropical de São Paulo

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2022, Volume 64 elocation e61

Resumo: En | Texto: En | PDF: En

ABSTRACT The Hepatitis C virus (HCV) infection is a public health problem. The high level of HCV replication and its lack of post-transcriptional correction mechanisms results in the emergence of viral variants and the difficulty in determining polymorphisms and variants that contain the substitutions associated with resistance towards new antivirals. The main focus of this study was to map the NS5A and NS5B polymorphisms and resistance mutations to new antiviral drugs in HCV strains genotype 1 from patients with chronic hepatitis C infection. Serum samples were collected from patients who underwent routine viral load tests at the Instituto Adolfo Lutz, Sao Paulo city, Brazil. A total of 698 and 853 samples were used for the characterization of NS5A and NS5B regions, respectively, which comprise the HCV genotypes 1a and 1b. The prevalence of resistance mutations found in the NS5A region was 6.4%, with Y93H, L31M, Q30R, and Y93N as the main resistance-associated substitutions (RAS). No NS5B-associated RAS was observed for any of the analyzed drugs. These findings support that the RAS test should be offered to individuals with poor response to double combination regimens prior to treatment initiation, thereby assisting strain vigilance and selection of effective treatment or retreatment options using DAA regimens.

https://doi.org/10.1590/s1678-9946202264061

SPORTS AND PERFORMANCE IN THE TRANSGENDER POPULATION: A SYSTEMATIC REVIEW AND META-ANALYSIS
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Nahon, Roberto Lohn

; Silva, Ana Paula Simões da

; Muniz-Santos, Renan

; Novaes, Rayanne Carneiro Torres de

; Pedroso, Laura Souza Prado Lobrigati

Revista Brasileira de Medicina do Esporte

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Dez 2021, Volume 27 Nº 6 Páginas 637 - 645

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Introdução: O debate sobre as regulamentações relativas à participação de transgêneros no esporte não é recente, mais ainda está em progresso. Algumas organizações esportivas são mais flexíveis nesse aspecto, enquanto outras são mais conservadoras. Objetivo: Mediante revisão sistemática e metanálise, este estudo resume as evidências científicas dos efeitos do tratamento hormonal de redesignação sexual nas medidas de força muscular, hematócritos e hemoglobina, parâmetros que parecem estar ligados ao desempenho esportivo. Métodos: Foram realizadas buscas eletrônicas de artigos publicados antes de 20 de novembro de 2020 incluídos em três bancos de dados (PubMed, SciELO e Lilacs), sem restrição de tempo ou idioma, sendo usados os descritores “transgender”, “gender dysphoria”, “strength”, “hematocrit” e “hemoglobin”. A sistematização PRISMA foi usada para a elaboração desta revisão, enquanto a metanálise foi realizada para evidenciar matematicamente os resultados. A metanálise foi realizada com o modelo de efeito aleatório para encontrar o efeito combinado estimado do tratamento hormonal de redesignação sexual sobre os parâmetros analisados. Resultados: A busca eletrônica recuperou 21 artigos elegíveis. O tratamento hormonal de redesignação sexual influenciou os três parâmetros analisados em quase todos os estudos. No geral, houve um aumento significativo da força muscular nos homens trans (FtMs) no grupo de músculos analisado: +17,7% (intervalo de confiança [IC] de 95% 14,9; 20,6). Nas mulheres trans (MtFs) os resultados da análise da força muscular foram mais controversos, mas o efeito de estimativa agrupado mostrou uma diminuição: −3,6% (intervalo de confiança [IC] de 95% 6,6; −0,6). Conclusão: Força muscular, hematócritos e hemoglobina tiveram níveis alterados em resposta ao tratamento hormonal de redesignação sexual tanto em FtMs quanto em MtFs. No entanto, há escassez de estudos que comparem os indivíduos transgênero com a população do mesmo gênero desejado. Esses estudos são necessários para melhor definir as regras da participação de transgêneros nos esportes olímpicos. Nível de Evidência I; Revisão Sistemática e Metanálise.

