Pesquisa | SciELO

The synthesis, characterization, acute toxicity, antitumor activity, and histopathological analysis of a novel dinuclear platinum(2+) complex - [Pt(DACH-κ2N)µ-(C4H2O6-κ4O)Pt(DACH-κ2N)] - is reported. Through acute toxicity tests, it was possible to place the platinum complexes into categories according to the OECD protocol. The dinuclear complex was classified in category 2 (cisplatin - category 1; and oxaliplatin - category 2). Analyzing the interaction between dsDNA and dinuclear complex was observed an Tm increase, suggesting that the dinuclear complex-dsDNA interact probably through of the interstrand form. Evaluations of tumor masses extracted from mice inoculated with Ehrlich carcinoma demonstrated a percent of tumor inhibition similar for cisplatin and oxaliplatin, but statistically different and superior for the case of the dinuclear complex. Cisplatin and oxaliplatin showed 41.4 and 40.8% inhibition, respectively, while the dinuclear complex presented 66.3%. The histopathological analysis demonstrated that the group treated with cisplatin showed more significant tissue damage, moderate hepatic steatosis, and nephritis. The livers, spleens, and kidneys of the animals treated with the dinuclear complex were within the normality range with no tissue lesions, and absence of metastasis.

https://doi.org/10.21577/0100-4042.20230032

The nonsynaptic plasticity in Parkinson's disease: Insights from an animal model
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Viegas, Mônica P.C.

; Santos, Luiz E.C.

; Aarão, Mayra C.

; Cecilio, Samyra G.

; Medrado, Joana M.

; Pires, Arthur C.

; Rodrigues, Antônio M.

; Scorza, Carla A.

; Moret, Marcelo A.

; Finsterer, Josef

; Scorza, Fulvio A.

; Almeida, Antônio-Carlos G.

Clinics

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2023, Volume 78 elocation 100242

Resumo: En | Texto: En | PDF: En

Abstract Background The 6-OHDA nigro-striatal lesion model has already been related to disorders in the excitability and synchronicity of neural networks and variation in the expression of transmembrane proteins that control intra and extracellular ionic concentrations, such as cation-chloride cotransporters (NKCC1 and KCC2) and Na+/K+-ATPase and, also, to the glial proliferation after injury. All these non-synaptic mechanisms have already been related to neuronal injury and hyper-synchronism processes. Objective The main objective of this study is to verify whether mechanisms not directly related to synaptic neurotransmission could be involved in the modulation of nigrostriatal pathways. Methods Male Wistar rats, 3 months old, were submitted to a unilateral injection of 24 µg of 6-OHDA, in the striatum (n= 8). The animals in the Control group (n= 8) were submitted to the same protocol, with the replacement of 6-OHDA by 0.9% saline. The analysis by optical densitometry was performed to quantify the immunoreactivity intensity of GFAP, NKCC1, KCC2, Na+/K+-ATPase, TH and Cx36. Results The 6-OHDA induced lesions in the striatum, were not followed by changes in the expression cation-chloride cotransporters and Na+/K+-ATPase, but with astrocytic reactivity in the lesioned and adjacent regions of the nigrostriatal. Moreover, the dopaminergic degeneration caused by 6-OHDA is followed by changes in the expression of connexin-36. Conclusions The use of the GJ blockers directly along the nigrostriatal pathways to control PD motor symptoms is conjectured. Electrophysiology of the striatum and the substantia nigra, to verify changes in neuronal synchronism, comparing brain slices of control animals and experimental models of PD, is needed.

https://doi.org/10.1016/j.clinsp.2023.100242

An interdisciplinary therapy for lifestyle change is effective in improving psychological and inflammatory parameters in women with grade I obesity
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SOUZA, ADRIANA P. DE

; CARVALHO, LORENZA OLIVEIRA T.

; PEDROSO, AMANDA PAULA

; MORAES, AMANDA DE SANTOS

; CIPULLO, MARCOS ALBERTO TADDEO

; DÂMASO, ANA RAIMUNDA

; TELLES, MÔNICA M.

; OYAMA, LILA M.

; TASHIMA, ALEXANDRE K.

; CARANTI, DANIELLE A.

; RIBEIRO, ELIANE B.

