ABSTRACT Objective: To assess the efficacy and safety of the use of midazolam as monotherapy, compared to the associated use of midazolam and hydroxyzine for minimum and moderate sedation of children in dental offices, using data obtained from clinical trials. Material and Methods: A systematic review protocol was developed and registered on PROSPERO (CR42020208633). An electronic search was carried out in Pubmed, Lilacs, Science Direct, Open Gray, Web of Science, and central Cochrane Library. No language restrictions were included. Clinical trials were carried out with children aged 0-12 years, using midazolam as monotherapy compared to the use of midazolam associated with hydroxyzine to verify the effectiveness and safety of oral sedation. The quality of the studies was individually assessed and grouped using the RoB 2 (Revised Cochrane risk-of-bias tool for randomized trials) and GRADE (Grading of Recommendations Assessment, Development and Evaluation) systems, respectively. Results: A total of 749 studies were found. After analyzing the inclusion and removal of duplicates, two studies were analyzed for the quality of evidence. Through this analysis, it was possible to verify the very low level of scientific evidence on the superiority of the efficacy and safety of the combined use of midazolam and hydroxyzine for oral sedation in children in dental offices. Conclusion: The conflicting results and limitations of the studies enabled to establish that there is insufficient evidence to support the use of these drugs combined. There is only evidence for the use of midazolam as monotherapy.

Boraginales comprises approximately 125 genera and 2,700 species distributed worldwide. In Brazil, it is represented by 14 genera and 148 species grouped in four families. In this paper, we present the taxonomic survey of Boraginales in a Caatinga area located in the Curimataú Microrregion, where 10 species, two genera and two families were recorded: Cordiaceae, with two genera Cordia (one species) and Varronia (four species) and Heliotropiaceae, with three genera Euploca (one species), Heliotropium (two species) and Myriopus (two species). A key to the recognition of the families and species, as well as descriptions, illustrations, taxonomic comments and geographic distribution data to the species are provided.

Boraginales compreende aproximadamente 125 gêneros e 2.700 espécies distribuídas em todo o mundo. No Brasil está representada por 14 gêneros e 148 espécies agrupadas em quatro famílias. Neste estudo, nós apresentamos o levantamento taxonômico de Boraginales em uma área de Caatinga localizada na Microrregião do Curimataú Paraibano, onde 10 espécies, cinco gêneros e duas famílias foram registradas: Cordiaceae, com dois gêneros, Cordia (uma espécie) e Varronia (quatro espécies); e Heliotropiaceae, com três gêneros, Euploca (uma espécie), Heliotropium (duas espécies) e Myriopus (duas espécies). Chave para o reconhecimento das famílias e espécies, além de descrições, ilustrações, comentários taxonômicos e dados sobre distribuição geográfica dos taxa são fornecidos.

ABSTRACT This paper discusses the potential risk that COVID-19 generates for the development of enamel defects. This hypothesis was built based on the etiopathogenesis of enamel defects and the relationship with the symptom's characteristic of COVID-19. Pregnancy is a critical period for the child's development; exposure to pathological agents can cause systemic imbalances and risks of adverse perinatal and prenatal outcomes. The main clinical symptoms of this disease and its association with that dental outcome were considered. Fever, breathing, cardiovascular disorders, and diarrhea were related as potential etiological factors of ameloblast metabolism imbalance, which can interfere qualitatively and quantitatively in the development, maturation and mineralization of the tooth enamel. Molecular disorders derived from COVID-19, as well as their clinical symptoms, can be considered potential risk factors for the development of enamel defects. Individuals with enamel defects experienced high stress levels during pregnancy or early childhood. The approach adopted may help build new research to ensure understanding of the etiology of the development of dental enamel defects and its relationship with COVID-19. However, longitudinal studies need to be conducted to confirm the association between COVID-19 and adverse events during pregnancy.

RESUMO Boraginales compreende aproximadamente 125 gêneros e 2.700 espécies distribuídas em todo o mundo. No Brasil está representada por 14 gêneros e 148 espécies agrupadas em quatro famílias. Neste estudo, nós apresentamos o levantamento taxonômico de Boraginales em uma área de Caatinga localizada na Microrregião do Curimataú Paraibano, onde 10 espécies, cinco gêneros e duas famílias foram registradas: Cordiaceae, com dois gêneros, Cordia (uma espécie) e Varronia (quatro espécies); e Heliotropiaceae, com três gêneros, Euploca (uma espécie), Heliotropium (duas espécies) e Myriopus (duas espécies). Chave para o reconhecimento das famílias e espécies, além de descrições, ilustrações, comentários taxonômicos e dados sobre distribuição geográfica dos taxa são fornecidos.

ABSTRACT Boraginales comprises approximately 125 genera and 2,700 species distributed worldwide. In Brazil, it is represented by 14 genera and 148 species grouped in four families. In this paper, we present the taxonomic survey of Boraginales in a Caatinga area located in the Curimataú Microrregion, where 10 species, two genera and two families were recorded: Cordiaceae, with two genera Cordia (one species) and Varronia (four species) and Heliotropiaceae, with three genera Euploca (one species), Heliotropium (two species) and Myriopus (two species). A key to the recognition of the families and species, as well as descriptions, illustrations, taxonomic comments and geographic distribution data to the species are provided.

