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ABSTRACT Patients undergoing hematopoietic stem cell transplantation (HSCT) might present acute and late toxicities and the oral tissues are frequently affected. With the survival increasing, patients show late and long-term morbidities, and there is an important association between the general and the oral health. The first and second parts of this Consensus have showed the importance of the adequacy of oral health in the pre-HSCT, and the main alterations and oral care during the period of admission for HSCT. This third part aims to review specific themes of post-HSCT dental care, such as graft-versus-host disease (GVHD) and the pediatric patient. It also aims to review pertinent subjects, both during the HSCT period and post-HSCT, concerning quality of life, pain, cost-effectiveness, and remote care. Based on this review, it is evident the importance of the work of the dental surgeon (DS) in the follow-up and treatment of the HSCT patient, always collaborating with the whole multidisciplinary team.

https://doi.org/10.1016/j.htct.2023.04.004

Dental consensus on HSCT – Part II: dental Care during HSCT
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Gobbi, Marcella Ferreira

; Ferreira, Mariana Henriques

; Carvalho, Danielle Lima Corrêa de

; Silva, Geisa Badauy Lauria

; Macari, Karina Silva Moreira

; Neves, Lilian de Jesus

; Santos, Paulo Sérgio da Silva

; Soares Junior, Luiz Alberto Valente

; Melo, Walmyr Ribeiro

; Antunes, Héliton Spíndola

; Macedo, Leandro Dorigan De

; Eduardo, Fernanda de Paula

; Bezinelli, Leticia Mello

Hematology, Transfusion and Cell Therapy

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Set 2023, Volume 45 Nº 3 Páginas 368 - 378

Resumo: En | Texto: En | PDF: En

ABSTRACT During the state of immune vulnerability in hematopoietic stem cell transplantation (HSCT), the patient has an increased risk of developing a vast number of complications, including severe problems in the oral cavity. These situations require professional oral care to act in the diagnosis and treatment of these conditions, as well as to develop prevention protocols to minimize patient's complications. Oral mucositis, opportunistic infections, bleeding, specific microbiota, taste, and salivary alterations are complications that can occur during HSCT and interfere with various aspects, such as pain control, oral intake, nutrition, bacteremia and sepsis, days of hospitalization and morbidity. Several guidelines have been published to address the role of professional oral care during the HSCT, we describe a consensus regarding these recommendations.

https://doi.org/10.1016/j.htct.2023.04.003

Brazilian dental consensus on dental management in hematopoietic stem cell transplantation−Part I−pre-HSCT
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Correa, Maria Elvira Pizzigati

; Granzotto, Fabiana Caramori Noal

; Innocentini, Lara Maria Alencar Ramos

; Reis, Thiago de Carvalho

; Lima, Emilze Mafra de

; Varanda, Renata de Freitas

; Santos, Paulo Sérgio da Silva

; Soares Junior, Luiz Alberto Valente

; Bezinelli, Leticia Mello

; Eduardo, Fernanda de Paula

; Melo, Walmyr Ribeiro

; Antunes, Héliton Spíndola

; Macedo, Leandro Dorigan De

Hematology, Transfusion and Cell Therapy

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Set 2023, Volume 45 Nº 3 Páginas 358 - 367

Resumo: En | Texto: En | PDF: En

ABSTRACT The oral involvement in the Hematopoietic Stem Cell Transplantation is well described in the literature. The goal of the dental treatment and management of the oral lesions related to the HSCT is to reduce the harm caused by preexisting oral infection or even the worsening of oral acute/chronic GVHD and late effects. The aim of this guideline was to discuss the dental management of patients subjected to HSCT, considering three phases of the HSCT: pre-HSCT, acute phase, and late phase. The literature published from 2010 to 2020 was reviewed in order to identify dental interventions in this patient population. The selected papers were divided into three groups: pre-HSCT, acute and late, and were reviewed by the SBTMO Dental Committee's members. When necessary, an expertise opinion was considered for better translating the guideline recommendations to our population dental characteristics. This manuscript focused on the pre-HSCT dental management. The objective of the pre-HSCT dental management is to identify possible dental situations that On behalf of the Dental Committee of the Brazilian Society of Gene Therapy and Bone Marrow Transplantation (SBTMO) can worsening during the acute phase after the HSCT. Each guideline recommendations were made considering the Dentistry Specialties. The clinical consensus on dental management prior to HSCT provides professional health caregivers with clinical setting-specific information to help with the management of dental problems in patients to be subjected to HSCT.

https://doi.org/10.1016/j.htct.2023.04.001

Brazilian experts' consensus on the treatment of infantile epileptic spasm syndrome in infants
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Sampaio, Letícia Pereira de Brito

; Henriques-Souza, Adélia Maria de Miranda

; Silveira, Mariana Ribeiro Marcondes da

; Seguti, Lisiane

; Santos, Mara Lúcia Schmitz Ferreira

; Montenegro, Maria Augusta

; Antoniuk, Sérgio

; Manreza, Maria Luíza Giraldes de

Arquivos de Neuro-Psiquiatria

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Set 2023, Volume 81 Nº 9 Páginas 844 - 856

