Pesquisa | SciELO

Juvenile hormone (JH III) is an important example of a chemical signaling derived from the terpene biosynthetic pathway. Because of its impact on many species’ reproductive and developmental processes, analytical approaches must be developed to accurately identify and measure it in biological samples. In this technical note, we explored the gas-phase dissociative behavior of JH III using tandem mass spectrometry combined with electrospray ionization to provide diagnostic fragment-ions for quantitative purposes.

https://doi.org/10.21577/0100-4042.20230091

Advances in Breast Cancer Drug Discovery: A Review of Therapeutic Strategies and Studies Involving Photosensitizers, Caged Xanthones and Thiosemicarbazones Derivatives Discovery Photosensitizers
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Oliveira, Douglas D. S.

; Lapierre, Thibault J. W. Jacques Dit

; Silva, Fernanda C.

; Cunha, Ieda V.

; Souza, Rafael A. C.

; Matos, Patrícia A.

; Almeida, Gustavo M.

; Oliveira, Carolina G.

; Araújo, Thaise G.

; Tsubone, Tayana M.

; Rezende Jr., Celso O.

Journal of the Brazilian Chemical Society

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2024, Volume 35 Nº 1 elocation e-20230128

Resumo: En | Texto: En | PDF: En

Cancer is one of the major causes of death worldwide, and breast cancer is the most prevalent and deadly type among women. Despite the side effects and the phenomena of chemoresistance associated with the drugs involved, chemotherapy remains the main therapeutic strategy to combat and control breast cancer. Therefore, several new classes of compounds against breast cancer have been explored, in an effort to identify new drug candidates with alternative mechanisms of action. The principal results of such exploration, focusing on caged xanthones, thiosemicarbazones and photosensitizers, are presented in this review, along with the main aspects of the drug discovery process against breast cancer. More specifically, the design, structure-activity relationship investigations and anti-breast cancer properties of these three classes are described and discussed in this work. worldwide women involved Therefore explored action exploration xanthones photosensitizers review specifically design structureactivity structure activity antibreast anti work

https://doi.org/10.21577/0103-5053.20230128

Long-term oncological and surgical outcomes after Video Endoscopic Inguinal Lymphadenectomy (VEIL) in patients with penile cancer
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Tobias-Machado, Marcos

; Ornellas, Antonio A.

; Hidaka, Alexandre K.

; Medina, Luis G.

; Mattos, Pablo A. L.

; Besio, Ruben S.

; Abreu, Diego

; Castro, Pedro R.

; Nishimoto, Ricardo H.

; Astigueta, Juan

; Dourado, Aurus

; Machado, Roberto D.

; Magnabosco, Wesley J.

; Corona-Montes, Victor

; Villoldo, Gustavo M.

; Zampolli, Hamilton C.

; Taha, Anis

; Auad, Pericles R.

; Faria, Eliney F.

; Arantes, Paulo B. O.

; Tavares, Alessandro

; Nascimento, Francisco S. M. S.

; Brazão Jr., Eder S.

; Rocha, Maurício M.

; Costa, Walter H.

; Panico, Vinicius

; Reis, Leonardo O.

; Almeida-Carrera, Roberto J.

; Silva, Rafael C.

; Zequi, Stênio C.

; Calixto, José R. R.

; Sotelo, Rene

International braz j urol

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Out 2023, Volume 49 Nº 5 Páginas 580 - 589

