RESUMO Os resíduos orgânicos disponíveis na região Oeste do Maranhão, Brasil, são abundantes, devido à atividade agropecuária. Estes podem ser utilizados na composição de substratos para produção de mudas de mogno africano, porém há necessidade de demonstrar a eficiência técnica de resíduos orgânicos com solos da região. O objetivo foi avaliar substratos compostos de proporções varáveis de terra de diferente textura e resíduos orgânicos, para a obtenção de mudas de mogno africano de boa qualidade. O experimento foi conduzido em duas etapas, uma em viveiro florestal e outra no campo, ambos localizados no bioma Cerrado, Oeste do Maranhão, região Nordeste do Brasil. O delineamento foi em blocos casualizados, com onze tratamentos e sete repetições. As variáveis morfológicas de crescimento e qualidade foram avaliadas por 105 dias no viveiro e 270 dias no campo. Os resultados demonstraram que todos os substratos produziram mudas com índice de robustez e índice de qualidade de Dickson adequados, e as mudas de mogno africano produzidas nos substratos com proporção que vária entre 70 a 30% de solo, 15 a 30% de esterco bovino curtido e 15 a 20% de casca de arroz carbonizada apresentaram melhor padrão de qualidade considerando-se os maiores valores de teor de nutrientes, características morfológicas e índice de qualidade de Dickson. No entanto, ao serem plantadas no campo, apenas as mudas que foram produzidas nos substratos com terra de subsolo de textura argilosa, com até 20% de casca de arroz carbonizada, apresentaram maior crescimento em altura, pois o substrato permaneceu aderido à raiz ao serem retirados do recipiente. Portanto, a aderência do substrato ao sistema radicular das mudas foi o fator preponderante para o maior crescimento das mudas em condições de campo.

ABSTRACT The organic residues can be used in the composition of substrates, but there is a need to demonstrate the technical efficiency of organic residues. The objective was to evaluate substrates composed of varying proportions of soil of different texture and organic residues, in order to obtain good quality African mahogany seedlings. The experiment was carried out in two stages, one in a forest nursery and the other in the field, both located in the Cerrado biome, Western Maranhão, Northeast region of Brazil. The design was in randomized blocks, with eleven treatments and seven replications. The morphological variables of growth and quality were evaluated for 105 days in the nursery and 270 days in the field. The results showed that all substrates produced seedlings with adequate robustness and Dickson quality index. The seedlings produced in substrates with proportions ranging from 70 to 30% of soil, 15 to 30% of tanned cattle manure and 15 to 20% of carbonized rice husks presented a better quality standard, considering the higher values of nutrient content, morphological characteristics and Dickson quality index. However, when planted in the field, only seedlings that were produced in substrates with clayey textured soil, with up to 20% of carbonized rice husk, showed greater growth in height, as the substrate remained adhered to the root when removed from the container. Therefore, the adherence of the substrate to the root system of the seedlings was the main factor for the greater growth of the seedlings under field conditions.

ABSTRACT Selection indexes represent the real efforts of a breeding program to obtain genetic gains for various significant traits simultaneously. As such, this study selected superior F5 lines by combined selection for fruit quality using an index based on predicted genotypic values via residual or restricted maximum likelihood/best linear unbiased prediction (REML/BLUP) methodology weighted by agronomic weights. To do so, 97 F5 papaya lines obtained by the single seed descent method, resulting from the biparental cross between the genotypes JS-12 and Sekati, were evaluated for the main traits related to fruit quality. Results of the analysis of deviance and the genetic parameters indicated that there was genetic variability, indicating possible success in the selection process. Based on the selection index, 29 lines were selected as superior for fruit quality with ‘Formosa’ pattern. The strategy of the selection index combining BLUPs of multiple traits of interest associated with agronomic weights allows maximizing genetic progress while discarding less-promising genotypes.