ABSTRACT Introduction: The debate surrounding the regulations on the participation of transgender individuals in sports is not recent, but it is still ongoing. Some sports organizations are more flexible in this regard, while others are more conservative. Objective: Through a systematic review and meta-analysis, this study summarizes the scientific evidence of the effects of cross-sex hormone therapy on muscle strength, hematocrit, and hemoglobin measurements, parameters that seem to be linked to sports performance. Methods: We conducted electronic searches for manuscripts published before November 20th, 2020. Studies published in three different databases (PubMed, SciELO, and Lilacs) were included, without any time or language restriction, and using keywords such as “transgender”, “gender dysphoria”, “strength”, “hematocrit”, and “hemoglobin”. The PRISMA systematization was used for the elaboration of this review, while a meta-analysis was conducted to mathematically evidence the results. The meta-analysis was performed using the random effect model, to find the pooled estimate effect of cross-sex hormone therapy on the parameters analyzed. Results: The electronic search retrieved 21 articles that were eligible for inclusion. Cross-sex hormone therapy influenced the three parameters analyzed in almost all the studies. Overall, there was a significant increase in muscle strength in female-to-males (FtMs), per muscle group analyzed: +17.7% (95% confidence interval [CI]14.9;20.6). In male-to-females (MtFs) the results of the muscle strength analysis were more controversial, but the pooled estimate effect showed a decrease: −3.6% (95% confidence interval [CI] −6.6; −0.6). Conclusion: Muscle strength, hematocrit, and hemoglobin were altered as a result of cross-sex hormone therapy in both FtMs and MtFs. However, there was a lack of studies comparing the transgender individuals to the population of the same desired gender. Such studies are needed, to better infer rules for the participation of transgender athletes in Olympic sports. Level of Evidence I; Systematic Review and Meta-analysis.

RESUMEN Introducción: El debate sobre las regulaciones relativas a la participación de las personas transgénero en el deporte no es reciente. Algunas organizaciones deportivas son más flexibles, mientras que otras, más conservadoras. Objetivo: Este estudio tuvo como objetivo resumir la evidencia científica sobre los efectos de la terapia hormonal cruzada en la fuerza muscular, hematocrito, y hemoglobina, parámetros que parecen estar vinculados al rendimiento deportivo, mediante revisión sistemática y metanálisis. Métodos: Realizamos búsquedas electrónicas de manuscritos publicados antes del 20 de noviembre de 2020. Se incluyeron estudios publicados en tres bases de datos (PubMed, SciELO y Lilacs) sin restricción de tiempo o lenguaje. Se utilizaron palabras clave como “transgénero”, “disforia de género”, “fuerza”, “hematocrito” y “hemoglobina”. Para la elaboración de esta revisión se utilizó la sistematización PRISMA, mientras que se realizó un metanálisis para evidenciar matemáticamente los resultados. El metanálisis se realizó utilizando el modelo de efecto aleatorio, para encontrar el efecto de estimación agrupado de la terapia hormonal cruzada en los parámetros analizados. Resultados: La búsqueda electrónica incluyó 21 artículos. La terapia hormonal cruzada influyó en los tres parámetros analizados en casi todos los estudios. En general, hubo un aumento significativo en la fuerza muscular en hombres trans (FtMs), por grupo muscular analizado: +17.7% (95% intervalo de confianza [CI]14.9;20.6). En mujeres trans (MTFs) los resultados en el análisis de fuerza muscular fueron más controvertidos, pero el efecto de estimación agrupado mostró una disminución: −3.6% (95% intervalo de confianza [CI] −6.6; −0.6). Conclusión: Fuerza muscular, hematocrito, y hemoglobina han cambiado sus niveles en respuesta a la terapia hormonal cruzada en hombres trans y mujeres trans. Sin embargo, encontramos una falta de estudios que compararan a las personas transgénero con la población del mismo género deseado, lo que sería necesario para inferir mejor las reglas sobre la participación de los transexuales en los deportes olímpicos. Nivel de Evidencia I; Revisión sistemática y Metanálisis.

https://doi.org/10.1590/1517-8692202127062021_0054 1 downloads

Chronic use of hydroxychloroquine did not protect against COVID-19 in a large cohort of patients with rheumatic diseases in Brazil
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Pileggi, Gecilmara Salviato

; Ferreira, Gilda Aparecida

; Gomides Reis, Ana Paula Monteiro

; Reis Neto, Edgard Torres

; Abreu, Mirhelen Mendes

; Albuquerque, Cleandro Pires

; Araújo, Nafice Costa

; Bacchiega, Ana Beatriz

; Bianchi, Dante Valdetaro

; Bica, Blanca

; Bonfa, Eloisa Duarte

; Borba, Eduardo Ferreira

; Brito, Danielle Christinne Soares Egypto

; Duarte, Ângela Luzia Branco Pinto

; Santo, Rafaela Cavalheiro Espírito

; Fernandes, Paula Reale

; Guimarães, Mariana Peixoto

; Gomes, Kirla Wagner Poti

; Kakehasi, Adriana Maria

; Klumb, Evandro Mendes

; Lanna, Cristina Costa Duarte

; Marques, Claudia Diniz Lopes

; Monticielo, Odirlei André

; Mota, Licia Maria Henrique

; Munhoz, Gabriela Araújo

; Paiva, Eduardo Santos

; Pereira, Helena Lucia Alves

; Provenza, José Roberto

; Ribeiro, Sandra Lucia Euzébio

; Rocha Junior, Laurindo Ferreira

; Sampaio, Camila Santana Justo Cintra

; Sampaio, Vanderson Souza

; Sato, Emília Inoue

; Skare, Thelma

; de Souza, Viviane Angelina

; Valim, Valeria

; Lacerda, Marcus Vinícius Guimarães

; Xavier, Ricardo Machado

; Pinheiro, Marcelo Medeiros

Advances in Rheumatology

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2021, Volume 61 elocation 60