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Supl. 2 elocation e20230365

Resumo: En | Texto: En | PDF: En

Abstract Obesity and depression, disorders associated with inflammation, have high incidences in women. Understanding the derangements present in the initial phase of obesity may point to factors that could help avoiding disease aggravation. The present study aimed at investigating the effects of a 6-months interdisciplinary therapy for weight loss in women with grade I obesity. Before and after the therapy, 37 middle-aged women donated blood and responded to questionnaires for depression and anxiety symptoms. Inflammatory parameters were evaluated in serum and a preliminary screening of the plasma proteome was performed. The therapy decreased anthropometric, psychological scores, and serum levels of inflammatory parameters. Depression and anxiety scores correlated positively with some inflammatory parameters. The proteomic analysis showed changes in proteins related to cholesterol metabolism and inflammatory response. Interdisciplinary therapy improves anthropometric and inflammatory statuses and ameliorating psychological symptoms. The decrease of MCP-1 levels after interdisciplinary therapy has not been reported so far, at the best of our knowledge. The present demonstration of positive associations of inflammatory markers and psychological scores indicate that these mediators may be useful to monitor psychological status in obesity. The present proteome data, although preliminary, pointed to plasma alterations indicative of improvement of inflammation after interdisciplinary therapy.

https://doi.org/10.1590/0001-3765202320230365

Antibacterial Profile in vitro and in vivo of New 1,4-Naphthoquinones Tethered to 1,2,3-1H-Triazoles Against the Planktonic Growth of Streptococcus mutans
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Gomes, Mônica P.

; Correia, Eduardo M.

; Gomes, Max W. L.

; Santos, Claudio C. C. dos

; Barros, Caroline S.

; Abreu, Fernanda V. de

; Antunes, Leonardo S.

; Ferreira, Vitor F.

; Gonçalves, Mariana C.

; Resende, Gabriel O. de

; Gonzaga, Daniel T. G.

; Pinto, Carla E. C.

; Paixão, Izabel C. N. P.

; Silva, Fernando C. da

Journal of the Brazilian Chemical Society

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Set 2022, Volume 33 Nº 9 Páginas 1028 - 1040

Resumo: En | Texto: En | PDF: En

The cariogenic processes are mainly caused by the bacterium Streptococcus mutans (S. mutans) and consist of the demineralization of the tooth that occurs when the acid production overcomes the natural repair or if a problem occurs in the last one. In this work, we performed the synthesis of twenty-one 1,4-naphthoquinones tethered to 1,2,3-1H-triazoles (8a-8k and 9a-9j), antibacterial evaluation against the S. mutans in vitro and the acute toxicity of the better ones in vivo. We observed strong inhibition results in the disc diffusion test ranging, the halos of inhibitions, from 18.66 (± 0.57) to 29 (± 2.64) mm, and good values in the minimum inhibitory concentration (5 to 50 μg), for the compounds 9e, 9h, 9i and 9j: Furthermore, they do not have a cytotoxic effect at the concentrations tested. Besides that, in the in vivo test, they show some slight alteration in the histopathological analyses and the biochemistry. Thus, we found four potential candidates to become instruments for the treatment of cavities.

https://doi.org/10.21577/0103-5053.20220014

ESTUDO DA ATIVIDADE ANTITUMORAL DE UM NOVO COMPLEXO DE RU3+: UMA PROPOSTA PARA O DESIGN DE METALOFÁRMACOS DE BAIXA TOXICIDADE
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Andrade, Maria Helena P. S. de

; Aguiar, Jaciana S.

; Silva, Teresinha G. da

; Santos, Jandyson M.

; Silva, Wagner E.

; Belian, Mônica F.

Química Nova

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Ago 2022, Volume 45 Nº 8 Páginas 906 - 912

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

In this article the synthesis, characterization, acute toxicity, and antitumor activity of the novel Ru3+ complex are described. Through the acute toxicity tests, it was possible to fit the complexes into categories according to the OECD protocol guideline 423. The cisplatin complex was classified in category 1 and the sodium diaquodimalonateruthenate(3+) - Na[Ru(H2O)2(Mal-κ2O)2] - was classified in category 4. This result demonstrates the lower toxicity achieved by the ruthenium complex in comparison with metallopharmaceuticals compound. Evaluations of tumor masses extracted from mice inoculated with Ehrlich ascites carcinoma demonstrated percent inhibition lowest to cisplatin. Cisplatin showed 58% inhibition (1 mg/kg), while Na[Ru(H2O)2(Mal-κ2O)2] complex (5 mg/kg) presented 77%.

https://doi.org/10.21577/0100-4042.20170886

Arteritis de takayasu. alternativas terapéuticas y pronóstico a largo plazo
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Santos, José M.