Resumo O objetivo deste trabalho é analisar se o hábito alimentar das famílias quilombolas paraenses segue as orientações do Guia Alimentar para a População Brasileira, publicado pelo Ministério da Saúde, em 2014. Foram realizadas entrevistas semiestruturadas nas comunidades de Santo Antônio (Concórdia do Pará, nordeste paraense) e São João (Salvaterra, ilha do Marajó) sob o protocolo CEP 060/07. Foram feitas análises do consumo e das preferências alimentares de acordo com o guia. Os resultados evidenciam: alto consumo de café adoçado, feijão, arroz e farinha; baixa participação de verduras, legumes e frutas na dieta dos entrevistados. Alimentos como pão, leite de vaca, macarrão, margarina e bolacha salgada são as formas comuns de diversificar os alimentos consumidos pelo grupo. Como fontes proteicas, destacam-se a carne vermelha - silvestre ou não -, o pescado, o charque, o frango e o ovo de galinha. São apresentadas algumas contradições do guia quando aplicado às comunidades. Apesar dos avanços do guia, conclui-se que o cumprimento das orientações para uma alimentação adequada e saudável nos grupos quilombolas da região amazônica enfrenta desafios. Guias alimentares são importantes para a saúde e a nutrição da população, porém precisam ser combinados com outros tipos de intervenções que respeitem a diversidade cultural do país.

Abstract The objective of this study is to analyze the food habit of quilombola families in Pará, following the guidelines of the Food Guide for the Brazilian Population published by the Brazilian Health Ministry in 2014. Semi-structured interviews were conducted in the communities of Santo Antônio (Concórdia do Pará, in the Northeast) and São João (Salvaterra, on Marajó Island) under protocol CEP 060/07. Analysis of consumption and preferences were made according to the guide. The results show a high consumption of sweetened coffee, beans, rice and flour, and a low participation of vegetables and fruits in the interviewees’ diet. Foods such as bread, cow’s milk, pasta, margarine, and salt crackers are common means to diversify the foods consumed by the group. As protein sources, the most notable were red meat - wild or not -, fish, beef jerky, chicken and chicken eggs. Some contradictions of the Guide are discussed in relation to such communities. Despite the advancements promoted by the guide, we conclude that following the guidelines for an adequate and healthy food habit in quilombola groups in the Amazon region presents many challenges. Food guides are important for the health and nutrition of the population; however, they need to be combined with other types of interventions that respect the country’s cultural diversity.

Resumo O objetivo deste trabalho é analisar se o hábito alimentar das famílias quilombolas paraenses segue as orientações do Guia Alimentar para a População Brasileira, publicado pelo Ministério da Saúde, em 2014. Foram realizadas entrevistas semiestruturadas nas comunidades de Santo Antônio (Concórdia do Pará, nordeste paraense) e São João (Salvaterra, ilha do Marajó) sob o protocolo CEP 060/07. Foram feitas análises do consumo e das preferências alimentares de acordo com o guia. Os resultados evidenciam: alto consumo de café adoçado, feijão, arroz e farinha; baixa participação de verduras, legumes e frutas na dieta dos entrevistados. Alimentos como pão, leite de vaca, macarrão, margarina e bolacha salgada são as formas comuns de diversificar os alimentos consumidos pelo grupo. Como fontes proteicas, destacam-se a carne vermelha - silvestre ou não -, o pescado, o charque, o frango e o ovo de galinha. São apresentadas algumas contradições do guia quando aplicado às comunidades. Apesar dos avanços do guia, conclui-se que o cumprimento das orientações para uma alimentação adequada e saudável nos grupos quilombolas da região amazônica enfrenta desafios. Guias alimentares são importantes para a saúde e a nutrição da população, porém precisam ser combinados com outros tipos de intervenções que respeitem a diversidade cultural do país.

Abstract The objective of this study is to analyze the food habit of quilombola families in Pará, following the guidelines of the Food Guide for the Brazilian Population published by the Brazilian Health Ministry in 2014. Semi-structured interviews were conducted in the communities of Santo Antônio (Concórdia do Pará, in the Northeast) and São João (Salvaterra, on Marajó Island) under protocol CEP 060/07. Analysis of consumption and preferences were made according to the guide. The results show a high consumption of sweetened coffee, beans, rice and flour, and a low participation of vegetables and fruits in the interviewees’ diet. Foods such as bread, cow’s milk, pasta, margarine, and salt crackers are common means to diversify the foods consumed by the group. As protein sources, the most notable were red meat - wild or not -, fish, beef jerky, chicken and chicken eggs. Some contradictions of the Guide are discussed in relation to such communities. Despite the advancements promoted by the guide, we conclude that following the guidelines for an adequate and healthy food habit in quilombola groups in the Amazon region presents many challenges. Food guides are important for the health and nutrition of the population; however, they need to be combined with other types of interventions that respect the country’s cultural diversity.