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: To report outcomes from the largest multicenter series of penile cancer patients undergoing video endoscopic inguinal lymphadenectomy (VEIL). Materials and Methods: Retrospective multicenter analysis. Authors of 21 centers from the Penile Cancer Collaborative Coalition-Latin America (PeC-LA) were included. All centers performed the procedure following the same previously described standardized technique. Inclusion criteria included penile cancer patients with no palpable lymph nodes and intermediate/high-risk disease and those with non-fixed palpable lymph nodes less than 4 cm in diameter. Categorical variables are shown as percentages and frequencies whereas continuous variables as mean and range. Results: From 2006 to 2020, 210 VEIL procedures were performed in 105 patients. Mean age was 58 (45-68) years old. Mean operative time was 90 minutes (60-120). Mean lymph node yield was 10 nodes (6-16). Complication rate was 15.7%, including severe complications in 1.9% of procedures. Lymphatic and skin complications were noted in 8.6 and 4.8% of patients, respectively. Histopathological analysis revealed lymph node involvement in 26.7% of patients with non-palpable nodes. Inguinal recurrence was observed in 2.8% of patients. 10y- overall survival was 74.2% and 10-y cancer specific survival was 84.8%. CSS for pN0, pN1, pN2 and pN3 were 100%, 82.4%, 72.7% and 9.1%, respectively. Conclusion: VEIL seems to offer appropriate long term oncological control with minimal morbidity. In the absence of non-invasive stratification measures such as dynamic sentinel node biopsy, VEIL emerged as the alternative for the management of non-bulky lymph nodes in penile cancer.

https://doi.org/10.1590/s1677-5538.ibju.2023.0065

Larvicidal Activity of Calcium Alginate Microcapsules Containing Clove Essential Oil Obtained by Microfluidics
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Condé, Débora T.

; Mendes, Luiza A.

; Ramos, Guilherme P.

; Silva, Rafael R. A.

; Teixeira, Alvaro V. N. C.

; Teixeira, Róbson Ricardo

; Martins, Gustavo F.

; Cerceau, Cristiane I.

; Lopes, Renata P.

Journal of the Brazilian Chemical Society

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Ago 2023, Volume 34 Nº 8 Páginas 1166 - 1174

Resumo: En | Texto: En | PDF: En

Essential oils (EO) have diverse applications, such as antibacterial and antifungal activity. However, they are susceptible to oxidation in the presence of air, light, and moisture. In addition, they are thermally unstable. In this sense, it is necessary to develop techniques to increase the lifespan of EO. In this work, EO was obtained from cloves and characterized by different techniques. The major compounds found were eugenol (83%), eugenol acetate (9%), and β-caryophyllene (8%). The EO was encapsulated by extrusion using a microfluidic device. The sodium alginate was used as wall material, and the CaCl2 solution was used as a crosslinking agent. The microcapsule presented sizes of 164.7 ± 0.3 μm, with an encapsulation yield of 64 ± 14%. Functional characteristic groups of EO were observed in the microcapsule by infrared and Raman spectroscopies. The microcapsule increased the thermal decomposition of the EO from 162 to 230 °C. Release kinetics of the capsule was performed, with an equilibrium time of 72 h and release of 54% of the EO. Finally, the pure EO and encapsulated EO-microcapsules were applied in the Aedes aegypti larvae control, showing mean lethal concentration necessary to eliminate 50% (LC50) values of 74.4 and 96.9 μg mL-1 and lethal concentration necessary to eliminate 90% (LC90) of 106.2 and 133.3 μg mL-1 for pure EO and encapsulated EO, respectively. Therefore, it was concluded that these microcapsules have the potential for application in the Aedes aegypti larvae control.

https://doi.org/10.21577/0103-5053.20230029

Critical Success Factors of Six Sigma and Lean Manufacturing Projects
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Bribiescas Silva, Francisco

; Hernández Gómez, Jesús A.