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Background Infantile epileptic spasms syndrome (IESS) is a rare but severe condition affecting children early and is usually secondary to an identifiable brain disorder. It is related to psychomotor deterioration in childhood and epilepsy in adult life. Treatment is challenging as infantile spasms may not respond to most antiseizure medication, and relapse is frequent. Objective To evaluate the literature regarding treatment of IESS and provide a practical guidance to a healthcare system with limited resources. Methods An expert committee from the Brazilian Society of Child Neurology reviewed and discussed relevant scientific evidence in the treatment of IESS regarding the drugs available in Brazil. Results Oral prednisolone and vigabatrin are the most common drugs used as first-line therapy; they are efficient and affordable therapy as both are available in the Brazilian unified health system (SUS, in the Portuguese acronym). Intramuscular adrenocorticotropic hormone (ACTH) presents similar efficacy as oral prednisolone but has a higher cost and is not available in Brazil. Other antiseizure medications such as topiramate, levetiracetam, or benzodiazepines have limited response and are prescribed as adjuvant therapy. If the health service has nutritionists, a ketogenic diet should be implemented for those not responding to hormonal and vigabatrin treatment. Epilepsy surgery is mainly indicated for patients with focal lesions that do not respond to pharmacological therapy. Conclusion Early treatment of IESS with efficient drugs is feasible in our country. Using standard protocols increases the odds of achieving complete cessation in a shorter time and decreases relapse.

Resumo Antecedentes A síndrome do espasmo epiléptico infantil (IESS) é uma condição rara, mas grave, que afeta crianças precocemente e geralmente é secundária a um distúrbio cerebral identificável, estando relacionada a deterioração psicomotora na infância e a epilepsia na vida adulta. O tratamento é desafiador, pois os espasmos infantis podem não responder à maioria dos medicamentos anticrises e as recidivas são frequentes. Objetivo Avaliar a literatura sobre o tratamento de IESS e fornecer uma orientação prática para um sistema de saúde com recursos limitados. Métodos Um comitê de especialistas da Sociedade Brasileira de Neurologia Infantil revisou e discutiu evidências científicas relevantes no tratamento da IESS em relação aos medicamentos disponíveis no Brasil. Resultados Prednisolona oral e vigabatrina são os fármacos mais comumente usados como terapia de primeira linha; são eficientes e acessíveis, já que ambos estão disponíveis no sistema único de saúde brasileiro (SUS). O ACTH intramuscular apresenta eficácia semelhante à prednisolona oral, mas tem custo mais elevado e não está disponível no Brasil. Outros medicamentos anticonvulsivos, como topiramato, levetiracetam ou benzodiazepínicos, têm resposta limitada e são prescritos como terapia adjuvante. Se o serviço de saúde tiver nutricionista, deve-se implementar dieta cetogênica para aqueles que não respondem ao tratamento hormonal e vigabatrina. A cirurgia de epilepsia é indicada principalmente para pacientes com lesões focais que não respondem à terapia farmacológica. Conclusão O tratamento precoce da IESS com fármacos eficazes é factível em nosso meio. O uso de protocolos padronizados aumenta as chances de alcançar a cessação completa em um tempo menor e diminui a recaída.

https://doi.org/10.1055/s-0043-1772835

Production of highly soluble foliar fertilizer in a spouted bed dryer
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Stoppe, Ana Carolina Ribeiro

; Luz, Mario Sérgio da

; Vieira Neto, José Luiz

; Santos, Kássia Graciele dos

Ciência e Agrotecnologia

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2023, Volume 47 elocation e000523

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT The drying process can be useful to change the particulate structure, improving the powder solubility. In this study, we investigated the drying of foliar fertilizer in a spouted bed using polyethylene pellets as inert particles to improve its solubility. A 23 factorial experimental design was used to evaluate how the powder yield and moisture were affected by the feeding time, intermittency time, and feed atomizer position. The spouting instability caused powder retention on the bed wall, which decreased the powder recovery efficiency by 2.3-26.6%. Although the powder recovery efficiency was low, the solubility time was reduced by 5.9 times, probably due to particle agglomeration, which increased the amorphous phase of the fertilizer. Design alterations, suggested by the CFD data, can increase spouted bed stability and facilitate centralized spouting. Based on this, the spouted bed drying technique was applied, and it effectively increased the solubility of commercial fertilizer, thus, incorporating more desirable characteristics for field applications.