ABSTRACT: The growing demand for quality of papaya by the domestic and international markets requires the development of genotypes that are capable of incorporating traits, such as high yield and fruit quality. This study estimated the genetic parameters and the specific combining ability of F4 papaya lines crossed to the SS-72/12 tester to identify genotypes with higher genetic value for hybrid production. We evaluated 169 treatments consisting of 62 topcross hybrid combinations, 97 F5 lines, and 10 controls in a 13 × 13 lattice design with five replicates and two plants per plot. The following traits were evaluated: plant height (PH), stem diameter (SD), first-fruit insertion height (FFIH), number of marketable fruits (NMF), number of deformed fruits (NDF), number of fruitless nodes (NFN), average fruit weight (FW), and yield (YLD). Differences p < 0.05 were found in most traits evaluated. The specific combining ability estimates indicate that hybrids formed by the cross between SS-72/12 tester and the following lines are promising, considering the multiple traits: UCLA08-088, UCLA08-101, UCLA08-071, UCLA08-014, UCLA08-025, UCLA08-028, UCLA08-122, UCLA08-055, UCLA08-026, and UCLA08-092. These hybrids meet the demands for domestic and international markets and may be available to producers as new papaya cultivars.

Resumo Contexto A redução das dificuldades no aprendizado da técnica cirúrgica levou ao surgimento de ferramentas complementares. Este trabalho descreve a curva de aprendizado dos alunos sujeitos da pesquisa, utilizando um modelo alternativo para a prática de anastomose vascular. Objetivos Avaliar a curva de aprendizado da técnica de anastomose vascular e do desenvolvimento de habilidades manuais a partir da utilização de um modelo experimental de baixo custo. Métodos Este trabalho é um estudo experimental e prospectivo, com a realização de anastomoses vasculares do tipo terminolateral em balões de látex durante cinco fases sucessivas, iniciadas após orientação teórico-prática de uma cirurgiã vascular experiente. Os sujeitos foram seis graduandos do curso de Medicina, do terceiro ao quinto ano, da Universidade Federal da Paraíba (UFPB), João Pessoa, Paraíba, Brasil. A interpretação do material coletado acerca da qualidade das anastomoses e do tempo utilizado seguiu a análise de agrupamento. Resultados Houve redução do tempo de realização das anastomoses de todos os alunos, com diferença estatística da fase 1 quando comparada às fases 4 e 5, bem como tendência crescente no índice de qualidade ao longo das fases. Porém, não foi detectada diferença estatística a partir do teste de Friedman, apropriado para dados com nível de mensuração ordinal (escala de 1 a 5 na avaliação da qualidade). Conclusões O modelo de treinamento utilizado foi efetivo para incremento do aprendizado dessa técnica, acreditando-se que amostras de maior tamanho ou com maior número de fases em trabalhos futuros poderiam demonstrar redução do tempo associada a melhora da qualidade da anastomose realizada com significância estatística.

Abstract Background In order to reduce difficulties with learning surgical techniques, supplementary tools for training were developed. This paper describes the learning curve followed by student volunteer research subjects who used an alternative model for practicing vascular anastomosis. Objectives To evaluate the vascular anastomosis technique learning curve and development of manual skills using a low-cost experimental model. Methods Experimental and prospective study using end-to-side vascular anastomosis in latex balloons over five successive phases, initiated after theoretical and practical guidance given by experienced vascular surgeon. The study subjects were six undergraduate medical students from Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brazil, in their third to fifth years of the course. Cluster analysis was used to interpret the data collected on the quality of anastomoses and the time taken. Results The time taken to perform anastomosis reduced for all students, with statistical differences from phase 1 compared to phases 4 and 5. There was also a trend to increasing scores on the quality index as the phases progressed. However, no statistical differences were detected using the Friedman test, which is appropriate for data measured with ordinal levels (quality was assessed on a scale of 1 to 5). Conclusions It was found that the training model used was effective for increasing learning of this technique. It is believed that future studies with larger samples or a higher number of phases could demonstrate both reduced time and improved quality of the anastomoses performed with statistical significance.