; Poblano-Ojinaga, Eduardo Rafael

; Valles Chávez, Adán

; Noriega Morales, Salvador Anacleto

RIDE. Revista Iberoamericana para la Investigación y el Desarrollo Educativo

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Jun 2023, Volume 13 Nº 26 elocation e053

Resumo: Es En Pt | Texto: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen La literatura de factores de la eficiencia de proyectos se Manufactura Esbelta y Seis Sigma es extensa, incluye reportes de sus cuestionables resultados y se observa la falta de explicaciones razonables, objetivas ellos. En la búsqueda de los factores de los proyectos ME/SS la literatura no es concluyente. Por ello, el objetivo de este proyecto de investigación es determinar esos factores. Para ese propósito, se realizó una revisión de literatura, determinado una lista de 29 factores en 48 artículos, dicha lista se redujo a 21 por Meta-Análisis. Con los factores se construyó un cuestionario, con 4 constructos y 25 indicadores, mismo que se validó con las pruebas de KMO y Bartlett. El cuestionario se aplicó a una muestra de 225 ingenieros con experiencia en proyectos de ME/SS desarrollados en plantas industriales que operan tecnologías de alto nivel. La especificación del modelo estructural inicia con un Análisis Factorial Exploratorio con rotación oblicua y por el método de Componentes Principales con rotación Promax y se aplicaron varios indicadores para la evaluación empírica. Se determinaron los factores críticos del éxito de proyectos de ME/SS y se comprobó la bondad de los métodos de ecuaciones estructurales. Se presenta y discute el modelo estructural y sus componentes.

Abstract Literature is extensive regarding the increases of efficiency by Six Sigma and Lean Manufacturing (SS/LM) projects, including reports of questionable results and the lack of reasonable explanations about those cases. In the search of the factors influencing the success of the projects, the literature is inconclusive. Therefore, the objective of this work is to determine the factors influencing the success of those projects. For which, a literature review was carried out finding that 48 publications gave a list of 29 factors, which is reduced to 21 by a Meta-Analysis study. These factors are used for the development of a questionnaire with 4 constructs and 25 indicators, which is validated with KMO and Bartlett’s tests. To identify the factors used in the industrial practice and their contributions to success, the questionnaire was applied to a sample of 225 engineers with experience in Six Sigma and Lean Manufacturing projects working in high tech manufacturing companies. The specification of the structural model starts with an exploratory factorial analysis-oblique rotation and the method of Principal Axes with Promax rotation, afterward for the empirical evaluation several indexes were used. The critical success factors and the usefulness of SEM for these purposes were determined. The structural model and its components are presented in this paper.

Resumo A literatura sobre os fatores de eficiência do projeto Lean Manufacturing e Seis Sigma é extensa, inclui relatórios de seus resultados questionáveis e carece de explicações razoáveis e objetivas para eles. Na busca dos fatores dos projetos ME/SS, a literatura não é conclusiva. Portanto, o objetivo deste projeto de pesquisa é determinar esses fatores. Para tanto, foi realizada uma revisão da literatura, determinando uma lista de 29 fatores em 48 artigos, esta lista foi reduzida para 21 por Meta-Análise. Foi construído um questionário com os fatores, com 4 construtos e 25 indicadores, o qual foi validado com os testes KMO e Bartlett. O questionário foi aplicado a uma amostra de 225 engenheiros com experiência em projetos de ME/SS desenvolvidos em plantas industriais que operam tecnologias de alto nível. A especificação do modelo estrutural inicia-se com uma Análise Exploratória de Fatores com rotação oblíqua e pelo método de Componentes Principais com rotação Promax e vários indicadores foram aplicados para avaliação empírica. Foram determinados os fatores críticos para o sucesso de projetos de ME/SS e verificada a qualidade dos métodos de equações estruturais. O modelo estrutural e seus componentes são apresentados e discutidos.

https://doi.org/10.23913/ride.v13i26.1497

Guía de práctica clínica para el manejo del cáncer de pulmón de células pequeñas: enfermedad limitada
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Cabrera-Miranda, Luis A.

; Lozano-Ruiz, Francisco J.

; Blake-Cerda, Mónika

; Corona-Cruz, José F.

; Sánchez-Reyes, Roberto

; Pérez-Álvarez, Sandra I.

; Díaz-García, Diego A.

; Álvarez-Bojórquez, Mario E.

; Rivera-Márquez, Raúl

; López-Saucedo, Raúl A.

; Bolaño-Guerra, Laura M.