RESUMO O processo de secagem pode alterar a estrutura de sólidos, aumentando a solubilidade de pós. Este trabalho investigou a secagem de um fertilizante foliar em leito de jorro, empregando pellets de polietileno como sólido inerte, a fim de aumentar sua solubilidade. Utilizou-se um planejamento fatorial 23 para avaliar como a produtividade de pó e sua umidade foram influenciados pelo tempo de alimentação, tempo de intermitência a posição do bico atomizador dentro do leito. A instabilidade do jorro, causou a retenção de pó nas paredes do leito, o que conduziu a baixas eficiências de recuperação de pó (2,3 a 26,6%). Foram propostas alterações na geometria do leito, baseadas nas simulações CFD, a fim de aumentar a estabilidade do leito e centralização da fonte. Apesar da baixa produção de pó, a solubilidade foi reduzida em 5,9 vezes, provavelmente devido à aglomeração e aumento da fase amorfa na estrutura do pó. Assim, a secagem em leito de jorro foi efetiva em aumentar a solubilidade do fertilizante, incorporando uma característica atrativa à sua aplicação nas lavouras.

https://doi.org/10.1590/1413-7054202347000523

Herd-level based seroprevalence and associated factors for Toxoplasma gondii in cows in the state of Paraíba, Northeastern Brazil
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Maia, Amanda Rafaela Alves

; Bezerra, Roberto Alves

; Silva, Samara Santos

; Álvares, Felipe Boniedj Ventura

; Santos, Carolina de Sousa Américo Batista

; Alves, Clebert José

; Clementino, Inácio José

; Feitosa, Thais Ferreira

; Vilela, Vinícius Longo Ribeiro

; Azevedo, Sérgio Santos de

Revista Brasileira de Parasitologia Veterinária

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2023, Volume 32 Nº 2 elocation e017222

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract We aimed to determine the herd and animal levels seroprevalence and associated factors for Toxoplasma gondii infections in cattle from the state of Paraíba, Northeastern Brazil. Herds (n = 434) and cows aged ≥ 24 months (n = 1,895) were randomly selected, and serum samples were tested with the immunofluorescence antibody test (IFAT) using as cutoff of 64. Of the 434 farms investigated, 197 had at least one seropositive cow (prevalence of 49.0%; 95% CI = 44.3%-53.8%), and the prevalence at animal level was 18.0% (95% CI = 5.3%-21.1%). The antibody titers ranged from 64 to 1024, with the most frequent titers being 64 (10.8%) and 128 (3.7%). The risk factors identified were property located in Sertão region (odds ratio [OR] = 3.07), property located in Agreste/Zona da Mata regions (OR = 2.00), animal purchasing (OR = 2.68), herd size of 34-111 animals (OR = 2.91) and herd size > 111 animals (OR = 6.97). The results suggest the wide distribution of T. gondii infections in cattle throughout the state of Paraíba, and the risk factors identified are not possible to correct.

Resumo Objetivou-se determinar a soroprevalência do rebanhos e de animais e os fatores associados à infecção por Toxoplasma gondii em bovinos do estado da Paraíba, Nordeste do Brasil. Rebanhos (n = 434) e vacas com idade ≥ 24 meses (n = 1.895) foram selecionados aleatoriamente, e as amostras de soro foram testadas com o teste de imunofluorescência (RIFI), usando-se como ponto de corte 64. Das 434 fazendas investigadas, 197 tiveram pelo menos uma vaca soropositiva (prevalência de 49%; IC 95% = 44,3%-53,8%), e a prevalência em nível de animais foi de 18% (IC 95% = 5,3%-21,1%). Os títulos de anticorpos variaram de 64 a 1024, sendo os títulos mais frequentes 64 (10,8%) e 128 (3,7%). Os fatores de risco identificados foram na propriedade localizada na região do Sertão ("odds ratio" [OR] = 3,07), na propriedade localizada na região do Agreste/Zona da Mata (OR = 2,00), na compra de animais (OR = 2,68), no tamanho do rebanho de 34-111 animais (OR = 2,91) e no tamanho do rebanho > 111 animais (OR = 6,97). Os resultados sugerem a ampla distribuição de infecções por T. gondii em bovinos em todo o estado da Paraíba, e os fatores de risco identificados não são passíveis de correção.

https://doi.org/10.1590/s1984-29612023025

Salubridade ambiental: conceituação e aplicabilidade
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Braga, Débora de Lima

; Santos, Silene Lima Dourado Ximenes

; Bezerra, Nolan Ribeiro

; Bernardino, Tales Emanuel Silva

; Moraes, Luiz Roberto Santos

; Moraes, Valmir de

; Piza, Francisco José de Toledo

; Teixeira, Diogo Araújo

; Scalize, Paulo Sergio

Engenharia Sanitaria e Ambiental

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Jun 2022, Volume 27 Nº 3 Páginas 457 - 464

