RESUMO As Intervenções Breves têm sido preconizadas há mais de 20 anos pela Organização Mundial da Saúde como uma estratégia de prevenção aos problemas relacionados ao uso de Substâncias Psicoativas, tendo como prioridade a aplicação nos serviços de atenção primária à saúde visando a diminuição dos riscos relacionados a esse fenômeno. Diante disso, o objetivo do presente estudo foi mapear e descrever as evidências científicas existentes na literatura sobre o uso de Intervenção Breve para o uso de Substâncias Psicoativas desenvolvidas no Brasil. Trata-se de revisão sistemática. As buscas foram realizadas em sete fontes de informações, em agosto de 2021. Todos os estudos foram desenvolvidos com abordagem quantitativa. O álcool esteve presente na maioria dos estudos, seguido da maconha e nicotina. O cenário predominante foi a unidade básica de saúde, com público de adultos de ambos os sexos e universitários. A maioria apresentou como proposta a Intervenção Breve grupal presencial e somente dez indicaram o referencial norteador da Intervenção Breve utilizada. No Brasil, as Intervenções Breves são incipientes e os estudos apresentados não destacam com exatidão o referencial norteador da intervenção utilizada.

ABSTRACT Brief Interventions have been recommended for more than 20 years by the World Health Organization as a strategy to prevent problems related to the use of Psychoactive Substances, with priority being applied in primary health care services in order to reduce the risks related to this substance. phenomenon. Therefore, the objective of the present study was to map and describe the existing scientific evidence in the literature on the use of Brief Intervention for the use of Psychoactive Substances developed in Brazil. This is a systematic review. Searches were carried out in seven sources of information in August 2021. All studies were developed with a quantitative approach. Alcohol was present in most studies, followed by marijuana and nicotine. The predominant scenario was the basic health unit, with a public of adults of both sexes and university students. The majority presented a brief face-to-face group intervention as a proposal and only ten indicated the guiding reference of the Brief Intervention used. In Brazil, Brief Interventions are incipient and the studies presented do not accurately highlight the guiding reference for the intervention used.

ABSTRACT Brief Interventions have been recommended for more than 20 years by the World Health Organization as a strategy to prevent problems related to the use of Psychoactive Substances, with priority being applied in primary health care services in order to reduce the risks related to this substance. phenomenon. Therefore, the objective of the present study was to map and describe the existing scientific evidence in the literature on the use of Brief Intervention for the use of Psychoactive Substances developed in Brazil. This is a systematic review. Searches were carried out in seven sources of information in August 2021. All studies were developed with a quantitative approach. Alcohol was present in most studies, followed by marijuana and nicotine. The predominant scenario was the basic health unit, with a public of adults of both sexes and university students. The majority presented a brief face-to-face group intervention as a proposal and only ten indicated the guiding reference of the Brief Intervention used. In Brazil, Brief Interventions are incipient and the studies presented do not accurately highlight the guiding reference for the intervention used.

RESUMO As Intervenções Breves têm sido preconizadas há mais de 20 anos pela Organização Mundial da Saúde como uma estratégia de prevenção aos problemas relacionados ao uso de Substâncias Psicoativas, tendo como prioridade a aplicação nos serviços de atenção primária à saúde visando a diminuição dos riscos relacionados a esse fenômeno. Diante disso, o objetivo do presente estudo foi mapear e descrever as evidências científicas existentes na literatura sobre o uso de Intervenção Breve para o uso de Substâncias Psicoativas desenvolvidas no Brasil. Trata-se de revisão sistemática. As buscas foram realizadas em sete fontes de informações, em agosto de 2021. Todos os estudos foram desenvolvidos com abordagem quantitativa. O álcool esteve presente na maioria dos estudos, seguido da maconha e nicotina. O cenário predominante foi a unidade básica de saúde, com público de adultos de ambos os sexos e universitários. A maioria apresentou como proposta a Intervenção Breve grupal presencial e somente dez indicaram o referencial norteador da Intervenção Breve utilizada. No Brasil, as Intervenções Breves são incipientes e os estudos apresentados não destacam com exatidão o referencial norteador da intervenção utilizada.