Resumo: En | Texto: En | PDF: En

Abstract Background: There is a lack of information on the role of chronic use of hydroxychloroquine during the SARS-CoV-2 outbreak. Our aim was to compare the occurrence of COVID-19 between rheumatic disease patients on hydroxychloroquine with individuals from the same household not taking the drug during the first 8 weeks of community viral transmission in Brazil. Methods: This baseline cross-sectional analysis is part of a 24-week observational multi-center study involving 22 Brazilian academic outpatient centers. All information regarding COVID-19 symptoms, epidemiological, clinical, and demographic data were recorded on a specific web-based platform using telephone calls from physicians and medical students. COVID-19 was defined according to the Brazilian Ministry of Health (BMH) criteria. Mann-Whitney, Chi-square and Exact Fisher tests were used for statistical analysis and two binary Final Logistic Regression Model by Wald test were developed using a backward-stepwise method for the presence of COVID-19. Results: From March 29th to May 17st, 2020, a total of 10,443 participants were enrolled, including 5166 (53.9%) rheumatic disease patients, of whom 82.5% had systemic erythematosus lupus, 7.8% rheumatoid arthritis, 3.7% Sjögren’s syndrome and 0.8% systemic sclerosis. In total, 1822 (19.1%) participants reported flu symptoms within the 30 days prior to enrollment, of which 3.1% fulfilled the BMH criteria, but with no significant difference between rheumatic disease patients (4.03%) and controls (3.25%). After adjustments for multiple confounders, the main risk factor significantly associated with a COVID-19 diagnosis was lung disease (OR 1.63; 95% CI 1.03-2.58); and for rheumatic disease patients were diagnosis of systemic sclerosis (OR 2.8; 95% CI 1.19-6.63) and glucocorticoids above 10 mg/ day (OR 2.05; 95% CI 1.31-3.19). In addition, a recent influenza vaccination had a protective effect (OR 0.674; 95% CI 0.46-0.98). Conclusion: Patients with rheumatic disease on hydroxychloroquine presented a similar occurrence of COVID-19 to household cohabitants, suggesting a lack of any protective role against SARS-CoV-2 infection. Trial registration Brazilian Registry of Clinical Trials (ReBEC; RBR - 9KTWX6).

https://doi.org/10.1186/s42358-021-00217-0 22 downloads

Risco nutricional e fatores associados em idosos com HIV/aids em uso de terapia antirretroviral nas unidades de referência
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Silva, Suelane Renata de Andrade

; Marques, Ana Paula de Oliveira

; Leal, Márcia Carréra Campos

; Santos, Lilian Guerra Cabral dos

; Araújo, Janaína Gabriela Coelho de

; Araújo, Kydja Milene Souza Torres de

Revista Brasileira de Geriatria e Gerontologia

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2021, Volume 24 Nº 5 elocation e210209

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo identificar o risco nutricional de pessoas idosas com HIV/aids em uso de terapia antirretroviral (TARV) e fatores associados. Método estudo de natureza transversal e analítico. Participaram 241 idosos cadastrados nos Serviços de Referência para tratamento de HIV/aids do Município de Recife/PE, Brasil. A variável dependente correspondeu ao risco nutricional, avaliado por meio da Mini Avaliação Nutricional e as independentes incluíram: dados sociodemográficos, estilo de vida e condições de saúde. ResuItados foram identificados 44% dos participantes com risco nutricional e verificada associação entre risco nutricional e sexo feminino, escolaridade entre 1-4 anos de estudo e sintomatologia depressiva. Conclusão Sugere-se a inclusão de medidas de rastreio para intervenção precoce do estado nutricional como a Mini Avaliação Nutricional na rotina do cuidado, com vistas a possibilitar maior integralidade na assistência e redução de riscos de morbimortalidade associada ao HIV.