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O entendimento da terminologia “salubridade” tem raízes na saúde social e pública e, desde então, vem sendo utilizado na literatura e em políticas públicas e sociais com o intuito de promover ações conjuntas em saúde pública e questões ambientais. Entretanto, o termo tem sido apresentado com conceitos diferentes em diversos estudos publicados no Brasil. Diante desse cenário, os objetivos deste artigo foram apresentar subsídios teóricos e práticos para a proposição de um conceito de salubridade ambiental e relatar a experiência referente a sua elaboração. Para isso, a metodologia foi realizada em duas etapas: i) revisão sistemática sobre a aplicação do termo salubridade e a evolução do conceito de salubridade ambiental; e ii) proposição do conceito de salubridade ambiental por meio de especialistas. A revisão sistemática resultou em 999 publicações do período entre 1670 e 2021, das quais apenas 12 apresentaram a definição de forma explícita, utilizando seis conceituações diferentes. A discussão dos especialistas culminou com uma definição básica de salubridade ambiental, que pode ser ampliada para cada área de estudo quando necessário. Assim, a presente pesquisa contribuiu para evidenciar a amplitude do termo salubridade e possibilitou a elaboração de um conceito de salubridade ambiental. Destaca-se que o conceito de salubridade tende a uma constante construção social e, por isso, há necessidade de discussões adicionais acerca de sua utilização.

ABSTRACT The understanding of the term “salubrity” has its roots in social and public health and has since been used in the literature and in public and social policies with the aim of promoting joint actions in public health and environmental issues. However, the term environmental health has been presented with different concepts in several studies published in Brazil. Given this scenario, the objective of this article was to present theoretical and practical subsidies for the proposition of a concept of environmental health and to report the experience regarding its elaboration. For this, the methodology was carried out in two stages: i) systematic review of the application of the term salubrity and the evolution of the concept of environmental healthiness; and ii) proposition of the concept of environmental health by experts. The systematic review resulted in 999 publications, from the period between 1670 and 2021, of which only 12 publications presented the definition explicitly using 6 different concepts. The experts’ discussion culminated in a basic definition of environmental health, which can be extended to each area of study, when necessary. Thus, this research contributed to highlighting the breadth of the salubrity terminology and enabled the elaboration of a concept of Environmental Health. It is noteworthy that the concept of salubrity tends to a constant social construction and, therefore, there is a need for additional discussions about its use.

https://doi.org/10.1590/s1413-415220210294

Influence of clinical factors, IL4 and IL6 genes polymorphisms in functional healing in late replantation
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Roskamp, Liliane

; Souza, Cleber Machado

; Ignácio, Sergio Aparecido

; Perin, Camila Paiva

; Mattos, Natanael Henrique Ribeiro

; Sunye, Isabela Roskamp

; Santos, Letícia Capote

; Westphalen, Vania Portela Ditzel

; Jacob, Carolina da Silveira

; Baratto-Filho, Flares

Brazilian Dental Journal

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Fev 2022, Volume 33 Nº 1 Páginas 13 - 21

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Para investigar a influência genética em uma amostra de dentes reimplantados, é necessário observar os fenótipos extremos, como os dentes que sofreram cura funcional e os extraídos devido à reabsorção radicular externa severa. Assim, este estudo teve como objetivo investigar a associação da idade dos pacientes, desenvolvimento radicular dos dentes, assim como o meio de transporte até o reimplante e polimorfismos nos genes da interleucina 4 (IL4) e da interleucina 6 (IL6) com dentes que apresentaram cura funcional ou extração, em um grupo cujas técnicas de reimplante não seguiu a International Association of Dental Traumatology (IADT) 2012. Foram incluídos 43 dentes avulsionados e reimplantados que não seguiram as diretrizes do IADT, e tiveram cura funcional ou foram extraídos. As radiografias periapicais utilizadas para este estudo foram feitas logo após o reimplante dentário e após 1 ano. Para a análise genotípica dos genes IL4 e IL6, foi extraído DNA de células da mucosa oral. PCR em tempo real realizou a análise dos polimorfismos dos genes. As variáveis clínicas e genéticas foram analisadas pelos testes Qui-quadrado e “Z”. Valores de p <0,05 foram considerados significativos. Os resultados mostraram que a cura ou perda dos dentes está associada ao meio de armazenamento e polimorfismos no gene rs2243268 da IL-4. Como conclusão, o alelo C rs2243268 do gene IL4 pode ter uma relação positiva com a cura functional do dente reimplantado. Manter o dente seco está associado a uma perda rápida de dentes avulsionados e reimplantados que não seguiram o IADT 2012.

Abstract To investigate the genetic association in a sample of replanted teeth, it is necessary to observe the extreme phenotypes, such as, teeth that underwent functional healing and those extracted due to severe external root resorption. Thus, this study aimed to investigate the association of age of the patients, root development, storage media, and polymorphisms in the interleukin 4 (IL4) and interleukin 6 (IL6) genes with teeth that presented extreme outcomes, as functional healing or extraction, in a group whose replantation techniques did not follow the International Association of Dental Traumatology (IADT) 2012 guidelines. Forty-three avulsed and replanted teeth that did not follow IADT 2012 guidelines and underwent functional healing or were extracted were included. Periapical radiographs employed for this study were taken soon after tooth replantation and after 1 year. For genotypic IL4 and IL6 genes analysis, DNA of oral mucosa cells was extracted. Real-time- PCR performed for genotyping polymorphisms in IL4 and IL6 genes. Clinical and genetic variables were analyzed by the Chi-square test and the “Z” test. P values < .05 were considered significant. The results showed that functional healing and extraction were associated with storage media and with the rs2243268 of IL- 4 gene polymorphisms. As conclusion, the C rs2243268 allele of IL4 gene may have a positive relationship with functional healing teeth that were replanted not following the 2012 IADT guidelines. Keeping the tooth dry is associated to a fast loss of avulsed and replanted teeth after 1-year follow-up.