Abstract Samanea tubulosa Benth. it has been widely used in traditional medicine to treat inflammatory processes. The present study aimed to investigate the antinociceptive effect and mechanism of action of the fractions obtained from the Samanea tubulosa pods in mice. The antinociceptive activity was evaluated in formalin, capsaicin and glutamate tests and the. The possible mechanisms of action involved in the antinociceptive effect of the hexane and ethyl acetate fraction in the opioid system, also the the K + ATP channels and the L-arigine pathways of nitric oxide were evaluated. The chemical characterization analysis revealed in the hexane fraction the presence of triterpenes such as lupenone and lupeol. In the glutamate test, the hexane and ethyl acetate fractions showed antinociceptive activity at the dose of 12.5 and 25 mg kg-1. The antinociception produced by the hexane and ethyl acetate fractions was significantly reversed by naloxone, indicating that the fractions act through the opioid pathway. Antinociceptive response of the ethyl acetate fraction was blocked by glibenclamide, indicating that this fraction acts via the K + ATP channels activation. It is concluded that the fractions under study exert antinociceptive activity possibly related to the opioid route and through K+ ATP channels activation.

SUMMARY OBJECTIVE: A surgery is essential for the management of early endometrial carcinoma. Due to the comorbidities associated with the disease, the complications of surgery are common. Laparoscopic surgery may reduce surgical complications but also have oncological risks. We aimed to compare recurrence and overall survival (OS) associated with laparoscopy and laparotomy for early endometrial cancer. METHODS: We included women treated for presumed early endometrial carcinoma at the Clinics Hospital of Ribeirão Preto Medical School from January 1998 to December 2017. We designed a 1:2 propensity score-matched case-control and compared the patients’ characteristics, short-term outcomes, recurrence, and OS. RESULTS: A total of 252 women were included in this study, 168 underwent laparotomy, and 84 underwent laparoscopy. The two groups were well balanced according to most of the variables, and obesity was a characteristic of patients in both groups. Laparoscopy was associated with increased surgical time (194.7 min vesus 165.6 min; p<0.001) and reduced rate of surgical complications (6.5% versus 0; p=0.038). Laparoscopic surgery was not associated with the risk of tumor recurrence (HR: 0.41, 95%CI 0.14-1.19, p=0.100) or all-cause mortality (HR: 0.49, 95%CI 0.18-1.35, p=0.170). CONCLUSION: Laparoscopy was safe in terms of oncological outcomes and was associated with a lower rate of surgical complications. Our data support the use of minimally invasive surgery as the preferential approach in the management of early endometrial carcinoma.

SUMMARY OBJECTIVE: This study aims to investigate the association between the immunohistochemical expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 and plasma zinc in women with fibroadenoma. METHODS: This cross-sectional study included 37 premenopausal women with fibroadenoma. Waist circumference and body mass index of the participants were measured. Plasma zinc concentrations were determined using atomic flame absorption spectrophotometry. Fragments of breast tissue were fixed and incubated with primary mouse monoclonal antibodies (monoclonal antibodies matrix metalloproteinase -2 -507 and monoclonal antibodies matrix metalloproteinase -9-439). Semi-quantitative analysis of matrix metalloproteinase-2 and matrix metalloproteinase-9 immunoreactivity was performed. Spearman’s test and Friedman’s test were used for statistical analyses. The p<0.05 were considered statistically significant. RESULTS: The average age of the participants was 32.81±9.51 years. The body mass index and waist circumference values were within the normal range. The mean plasma zinc concentration was 42.73±13.84 µg/dL, with 94.6% inadequacy. A statistically significant difference was found between the positive expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 (p=0.0184). There was no significant correlation between the matrix metalloproteinase expression and the plasma zinc levels. CONCLUSIONS: Women with fibroadenoma had hypozincemia and positive expression of metalloproteinases.