; Maldonado-Magos, Federico

; Aldaco-Sarvide, Fernando

; Alvarado-Zermeño, Adriana

; Barajas-Figueroa, Luis J.

; Bautista-Aragón, Yolanda

; Bolaños-Morales, Francina V.

; Castillo-Ortega, Graciano

; Félix-Leyva, Jesús A.

; Gerson-Cwilich, Raquel

; Guzmán-de Alba, Enrique

; López-Galindo, Ángel A.

; Mariscal-Ramírez, Carlos

; Piñeiro-Retif, Rafael

; Ramos-Prudencio, Rubí

; Rodríguez-Cid, Jerónimo

; Silva-Bravo, Fernando

; Arrieta, Óscar

Gaceta mexicana de oncología

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Mar 2023, Volume 22 Nº 1 Páginas 3 - 23

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Antecedentes: El cáncer de células pequeñas (CPCP) representa el 13-15% del total de neoplasias primarias de pulmón. Se caracteriza por su rapidez en la tasa de crecimiento y en el desarrollo de metástasis a distancia. Objetivos: Orientar y estandarizar el tratamiento del CPCP, enfermedad limitada, en México, basado en evidencia clínica nacional e internacional. Material y métodos: Este documento se desarrolló como una colaboración entre el Instituto Nacional de Cancerología y la Sociedad Mexicana de Oncología en cumplimiento con estándares internacionales. Se integró un grupo conformado por oncólogos médicos, cirujanos oncólogos, cirujanos de tórax, radio-oncólogos y metodólogos con experiencia en revisiones sistemáticas de la literatura y guías de práctica clínica. Resultados: Se consensuaron, por el método Delphi y en reuniones a distancia, las recomendaciones en CPCP enfermedad limitada, producto de las preguntas de trabajo. Se identificó y evaluó críticamente la evidencia científica que responde a cada una de dichas preguntas clínicas, antes de incorporarla a la guía. Conclusión: Esta guía proporciona recomendaciones clínicas para el manejo de la enfermedad limitada del CPCP y durante el proceso de toma de decisiones de los clínicos involucrados con su manejo en nuestro país para mejorar la calidad de la atención clínica en estos pacientes.

Abstract Background: Small cell lung cancer (SCLC) represents 13-15% of all primary lung neoplasms and is characterized by rapid growth rate and development of distant metastases. Objectives: To guide and standardize the treatment of limited disease small cell lung cancer in Mexico based on national and international clinical evidence. Material and methods: This document was developed as a collaboration between the National Cancer Institute and the Mexican Society of Oncology in compliance with international standards. An interdisciplinary group was formed, including medical oncologists, oncological surgeons, thoracic surgeons, radiation oncologists, and methodologists with experience in systematic reviews of the literature and clinical practice guidelines. Results: Consensus recommendations were reached, both by the Delphi method and in remote meetings, for limited SCLC disease resulting from the same number of work questions. The scientific evidence that answers each of these clinical questions was identified and critically evaluated, before being incorporated into the body of evidence of the guide. Conclusion: This guide provides clinical recommendations for the management of limited disease SCLC to contribute to the decision-making process of the clinicians involved with its management in our country, hoping that this will contribute to improving the quality of clinical care in these patients.

https://doi.org/10.24875/j.gamo.22000121

Green Synthesis of Cellulose-Based Biofilms Doped with AgNPs with Antibacterial Activity
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Pereira, Arthur B. D.

; Silva, Rafael R. A.

; Marques, Clara S.

; Nascimento, Mayra Aparecida

; Soares, Nilda de Fatima F.

; Lopes, Renata P.