; Casabé, J. Horacio

; Fava, Carlos

; Godoy Armando, Casandra L.

; Perandones, Carlos E.

; Segura, Mónica

; Raffaelli, Héctor

; Favaloro, Roberto R.

Medicina (Buenos Aires)

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Fev 2022, Volume 82 Nº 1 Páginas 74 - 80

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract The aim of this study was to describe the long term prognosis of 34 patients with Takayasu arteritis and the results of surgi cal and endovascular treatment. A total of 5 central surgeries and 53 endovascular procedures were performed including 18 bypass surgeries (33.8%) and 35 angioplasties (66.2%). The median follow-up was 7.5 years, in terquartile range [IQR] 2.6-12.5. Among the 18 bypass surgeries 6 (33.3%) had events, while in the 35 patients with endovascular treatment there were 16 events (45.7%). The overall 1-, 3-, 5-, and 10-year death and arterial complication-free survival rates were 80% (95% CI between 74 and 89%), 68% (95% CI between 58 and 79%), 65% (95% CI between 54 and 76%) and 47% (95% CI between 41 and 62%). Both revascularization techniques were initially successful. In long term follow-up there was a high restenosis recurrence rate with endovascular treatment requiring repeated revascularization to the same vessel in 41% of the cases. Surgery had higher mor tality in patients with aortic and ascending aortic valve disease, combined coronary artery disease and carotid disease. In long term follow up Takayasu arteritis frequently requires revascularization and restenosis or new lesions are common. Surgical treatment had better results with less restenosis than angioplasty.

Resumen Se analizaron los resultados del tratamiento quirúrgico y endovascular a 7.5 años, rango intercuartilo (RIC) entre 2.6 y 12.5 años de seguimiento en 34 pacientes con arteritis de Takayasu. Se reali zaron en total 5 cirugías cardíacas centrales y 53 procedimientos vasculares,18 cirugías de bypass (33.9%) y 35 angioplastías (66.1%). Entre los 18 procedimientos quirúrgicos realizados, 6 (33.3%) presentaron eventos, mientras que en los 35 con intervención percutánea hubo 16 eventos (45.7%). La supervivencia actuarial y otras complicaciones vasculares (método de Kaplan y Meier) a 1,3,5 y 10 años fue: 80% (IC 95% entre 74 y 89%), 68% (IC 95% entre 58 y 79%), 65% (IC 95% entre 54 y 76%) y 47% (IC 95% entre 41 y 62%).Tanto la revascularización endovascular como la quirúrgica fueron inicialmente exitosas. En el seguimiento del tratamiento endovascular hubo una alta tasa de eventos con necesidad de revascularización repetida a un mismo vaso en el 41% de los casos. La cirugía tuvo mayor mortalidad en pacientes con valvulopatía aórtica, de aorta ascendente y enfermedad coronaria y carotidea combinada. La arteritis de Takayasu requiere frecuentemente revascularización debido a reestenosis y lesiones de novo. En su evolución alejada, el procedimiento quirúrgico ofreció mejores resultados con menor reestenosis.

85 downloads

Effect of parity segregation on Mycoplasma hyopneumoniae infection dynamics and pneumonic lesions in pigs
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Forner, Ricardo Augusto Neves

; Takeuti, Karine Ludwig

; Conti, Elisa Rigo De

; Santi, Monica

; Bortolozzo, Fernando Pandolfo

; Barcellos, David Emilio Santos Neves de

Ciência Rural

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2022, Volume 52 Nº 2 elocation e20210081