Abstract Objective To identify the nutritional risk of older people with HIV / AIDS and the associated factors. Method It is a cross-sectional and analytical study. 241 older people from the Reference Services in Recife/PE, Brazil participated. The dependent variable was Nutritional risk, assessed by the Mini Nutritional Assessment and the independent ones, the sociodemographic, lifestyle and health conditions. Results 44% of participants with nutritional risk were identified. There was an association between nutritional risk and female gender, education between 1-4 years of study and symptoms of depression. Conclusion It is suggested to include screening measures for early intervention of nutritional status, such as Mini Nutritional Assessment in the care routine, with a view to enabling greater comprehensiveness in care in Gerontology and reducing the risk of morbidity and mortality associated with the disease, and promoting longevity of better quality for those living with HIV.

https://doi.org/10.1590/1981-22562021024.210209.pt

Correlation between quality of life, depression, satisfaction and functionality of older people with HIV
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Araújo, Kydja Milene Souza Torres de

; Silva, Suelane Renata de Andrade

; Freire, Daniela de Aquino

; Leal, Márcia Carréra Campos

; Marques, Ana Paula de Oliveira

; Baptista, Rosilene Santos

; Silva, Antônia Leda Oliveira

Revista Brasileira de Enfermagem

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2021, Volume 74 Supl. 2 elocation e20201334

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: Analisar a correlação entre qualidade de vida, depressão, satisfação com a vida e capacidade funcional nas pessoas idosas que vivem com o Vírus da Imunodeficiência Humana (HIV). Métodos: estudo de corte transversal, desenvolvido em hospitais de referência para tratamento e acompanhamento de pessoas com HIV. Participaram 241 idosos, mediante a aplicação de um questionário contendo variáveis sociodemográficas, o HIV/AIDS Target Quality of Life, do Índice de Barthel, da Escala de Satisfação com a Vida e da versão abreviada com 15 itens da Escala de Depressão Geriátrica de Yesavage. Resultados: as análises evidenciaram correlação inversa entre as dimensões do HAT-Qol com a depressão, correlação positiva no domínio satisfação com a vida e estatisticamente significante, porém fraca, com a funcionalidade. Conclusão: a depressão prejudica a qualidade de vida em todas as dimensões, enquanto a satisfação com a vida influencia mais positivamente este aspecto do que a capacidade funcional.

ABSTRACT Objective: To analyze the correlation between the quality of life, depression, life satisfaction, and functional capacity in elderly people living with the Human Immunodeficiency Virus (HIV). Methods: A cross-sectional study developed in reference hospitals for treatment and follow-up of people with HIV. 241 elderly people participated by applying a questionnaire containing sociodemographic variables, the HIV/AIDS target quality of Life, the Barthel Index, the Life Satisfaction Scale, and the abbreviated version with 15 items of the Yesavage Geriatric Depression Scale. Results: The analyses showed an inverse correlation between the dimensions of the HAT-Qol with depression, a positive correlation in the domain satisfaction with life, and statistically significant, but weak, with functionality. Conclusion: Depression impairs quality of life in all dimensions, while life satisfaction influences this aspect more positively than functional capacity. Descriptors: Quality of Life; Depression; Personal Satisfaction; Aged; HIV.

RESUMEN Objetivo: Analizar la correlación entre calidad de vida, depresión, satisfacción con la vida y capacidad funcional en personas mayores que conviven con el Virus de Inmunodeficiencia Humana (VIH). Métodos: estudio transversal, desarrollado en hospitales de referencia para el tratamiento y seguimiento de personas con VIH. Participaron 241 personas mayores mediante la aplicación de un cuestionario con variables sociodemográficas, del HIV/AIDS-Target Quality of Life, del Índice de Barthel, de la Escala de Satisfacción con la Vida y la versión abreviada con 15 ítems de la Escala Yesavage para Depresión Geriátrica. Resultados: los análisis mostraron correlación inversa entre las dimensiones del HIV/AIDS-Target Quality of Life y depresión, correlación positiva en el dominio de satisfacción con la vida y estadísticamente significativa, pero débil con funcionalidad. Conclusión: la depresión afecta la calidad de vida en todas las dimensiones, mientras que la satisfacción con la vida influye más positivamente en este aspecto que la capacidad funcional.

https://doi.org/10.1590/0034-7167-2020-1334 261 downloads

Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases
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Reis Neto, Edgard Torres dos

; Kakehasi, Adriana Maria

; Pinheiro, Marcelo de Medeiros

; Ferreira, Gilda Aparecida

; Marques, Cláudia Diniz Lopes

; Mota, Licia Maria Henrique da

; Paiva, Eduardo dos Santos

; Pileggi, Gecilmara Cristina Salviato

; Sato, Emília Inoue

; Reis, Ana Paula Monteiro Gomides

; Xavier, Ricardo Machado

; Provenza, José Roberto

Advances in Rheumatology

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2020, Volume 60 elocation 32