Abstract Aim: This study contextualizes the establishment of Montes Claros Sports Square, in Minas Gerais, through the look of Gazeta do Norte newspaper, and its alignment with a nation project to be established by the government of Getúlio Vargas, who took office in 1930. He formulated actions for a ‘national reconstruction’ project, for which, from society, it was necessary to emerge both physically and morally healthy subjects, fundamental conditions for the construction of the aforementioned new nation, and which could reach the Brazilians in the hinterlands. Thus, this study aimed to narrate a history of the construction of Montes Claros Sports Square, from the end of the 1930s until 1945, during Getúlio Vargas’ first term as President of the Republic, with Benedito Valadares as Governor of Minas Gerais. Methods: The study was based on the extensive collection of data researched in Gazeta do Norte newspaper. Results: Symbol of a modern project for sports, the Sports Square was announced by the governor during his visit to the city, in January 1939, and established on the Oswaldo Cruz meadow. It is possible to verify that, notably, in the 15 years of Getúlio Vargas’ first term, the practice of sports is developed and consolidates itself as an ‘actor’ in the social space of Montes Claros. Conclusion: In this city, in addition to the construction of the Sports Square, it was necessary to educate and inform the individuals. It can be said that the newspaper Gazeta do Norte firmly contributed to Vargas’ nation project.

Resumo Objetivo Analisar as variações anatômicas dos ramos motores do nervo radial na região do cotovelo. Foram avaliadas a origem, curso, comprimento, ramificações, pontos motores e relações com estruturas vizinhas. Materiais e Métodos Foram dissecados 30 membros de 15 cadáveres adultos, preparados por injeção intra-arterial de uma solução de glicerina e formol a 10%. Resultados O primeiro ramo do nervo radial no antebraço foi para o músculo braquiorradial (BR), que se origina proximalmente à divisão do nervo radial em ramo superficial do nervo radial (RSNR) e nervo interósseo posterior (NIP) em todos os membros. Os ramos para o músculo extensor radial longo do carpo (ERLC) se desprenderam do nervo radial proximalmente à sua divisão em 26 membros, em 2, nos pontos de divisão, em outros 2, do NIP. Em seis, os ramos para os músculos BR e ERLC originavam-se de um tronco comum. Identificamos a origem do ramo para o músculo extensor radial curto do carpo (ERCC) no NIP em 14 membros, no RSNR em 12, e no nervo radial em apenas 4. O ramo para o músculo supinador originou-se do NIP em todos os membros. Conclusão O conhecimento da anatomia dos ramos motores do nervo radial é importante quando se realizam procedimentos cirúrgicos na região, como a abordagem do terço proximal e da cabeça do rádio, a liberação das síndromes compressivas do nervo interósseo posterior e do túnel radial, as transferências nervosas distais, e para entender a ordem de recuperação da função muscular após uma lesão nervosa.

Abstract Objective To analyze the anatomical variations of the motor branches of the radial nerve in the elbow region. The origin, course, length, branches, motor points and relationships with neighboring structures were evaluated. Materials and Methods Thirty limbs from15 adult cadavers were dissected and prepared by intra-arterial injection of a 10% glycerin and formaldehyde solution. Results The first branch of the radial nerve in the forearm went to the brachioradialis muscle (BR), originating proximally to the division of the radial nerve into superficial branch of the radial nerve (SBRN) and posterior interosseous nerve (PIN) in all limbs. The branches to the extensor carpi radialis longus muscle (ECRL) detached from the proximal radial nerve to its division into 26 limbs, in 2, at the dividing points, in other 2, from the PIN. In six limbs, the branches to the BR and ECRL muscles originated from a common trunk. We identified the origin of the branch to the extensor carpi radialis brevis muscle (ECRB) in the PIN in 14 limbs, in the SBRN in 12, and in the radial nerve in only 4. The branch to the supinator muscle originated from the PIN in all limbs. Conclusion Knowledge of the anatomy of the motor branches of the radial nerve is important when performing surgical procedures in the region (such as the approach of the proximal third and the head of the radius, release of compressive syndromes of the posterior interosseous nerve and radial tunnel, and distal nerve transfers) in order to understand the order of recovery of muscle function after a nerve injury.