Abstract Due to the good silvicultural characteristics of Schizolobium amazonicum (parica) and its versatility (planting and use), the species has become an alternative in commercial exploitation. Aiming to verify the influence of irrigation depth and substrate on the germination and growth of Parica seedlings, a greenhouse experiment was conducted using randomized blocks in a 2 × 4 bifactorial scheme, with two types of substrates (washed sand and commercial substrate) and four irrigation depths corresponding to 50%, 100%, 150% and 200% of the reference evapotranspiration (ETo), with five replications. Germination rate, emergency speed index and biometric variables were evaluated. The commercial substrate combined with the irrigation level of 50% of ETo favored a higher emergence speed and germination rate. In the growing phase, the irrigation level of 150% of ETo combined with the commercial substrate produced better results, indicating greater survival and development in the field.

Abstract This study analyzed the effect of prior application of copaiba oil (CO) emulsions as a dentin cleaning substance on microleakage and microtensile adhesive strength. Twenty-five premolars and sixty-four molars were used for microleakage and microtensile assays. For the microleakage assays, specimens with standard class V cavities were divided (n = 5), according to the tested CO emulsions: CO10%X, CO10%Y, and CO10%Z, as well as chlorhexidine 2% (CHX) and distilled water (DW), as positive and negative controls, respectively. Restorations were performed using the Adper Single Bond® and/or Clearfil SE Bond® systems. Cervical, occlusal, distal and mesial sections were assessed for tracer penetration degree at the composite/tooth interface. For the microtensile assay, healthy molars were divided into sixteen groups, in which artificial caries were induced in half of the groups. Dentin surfaces were treated with CO10%X and CO10%Y, CHX and DW. Microtensile bond strength was measured by fixing each sample to the plate of a universal testing machine operated at a speed of 0.5 mm/minute until failure. Dentin treated with CO10%X showed a lower infiltration rate than dentin treated with the other CO emulsions, CHX2% and DW. According to the microtensile assay, both healthy and affected dentin treated with CO10%X and Adper Single Bond® adhesive system presented higher adhesive strength. CO emulsion, used as a dentin biomodifier, interfered positively in microleakage and improved adhesive strength after acid etching in the Adper Single Bond® adhesive system, or before applying the Clearfil SE Bond® self-etching system.

RESUMEN Introducción: La inestabilidad hemodinámica, que se caracteriza por las oscilaciones de la presión arterial, es frecuente durante las sesiones de hemodiáilisis (HD) y tiene como resultado la hipotensión intradialítica, causada por una disminución en el volumen sanguíneo del sistema cardiovascular. Es esencial realizar ajustes inmediatos en el sistema cardiovascular, mediados principalmente por el sistema nervioso autónomo, a fin de mantener la estabilidad hemodinámica durante la hemodiálisis. Objetivo: El objetivo de nuestro estudio fue investigar la relación entre la actividad del sistema nervioso simpático y la estabilidad hemodinámica en pacientes con enfermedad renal crónica (ERC) durante las sesiones de hemodiálisis, así como la relación entre la actividad del sistema nervioso simpático y el estado urémico. Material y métodos: Se registraron, durante las sesiones de hemodiálisis, los intervalos RR sucesivos de 14 pacientes con enfermedad renal crónica (8 mujeres y 6 hombres) sin antecedentes de episodios recurrentes de hipotensión intradialítica (HI). Se realizaron registros de la tensión arterial en intervalos regulares de 30 minutos durante 4 horas en cada sesión. La estabilidad hemodinámica se estableció mediante la desviación estándar, el coeficiente de variación (CV) y delta (diferencia entre la medida más alta y la más baja) de la tensión arterial sistólica (TAS), la diastólica (TAD) y la media (TAM), así como la tensión diferencial (TD) a partir de los ocho registros obtenidos durante cada sesión. Se utilizó el análisis espectral de transformaciones logarítmicas de baja frecuencia (LnLFnu, por su sigla en inglés) expresados en unidades normalizadas mediante transformación logarítmica. El estado urémico se determinó a través del promedio de los valores de uremia obtenidos durante los últimos doce meses. Se utilizó el coeficiente de correlación de Pearson para analizar las variables estudiadas. Resultados: Mediante los distintos cálculos, se hallaron las siguientes correlaciones negativas con los valores de lnLFnu : SD (TAS [r = -0,480; p = 0,010]; TD [r = -0,504; p = 0,006] , y TAM [r = -0,449; p = 0,017]); CV (TAS [r = -0,390; p = 0,040]); y delta (TAS [r = -0,438; p = 0,020]; TD [r = -0,490; p = 0,008], y TAM [r = -0,382; p = 0,045]). También se observó una correlación negativa entre lnLFnu y el estado urémico (r = -0,601; p = 0,01). Conclusiones: Nuestros resultados indican que los valores más elevados de LnLFnu se asocian con una mejor estabilidad hemodinámica, es decir, menor oscilación de la tensión arterial, durante las sesiones de hemodiálisis. A su vez, el promedio de concentración de urea en sangre registrado durante los últimos doce meses, al cual definimos como el estado urémico, se relacionó con valores más bajos de LnLFnu durante las sesiones de hemodiálisis.