https://doi.org/10.1590/0103-6440202204683

The Influence of the Shoe over the Medial Foot Arch and the Lower Limbs Kinematics in Toddlers
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Okai-Nobrega, Liria Akie

; Santos, Thiago Ribeiro Teles

; Lage, Ana Paula

; Araújo, Priscila Albuquerque de

; Souza, Thales Rezende de

; Fonseca, Sérgio Teixeira

Revista Brasileira de Ortopedia

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Jan 2022, Volume 57 Nº 1 Páginas 167 - 174

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Avaliar o comportamento do arco longitudinal medial do pé (ALM) e os parâmetros cinemáticos dos membros inferiores durante a deambulação com calçados biomiméticos (CBs) e não biomiméticos (NB1, NB2, NB3 e NB4) em crianças no início da fase de aquisição da marcha. Métodos Foram avaliadas quatro crianças no início da fase de aquisição da marcha nas seguintes condições: andar descalço, andar com CBs e calçados NB1, NB2, NB3 e NB4 em solo plano. O calçado biomimético é descrito como biomimético por emular pisos naturais e irregulares por meio de uma palmilha interna dinâmica. O ALM e a cinemática do quadril, joelho e tornozelo durante a marcha foram avaliados por meio de sistema de análise do movimento tridimensional. A similaridade entre as curvas cinemáticas das condições descalça e com calçado foi analisada por meio do cálculo de root mean square error (RMSE). Resultados O CB foi o que apresentou maior magnitude do ALM e maior diferença do ALM em relação à condição descalça (maior RMSE). O CB apresentou ainda menor diferença na cinemática das articulações do joelho e tornozelo durante a marcha quando comparado à condição descalça (menor RMSE). O calçado NB2 apresentou a cinemática do quadril mais semelhante à condição descalça (menor RMSE). Conclusão Os calçados CB e NB2 que apresentam a região do antepé mais larga geraram menores diferenças na cinemática dos membros inferiores. Além disso, o ALM foi maior no CB provavelmente devido a seu design ser diferente daquele dos demais calçados.

Abstract Objective To evaluate the biomechanical behavior of the medial longitudinal arch (MLA) of the foot and the kinematic parameters of the lower limbs with biomimetic footwear (BF) and non-biomimetic (NB1, NB2, NB3 and NB4) footwear in children at the beginning of the gait acquisition phase. Methods Four toddlers were evaluated at the beginning of the gait acquisition phase under the following conditions: walking barefoot, ambulation with BF and NB1, NB2, NB3 and NB4 footwear in hard floor. BF is described as biomimetic because of its property of emulating natural and irregular floors through a dynamic internal insole. The MLA and kinematics of the hip, knee, and ankle during gait were evaluated by three-dimensional motion analysis system. The similarity between the kinematic curves of barefoot and footwear conditions was analyzed by root mean square error (RMSE). Results The use of BF presented the highest magnitude of MLA and the greatest difference in relation to barefoot condition (higher RMSE). The BF showed less difference in the kinematics of the knee and ankle joints during gait when compared to barefoot condition (lower RMSE). NB2 footwear presented hip kinematics more similar to barefoot condition (lower RMSE). Conclusion Biomimetics footwear and NB2 shoes (both with wider forefoot region) generated smaller differences in lower limbs compared to barefoot. In addition, the MLA was higher in the BF, probably because different design from other shoes.

https://doi.org/10.1055/s-0041-1741021

10.

Combining disease resistance and postharvest quality traits by early marker-assisted backcrossing in carioca beans
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Paulino, Jean Fausto de Carvalho

; Almeida, Caléo Panhoca de

; Santos, Isabella Laporte

; Gonçalves, João Guilherme Ribeiro

; Carbonell, Sérgio Augusto Morais

; Chiorato, Alisson Fernando

; Benchimol-Reis, Luciana Lasry

Scientia Agricola

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2022, Volume 79 Nº 2 elocation e20200233