Journal of the Brazilian Chemical Society

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Mar 2023, Volume 34 Nº 3 Páginas 366 - 376

Resumo: En | Texto: En | PDF: En

In this work, cellulose-based composite biofilms doped with silver nanoparticles (AgNPs) have been produced by eco-friendly process. The AgNPs were synthesized from Ilex paraguariensis with an average size of 45 nm, a characteristic plasmon band at 450 nm and zeta potential of -23 mV. The biofilm has been synthesized by casting method, using different volumes of AgNPs suspension with glycerol plasticizing agent (T6-T10) or not (T1-T5). The AgNPs were successfully incorporated into the biofilms, which was confirmed by scanning electron microscopy. The mechanical and optical structural and the antimicrobial properties of the biofilms have been determined. In the presence of AgNPs, the mechanical properties, thermal stability and water vapor barrier of the biofilms have not been altered. However, the addition of glycerol decreased the tensile strength and the modulus of elasticity, in addition to increasing the elongation of the biofilms and the water vapor barrier. The biofilm T10 showed a transmittance of ca. 10%, with high potential to be used as a UV light blocker. Finally, the biofilms doped with AgNPs showed activity against the bacterium Pseudomonas fluorescens. Given the above, this work presented a new biofilm with activity against the bacterium Pseudomonus fluorescens obtained by eco-friendly process.

https://doi.org/10.21577/0103-5053.20220114

Oceanographic conditions of the continental slope and deep waters in Santos Basin: the SANSED cruise (winter 2019)
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Silveira, Ilson C. A. da

; Bernardo, Piero S.

; Lazaneo, Cauê Z.

; Amorim, João P. M.

; Borges-Silva, Milton

; Martins, Rafael C.

; Santos, Daniel M. C.

; Dottori, Marcelo

; Belo, Wellington C.

; Martins, Renato P.

; Guerra, Luiz A. A.

; Moreira, Daniel L.

Ocean and Coastal Research

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2023, Volume 71 Supl. 3 elocation e23008

Resumo: En | Texto: En | PDF: En

Abstract This work describes the circulation over the continental slope and the São Paulo Plateau in the Santos Basin during the SANSED winter 2019 survey. The cruise consisted of four legs in the period between June, 11 and August, 03 2019. The observed circulation is dominated by the Atlantic southwestern boundary current regime and remotely-generated anticyclones and cyclones. The former is composed by the Brazil Current, the Intermediate Western Boundary Current and their mesoscale meanders; the latter are 300km vortical rings with origin in the eastern side of the South Atlantic Basin. A Lagrangian scheme applied over satellite altimeter maps indicate that the origin of these rings is primarily the Cape Basin of South Africa. The interaction between the boundary currents, their cyclonic meanders, and the anticyclonic rings is complex, and varies widely. During the SANSED winter 2019 survey period, three anticyclones interacted with the Brazil Current, instabilizing it, forming dipoles with the current cyclonic meanders, leading to their downstream propagation. Ancienter cyclonic eddies within Santos Basin may interfere with the propagation of the large anticyclones further south. In addition, the continuous arrival of remotely-originated anticyclones, the larger portion over the São Paulo Plateau presented a tendency of counter-clockwise circulation during the whole cruise period.

https://doi.org/10.1590/2675-2824071.2206icas

DIFFUSION STUDY OF NaCl AND KCl AT THE SOLUTION/OLIVE INTERFACE: MATHEMATICAL MODELING USING THE FINITE ELEMENT METHOD AND SELF-ORGANIZING FEATURE MAP (SOFM)-TYPE NEURAL NETWORKS
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Borsato, Dionisio

; Clemente, Marco A. J.

; Silva, Heloisa H. P.

; Silva, Nathan F.

; Campos, Julia W.

; Sousa, Eduardo G. de

; Silva, Hágata C.

; Angilelli, Karina B.

; Mantovani, Ana C. G.

; Mantovani, Rafael G.