ABSTRACT Introduction: Hemodynamic instabilities, characterized by oscillations of blood pressure, are common during hemodialysis sessions (HD), culminating in intradialytic hypotension owing to volume withdrawal from the cardiovascular system. The ability to carry out immediate adjusts in cardiovascular system, mainly mediated by the autonomic nervous system, is essential to the maintenance of hemodynamic stability during HD. Objective: This study aimed to investigate the relationship between the sympathetic activity, and the hemodynamic stability from chronic kidney disease (CKD) patients during the HD, as well as the relationship between sympathetic activity and the uremic state. Methods: Fourteen CKD patients (8 women and 6 men) with no history of recurrent intradialytic hypotension (ID) episodes had the successive RR intervals recorded during HD. Blood pressure measurements were recorded at regular intervals of 30 minutes along 4 hours of each session. Hemodynamic stability was established by the standard deviation (SD), coefficient of variation (CV) and the Delta (difference between the highest and the lowest measure) of systolic (SBP), diastolic (DBP), and mean (MBP) blood pressures, as well as the pulse pressure (PP) from the 8 recordings obtained during each session. As a measure of autonomic heart control, the low-transformed low frequency (lnLFnu) spectral band was used. The uremic state was established by the mean of uremia from the last 12 months. Pearson's correlation was used to analyze the correlation between the studied variables. Results: The lnLFnu values were negatively associated SD (SBP [r = -0.480; p = 0.010], PP [r = -0.504; p = 0.006] and MBP [r = -0.449; p = 0.017]), CV (SBP [r = -0.390; p = 0.040]) and delta (SBP [r = -0.438; p = 0.020], PP [r = -0.490; p = 0.008] and MBP [r = -0.382; p = 0.045]). lnLFnu was also negatively associated to the uremic state (r = -0.601; p = 0.01). Conclusions: Our results indicate that higher values of the lnLFnu are associated with better hemodynamic stability (i.e., smaller blood pressure oscillations) during HD sessions, in turn, the mean of blood urea concentration in the last 12 months, defined here as the uremic state, was associated with lower values of the lnLFnu during HD sessions.

Resumo O objetivo deste artigo é analisar os critérios de acreditação dos estudos que avaliaram as ações de promoção da saúde e prevenção de fatores de risco das Escolas Promotoras de Saúde (EPSs). Realizou-se uma revisão sistemática conduzida a partir das recomendações propostas no guia Preferred Reporting Items for Systematic Reviewsand Meta-Analyses (PRISMA) dos artigos que avaliaram as EPSs nas bases de dados: SciELO, Lilacs, Medline, PubMed e Portal Capes. A partir da análise dos três eixos para acreditação das EPS, três dos estudos analisados não contemplaram todos os critérios para serem certificadas como EPS nos eixos “Processo de Planejamento” e “Atividades de Promoção de Saúde desenvolvidas”. As escolas citadas nestes estudos apresentam atividades de educação em saúde, prevenção e/ou promoção da saúde, no entanto, é equivocado se autodenominarem EPS. Identificou-se como principais desafios enfrentados para a implantação, o desenvolvimento e a continuidade das EPS, a intersetorialidade e a insuficiência de recursos financeiros e humanos capacitados. As EPSs precisam ser certificadas e submetidas a um processo avaliativo contínuo. Sugere-se ainda a inclusão do tema promoção de saúde nos currículos dos cursos de formação dos professores e outros profissionais da educação e da saúde.