Resumo: En | Texto: En | PDF: En

Abstract Hydroxychloroquine and chloroquine, also known as antimalarial drugs, are widely used in the treatment of rheumatic diseases and have recently become the focus of attention because of the ongoing COVID-19 pandemic. Rheumatologists have been using antimalarials to manage patients with chronic immune-mediated inflammatory rheumatic diseases for decades. It is an appropriate time to review their immunomodulatory and anti-inflammatory mechanisms impact on disease activity and survival of systemic lupus erythematosus patient, including antiplatelet effect, metabolic and lipid benefits. We also discuss possible adverse effects, adding a practical and comprehensive approach to monitoring rheumatic patients during treatment with these drugs.

https://doi.org/10.1186/s42358-020-00134-8 2393 downloads

Hepatitis B: Prevalence and occult infection in HIV-infected patients
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Calux, Samira Julien

; Silva, Vanessa Cristina Martins

; Compri, Adriana Parise

; Lemos, Marcílio Figueiredo

; Santos, Ana Paula de Torres

; Oba, Isabel Takano

; Mendes-Correa, Maria Cássia J.

; Moreira, Regina Célia

Revista da Sociedade Brasileira de Medicina Tropical

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2020, Volume 53 elocation e20180533

Resumo: En | Texto: En | PDF: En

Abstract INTRODUCTION: HBV and HIV have identical transmission routes. The aim of this study was to determine the prevalence of HBV in HIV patients and to detect the presence of occult HBV infection. METHODS: All samples were tested for serology markers and using qPCR. RESULTS: This study included 232 individuals, out of which 36.6% presented with HBV markers and 11.8% presented with HBsAg or HBV-DNA, including 3 patients that showed OBI. CONCLUSIONS: We observed a high prevalence of HBV among HIV patients. In addition, the results suggest that OBI can occur in patients with serological profiles that are indicative of past infection. Therefore, the application of molecular tests may enable the identification of infections that are not evident solely based on serology.

https://doi.org/10.1590/0037-8682-0533-2018 598 downloads

Atualização da Diretriz de Ressuscitação Cardiopulmonar e Cuidados Cardiovasculares de Emergência da Sociedade Brasileira de Cardiologia - 2019
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Bernoche, Claudia