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: As leitoas consistem em um grupo de risco na transmissão vertical de Mycoplasma hyopneumoniae dentro do sistema de produção de suínos. Dessa forma, a segregação de partos poderia ser utilizada como alternativa para controlar as infecções por M. hyopneumoniae. O objetivo deste estudo foi avaliar o efeito da segregação de partos sobre a dinâmica de infecção de M. hyopneumoniae e a ocorrência e severidade das lesões pulmonares ao abate. Para isso três sistemas de produção de suínos com três sítios cada foram incluídos no estudo. A granja A consistia da unidade onde as leitoas tem o primeiro parto, ou seja, alojava somente de fêmeas de ordem de parto 1 (Granja OP1). Após o primeiro parto as fêmeas OP1 foram transferidas para a granja B (Granja OP2-6), ou seja, consistia de fêmeas de ordem de parto 2 a 6, e a granja C consistiu em uma granja convencional com reposição de leitoas (Granja OP1-6), com fêmeas de ordem de parto 1 a 6. Os leitões nascidos de cada granja foram transferidos e criados em creches e terminações segregadas. As matrizes (n = 33 (A), 37 (B), 34 (C)) de todas as granjas do estudo foram amostradas previamente ao parto e os leitões (n = 54 (A), 71 (B), 66 (C)) foram amostrados longitudinalmente aos 21, 63, 100 e 140 dias de idade e ao abate. Em todos os momentos de coleta, as amostras foram avaliadas por PCR para detecção de M. hyopneumoniae. As lesões pulmonares foram avaliadas e escores de lesão foram atribuídos ao abate. A prevalência de matrizes positivas para M. hyopneumoniae não diferiu entre as granjas (P > 0,05). A prevalência ao desmame foi maior na granja A (OP1) (P < 0,05). No entanto, dos 100 dias de idade até o abate a prevalência de leitões positivos para M. hyopneumoniae foi maior na granja B (OP2-6) (P < 0,05). A ocorrência e severidade de lesões pulmonares foram maiores na granja B. Os autores sugerem que a falta de uma aclimatação adequada das leitoas pode ter influenciado nos resultados, levando à detecção de matrizes positivas ao parto, independente da ordem de parto.

ABSTRACT: Gilts represent a group risk for Mycoplasma hyopneumoniae vertical transmission in swine herds. Therefore, parity segregation can be an alternative to control M. hyopneumoniae infections. The study evaluated the effect of parity segregation on M. hyopneumoniae infection dynamics and occurrence and severity of lung lesions at slaughter. For that, three multiple site herds were included in the study. Herd A consisted of the farm where gilts would have their first farrowing (parity order (PO) 1). After the first farrowing PO 1 sows were transferred to herd B (PO2-6). Herd C was a conventional herd with gilt replacement (PO1-6). Piglets born in each herd were raised in separated nursery and finishing units. Sows (n = 33 (A), 37 (B), 34 (C)) in all herds were sampled prior to farrowing and piglets (n = 54 (A), 71 (B), 66 (C)) were sampled longitudinally at 21, 63, 100, 140 days of age and at slaughter for M. hyopneumoniae detection by PCR and lung lesions scoring. M. hyopneumoniae prevalence in sows did not differ among herds. Prevalence of positive piglets was higher at weaning in the PO1 herd (A) (P < 0.05). However, prevalence of positive pigs from 100 days of age to slaughter age was higher in the PO2-6 herd (B) (P < 0.05). Lung lesion occurrence and severity were higher in herd B. The authors suggested that the lack of a proper gilt acclimation might have influenced the results, leading to sows being detected positive at farrowing, regardless of the parity.

https://doi.org/10.1590/0103-8478cr20210081 67 downloads

Guía de práctica clínica de la Sociedad Interamericana de Cardiología sobre prevención primaria de enfermedad cardiovascular en la mujer
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Sueldo, Mildren A. del

; Rivera, María A. Mendonça

; Sánchez-Zambrano, Martha B.

; Zilberman, Judith

; Múnera-Echeverri, Ana G.

; Paniagua, María

; Campos-Alcántara, Lourdes

; Almonte, Claudia

; Paix-Gonzales, Amalia

; Anchique-Santos, Claudia V.

; Coronel, Claudine J.

; Castillo, Gabriela

; Parra-Machuca, María G.

; Duro, Ivanna

; Varletta, Paola

; Delgado, Patricia

; Volberg, Verónica I.

; Puente-Barragán, Adriana C.

; Rodríguez, Adriana

; Rotta-Rotta, Aida

; Fernández, Anabela

; Izeta-Gutiérrez, Ana C.

; Ancona-Vadillo, Ana E.

; Aquieri, Analía

; Corrales, Andrea

; Simeone, Andrea

; Rubilar, Bibiana

; Artucio, Carolina

; Pimentel-Fernández, Carolina

; Marques-Santos, Celi

; Saldarriaga, Clara

; Chávez, Christian

; Cáceres, Cristina

; Ibarrola, Dahiana

; Barranco, Daniela

; Muñoz-Ortiz, Edison

; Ruiz-Gastelum, Edith D.

; Bianco, Eduardo

; Murguía, Elena

; Soto, Enrique

; Rodríguez-Caballero, Fabiola

; Otiniano-Costa, Fanny

; Valentino, Giovanna

; Rodríguez-Cermeño, Iris B.

; Rivera, Ivan R.

; Gándara-Ricardo, Jairo A.

; Velásquez-Penagos, Jesús A.