RESUMO O planejamento espacial dos arranjos de cultivo é fundamental para garantir a superioridade do consórcio em relação ao monocultivo. Assim, objetivou-se avaliar o desempenho agronômico do consórcio rúcula e nirá em diferentes arranjos de cultivo. O experimento foi conduzido no delineamento em blocos casualizados, em esquema de parcela subdividida, com as parcelas sendo os arranjos de cultivo e as subparcelas os ciclos de produção (inverno e primavera). Os arranjos foram T1= monocultivo de rúcula; T2= duas linhas de rúcula alternadas com três de nirá (2R:3N); T3= duas linhas de rúcula alternadas com duas de nirá (2R:2N); T4= duas linhas de rúcula alternadas com uma de nirá (2R:1N); T5= monocultivo de nirá. Foram avaliadas as características produtivas e os índices de desempenho agronômico dos consórcios. A rúcula solteira e o cultivo consorciado 2R:1N alcançaram produtividade semelhante, porém o cultivo consorciado 2R:1N foi o que apresentou maior eficiência produtiva, com uso eficiente da terra (UET) de 1,16%, tendo a rúcula uma contribuição relativa de 84,3% no rendimento produtivo do sistema. O cultivo consorciado 2R:1N pode ser utilizado para a maior otimização no uso dos insumos produtivos em cultivo de rúcula.

ABSTRACT Spatial planning of cultivation arrangements is essential to ensure the superiority of intercropping when compared with monocrop. Thus, the aim of this study was to evaluate the agronomic performance of arugula/nira intercropping in different cultivation arrangements. The experiment was carried out in a randomized block design, in a split plot scheme, the plots represented the cultivation arrangements and the subplots the production cycles (winter and spring). The arrangements were T1= arugula monoculture; T2= two rows of arugula alternating with three rows of nira (2R:3N); T3= two rows of arugula alternating with two rows of nira (2R:2N); T4= two rows of arugula alternating with one row of nira (2R:1N); T5= nira monoculture. Productive traits and agronomic performance indexes of the intercropping systems were evaluated. Single arugula cultivation and 2R:1N intercropping achieved similar productivity, 2R:1N intercropping showed the highest productive efficiency, with land-use efficiency of 1.16%, though arugula showed a relative contribution of 84.3% in production yield of the system. We concluded that 2R:1N intercropping can be used to optimize the use of productive inputs in arugula cultivation.

RESUMO A consorciação de culturas é uma estratégia de manejo que visa a sustentabilidade dos agrossistemas, sendo adequada à produção de hortaliças. A couve é preponderantemente manejada sob cultivo solteiro, mas observações de campo tem indicado que a cultura tem potencial produtivo satisfatório quando cultivada em consórcio com outras hortaliças. Neste trabalho, avaliou-se o desempenho produtivo e a eficiência biológica do consórcio de couve com espécies condimentares. O experimento foi realizado na Horta didática da Universidade Federal do Ceará, Fortaleza - CE. Os tratamentos consistiram do cultivo de couve solteira e consorciada com espécies condimentares (cebolinha, coentro, manjericão e salsa), bem como seus respectivos cultivos solteiros. O delineamento experimental utilizado foi blocos ao acaso, com cinco repetições. Avaliou-se as massas fresca e seca das folhas de couve e da parte aérea para as espécies condimentares. A eficiência biológica foi avaliada pelo índice de uso eficiente da terra, contribuição relativa da cultura de couve ao UET, razão de área equivalente no tempo e índice de produtividade do sistema. O consórcio com salsa resultou nas maiores produções de massas fresca e seca de folhas de couve, mostrando-se com a maior eficiência agronômica.