Abstract The scope of this article is to analyze the accreditation criteria of the studies that evaluated actions of health promotion and risk factor prevention of Health Promoting Schools (HPS). A systematic review was conducted based on the recommendations proposed in the “Preferred Reporting Items for Systematic Reviews and Meta-Analyses (Prisma)” protocol of articles that assessed HPS in the following databases: SciELO, Lilacs, Medline, PubMed and Portal Capes. From the analysis of the three pillars for accreditation of HPS, three of the studies analyzed did not include all the criteria for certification as HPS on the “Planning Process” and “Health Promotion Activities Developed” pillars. The schools cited in these studies perform health education, prevention and/or health promotion activities, however, it is misleading to refer to themselves as HPS. The main challenges for implementation, development and continuity of HPS were identified as being intersectionality and insufficient financial and qualified human resources. HPS need to be certified and submitted to an ongoing evaluation process. It is also suggested the topic of health promotion be included in the syllabuses of training courses of health education teachers and other health education professionals.

Resumo O objetivo deste artigo é analisar os critérios de acreditação dos estudos que avaliaram as ações de promoção da saúde e prevenção de fatores de risco das Escolas Promotoras de Saúde (EPSs). Realizou-se uma revisão sistemática conduzida a partir das recomendações propostas no guia Preferred Reporting Items for Systematic Reviewsand Meta-Analyses (PRISMA) dos artigos que avaliaram as EPSs nas bases de dados: SciELO, Lilacs, Medline, PubMed e Portal Capes. A partir da análise dos três eixos para acreditação das EPS, três dos estudos analisados não contemplaram todos os critérios para serem certificadas como EPS nos eixos “Processo de Planejamento” e “Atividades de Promoção de Saúde desenvolvidas”. As escolas citadas nestes estudos apresentam atividades de educação em saúde, prevenção e/ou promoção da saúde, no entanto, é equivocado se autodenominarem EPS. Identificou-se como principais desafios enfrentados para a implantação, o desenvolvimento e a continuidade das EPS, a intersetorialidade e a insuficiência de recursos financeiros e humanos capacitados. As EPSs precisam ser certificadas e submetidas a um processo avaliativo contínuo. Sugere-se ainda a inclusão do tema promoção de saúde nos currículos dos cursos de formação dos professores e outros profissionais da educação e da saúde.

Abstract The scope of this article is to analyze the accreditation criteria of the studies that evaluated actions of health promotion and risk factor prevention of Health Promoting Schools (HPS). A systematic review was conducted based on the recommendations proposed in the “Preferred Reporting Items for Systematic Reviews and Meta-Analyses (Prisma)” protocol of articles that assessed HPS in the following databases: SciELO, Lilacs, Medline, PubMed and Portal Capes. From the analysis of the three pillars for accreditation of HPS, three of the studies analyzed did not include all the criteria for certification as HPS on the “Planning Process” and “Health Promotion Activities Developed” pillars. The schools cited in these studies perform health education, prevention and/or health promotion activities, however, it is misleading to refer to themselves as HPS. The main challenges for implementation, development and continuity of HPS were identified as being intersectionality and insufficient financial and qualified human resources. HPS need to be certified and submitted to an ongoing evaluation process. It is also suggested the topic of health promotion be included in the syllabuses of training courses of health education teachers and other health education professionals.

RESUMO A febre reumática ainda é uma doença prevalente nos tempos atuais, sobretudo nos países em desenvolvimento. Deflagrada por uma infecção pelo Streptococcus β-hemolítico do grupo A, pode afetar pacientes geneticamente predispostos. A cardite reumática é a mais importante das manifestações clínicas, pode gerar sequelas incapacitantes e de grande impacto para o indivíduo e para a sociedade. Atualmente, seu diagnóstico é feito baseado nos Critérios de Jones, estabelecidos em 1992 pela American Heart Association (AHA). Em 2015, a AHA procedeu a uma significativa revisão desses critérios, com novos parâmetros e recomendações diagnósticas. No presente estudo, os autores fazem uma análise crítica dessa nova revisão e enfatizam os pontos de maior relevância para a prática clínica.

ABSTRACT Rheumatic fever is still currently a prevalent disease, especially in developing countries. Triggered by a Group A β-hemolytic Streptococcus infection, the disease may affect genetically predisposed patients. Rheumatic carditis is the most important of its clinical manifestations, which can generate incapacitating sequelae of great impact for the individual and for society. Currently, its diagnosis is made based on the Jones criteria, established in 1992 by the American Heart Association. In 2015, the AHA carried out a significant review of these criteria, with new diagnostic parameters and recommendations. In the present study, the authors perform a critical analysis of this new review, emphasizing the most relevant points for clinical practice.