; Timerman, Sergio

; Polastri, Thatiane Facholi

; Giannetti, Natali Schiavo

; Siqueira, Adailson Wagner da Silva

; Piscopo, Agnaldo

; Soeiro, Alexandre de Matos

; Reis, Amélia Gorete Afonso da Costa

; Tanaka, Ana Cristina Sayuri

; Thomaz, Ana Maria

; Quilici, Ana Paula

; Catarino, Andrei Hilário

; Ribeiro, Anna Christina de Lima

; Barreto, Antonio Carlos Pereira

; Azevedo Filho, Antonio Fernando Barros de

; Pazin Filho, Antonio

; Timerman, Ari

; Scarpa, Bruna Romanelli

; Timerman, Bruno

; Tavares, Caio de Assis Moura

; Martins, Cantidio Soares Lemos

; Serrano Junior, Carlos Vicente

; Malaque, Ceila Maria Sant’Ana

; Pisani, Cristiano Faria

; Batista, Daniel Valente

; Leandro, Daniela Luana Fernandes

; Szpilman, David

; Gonçalves, Diego Manoel

; Paiva, Edison Ferreira de

; Osawa, Eduardo Atsushi

; Lima, Eduardo Gomes

; Adam, Eduardo Leal

; Peixoto, Elaine

; Evaristo, Eli Faria

; Azeka, Estela

; Silva, Fabio Bruno da

; Wen, Fan Hui

; Ferreira, Fatima Gil

; Lima, Felipe Gallego

; Fernandes, Felipe Lourenço

; Ganem, Fernando

; Galas, Filomena Regina Barbosa Gomes

; Tarasoutchi, Flavio

; Souza, Germano Emilio Conceição

; Feitosa Filho, Gilson Soares

; Foronda, Gustavo

; Guimarães, Helio Penna

; Abud, Isabela Cristina Kirnew

; Leite, Ivanhoé Stuart Lima

; Linhares Filho, Jaime Paula Pessoa

; Moraes Junior, João Batista de Moura Xavier

; Falcão, João Luiz Alencar de Araripe

; Ramires, Jose Antônio Franchini

; Cavalini, José Fernando

; Saraiva, José Francisco Kerr

; Abrão, Karen Cristine

; Pinto, Lecio Figueira

; Bianchi, Leonardo Luís Torres

; Lopes, Leonardo Nícolau Geisler Daud

; Piegas, Leopoldo Soares

; Kopel, Liliane

; Godoy, Lucas Colombo

; Tobase, Lucia

; Hajjar, Ludhmila Abrahão

; Dallan, Luís Augusto Palma

; Caneo, Luiz Fernando

; Cardoso, Luiz Francisco

; Canesin, Manoel Fernandes

; Park, Marcelo

; Rabelo, Marcia Maria Noya

; Malachias, Marcus Vinícius Bolívar

; Gonçalves, Maria Aparecida Batistão

; Almeida, Maria Fernanda Branco de

; Souza, Maria Francilene Silva

; Favarato, Maria Helena Sampaio

; Carrion, Maria Julia Machline

; Gonzalez, Maria Margarita

; Bortolotto, Maria Rita de Figueiredo Lemos

; Macatrão-Costa, Milena Frota

; Shimoda, Mônica Satsuki

; Oliveira-Junior, Mucio Tavares de

; Ikari, Nana Miura

; Dutra, Oscar Pereira

; Berwanger, Otávio

; Pinheiro, Patricia Ana Paiva Corrêa

; Reis, Patrícia Feitosa Frota dos

; Cellia, Pedro Henrique Moraes

; Santos Filho, Raul Dias dos

; Gianotto-Oliveira, Renan

; Kalil Filho, Roberto

; Guinsburg, Ruth

; Managini, Sandrigo

; Lage, Silvia Helena Gelas

; Yeu, So Pei

; Franchi, Sonia Meiken

; Shimoda-Sakano, Tania

; Accorsi, Tarso Duenhas

; Leal, Tatiana de Carvalho Andreucci

; Guimarães, Vanessa

; Sallai, Vanessa Santos

; Ávila, Walkiria Samuel

; Sako, Yara Kimiko

Arquivos Brasileiros de Cardiologia

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Set 2019, Volume 113 Nº 3 Páginas 449 - 663

Resumo: Pt | Texto: Pt | PDF: Pt

https://doi.org/10.5935/abc.20190203 54793 downloads

10.

Sensory evaluation of fermented dairy beverages supplemented with iron and added by Cerrado fruit pulps
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FIGUEIREDO, Julliane Souza Barbosa

; SANTOS, Grazielle Layanne Mendes

; LOPES, João Pedro Antunes

; FERNANDES, Larissa Bessa

; SILVA, Fabiane Neves

; FARIA, Raquel Borges

; ROCHA, Ana Carolina Santos

; FARIAS, Paula Karoline Soares

; LIMA, William James Nogueira

; DURÃES, Carla Adriana Ferreira

; XAVIER, Alessandra Rejane Ericsson de Oliveira

; CARVALHO, Bruna Mara Aparecida de

; CARELI, Roberta Torres

; ALMEIDA, Anna Christina de

; BRANDI, Igor Viana

Food Science and Technology

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Jun 2019, Volume 39 Nº 2 Páginas 410 - 414

Resumo: En | Texto: En | PDF: En

Abstract Anemia due to iron deficiency is the most common in the world being characterized as a significant public health issue. Therefore, its prevention and treatment are considered important before it becomes either chronic or grievous; the interventions with superior potential are the medical supplementation with iron salts as well as food mineral enhancement. The objectives of this study were to develop fermented dairy beverages supplemented with iron and added by Cerrado fruit pulps: cagaita (Eugenia dysenterica ), coquinho-azedo (Butia capitata), tamarindo (Tamarindus indica), and umbu ( Spondias tuberosa). In addition, the research intended to evaluate the acceptance of these beverages by children and adolescents from public schools in the city of Montes Claros (MG). The methodology consisted in the production of dairy beverages followed by the evaluation of their quality through physicochemical and microbiological analyses. Posteriorly, children and adolescents assessed the sensorial acceptance. The analyses performed presented satisfactory results for physicochemical and microbiological properties regarding the acceptance of the product. The cagaita and coquinho azedo based dairy beverages were the most accepted whether compared with tamarindo and umbu beverages. The fermented dairy beverage supplemented with iron and added by Cerrado fruits come up as a feasible alternative for dietary supplementation, and can promote beneficial effects in human health due to their sensorial acceptance.

https://doi.org/10.1590/fst.32616 1047 downloads

11.