ABSTRACT Intercropping is a management strategy for the sustainability of agricultural systems, and is suitable for the production of vegetables. Kale is predominantly grown singly, but field observations have indicated that this crop has satisfactory productive potential when grown in intercrops with other vegetables. The objective of this work was to evaluate the agronomic performance and biological efficiency of kale plants intercropped with spice species. The experiment was carried out at the Didactic Horta of the Federal University of Ceará, Fortaleza, state of Ceará, Brazil. The experiment was conducted in a randomized block design with five replications. The treatments consisted of kale grown singly and intercropped with spice species (chives, coriander, basil, and parsley) and these spice species grown singly. The fresh and dry weights of the kale leaves, and the shoot of the spice species were evaluated. The biological efficiency was evaluated by the land use efficiency index (LUE), relative contribution of the kale crop to the LUE, area time equivalent ratio, and system productivity index. The intercropping of kale with parsley resulted in the highest fresh, and dry weights of kale leaves, showing the highest agronomic efficiency.

RESUMO Objetivo: Investigar os subtipos histológicos e perfis de mutação do carcinoma pulmonar de células não pequenas no Brasil, bem como as correlações entre os subtipos histológicos, a expressão do gene anaplastic lymphoma kinase (ALK, quinase do linfoma anaplásico), o estado de mutação do gene EGFR e a expressão de programmed death-ligand 1 (PD-L1, ligante de morte celular programada 1). Métodos: Avaliamos 173 espécimes provenientes de pacientes com adenocarcinoma pulmonar no Nordeste brasileiro. A expressão de PD-L1 e ALK foi avaliada por meio de imuno-histoquímica, ao passo que o estado de mutação do EGFR foi avaliado por meio de sequenciamento. Os subtipos histológicos foram classificados de acordo com a International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society. Resultados: Os subtipos histológicos mais comuns de adenocarcinoma pulmonar foram o predominantemente sólido (em 46,8%), o predominantemente acinar (em 37,0%) e o predominantemente lepídico (em 9,8%). A expressão de ALK foi detectada em 10,4% das amostras, e 22,0% dos tumores apresentavam mutações do gene EGFR. As mutações mais comuns do EGFR foram a mutação pontual L858R no éxon 21 (em 45,5%) e a deleção do éxon 19 (em 36,3%). O tumor proportion score relativo à expressão de PD-L1 foi ≥ 50% em 18,2% das amostras, = 1-49% em 32,7% e = 0% em 49,5%. O subtipo predominantemente sólido relacionou-se significativamente com EGFR selvagem (p = 0,047). A expressão positiva de PD-L1 não se relacionou significativamente com a expressão de ALK ou o estado de mutação do EGFR. Conclusões: Nossos resultados sugerem que o perfil molecular do carcinoma pulmonar de células não pequenas no Nordeste brasileiro difere do de populações em outras regiões do país: a expressão positiva de ALK é maior que os demais biomarcadores. Mais estudos com informações clínicas e genéticas são necessários para confirmar essas diferenças, além de estudos que se concentrem em populações em diferentes áreas do país.