Resumo: En | Texto: En | PDF: En

ABSTRACT: Common bean is a worldwide important crop. The development of varieties with durable resistance to diseases is a major challenge in common bean breeding. The present study aimed at evaluating the phenotypic and molecular selection of anthracnose resistance in a population obtained by assisted backcrossing from IAC Formoso (resistant, donor parent) × BRS Pérola (susceptible, recurrent parent). Nine microsatellites (SSRs) and one Sequence Tagged Sites (STS) markers previously linked to ANT resistance were used to genotype this progeny, and the results showed that the selection of the genotypes closest to the donor parent in the BC1F1 population decreased the number of backcrossing cycles necessary to obtain advanced isogenic lines, potentiating the use of this tool for early selection of resistant cultivars. A total of 31 % of the BC1F1 progeny was selected and backcrossed again. The progeny derived from the second backcross (BC2F3) was selected for the Carioca grain ideotype, and 42 % of the genotypes showed high resistance to anthracnose under controlled conditions of infection for races 65 and 81. Superior resistant plants were selected and evaluated under natural conditions of infection to fusarium wilt and angular leaf spot, allowing the selection of two inbred lines with higher resistance to anthracnose, fusarium wilt, angular leaf spot and postharvest quality traits such as yield, 100 seed weight, L value at seed harvest grain darkening and cooking time. The approach outlined in this paper proved to be effective to simultaneously select for disease resistance without losing technological quality aspects of the bean.

https://doi.org/10.1590/1678-992x-2020-0233 260 downloads

11.

Aggregation and spatio-temporal dynamics of fruit flies (Diptera, Tephritidae) in papaya orchards associated with different area delimitations in Brazil
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Araujo, Mayara Ribeiro de

; Martins, David dos Santos

; Fornazier, Maurício José

; Uramoto, Keiko

; Ferreira, Paulo Sérgio Fiuza

; Zucchi, Roberto Antonio

; Godoy, Wesley Augusto Conde

Acta Scientiarum. Agronomy

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2022, Volume 44 elocation e53466

Resumo: En | Texto: En | PDF: En

ABSTRACT. We investigated aggregation patterns in three fruit fly species economically important in Brazil, namely Ceratitis capitata, Anastrepha fraterculus, and A. obliqua. The study was carried out in a buffer zone and two neighbourhoods by comparing two-time series associated with the management strategy of fruit flies (systems approach). The abundance of these three species significantly decreased over the years with a negative binomial regression model describing the relationship between abundance and time in the entire area, buffer zone, and their neighbourhoods. In addition, the negative binomial model was also well fitted to the frequency distribution data of fruit flies in all analyzed scenarios. Anastrepha obliqua showed the highest aggregation degree, considering both the entire area and time series. A. fraterculus exhibited the lowest aggregation level, and C. capitata showed an intermediate degree. The buffer zone exhibited the highest aggregation degree for all species, and neighbourhood 2 exhibited the lowest aggregation degree. The aggregation degree was higher in the time series impacted by the systems approach than the series in the first years of its implementation.

https://doi.org/10.4025/actasciagron.v44i1.53466

12.

Recreational angling and related conflicts in a disturbed estuarine environment of the Southwest Atlantic
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Belruss, Carlos Gonçalves

; Tutui, Sergio Luis dos Santos

; Tomás, Acácio Ribeiro Gomes

Ocean and Coastal Research

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2022, Volume 70 elocation e22014

Resumo: En | Texto: En | PDF: En

Abstract We assessed the angling conducted in the Santos estuarine area (southeastern Brazil) between September 2012 and November 2013. The results, based on 189 interviews conducted in 38 different fishing locations, showed that shore-based anglers were predominantly residents (78%) and spent US$23 per fishing day. However, 61% of the onboard anglers were from the São Paulo metropolitan area and spent around US$100 per fishing day, generating a potentially important economic impact. Only two of the 15 variables analyzed showed no significant differences between the anglers' categories. According to the anglers' perception the possible pressure on the fishery resources and conflicts regarding resource use and areas in the face of port and industrial activities, urbanization, lack of security, as well as the anglers' time of experience, should be considered in any management measures to be proposed.

https://doi.org/10.1590/2675-2824070.21085cgb

13.

Brazilian guidelines for the treatment of outpatients with suspected or confirmed COVID-19. A joint guideline of the Brazilian Association of Emergency Medicine (ABRAMEDE), Brazilian Medical Association (AMB), Brazilian Society of Angiology and Vascular Surgery (SBACV), Brazilian Society of Geriatrics and Gerontology (SBGG), Brazilian Society of Infectious Diseases (SBI), Brazilian Society of Family and Community Medicine (SBFMC), and Brazilian Thoracic Society (SBPT)
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Falavigna, Maicon

; Belli, Karlyse Claudino

; Barbosa, Alexandre Naime

; Zavascki, Alexandre Prehn

; Nastri, Ana Catharina de Seixas Santos

; Santana, Christiane Machado

; Stein, Cinara

; Gräf, Débora Dalmas

; Cadegiani, Flavio Adsuara

; Guimarães, Hélio Penna

; Monteiro, José Tadeu

; Ferreira, Juliana Carvalho

; de Azevedo, Luciano Cesar Pontes

; Magri, Marcelo Mihailenko Chaves

; Sobreira, Marcone Lima

; Dias, Maria Beatriz Gandra de Souza

; de Oliveira, Maura Salaroli

; Corradi, Mirian de Freitas Dal Ben

; Rosa, Regis

; Heinzelmann, Ricardo Souza

; da Silva, Rosemeri Maurici

; Belfort Junior, Rubens

; Cimerman, Sergio

; Colpani, Verônica

; Veiga, Viviane Cordeiro

; de Carvalho, Carlos Roberto Ribeiro

Brazilian Journal of Infectious Diseases

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2022, Volume 26 Nº 2 elocation 102347