; Torales, Judith

; Scavenius, Karina

; Dueñas-Criado, Karen

; García, Laura

; Roballo, Laura

; Kazelian, Lucía R.

; Coussirat-Liendo, Macarena

; Costa-Almeida, María C.

; Drever, Mariana

; Lujambio, Mariela

; Castro, Marildes L.

; Rodríguez-Sifuentes, Maritza

; Acevedo, Mónica

; Giambruno, Mónica

; Ramírez, Mónica

; Gómez, Nancy

; Gutiérrez-Castillo, Narcisa

; Greatty, Onelia

; Harwicz, Paola

; Notaro, Patricia

; Falcón, Rocío

; López, Rosario

; Montefilpo, Sady

; Ramírez-Flores, Sara

; Verdugo, Silvina

; Murguía, Soledad

; Constantini, Sonia

; Vieira, Thais C.

; Michelis, Virginia

; Serra, César M.

Archivos de cardiología de México

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2022, Volume 92 Supl. 2 Páginas 1 - 68

Resumo: Es | Texto: Es | PDF: Es

https://doi.org/10.24875/acm.22000071 450 downloads

Guía de práctica clínica para el diagnóstico y el tratamiento de la otitis media aguda en niños
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Mayorga-Butrón, José L.

; Torre-González, Carlos de la

; Boronat-Echeverría, Nuria

; Aguirre-Mariscal, Héctor

; Montaño-Velázquez, Bertha B.

; Figueroa-Morales, Marco A.

; Aguilar-Gómez, Nancy E.

; Flores-Ruiz, Eric M.

; Solórzano-Santos, Fortino

; Gómez-Barreto, Demóstenes

; Moreno-Espinosa, Sarbelio

; González-Zamora, José F.

; Arredondo-García, José L.

; Xóchihua-Díaz, Luis

; Hernández-Porras, Marte

; Chavolla-Magaña, Rogelio

; Sánchez-Reyes, Blas

; Rodríguez-Carrasco, Carlos A.

; Greenawalt-Rodríguez, Sydney

; Cristerna-Tarrasa, Hernán

; Olvera-Salinas, Jorge

; Ávila-Iglesias, María C.

; Tinajero-Iriarte, Mónica G.

; Ramos-Zúñiga, José A.

; Montes-Narváez, Gabriel

Boletín médico del Hospital Infantil de México

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2022, Volume 79 Supl. 1 Páginas 1 - 31

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Background: Acute otitis media (AOM) is one of the most prevalent acute conditions in the pediatric population worldwide. This work aimed to elaborate a Clinical Practice Guideline with clinical recommendations systematically developed to assist decision-making of specialists, patients, caregivers, and public policymakers involved in managing patients with AOM in children. Methods: This document was developed by the College of Pediatric Otorhinolaryngology and Head, and Neck Surgery of Mexico (COPEME) in compliance with international standards. The SIGN quality of evidence classification was used. On behalf of the COPEME, the Guideline Development Group (GDG) was integrated, including otolaryngologists, infectologists, pediatricians, general practitioners, and methodologists with experience in systematic literature reviews and the development of clinical practice guidelines. Results: A consensus was reached on 18 clinical questions, covering what was previously established by the GDG in the scope document of the guidelines. Scientific evidence answering each of these clinical questions was identified and critically evaluated. The GDG agreed on the final wording of the clinical recommendations using the modified Delphi panel technique. Specialists and patient representatives conducted an external validation. Conclusions: This Clinical Practice Guideline presents clinical recommendations for the prevention, diagnosis, and management of AOM to assist shared decision-making among physicians, patients, and caregivers and improve the quality of clinical care.

Resumen Introducción: La otitis media aguda (OMA) es uno de los padecimientos agudos más prevalentes en la población pediátrica a escala global. El objetivo de este trabajo fue elaborar una guía de práctica clínica con recomendaciones para asistir la toma de decisiones de médicos especialistas, pacientes, cuidadores de pacientes y elaboradores de políticas públicas involucrados en el manejo de la OMA en niños. Métodos: El documento ha sido desarrollado por parte del Colegio de Otorrinolaringología y Cirugía de Cabeza y Cuello Pediátricas de México (COPEME) en cumplimiento con los estándares internacionales. Se empleó la clasificación de calidad de la evidencia de SIGN. En representación del COPEME, se integró el Grupo de Desarrollo de la Guía (GDG), que incluyó otorrinolaringólogos, infectólogos, pediatras, médicos generales y metodólogos con experiencia en revisiones sistemáticas de la literatura y el desarrollo de guías de práctica clínica. Resultados: Se consensuaron 18 preguntas clínicas que abarcaron lo establecido previamente por el GDG en el documento de alcances de la Guía. Se identificó la evidencia científica que responde a cada una de estas preguntas clínicas y se evaluó críticamente. El GDG acordó la redacción final de las recomendaciones clínicas mediante la técnica Delphi de panel. Se llevó a cabo una validación externa por colegas especialistas y representantes de pacientes. Conclusiones: En esta Guía de Práctica Clínica se presentan recomendaciones clínicas para la prevención, el diagnóstico y el manejo de la OMA, con el fin de asistir la toma de decisiones compartidas entre médicos, pacientes y cuidadores con la intención de contribuir a mejorar la calidad de la atención clínica.