ABSTRACT Objective: To investigate the histological subtypes and mutational profiles of non-small cell lung cancer in Brazil, looking for correlations among histological subtypes, expression of anaplastic lymphoma kinase (ALK), EGFR mutation status, and programmed death-ligand 1 (PD-L1) expression. Methods: We evaluated 173 specimens obtained from patients with lung adenocarcinoma in northeastern Brazil. Expression of PD-L1 and ALK was evaluated by immunohistochemistry; EGFR mutation status was evaluated by sequencing. We categorized the histological subtypes in accordance with the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. Results: The most common histological subtypes of lung adenocarcinoma were solid predominant (in 46.8%), acinar predominant (in 37.0%), and lepidic predominant (in 9.8%). ALK expression was detected in 10.4% of the samples, and 22.0% of the tumors harbored EGFR mutations. The most common EGFR mutation was an exon 21 L858R point mutation (in 45.5%), followed by an exon 19 deletion (in 36.3%). The tumor proportion score for PD-L1 expression was ≥ 50% in 18.2% of the samples, 1-49% in 32.7%, and 0% in 49.5%. The solid predominant subtype was significantly associated with wild-type EGFR status (p = 0.047). Positivity for PD-L1 expression was not found to be significantly associated with ALK expression or EGFR mutation status. Conclusions: Our results suggest that the molecular profile of non-small cell lung cancer in northeastern Brazil differs from those of populations in other regions of the country, with ALK positivity being higher than the other biomarkers. Further studies including clinical and genetic information are required to confirm these differences, as well as studies focusing on populations living in different areas of the country.

RESUMO A otimização de espaçamentos de plantio, bem como o uso de sistemas de tutoramento de plantas, são práticas culturais que têm melhorado a eficiência produtiva de várias espécies de hortaliças. Objetivou-se com este trabalho avaliar a produção do feijão de metro conduzido em diferentes sistemas de tutoramento e espaçamentos. O experimento foi conduzido no delineamento em blocos ao acaso, em esquema fatorial (4x3), com quatro repetições. O primeiro fator foi constituído por quatro formas de tutoramento [fitilho vertical (FV), “V” normal (VN), “V” invertido (VI) e rasteiro (R)]. O segundo fator foi constituído por três espaçamentos entre plantas (20; 40; e 60 cm) mantendo-se fixo o espaçamento entre linhas de cultivo em 1 m. Foram avaliados a precocidade de produção (ciclo de cultivo); número de vagens, massa de grãos e de vagens por planta; comprimento de vagens; número de grãos e massa de grãos por vagem; produtividade de grãos e de vagem. Também foram avaliadas as trocas gasosas, bem como o custo de implantação de cada um dos tratamentos. A densidade de 50.000 plantas/ha (espaçamento 20 cm) foi a que proporcionou a maior produtividade nos sistemas FV e VI, com 9,10 e 6,72 t/ha, além de promover maior renda líquida ao produtor, com médias de aproximadamente 23 e 15 mil reais acima do sistema R. Para as variáveis de trocas gasosas, houve redução na fotossíntese líquida com o incremento da densidade. Indica-se a utilização de maiores densidades de plantio combinadas com o uso dos sistemas de tutoramento FV e VI em detrimento ao sistema R, por gerarem maior produtividade e receita líquida ao produtor.

ABSTRACT The optimization of plantation spacing, just like the use of staking plant systems, are cultural practices that have improved production efficiency of various kinds of vegetable. The aim of this study was to compare the asparagus bean cultivation conducted in different staking and spacing systems. The experiment was conducted in the design of randomized blocks in a factorial scheme (4x3) with four replicates. The first factor was constituted by four staking types [narrow ribbon vertical (FV), “V” normal (VN), inverted “V” (VI) and creeping (R)]. The second factor was constituted of three plant spacing (20, 40, and 60 cm), keeping constant the spacing of 1 m between crop rows. The evaluated characteristics were precocity (cultivation cycle); number of pods, mass of grains and pods per plant; length of pods; number of grains and mass of grains per pod; grain and pod yield. The gas exchange as well as the cost of deploying each of the treatments were also evaluated. The density of 50,000 plants/ha (spacing of 20 cm) provided the highest productivity in the FV and VI systems, with 9.10 and 6.72 t/ha, in addition to promoting higher net income to the producer, with averages of approximately 23 and 15 thousand R$ above R system. For the gas exchange variables, there was a reduction in net photosynthesis with density increase. The use of higher planting densities are indicated, combined with the use of FV and VI systems, in detriment to R system. The higher planting densities generate higher productivity and net income to the producer.