Resumo: En | Texto: En | PDF: En

ABSTRACT Background Several therapies have been used or proposed for the treatment of COVID-19, although their effectiveness and safety have not been properly evaluated. The purpose of this document is to provide recommendations to support decisions about the drug treatment of outpatients with COVID-19 in Brazil. Methods A panel consisting of experts from different clinical fields, representatives of the Brazilian Ministry of Health, and methodologists (37 members in total) was responsible for preparing these guidelines. A rapid guideline development method was used, based on the adoption and/or adaptation of recommendations from existing international guidelines combined with additional structured searches for primary studies and new recommendations whenever necessary (GRADE-ADOLOPMENT). The rating of quality of evidence and the drafting of recommendations followed the GRADE method. Results Ten technologies were evaluated, and 10 recommendations were prepared. Recommendations were made against the use of anticoagulants, azithromycin, budesonide, colchicine, corticosteroids, hydroxychloroquine/chloroquine alone or combined with azithromycin, ivermectin, nitazoxanide, and convalescent plasma. It was not possible to make a recommendation regarding the use of monoclonal antibodies in outpatients, as their benefit is uncertain and their cost is high, with limitations of availability and implementation. Conclusion To date, few therapies have demonstrated effectiveness in the treatment of outpatients with COVID-19. Recommendations are restricted to what should not be used, in order to provide the best treatment according to the principles of evidence-based medicine and to promote resource savings by aboiding ineffective treatments.

https://doi.org/10.1016/j.bjid.2022.102347

14.

Recommendations by the Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and the Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) on vaccination in general and specifically against SARS-CoV-2 for patients with demyelinating diseases of the central nervous system
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Becker, Jefferson

; Ferreira, Lis Campos

; Damasceno, Alfredo

; Bichuetti, Denis Bernardi

; Christo, Paulo Pereira

; Callegaro, Dagoberto

; Peixoto, Marco Aurélio Lana

; Sousa, Nise Alessandra De Carvalho

; Almeida, Sérgio Monteiro De

; Adoni, Tarso

; Santiago-Amaral, Juliana

; Junqueira, Thiago

; Pereira, Samira Luisa Apóstolos

; Gomes, Ana Beatriz Ayroza Galvão Ribeiro

; Pitombeira, Milena

; Paolilo, Renata Barbosa

; Grzesiuk, Anderson Kuntz

; Piccolo, Ana Claudia

; D´Almeida, José Arthur Costa

; Gomes Neto, Antonio Pereira

; Oliveira, Augusto Cesar Penalva De

; Oliveira, Bianca Santos De

; Tauil, Carlos Bernardo

; Vasconcelos, Claudia Ferreira

; Kaimen-Maciel, Damacio

; Varela, Daniel

; Diniz, Denise Sisterolli

; Oliveira, Enedina Maria Lobato De

; Malfetano, Fabiola Rachid

; Borges, Fernando Elias

; Figueira, Fernando Faria Andrade

; Gondim, Francisco De Assis Aquino

; Passos, Giordani Rodrigues Dos

; Silva, Guilherme Diogo

; Olival, Guilherme Sciascia Do

; Santos, Gutemberg Augusto Cruz Dos

; Ruocco, Heloisa Helena

; Sato, Henry Koiti

; Soares Neto, Herval Ribeiro

; Cortoni Calia, Leandro

; Gonçalves, Marcus Vinícius Magno

; Vecino, Maria Cecilia Aragón De

; Pimentel, Maria Lucia Vellutini

; Ribeiro, Marlise De Castro

; Boaventura, Mateus

; Parolin, Mônica Koncke Fiuza

; Melo, Renata Brant De Souza

; Lázaro, Robson

; Thomaz, Rodrigo Barbosa

; Kleinpaul, Rodrigo

; Dias, Ronaldo Maciel

; Gomes, Sidney

; Lucatto, Simone Abrante

; Alves-Leon, Soniza Vieira

; Fukuda, Thiago

; Ribeiro, Taysa Alexandrino Gonsalves Jubé

; Winckler, Thereza Cristina D’ávila

; Fragoso, Yara Dadalti

; Nascimento, Osvaldo José Moreira Do

; Ferreira, Maria Lucia Brito

; Mendes, Maria Fernanda

; Brum, Doralina Guimarães

; Glehn, Felipe Von

Arquivos de Neuro-Psiquiatria

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Nov 2021, Volume 79 Nº 11 Páginas 1049 - 1061