RESUMO O feijão apresenta baixa capacidade de fixação biológica de nitrogênio, o qual pode ser mais eficiente com o fornecimento de molibdênio (Mo). O objetivo deste estudo foi avaliar doses de Mo no crescimento e na fixação biológica de nitrogênio em duas cultivares de feijoeiro usando a técnica de diluição isotópica. O experimento foi realizado em 2014 em delineamento inteiramente casualizado e em esquema fatorial 5 x 3, correspondendo a cinco doses de Mo (controle, 40, 80, 120 e 240 g ha-1), cultivares de feijoeiro Aporé, Ouro Negro e NORH-54, cultivar de feijão não nodulante e três repetições. A aplicação de Mo e a inoculação das sementes com uma estirpe de rizóbio contribuíram para melhorar a fixação de nitrogênio e o peso de grãos. A cultivar Ouro Negro apresentou maior número e peso de nódulos do que a cultivar Aporé e maiores valores de nitrogênio proveniente da atmosfera. A fixação biológica do nitrogênio foi mais dependente da aplicação de Mo na cultivar Aporé. Esses resultados indicaram que a inoculação com rizóbio e o fornecimento de Mo contribuíram com a fixação biológica de nitrogênio e produção de grãos.

ABSTRACT The common bean has been considered to have low biological nitrogen fixation capacity; however, this process can be made more effective with molybdenum (Mo) supplementation. The objective of this study was to evaluate the influence of Mo rates on the growth and biological nitrogen fixation by two Brazilian common bean cultivars using the 15N isotope dilution technique. The experiment was performed in 2014 in a completely randomized design arranged in a 5 x 3 factorial scheme, corresponding to 5 rates of Mo (control, 40, 80, 120 and 240 g ha-1), the common bean cultivars Aporé, Ouro Negro and NORH-54 (a non-nodulating common bean cultivar), and three replicates. The application of Mo and the inoculation with rhizobia strains contributed to improving nitrogen fixation and grain weight. The cultivar Ouro Negro showed a higher number and weight of nodules and a higher amount of nitrogen derived from the atmosphere than the cultivar Aporé. The biological nitrogen fixation of Aporé was more dependent on the application of Mo. These results indicated that inoculation with Rhizobium strains and Mo supply effectively contributed to biological nitrogen fixation and improving grain production.

Resumo O objetivo deste estudo foi caracterizar físico-químicamente e avaliar o reparo ósseo de discos de hidroxiapatita porosa contendo zinco após a implantação em calvária de coelhos (nZnHA). O pó de nZnHA e o pó hidroxiapatita porosa estequiométrica nanoestruturada (controle - nHA) foram confeccionados em discos (8 mm) e calcinados a 550˚C. Dois defeitos cirúrgicos foram criados na calvária de seis coelhos para a implantação dos discos. Após 12 semanas, os animais foram eutanasiados e as áreas enxertadas foram removidas, fixadas em formol a 10% e embebidas em parafina (n=10) para avaliação histomorfométrica. Além disso, uma amostra de cada grupo (n=2) foi embebida em metilmetacrilato para análise de MEV e EDS. O tratamento térmico dos discos de nZnHA transformou-os em implantes bifásicos compostos por HA contendo Zinco e β fosfato tricálcico com Zinco (ZnHA/βZnTCP). Os discos de nHA, apresentaram-se altamente cristalinos e com baixa solubilidade quando comparados aos discos de ZnHA. A análise histológica revelou que ambos os materiais foram biologicamente compatíveis e promoveram a osteocondução. As análises de FRX e MEV-EDS confirmaram a presença do zinco nas amostras de nZnHA. A avaliação histomorfométrica revelou a presença de neoformação óssea em ambos os grupos, porém sem diferenças estatísticas entre eles, com base no teste de Wilcoxon (p>0,05). O presente estudo confirmou que ambos os biomateriais otimizaram o reparo ósseo, foram biocompatíveis e osseocondutivos e a presença do zinco não favoreceu o reparo ósseo. Estudos adicionais in vivo devem ser conduzidos a fim de investigar o efeito de maiores concentrações de zinco.