RESUMO Para definir as recomendações baseadas em evidências científicas sobre o diagnóstico e tratamento das doenças autoimnus do fígado, a Sociedade Brasileira de Hepatologia organizou em Outubro de 2014, encontro monotemático em São Paulo. Um Comitê organizador de sete investigadores foi selecionado pela Diretoria da Sociedade para organizar a agenda científica, assim como para selecionar vinte debatedores para fazer uma revisão sistemática e apresentar tópicos relacionados à hepatite autoimune, colangite esclerosante primária, cirrose biliar primária e suas síndromes de superposição (overlap). O texto inicial do submetidoo a apreciação e aprovação da Sociedade Brasileira de Hepatologia através de consulta a todos associados através da home page da Sociedade, O trabalho apresentado representa a versão final do trabalho original, devidamente revisado e organizado em tópicos, segundo as recomendações da Sociedade Brasileira de Hepatologia.

ABSTRACT In order to draw evidence-based recommendations concerning the management of autoimmune diseases of the liver, the Brazilian Society of Hepatology has sponsored a single-topic meeting in October 18th, 2014 at São Paulo. An organizing committee comprised of seven investigators was previously elected by the Governing Board to organize the scientific agenda as well as to select twenty panelists to make a systematic review of the literature and to present topics related to the diagnosis and treatment of autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cirrhosis and their overlap syndromes. After the meeting, all panelists gathered together for the discussion of the topics and the elaboration of those recommendations. The text was subsequently submitted for suggestions and approval of all members of the Brazilian Society of Hepatology through its homepage. The present paper is the final version of the reviewed manuscript organized in topics, followed by the recommendations of the Brazilian Society of Hepatology.

Introdução: Pacientes com a síndrome da apneia obstrutiva do sono (SAOS) geralmente apresentam alterações na morfologia das vias aéreas superiores e/ou na distribuição da gordura corporal, que podem ocorrer durante a vida e aumentar a gravidade da SAOS com a idade. Objetivo: Correlacionar medidas cefalométricas e antropométricas com a gravidade da SAOS em diferentes faixas etárias. Método: Estudo retrospectivo de medidas cefalométricas e antropométricas de 102 pacientes portadores de SAOS. Os pacientes foram divididos em três faixas etárias (≥20 e <40 anos, ≥40 e <60 anos, e ≥60 anos). Foi realizada correlação de Pearson destas medidas com o índice de apneia-hipopneia (IAH) na amostra completa e depois por faixa etária. Resultados: As medidas cefalométricas MP-H (distância entre o plano mandibular e o osso hioide) e PNS-P (distância entre a espinha nasal posterior e a ponta do palato mole) e as circunferências cervical e abdominal apresentaram correlação estatisticamente significante com o IAH tanto na amostra total quanto na faixa de <40 e ≥ 60 anos. Estas variáveis não mostraram correlação significante com as outras duas faixas etárias (≤ 40 e ≥ 60 anos). Conclusão: As medidas cefalométricas MP-H e PNS-P e as circunferências cervical e abdominal apresentaram correlação com a gravidade da SAOS em pacientes na faixa etária de ≥40 e <60 anos.