https://doi.org/10.24875/bmhim.21000168

10.

Posicionamento Brasileiro sobre o Uso da Multimodalidade de Imagens na Cardio-Oncologia – 2021
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Melo, Marcelo Dantas Tavares de

; Paiva, Marcelo Goulart

; Santos, Maria Verônica Câmara

; Rochitte, Carlos Eduardo

; Moreira, Valéria de Melo

; Saleh, Mohamed Hassan

; Brandão, Simone Cristina Soares

; Gallafrio, Claudia Cosentino

; Goldwasser, Daniel

; Gripp, Eliza de Almeida

; Piveta, Rafael Bonafim

; Silva, Tonnison Oliveira

; Santo, Thais Harada Campos Espirito

; Ferreira, Waldinai Pereira

; Salemi, Vera Maria Cury

; Cauduro, Sanderson A.

; Barberato, Silvio Henrique

; Lopes, Heloísa M. Christovam

; Pena, José Luiz Barros

; Rached, Heron Rhydan Saad

; Miglioranza, Marcelo Haertel

; Pinheiro, Aurélio Carvalho

; Vrandecic, Bárbara Athayde Linhares Martins

; Cruz, Cecilia Beatriz Bittencourt Viana

; Nomura, César Higa

; Cerbino, Fernanda Mello Erthal

; Costa, Isabela Bispo Santos da Silva

; Coelho Filho, Otavio Rizzi

; Carneiro, Adriano Camargo de Castro

; Burgos, Ursula Maria Moreira Costa

; Fernandes, Juliano Lara

; Uellendahl, Marly

; Calado, Eveline Barros

; Senra, Tiago

; Assunção, Bruna Leal

; Freire, Claudia Maria Vilas

; Martins, Cristiane Nunes

; Sawamura, Karen Saori Shiraishi

; Brito, Márcio Miranda

; Jardim, Maria Fernanda Silva

; Bernardes, Renata Junqueira Moll

; Diógenes, Tereza Cristina

; Vieira, Lucas de Oliveira

; Mesquita, Claudio Tinoco

; Lopes, Rafael Willain

; Segundo Neto, Elry Medeiros Vieira

; Rigo, Letícia

; Marin, Valeska Leite Siqueira

; Santos, Marcelo José

; Grossman, Gabriel Blacher

; Quagliato, Priscila Cestari

; Alcantara, Monica Luiza de

; Teodoro, José Aldo Ribeiro

; Albricker, Ana Cristina Lopes

; Barros, Fanilda Souto

; Amaral, Salomon Israel do

; Porto, Carmen Lúcia Lascasas

; Barros, Marcio Vinícius Lins

; Santos, Simone Nascimento dos

; Cantisano, Armando Luís

; Petisco, Ana Cláudia Gomes Pereira

; Barbosa, José Eduardo Martins

; Veloso, Orlando Carlos Glória

; Spina, Salvador

; Pignatelli, Ricardo

; Hajjar, Ludhmilla Abrahão

; Kalil Filho, Roberto

; Lopes, Marcelo Antônio Cartaxo Queiroga

; Vieira, Marcelo Luiz Campos

; Almeida, André Luiz Cerqueira

Arquivos Brasileiros de Cardiologia

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Out 2021, Volume 117 Nº 4 Páginas 845 - 909

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20200266 103 downloads

11.