Química Nova

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2023, Volume 46 Nº 8 Páginas 785 - 790

Resumo: En | Texto: En | PDF: En

Olive samples were subjected to the salting process in brine containing 1196 mol m−3 of NaCl and 402 mol m−3 of KCl. Samples were collected during 60 h and salt concentration values were determined. With the finite element method (FEM) and the minimization of the errors percentage between the simulated and experimental values, the mass transfer coefficients in the film (hm) were obtained, being 1.0072 × 10−8 and 1.2499 × 10−8 for NaCl and KCl, respectively. The salts concentration at the olive/brine interface was simulated by FEM and analyzed via SOFM. A network with 4 × 4 topology and 10000 training epochs was used. It was observed that the influence of the stationary film formed on the surface of the olives during the salting process depends on the position, the salt involved in the diffusion and that the concentration of the salts, at each point, varies according to the immersion time.

https://doi.org/10.21577/0100-4042.20230053

10.

Use of Ozonized Water in the Prevention of Surgical Site Infection in Children Undergoing Cardiovascular Surgery
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Murakami, Alexandre Noboru

; Croti, Ulisses Alexandre

; Borim, Bruna Cury

; Marchi, Carlos Henrique De

; Murakami, Rouse Mary Rossini

; Almeida, Margarete Teresa Gottardo de

; Policarpo, Rafael da Silva

; Avona, Fabiana Nakamura

; Godoy, Moacir Fernandes de

Brazilian Journal of Cardiovascular Surgery

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2023, Volume 38 Nº 6 elocation e20230006

Resumo: En | Texto: En | PDF: En

ABSTRACT Introduction: Since the reduction of healthcare-associated infections has been a focus for quality patient care, this study aimed to evaluate the surgical site infection rate of children who underwent cardiovascular surgery after implementation of ozonized water system for hand and body hygiene allied to previously implemented preventive measures. Methods: Two uniformly comparable groups of pediatric patients underwent cardiovascular surgery. Group A (187) patients were operated prior to installation of ozonized water system (March 1 to August 31, 2019), and group B (214) patients were operated after installation of ozonized water system (October 1, 2019, to March 31, 2020). Ozonized water was used for professional hand hygiene and patient body hygiene. Results: There was statistical significance for surgical site infection reduction in group B (P=0.0289), with a relative risk of 0.560 (95% confidence interval = 0.298 to 0.920), inferring the risk of being diagnosed with surgical site infections in group B was 44% less than in group A. There was no statistical significance regarding mechanical ventilation time (P=0.1998) or mortality (P=0.4457). Conclusion: Ozonized water for professional hand hygiene and patient body hygiene was an adjuvant combined with traditional preventive methods to reduce the risk of surgical site infection, although no impact on hospital stay or mortality was observed.

https://doi.org/10.21470/1678-9741-2023-0006

11.

Stabilization of β-Galactosidase Encapsulated in Pectin-Alginate Hydrogel and Hydrolysis of Whey Lactose and Whole Milk
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Paiva, Maykon J.

; Paula-Elias, Fabrício C.

; Pereira, Luciana A.

; Carreiro, Solange C.

; Vieira-Almeida, Erika C.

; Silva, Ezequiel M.

; Dias, Giancarlo S.

; Xavier, Michelle A. C.

; Morales, Sergio A.

; Perna, Rafael F.

; Almeida, Alex F.

Journal of the Brazilian Chemical Society

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2023, Volume 34 Nº 12 Páginas 1743 - 1752

Resumo: En | Texto: En | PDF: En

The operational conditions of β-galactosidase encapsulated in pectin-alginate hydrogel were investigated as well as its catalytic activity in the hydrolysis of lactose from whey and whole milk. β-Galactosidase encapsulated in pectin-alginate hydrogel showed the best results to yields and diffusional effect and pH range. Thermostability showed considerable income gain for half-life (1.7-fold), activation energy of denaturation (31.6-fold), activation of denaturation (217.3-fold at 40 ºC; 266.8-fold at 50 ºC; 345.6-fold at 60 ºC), and entropy of activation of denaturation (-42.0 J mol 1 K-1). Reusability of encapsulated β-galactosidase was observed in 8-cycles for the milk whey lactose hydrolysis (51.9%) and 7-cycles for whole milk (55.6%), and the lactose hydrolysis was observed in 13% in milk whey and 10.3% in whole milk after 10 cycles. These results revealed an industrial application potential of β-galactosidase encapsulated in pectin-alginate hydrogel for lactose hydrolysis of milk whey and whole milk processes.

https://doi.org/10.21577/0103-5053.20230067

12.