Abstract The aim of this study was to characterize the physico-chemical properties and bone repair after implantation of zinc-containing nanostructured porous hydroxyapatite scaffold (nZnHA) in rabbits' calvaria. nZnHA powder containing 2% wt/wt zinc and stoichiometric nanostructured porous hydroxyapatite (nHA - control group) were shaped into disc (8 mm) and calcined at 550 °C. Two surgical defects were created in the calvaria of six rabbits (nZnHA and nHA). After 12 weeks, the animals were euthanized and the grafted area was removed, fixed in 10% formalin with 0.1 M phosphate buffered saline and embedded in paraffin (n=10) for histomorphometric evaluation. In addition, one sample from each group (n=2) was embedded in methylmethacrylate for the SEM and EDS analyses. The thermal treatment transformed the nZnHA disc into a biphasic implant composed of Zn-containing HA and Zn-containing β-tricalcium phosphate (ZnHA/βZnTCP). The XRD patterns for the nHA disc were highly crystalline compared to the ZnHA disc. Histological analysis revealed that both materials were biologically compatible and promoted osteoconduction. X-ray fluorescence and MEV-EDS of nZnHA confirmed zinc in the samples. Histomorphometric evaluation revealed the presence of new bone formation in both frameworks but without statistically significant differences (p>0.05), based on the Wilcoxon test. The current study confirmed that both biomaterials improve bone repair, are biocompatible and osteoconductive, and that zinc (2wt%) did not increase the bone repair. Additional in vivo studies are required to investigate the effect of doping hydroxyapatite with a higher Zn concentration.

RESUMO A grande dificuldade para a produção de alface de qualidade na região semiárida se deve aos fatores climáticos, como temperatura elevada, alta luminosidade e baixa umidade relativa do ar, que afetam as características de qualidade das hortaliças folhosas. Diante disso, o objetivo da pesquisa foi avaliar a qualidade de cultivares de alface dos grupos Americana (Angelina, Amélia e Tainá), Mimosa (Mila, Mimosa e Lavínia), Crespa (Scarlet, Vera, Isabella e Vanda) e Lisa (Elisa e Regiane) em quatro épocas do ano: verão (21/12/2012), outono (21/03/2013), inverno (21/06/2013) e primavera (23/09/2013) nas condições de Mossoró, RN. O delineamento experimental adotado foi o de blocos casualizados completos com quatro repetições. Foram quantificadas as características: pH, acidez titulável, sólidos solúveis (SS) e açúcares solúveis totais. A qualidade da alface foi influenciada pela cultivar e condições ambientais. Os grupos Crespa e Lisa registraram menor acidez titulável no verão e as Americanas no outono. Os maiores teores de SS foram obtidos no outono para as cultivares Vera, Vanda, Isabela, Elisa e Regiane; para Lavínia, Angelina, Amélia e Tainá, o verão e outono se destacaram das demais épocas de cultivo, para esta característica. As cultivares Scarlet, Angelina e Amélia apresentaram maior teor de açúcares solúveis totais no verão, Mila e Lavínia na primavera, Elisa e Regiane no inverno e Tainá na primavera.

ABSTRACT The major challenge in producing good quality lettuce in the semiarid region is the climatic factors such as high temperature, high luminosity and low air relative humidity, which affect the quality characteristics of leafy vegetables. Thus, the objective of this study was to evaluate the quality of lettuce cultivars of Crisphead (Angelina, Amelia and Taina), Mimosa (Mila, Mimosa and Lavinia), Green-leaf (Scarlet, Vera, Isabella and Vanda) and Loose-leaf (Elisa and Regiane) in four seasons: summer (12/21/2012), autumn (3/21/2013), winter (06/21/2013) and spring (09/23/2013) in the conditions of Mossoró, Rio Grande do Norte state. The experimental design was a complete randomized block with four replications. The following characteristics were quantified: pH, titratable acidity, soluble solids (SS) and total soluble sugars. The quality of the lettuce was influenced by the cultivar and environmental conditions. Lower titratable acidity was recorded for Green-leaf and Loose-leaf groups in the summer and for Crisphead groups in the autumn. The highest content of soluble solids were achieved in autumn for cultivars Vera, Vanda, Isabela, Elisa and Regiane; to Lavinia, Angelina, Amelia and Tainá, and summer and autumn stood out from the other growing seasons for this trait. Cultivars Scarlet, Angelina and Amelia had higher levels of total soluble sugars in the summer; Mila and Lavinia in spring; Elisa and Regiane in winter and Tainá in spring.