Introduction: Patients with obstructive sleep apnea syndrome usually present with changes in upper airway morphology and/or body fat distribution, which may occur throughout life and increase the severity of obstructive sleep apnea syndrome with age. Objective: To correlate cephalometric and anthropometric measures with obstructive sleep apnea syndrome severity in different age groups. Methods: A retrospective study of cephalometric and anthropometric measures of 102 patients with obstructive sleep apnea syndrome was analyzed. Patients were divided into three age groups (≥20 and <40 years, ≥40 and <60 years, and ≥60 years). Pearson's correlation was performed for these measures with the apnea-hypopnea index in the full sample, and subsequently by age group. Results: The cephalometric measures MP-H (distance between the mandibular plane and the hyoid bone) and PNS-P (distance between the posterior nasal spine and the tip of the soft palate) and the neck and waist circumferences showed a statistically significant correlation with apnea-hypopnea index in both the full sample and in the ≥40 and <60 years age group. These variables did not show any significant correlation with the other two age groups (<40 and ≥60 years). Conclusion: Cephalometric measurements MP-H and PNS-P and cervical and waist circumfer- ences correlated with obstructive sleep apnea syndrome severity in patients in the ≥40 and <60 age group.

Objetivo:Descrever o trajeto do ramo infrapatelar do nervo safeno (RIPNS) com o uso da linha articular medial, da tuberosidade anterior da tíbia (TAT), do ligamento colateral tibial e de uma linha horizontal, paralela à linha articular medial e que passa sobre a TAT, como pontos de referência, a fim de poder auxiliar os cirurgiões a diminuir a probabilidade de lesão desse ramo nervoso na reconstrução do ligamento cruzado anterior (LCA) com tendões flexores.Métodos:Foram examinados 10 joelhos congelados, originados de amputações. Na dissecação anatômica, feita com as peças flexionadas, procuramos encontrar o RIPNS, desde a sua porção mais medial e proximal até sua porção mais lateral e distal. Em seguida, as peças anatômicas foram fotografadas e, com o programa ImageJ, determinamos a distância do RIPNS até a linha articular medial e até uma linha horizontal inferior, que passa pela TAT e é paralela à primeira. Medimos, também, o ângulo da direção do trajeto do ramo nervoso em relação a essa linha horizontal inferior.Resultados:O ângulo médio do trajeto do ramo nervoso, em relação à linha horizontal inferior, foi de 17,50° ±6,17°. A distância média do RIPNS até a linha articular medial foi de 2,61 ± 0,59 cm e até a linha horizontal inferior, de 1,44 ± 0,51 cm.Conclusão:O RIPNS foi encontrado em todos os joelhos estudados; em três, encontramos um segundo ramo, proximal ao primeiro. A direção de seu trajeto foi sempre de proximal e medial para distal e lateral. O RIPNS esteve sempre proximal e medial à TAT e distal à linha articular medial. A angulação média de sua direção, em relação a uma linha horizontal que passa pela TAT, foi de 17,50° ± 6,17°.

Objective:To describe the path of the infrapatellar branch of the saphenous nerve (IBSN) using the medial joint line, anterior tibial tuberosity (ATT), tibial collateral ligament and a horizontal line parallel to the medial joint line that passes over the ATT, as reference points, in order to help surgeons to diminish the likelihood of injuring this nerve branch during reconstruction of the anterior cruciate ligament (ACL) using flexor tendons.Methods:Ten frozen knees that originated from amputations were examined. Through anatomical dissection performed with the specimens flexed, we sought to find the IBSN, from its most medial and proximal portion to its most lateral and distal portion. Following this, the anatomical specimens were photographed and, using the ImageJ software, we determined the distance from the IBSN to the medial joint line and to a lower horizontal line going through the ATT and parallel to the first line. We also measured the angle of the direction of the path of the nerve branch in relation to this lower line.Results:The mean angle of the path of the nerve branch in relation to the lower horizontal line was 17.50 ±6.17°. The mean distance from the IBSN to the medial joint line was 2.61 ± 0.59 cm and from the IBSN to the lower horizontal line, 1.44 ±0.51 cm.Conclusion:The IBSN was found in all the knees studied. In three knees, we found a second branch proximal to the first one. The direction of its path was always from proximal and medial to distal and lateral. The IBSN was always proximal and medial to the ATT and distal to the medial joint line. The medial angle between its direction and a horizontal line going through the ATT was 17.50 ± 6.17°.