Deep sea ecosystem exploration and ‘health check’: sampling strategy and methods applied during the iAtlantic_BR10_Petrobras cruise in the Santos Basin, Southwest Atlantic
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Perez, Jose Angel A.

; Barros Neto, Halésio M.C. de

; Arantes, Renata C.M.

; Gaurisas, Daniela Y.

; Silva, Camila F.

; Alves, Fernanda Maria M.

; Costa, Júlia A.

; Eloi, Paula D.C.

; Fonseca, Thayse S.

; Gavazzoni, Lucas

; Lonskis, Isabella da S.

; Nardi, Ricardo U.

; Nascimento, Pedro O.

; Rodrigues, João Vitor M.

; Santos, Ana Lara F. dos

; Santos, Edson C. dos

; Schroeder, Rafael

; Silva, Luis Carlos da

; Souza, Fernanda dos S.S. de

; Bernardino, Ângelo F.

; Cavalcanti, Guarani H.

; Lindner, Alberto

; Mahiques, Michel M. de

; Millo, Christian

; Reis, Priscila

; Sweetman, Andrew K.

; Roberts, J. Murray

Ocean and Coastal Research

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2023, Volume 71 elocation e23046

Resumo: En | Texto: En | PDF: En

Abstract The iAtlantic Project has established an international collaborative strategy to improve mapping and characterization of deep and open ocean ecosystems in understudied regions of the Atlantic and evaluate their health. In December 2022, the first iAtlantic expedition in the South Atlantic set off to map and explore seafloor ecosystems in the Santos Basin slope (200-1,000 m depths) in collaboration with the Petrobras ‘Santos Basin - Regional Characterization Project.’ The 17-day ‘iAtlantic_BR10-Petrobras’ cruise was conducted on board the research vessel NPqHOc Vital de Oliveira (Brazilian Navy) and performed (a) water column structure characterization, (b) seafloor morphology mapping, (c) description of benthic habitats and communities by seafloor imagery and biological/ geological sampling, and (d) ex-situ experiments to assess the functioning of sedimentary ecosystems and their responses to climate-related environmental changes. This study describes the rationale behind the iAtlantic_BR10-Petrobras cruise science plan, reports its sampling strategy and methods, and summarizes its collected data and preliminary results.

https://doi.org/10.1590/2675-2824071.23069jaap

13.

Multidisciplinary Scientific Cruises for Environmental Characterization in the Santos Basin – Methods and Sampling Design
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Moreira, Daniel L.

; Dalto, Adriana G.

; Figueiredo JR, Alberto G.

; Valerio, Aline M.

; Detoni, Amalia M. S.

; Bonecker, Ana C. T.

; Signori, Camila N.

; Namiki, Cláudia

; Sasaki, Dalton K.

; Pupo, Daniel V.

; Silva, Danilo A.

; Kutner, Deborah S.

; Duque-Castaño, Diana C.

; Marcon, Eduardo H.

; Gallotta, Fabiana D. C.

; Paula, Fabiana S.

; Gallucci, Fabiane

; Roque, Gabriela C. F.

; Campos, Giulia S.

; Fonseca, Gustavo

; Mattos, Gustavo

; Lavrado, Helena P.

; Silveira, Ilson C. A. da

; Costa, Jessica O.

; Santos Filho, João R. dos

; Carneiro, Juliane C.

; Moreira, Julio C.F.

; Rozo, Laura

; Araujo, Leandro F.M.

; Lazzari, Letícia

; Silva, Letícia O. da

; Michelazzo, Luan S.

