Abstract Background: The presence of nucleated red blood cells (NRBCs) and increases in mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) in peripheral circulation are associated with poorer prognosis in patients with acute coronary disease. Objective: We developed a scoring system for in-hospital surveillance of all-cause mortality using hematological laboratory parameters in patients with acute myocardial infarction (AMI). Methods: Patients admitted for AMI were recruited in this prospective study. Exclusion criteria were age younger than 18 years, glucocorticoid therapy, cancer or hematological diseases and readmissions. NRBCs, MPV and NLR were measured during hospitalization. The scoring system was developed in three steps: first, the magnitude of the association of clinical and laboratory parameters with in-hospital mortality was measured by odds ratio (OR), second, a multivariate logistic regression model was conducted with all variables significantly (p < 0.05) associated with the outcome, and third, a β-coefficient was estimated by multivariate logistic regression with hematological parameters with a p < 0.05. Results: A total of 466 patients (mean age were 64.2 ± 12.8 years, 61.6% male) were included in this study. A hematological scoring system ranging from 0 to 49, where higher values were associated with higher risk of in-hospital death. The best performance was registered for a cut-off value of 26 with sensitivity of 89.1% and specificity of 67.2%, positive predictive value of 26.8% (95% CI: 0.204 - 0.332) and negative predictive value of 97.9% (95% CI: 0.962 - 0.996). The area under the curve for the scoring system was 0.868 (95% CI: 0.818 - 0.918). Conclusions: Here we propose a hematological scoring system for surveillance tool during hospitalization of patients with acute myocardial infarction. Based on total blood count parameters, the instrument can evaluate inflammation and hypoxemia due to in-hospital complications and, consequently, predict in-hospital mortality.

O biomonitoramento é uma técnica alternativa que utiliza organismos vivos para verificar mudanças no meio ambiente ocasionadas pela poluição da água, ar e solo. Tendo como foco as emissões atmosféricas localizadas na região da Fercal no Distrito Federal, o presente estudo objetivou coletar amostras de casca da árvore da espécie Myracrodruon urundeuva para verificar a variabilidade espacial dos elementos químicos presentes na área de estudo. A análise de componente principal (PCA) permitiu agrupar os elementos em três fatores, distribuídos no fator 1: Zn, Fe, Al, S e Ba; no fator 2: Cu, P, Ca e Sr; e no fator 3: Mg e K. O fator 1 é o que melhor descreve o objeto de pesquisa. Este estudo permitiu demonstrar a viabilidade do método de biomonitoramento com casca de aroeira vermelha (Myracrodruon urundeuva) como instrumento de mensuração da poluição atmosférica.

Biomonitoring is an alternative technique that uses living organisms to verify changes in the environment caused by pollution of water, air and soil. Focusing on atmospheric emissions at Fercal, located in the Federal District region, the present study aimed to collect samples of the bark of the species Myracrodruon urundeuva to verify the spatial variability of the chemical elements present in the study area. The principal component analysis (PCA) allowed to group the elements into three factors: factor 1: Zn, Fe, Al, S, and Ba; factor 2: Cu, P, Ca, and Sr; and factor 3: Mg and K. Factor 1 is the one that best describes the research object. This study has demonstrated the feasibility of the method of biomonitoring with the bark of aroeira vermelha (Myracrodruon urundeuva) as an instrument for measuring air pollution.