Fluctuations in serological hepatitis C virus levels in HIV patients
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Silva, Vanessa Cristina Martins

; Calux, Samira Julien

; Lemos, Marcilio Figueiredo

; Compri, Adriana Parise

; Santos, Ana Paula de Torres

; Oba, Isabel Takano

; Mendes-Correa, Maria Cássia Jacintho

; Moreira, Regina Célia

Revista da Sociedade Brasileira de Medicina Tropical

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Dez 2018, Volume 51 Nº 6 Páginas 737 - 741

Resumo: En | Texto: En | PDF: En

Abstract INTRODUCTION: Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) have identical transmission routes, explaining the high prevalence of coinfections. The main aim of this study was to detect fluctuations in serological HCV levels in HIV patients. METHODS: We analyzed samples of 147 patients who attended an outpatient service that supports HIV/AIDS patients in São Paulo city. We also recruited 22 HCV-monoinfected patients who attended the Instituto Adolfo Lutz Laboratory in São Paulo city, to compare the test results. Serological testing of the blood samples was performed for the detection of HCV antibodies. The samples were then analyzed using real-time PCR for RNA viral quantification and sequencing. RESULTS We found that 13.6% of the study population was coinfected with HIV and HCV. In 20% of coinfected patients, fluctuations in serology results were detected in samples collected during the follow-up. No changes in anti-HCV serological markers were observed in HCV-monoinfected patients. An HCV viral load was detected in 9,5% of the samples collected from HIV patients. CONCLUSIONS: Our findings provide important clinical data to public health professionals and highlight the importance of periodic monitoring of HCV/HIV coinfected patients.

https://doi.org/10.1590/0037-8682-0239-2018 1024 downloads

12.

Stunting in children under five years old is still a health problem in the Western Brazilian Amazon: a population-based study in Assis Brasil, Acre, Brazil
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Mantovani, Saulo Augusto Silva

; Ramalho, Alanderson Alves

; Pereira, Thasciany Moraes

; Branco, Fernando Luiz Cunha Castelo

; Oliart-Guzmán, Humberto

; Delfino, Breno Matos

; Braña, Athos Muniz

; Martins, Antonio Camargo

; Filgueira-Júnior, José Alcântara

; Santos, Ana Paula

; Campos, Rhanderson Gardinali

; Guimarães, Andréia Silva

; Araújo, Thiago Santos de

; Oliveira, Cristieli Sérgio de Menezes

; Codeço, Cláudia Torres

; Silva-Nunes, Mônica da

Ciência & Saúde Coletiva

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Jul 2016, Volume 21 Nº 7 Páginas 2257 - 2266

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Apesar do processo de transição nutricional no Brasil, em alguns lugares, como a região amazônica, o nanismo ainda é um importante problema de saúde pública. Identificou-se a prevalência e fatores associados ao déficit de crescimento em crianças menores de cinco anos de idade residentes na área urbana de Assis Brasil. Um inquérito foi realizado utilizando instrumento semiestruturado sobre características socioeconômicas, maternas e das crianças, e foram aferidas medidas antropométricas. As crianças com índice de estatura para idade inferior a -2 escores-Z foram consideradas com déficit de crescimento, de acordo com os critérios da Organização Mundial da Saúde. Quatrocentos e vinte e oito crianças foram avaliadas. Destas, 62 apresentaram déficit de crescimento. Os fatores associados à baixa estatura, de acordo com modelos ajustados, foram: presença de esgoto a céu aberto, índice de riqueza para as famílias, recebimento de ajuda financeira governamental, altura materna, idade e escolaridade maternas. Portanto, observou-se que as características familiares e da mãe, bem como fatores ambientais e socioeconômicos estavam intimamente relacionados com a ocorrência de déficit de crescimento na população estudada, e que a desnutrição ainda é um problema de saúde na Amazônia brasileira.

Abstract Despite the process of nutritional transition in Brazil, in some places, such as the Amazon region, stunting is still an important public health problem. We identified the prevalence and factors associated with stunting in children under five years old residing in the urban area of Assis Brasil. A survey was conducted in which a questionnaire on socioeconomic, maternal and children’s conditions was applied, and height or length was measured. The children with height for age index below -2 Z-scores were considered stunted, according to the criteria by the World Health Organization. Four hundred and twenty-eight children were evaluated. Of these, 62 were stunted. Factors associated with stunting, according to adjusted models, were: the presence of open sewer, the wealth index for households, the receipt of governmental financial aid and the mother’s height, age and education. Therefore, it was observed that family and the mother’s characteristics as well as environmental and socioeconomic factors were closely related to the occurrence of stunting in the population studied, and such nutritional disturbance is still a health problem in the Brazilian Amazon.

https://doi.org/10.1590/1413-81232015217.18602014 668 downloads

13.

Stunting in children under five years old is still a health problem in the Western Brazilian Amazon: a population-based study in Assis Brasil, Acre, Brazil
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Mantovani, Saulo Augusto Silva

; Ramalho, Alanderson Alves

; Pereira, Thasciany Moraes

; Branco, Fernando Luiz Cunha Castelo

; Oliart-Guzmán, Humberto

; Delfino, Breno Matos

; Braña, Athos Muniz

; Martins, Antonio Camargo

; Filgueira-Júnior, José Alcântara

; Santos, Ana Paula

; Campos, Rhanderson Gardinali

; Guimarães, Andréia Silva

; Araújo, Thiago Santos de

; Oliveira, Cristieli Sérgio de Menezes

; Codeço, Cláudia Torres

; Silva-Nunes, Mônica da

Ciência & Saúde Coletiva

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Jul 2016, Volume 21 Nº 7 Páginas 2257 - 2266

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232015217.18602014 2438 downloads

14.