Main etiological agents identified in 170 men with urethritis attended at the Fundação Alfredo da Matta, Manaus, Amazonas, Brazil,
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de Souza, Lucilene Sales

; Sardinha, José Carlos

; Talhari, Sinésio

; Heibel, Marcel

; Santos, Mônica Nunes dos

; Talhari, Carolina

Anais Brasileiros de Dermatologia

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Mar 2021, Volume 96 Nº 2 Páginas 176 - 183

Resumo: En | Texto: En | PDF: En

Abstract Background: Sexually transmitted infections (STI) are a global public health problem. Urethritis are among the most common STIs, and can cause several complications and facilitate the transmission of the HIV virus. Objectives: To investigate the main etiologic agents of urethritis in 170 men treated at Fundação Alfredo da Matta. Methods: To identify the agents, urethral exudate and urine were collected. Gram and culture tests were performed in Thayer-Martin medium for Neisseria gonorrhoeae and polymerase chain reaction for Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis, Mycoplasma genitalium, and herpes simplex types 1 and 2. Results: N. gonorrhoeae were identified in 102 (60.0%) patients, C. trachomatis in 50 (29.4%), U. urealyticum in 29 (17.0%), M. genitalium in 11 (6.5 %), U. parvum in ten (5.9%), and M. hominis in seven (4.1%). Herpes simplex type 2 was diagnosed in 24 (21.6%) of the 111 patients who underwent PCR for this pathogen. In 69 cases there was co-infection; the most frequent were: N. gonorrhoeae and C. trachomatis in 21 (14.7%) patients; N. gonorrhoeae and C. trachomatis in 21 (12.4%) patients; N. gonorrhoeae and herpes simplex type 2 in 11 (6.5%), and N. gonorrhoeae and U. urealyticum in nine (5.3%). Study limitations: Not relevant. Conclusion: N. gonorrhoeae, C. trachomatis, U. urealyticum, and herpes simplex type 2 were the pathogens most frequently identified in the present study. The main coinfection found was N. gonorrhoeae and C. trachomatis. T. vaginalis and herpes simplex type 1 were not identified in any of the patients.

https://doi.org/10.1016/j.abd.2020.07.007 167 downloads

12.

Reaction of jaboticaba trees cv. ‘Sabará’ to the species of gall forming nematodes
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Marques, Mônica Lau Silva

; Jesus, Jéssica Maria Israel de

; Oliveira, Marcos Fernandes

; Texeira, Renato Andrade

; Santos, Patrícia Resplandes Rocha dos

; Santos, Gil Rodrigues dos

; Rocha, Mara Rúbia da

Summa Phytopathologica

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Dez 2020, Volume 46 Nº 4 Páginas 342 - 344

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO A fruticultura tropical e subtropical tem um papel relevante no cenário econômico do país, e vem sendo prejudicada pelo nematoide das galhas. A jabuticabeira é uma planta bastante cultivada no Brasil e entre os problemas da cultura, estão os nematoides do gênero Meloidogyne. Este trabalho objetivou avaliar a hospedabilidade da jabuticabeira cv. Sabará, em diferentes concentrações de inóculos de Meloidogyne incognita e Meloidogyne javanica. Os inóculos utilizados no experimento foram obtidos a partir de raízes de tomateiro cv. Santa Cruz. As jabuticabeiras foram submetidas à inoculação com as concentrações de 2000, 4000 e 8000 ovos + juvenis planta-1, para ambas as espécies dos nematoides. As plantas de jabuticaba cv. Sabará demonstraram resistência em relação ao desenvolvimento dos nematoides de galhas M. incognita e M. javanica com Fator de Reprodução (FR) <1.

ABSTRACT Tropical and subtropical fruit production plays an important role in the country’s economic scenario and has been affected by root-knot nematode. The jaboticaba tree is a plant widely cultivated in Brazil, and among the problems of the crop is the root-knot nematode of the genus Meloidogyne. This study aimed to evaluate the hostability of jaboticaba tree cv. ‘Sabará’, in different inoculum concentrations of Meloidogyne incognita and Meloidogyne javanica. The inoculum used in the experiment was obtained from the roots of tomato cv. ‘Santa Cruz’. Jaboticaba trees were subjected to inoculation with concentrations of 0, 2000, 4000, and 8000 eggs + juvenile plant-1, for both species of nematodes. The plants of jaboticaba cv. ‘Sabará’ showed resistance concerning the development of M. incognita and M. javanica root-knot nematode with Reproduction Factor (RF) <1.

https://doi.org/10.1590/0100-5405/189841 406 downloads

13.

COMPLEXOS DE PLATINA(II) CONJUGADO E ANÁLOGO A O-GLICOSÍDEOS: SÍNTESE, CARACTERIZAÇÃO ESTRUTURAL E ATIVIDADE ANTITUMORAL
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Lima, Lidiane M. A. de

; Santos, Mirelly D. F.