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O DC de Neuroimunologia da ABN e o BCTRIMS trazem, nesse documento, as recomendações sobre vacinação da população com doenças desmielinizantes do sistema nervoso central (SNC) contra infecções em geral e contra o coronavírus da síndrome respiratória aguda grave 2 (SARS-CoV-2), causador da COVID-19. Destaca-se a gravidade do atual momento frente ao avanço da COVID-19 em nosso País, o que torna mais evidente e importante a criação de guia de referência para orientação aos médicos, pacientes e autoridades de saúde pública quanto à vacinação, meio efetivo e seguro no controle de determinadas doenças infecciosa. O DCNI/ABN e o BCTRIMS recomendam que os pacientes com doenças desmielinizantes do SNC (ex., EM e NMOSD) sejam constantemente monitorados, quanto a atualização do seu calendário vacinal, especialmente, no início ou antes da mudança do tratamento com uma droga modificadora de doença (DMD). É importante também salientar que as vacinas são seguras e os médicos devem estimular o seu uso em todos os pacientes. Evidentemente, deve ser dada especial atenção às vacinas com vírus vivos atenuados. Por fim, é importante que os médicos verifiquem qual DMD o paciente está em uso e quando foi feita a sua última dose, pois cada fármaco pode interagir de forma diferente com a indução da resposta imune.

ABSTRACT The Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) provide recommendations in this document for vaccination of the population with demyelinating diseases of the central nervous system (CNS) against infections in general and against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. We emphasize the seriousness of the current situation in view of the spread of COVID-19 in our country. Therefore, reference guides on vaccination for clinicians, patients, and public health authorities are particularly important to prevent some infectious diseases. The DCNI/ABN and BCTRIMS recommend that patients with CNS demyelinating diseases (e.g., MS and NMOSD) be continually monitored for updates to their vaccination schedule, especially at the beginning or before a change in treatment with a disease modifying drug (DMD). It is also important to note that vaccines are safe, and physicians should encourage their use in all patients. Clearly, special care should be taken when live attenuated viruses are involved. Finally, it is important for physicians to verify which DMD the patient is receiving and when the last dose was taken, as each drug may affect the induction of immune response differently.

https://doi.org/10.1590/0004-282x-anp-2021-0162 1 downloads

15.

Adipose tissue-derived stromal/stem cells + cholecalciferol: a pilot study in recent-onset type 1 diabetes patients
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Dantas, Joana Rodrigues

; Araújo, Débora Batista

; Silva, Karina Ribeiro

; Souto, Débora Lopes

; Pereira, Maria de Fátima Carvalho

; Luiz, Ronir Raggio

; Mantuano, Matheus dos Santos

; Claudio-da-Silva, Cesar

; Gabbay, Monica Andrade Lima

; Dib, Sérgio Atala

; Couri, Carlos Eduardo Barra

; Maiolino, Angelo

; Rebelatto, Carmen Lúcia Kuniyoshi

; Daga, Débora Regina

; Senegaglia, Alexandra Cristina

; Brofman, Paulo Roberto Slud

; Baptista, Leandra S.

; Oliveira, José Egídio Paulo de

; Zajdenverg, Lenita

; Rodacki, Melanie

Archives of Endocrinology and Metabolism

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Jun 2021, Volume 65 Nº 3 Páginas 342 - 351

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: Adipose tissue-derived stromal/stem cells (ASCs) and vitamin D have immunomodulatory actions that could be useful for type 1 diabetes (T1D). We aimed in this study to investigate the safety and efficacy of ASCs + daily cholecalciferol (VIT D) for 6 months in patients with recent-onset T1D. Materials and methods: In this prospective, dual-center, open trial, patients with recent onset T1D received one dose of allogenic ASC (1 x 106 cells/kg) and cholecalciferol 2,000 UI/day for 6 months (group 1). They were compared to patients who received chol-ecalciferol (group 2) and standard treatment (group 3). Adverse events were recorded; C-peptide (CP), insulin dose and HbA1c were measured at baseline (T0), after 3 (T3) and 6 months (T6). Results: In group 1 (n = 7), adverse events included transient headache (all), mild local reactions (all), tachycardia (n = 4), abdominal cramps (n = 1), thrombophlebitis (n = 4), scotomas (n = 2), and central retinal vein occlusion at T3 (n = 1, resolution at T6). Group 1 had an increase in basal CP (p = 0.018; mean: 40.41+/-40.79 %), without changes in stimulated CP after mixed meal (p = 0.62), from T0 to T6. Basal CP remained stable in groups 2 and 3 (p = 0.58 and p = 0.116, respectively). Group 1 had small insulin requirements (0.31+/- 0.26 UI/kg) without changes at T6 (p = 0.44) and HbA1c decline (p = 0.01). At T6, all patients (100%; n = 7) in group 1 were in honeymoon vs 75% (n = 3/4) and 50% (n = 3/6) in groups 2 and 3, p = 0.01. Conclusions: Allogenic ASC + VIT D without immunosuppression was safe and might have a role in the preservation of β-cells in patients with recent-onset T1D. ClinicalTrials.gov: NCT03920397.

https://doi.org/10.20945/2359-3997000000368 236 downloads

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