An in-house real-time polymerase chain reaction: standardisation and comparison with the Cobas Amplicor HBV monitor and Cobas AmpliPrep/Cobas TaqMan HBV tests for the quantification of hepatitis B virus DNA
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Santos, Ana Paula de Torres

; Levi, José Eduardo

; Lemos, Marcilio Figueiredo

; Calux, Samira Julien

; Oba, Isabel Takano

; Moreira, Regina Célia

Memórias do Instituto Oswaldo Cruz

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Fev 2016, Volume 111 Nº 2 Páginas 134 - 140

Resumo: En | Texto: En | PDF: En

This study aimed to standardise an in-house real-time polymerase chain reaction (rtPCR) to allow quantification of hepatitis B virus (HBV) DNA in serum or plasma samples, and to compare this method with two commercial assays, the Cobas Amplicor HBV monitor and the Cobas AmpliPrep/Cobas TaqMan HBV test. Samples from 397 patients from the state of São Paulo were analysed by all three methods. Fifty-two samples were from patients who were human immunodeficiency virus and hepatitis C virus positive, but HBV negative. Genotypes were characterised, and the viral load was measure in each sample. The in-house rtPCR showed an excellent success rate compared with commercial tests; inter-assay and intra-assay coefficients correlated with commercial tests (r = 0.96 and r = 0.913, p < 0.001) and the in-house test showed no genotype-dependent differences in detection and quantification rates. The in-house assay tested in this study could be used for screening and quantifying HBV DNA in order to monitor patients during therapy.

https://doi.org/10.1590/0074-02760150415 1487 downloads

15.

Identification of hepatitis B virus genotypes in the state of São Paulo
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Santos, Ana Paula de Torres

; Levi, José Eduardo

; Lemos, Marcílio Figueiredo

; Calux, Samira Julien

; Oba, Isabel Takano

; Moreira, Regina Célia

Revista da Associação Médica Brasileira

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Out 2014, Volume 60 Nº 5 Páginas 424 - 427

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Objetivo: o objetivo deste estudo foi identificar os genótipos do HBV nas amostras de soros recebidas pelo Laboratório de Hepatites do Centro de Virologia do Instituto Adolfo Lutz. Métodos: foram analisadas aleatoriamente 94 amostras de soropositivas, provenientes de diversos municípios do Estado de São Paulo. Para determinação dos genótipos, foi realizada Nested-PCR das regiões S e Pol do HBV. Os genótipos foram identificados comparando os resultados amplificados com as sequências depositadas no GenBank. Resultados: foi possível determinar o genótipo de 91 (97%) amostras do total analisado e os genótipos identificados foram: genótipos A (55,3%), D (32%), F (5,3%), C (3,2%) e G (1%). Há poucos dados a respeito da epidemiologia do genótipo G. Esse genótipo tem sido detectado em áreas restritas do mundo. Geralmente, a infecção pelo genótipo G ocorre em indivíduos HIV positivos do sexo masculino. Neste trabalho, a amostra identificada como G foi também positiva para HIV e era de uma paciente do sexo feminino, dado raro na literatura científica. Conclusão: neste trabalho, foram identificados os genótipos mais frequentes, assim como uma cepa do genótipo G, rara entre os encontrados em nosso meio.

Objective: the aim of this study was to identify HBV genotypes in serum samples from patients from the state of São Paulo, received by the viral hepatitis laboratory, at the Virology Centre of Instituto Adolfo Lutz, from various municipalities. Methods: a total of 94 serum samples were randomly analyzed. Genotyping was performed using nested PCR for amplification of S and Pol regions from viral genome. Genotypes were identified comparing the sequences obtained with the sequences deposited in GenBank. Results: we were able to determine the genotype of 91 (97%) samples, as follows: genotype A (55.3%), D (32%), F (5.3%), C (3.2%) and G (1%). There are few data on the epidemiology of genotype G. This genotype has been detected in restricted areas around the world. Frequently, the genotype G infection occurs in HIV-positive male patients. In our case, the sample identified as G was also positive for HIV but in a female patient, which is an uncommon finding in the scientific literature. Conclusion: in this work, we identified the most frequent genotypes in São Paulo as well as the genotype G, rare among the genotypes found in our environment.

https://doi.org/10.1590/1806-9282.60.05.009 25315 downloads

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