; Albuquerque, Leonardo S.

; Belian, Mônica F.

; Silva, Wagner E.

; R. F. Filho, João

; Santos, Jandyson M.

; Aguiar, Jaciana S.

; Silva, Teresinha G. da

Química Nova

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Jun 2020, Volume 43 Nº 6 Páginas 752 - 759

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

The synthesis, characterization, cytotoxicity and antitumor activity of platinum(II) complexes coordinated to O-glycoside and analogous is reported. Through the acute toxicity tests, it was possible to fit the complexes into categories according to the OECD protocol. The cis-[PtCl2(C6H14S2O2)-κ2S] complex was classified in category 3 and the cis-[PtCl2(C26H38O12S2)-κ2S] complex was classified in category 4. This result demonstrates the lower toxicity achieved by the glycoside in comparison with its analogous system. Evaluations of tumor masses extracted from mice inoculated with Ehrlich carcinoma demonstrated percent inhibition similar to cisplatin and synthesized platinum complexes. Cisplatin showed 59% inhibition, while cis-[PtCl2(C6H14S2O2)-κ2S] and cis-[PtCl2(C26H38O12S2)-κ2S] complexes presented 57% and 59%, respectively. Although the glycosidic compounds exhibit tumor activity, reported in the literature, the presence of platinum ion was shown to be determinant for antitumor action according with the compounds tested, since the glycosidic ligand presented tumor inhibition of only 38%, with a similar antitumor activity in relation to cisplatin.

https://doi.org/10.21577/0100-4042.20170546 390 downloads

14.

Direct Analysis of Human Hair Before and After Cosmetic Modification Using a Recent Data Fusion Method
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Santos, Mônica C.

; Pereira, Fabíola M. V.

Journal of the Brazilian Chemical Society

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Jan 2020, Volume 31 Nº 1 Páginas 33 - 39

Resumo: En | Texto: En | PDF: En

The cosmetic modification of hair is a very common procedure used to mask or cover evidence at a crime scene. Deoxyribonucleic acid (DNA) tests are expensive and require good-quality collection of samples and a database profile. To overcome these challenges, direct analysis was performed on a large set of hair strands collected from individuals, denoted original samples, and the data were compared with those of the same samples after cosmetic modification performed by bleaching the samples in the laboratory. A total of 127 samples were evaluated in this study using two analytical techniques, wavelength-dispersive X-ray fluorescence (WDXRF) and laser-induced breakdown spectroscopy (LIBS). Instead of testing many algorithms to develop classification models for the original and bleached samples, a recent method was applied that combines information from 17 classifiers. Data fusion was also evaluated to improve the accuracy of the classification model, which was higher than 99.2%, with no requirements to select eigenvectors or thresholds.

https://doi.org/10.21577/0103-5053.20190121 488 downloads

15.

ADDITION OF BOILER CHARCOAL WASTE TO COMPOST FOR USE AS SUBSTRATE FOR VEGETABLE SEEDLINGS
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Lorin, Higor E. F.

; Costa, Mônica S. S. de M.

; Chiarelotto, Maico

; Santos, Francielly T. dos

; Costa, Luiz A. de M.

Engenharia Agrícola

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Dez 2019, Volume 39 Nº 6 Páginas 753 - 762

Resumo: En | Texto: En | PDF: En

ABSTRACT The recovery of waste from the broiler production chain (BPC) is consistent with the principles of a circular economy. Besides turning waste into organic compost, its use as substrate for the production of vegetable seedlings further increases its economic value. However, it is necessary to adapt its characteristics to enable its use as substrate. To this end, the addition of boiler remnant charcoal wastes (BCW), another type of waste generated in the BPC, to the organic compost resulting from the composting of BPC waste with different bulking agents (BAs) was studied. The addition of BCW to agro-industrial compost reduced the electrical conductivity (EC) of substrates. Multiple linear regression showed that, of the 13 variables (physical, chemical and physicochemical) studied, three (EC, pH and N content) are sufficient to explain the seedling quality index (SQI). Simple nonlinear regression showed that, in order to achieve higher SQIs and easier removal of clod from tray, an additional 30% in weight of BCW is required for compost, using urban tree pruning, wood sawdust and sugarcane bagasse BAs. The use of cotton and Napier grass waste as BAs is not recommended for BPC waste mixtures, as they cause a large increase in substrate EC.

https://doi.org/10.1590/1809-4430-eng.agric.v39n6p753-762/2019 815 downloads

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