Resumo Introdução O estudo da qualidade de vida de crianças portadoras de doenças crônicas, como o HIV, é essencial, visando um cuidado integral e holístico para os portadores da doença. Objetivo Avaliar a qualidade de vida e os fatores sociodemográficos associados de crianças portadoras do HIV. Método Estudo descritivo transversal, amostra de 78 crianças de ambos os sexos, faixa etária de 3 a 13 anos, atendidas em serviço de referência da cidade do Recife-PE. Foram utilizados o questionário Critério de Classificação Econômica Brasil, para caracterização socioeconômica, e a Escala de Qualidade de Vida da Criança (AUQEI). Para avaliar associação entre as variáveis, foram utilizados o teste Qui-quadrado de Pearson e o teste Exato de Fischer. A margem de erro utilizada foi de 5%. Resultados No tocante à qualidade de vida, ficar doente, brincar sozinho e a presença de bullying na escola apresentaram baixos índices de satisfação. Já itens como férias, aniversário, estar à mesa com a família e assistir televisão apresentaram altos níveis de satisfação. Conclusão As crianças desta pesquisa demonstraram uma qualidade de vida influenciada pelos aspectos negativos presentes em suas vidas. Desta forma, é necessária uma equipe multidisciplinar para o tratamento e prevenção de comorbidades, inclusive as psicossociais.

Abstract Background Studying the quality of life of children with chronic diseases, such as HIV, is essential, aiming at comprehensive and holistic care for people with the disease. Objective To assess the quality of life and sociodemographic associated factors in children with HIV. Method A descriptive cross-sectional study, with a sample of 78 children of both genders, aged between 3 and 13 years old, attending a reference service in the city of Recife-PE. Two questionnaires were used to collect data, the Brazilian Economic Classification Criteria questionnaire, to accomplish the socioeconomic characteristics, and the Quality of Life Scale for Children (AUQEI). Pearson's Chi-square test and Fisher's exact test evaluated the association between the variables. The margin of error was 5%. Results The quality of life, being sick, playing alone and the presence of bullying in school had low satisfaction rates. On the other hand, items such as vacations, birthday, being at the table with the family, and watching television showed high levels of satisfaction. Conclusions The children in this research demonstrated a quality of life influenced by the negative aspects present in their lives. Thus, a multidisciplinary team is needed for the treatment and prevention of comorbidities, including psychosocial ones.

Abstract Objective: To develop an educational mobile application as a dynamic platform provided free of charge, including several clinical and laboratory protocols for a wider range of skills and greater knowledge on the strategic axes of child dental care: Pediatric Dentistry and Orthodontics. Material and Methods: The prototype tool was structured as follows: development of clinical and laboratory contents to be addressed, software selection, layout format, inclusion of features, applicability and acceptability tests of the operational system, and indexation on the Play Store® application store (free of charge). Results: The mobile application has shown to be a tool capable of storing and providing data through various audiovisual media formats on clinical and laboratory contents of child dental care. Media resources were developed for the following themes: restorative dentistry in pediatric dentistry, radiographic techniques with pediatric patients, pulp therapy in deciduous teeth, traumatic injuries in the primary dentition, and preventive and interceptive orthodontics. The short-duration multimedia content, with different audiovisual formats, proved to be coherent with the peculiarities of each procedure, enabling to better visualize and understand the techniques. Moreover, the rewind, fast forward, and pause features were included in the mobile application, as well as the possibility of saving print screens, as well as highlighting and searching for contents of interest. Conclusion: The OdontoPed-Helpbox® demonstrated to be able to reach new strategies for the dynamic teaching-learning process, through operational efficiency. It proved to be a useful and instant tool for providing information to support clinical decision making in Dentistry.

O efeito de fontes de cálcio sobre o desempenho e a qualidade da casca dos ovos, produzidos por 96 poedeiras da linhagem Lohmann - LSL, alojadas às 72 semanas de idade em densidade de duas aves/gaiola, foram avaliados durante e após muda forçada (MF) de 12 dias. O delineamento experimental foi inteiramente ao acaso com quatro tratamentos, cada um com quatro repetições de seis aves. Os tratamentos foram constituídos por: 1 - controle positivo, com ração à vontade em todas as fases do experimento; 2 - MF, sem fonte de cálcio; 3 - MF mais fosfato bicálcico à vontade; e 4 - MF mais carbonato de cálcio à vontade. Durante o segundo ciclo de produção, as aves foram alimentadas com ração comercial e água ad libitum. Foram avaliados os ovos produzidos nos três primeiros dias de MF e em cinco períodos de 30 dias do segundo ciclo de produção. Durante a MF, o uso de carbonato de cálcio resultou em maiores peso e porcentagem de casca dos ovos que o de fosfato bicálcico e o tratamento de MF sem fonte de cálcio. No período subseqüente à MF, o tratamento com carbonato de cálcio melhorou a produção de ovos em relação àquele com fosfato bicálcico e o controle. Estes resultados sugerem que o uso do carbonato de cálcio, durante a muda forçada, foi mais indicado que o de fosfato bicálcico e o tratamento convencional de muda forçada, pela retirada da ração.

The effect of calcium source on the performance and egg-shell quality of 96 white-egg layers hens, Lohmann LSL, allotted, at 72 weeks of age, to a density of two layers/pen, were evaluated during and after a forced molt (FM) for 12 days. A completely experimental randomized, with four treatments, each with four replicates of six layers, was used. The treatments were: 1 - positive control, with ad libitum diet during all experimental phases; 2 - FM with no calcium source; 3 - FM with ad libitum dicalcium phosphate; and, 4 - FM with ad libitum calcium carbonate. During the second cycle of production, the birds were full fed commercial diet and water. Egg production in the first three days during the FM and five periods of 30 days of second cycle were evaluated. During FM, the use of calcium carbonate improved the eggshell weight and eggshell percentage than the use of dicalcium phosphate and the treatment of FM without calcium source. In the subsequent period of FM, the use of calcium carbonate showed better egg production than the use of dicalcium phosphate and the control. These results suggest that the use of calcium carbonate during the forced molt was more indicated than the use of dicalcium phosphate and the fast forced conventional practice, by the diet withdraw.