; Fernandes, Luciano F.

; Dottori, Marcelo

; Araújo Jr., Marcus A. G. de

; Chuqui, Mateus G.

; Ceccopieri, Milena

; Borges-Silva, Milton

; Kampel, Milton

; Bergo, Natascha M.

; Silva, Paulo V. M.

; Tura, Pedro M.

; Moura, Rafael B. de

; Romano, Renato G.

; Martins, Renato P.

; Carreira, Renato S.

; Toledo, Rodrigo G.A.

; Bonecker, Sérgio L.C.

; Disaró, Sibelle T.

; Rodrigues, Silvana V.

; Corbisier, Thais N.

; Vicente, Thaisa M.

; Paiva, Vitor G. de

; Pellizari, Vivian H.

; Belo, Wellington C.

; Brandini, Frederico P.

; Sousa, Silvia H.M

Ocean and Coastal Research

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2023, Volume 71 Supl. 3 elocation e23022

Resumo: En | Texto: En | PDF: En

Abstract The Santos Basin (SB) is the main petroliferous basin in the Brazilian continental margin and one of the most studied marine areas in Brazil. However, historical data suggest that new efforts should be carried out to acquire quantitative biological data, especially in the deep sea, to establish the baseline of essential ocean variables in different ecosystems for future monitoring programs. The Brazilian energy company Petrobras planned and executed 24 oceanographic cruises over a period of 2 years to assess the benthic (SANSED cruise) and pelagic (SANAGU cruise) systems of the SB (356 days at sea in 2019 and 2021/2022). These efforts were part of the Santos Project, which comprised a comprehensive environmental study aimed at investigating benthic and pelagic variables to characterize ecology, biogeochemistry, thermohaline properties of water masses, and ocean circulation patterns, geomorphology, and sedimentology, as well as organic and inorganic chemistry. Here we present the detailed sampling designs and the field methods employed on board, during the SB scientific cruises. All sampling protocols were based on standardized approaches. For the benthos analyses, triplicate sediment samples were performed using a GOMEX-type box corer (0.25 m²) or a large modified Van Veen grab (0.75 m²) at 100 stations ranging from 25 to 2400 m depth. At each station, 25 geochemical and physico-chemical parameters were analyzed in addition to micro-, meio-, and macrofauna and living foraminifera samples. For the pelagic system, 60 stations were selected to investigate the plankton community, ranging in size from pico- to macroplankton, through vertical, horizontal, and oblique net hauls (20, 200, and 500 μm mesh size), as well as 25 biogeochemical parameters collected with an aid of a CTD-rosette sampler. Part of this scientific information also serves the Regional Environmental Characterization Project (PCR-BS) in support of Petrobras’ Santos Basin drilling licensing process led by the Brazilian Environmental Agency – IBAMA. This project contributes to the sustainable development of the SB, in line with the guidelines of the United Nations Decade of Ocean Science for Sustainable Development.

https://doi.org/10.1590/2675-2824071.22072dlm

14.

Resveratrol directly suppresses proteolysis possibly via PKA/CREB signaling in denervated rat skeletal muscle
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I.S. JÚNIOR, IVANILDO

; ZANETTI, GUSTAVO O.

; VIEIRA, TALES S.

; ALBUQUERQUE, FLÁVIA P.

; GOMES, DAYANE A.

; PAULA-GOMES, SILVA

; VALENTIM, RAFAEL R.

; GRAÇA, FLAVIA A.

; KETTLHUT, ISIS C.

; NAVEGANTES, LUIZ C.C.

; GONÇALVES, DAWIT A.P.

; LIRA, EDUARDO C.

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Supl. 2 elocation e20220877

Resumo: En | Texto: En | PDF: En

Abstract Although there are reports that polyphenol resveratrol (Rsv) may cause muscle hypertrophy in basal conditions and attenuate muscle wasting in catabolic situations, its mechanism of action is still unclear. Our study evaluated the ex vivo effects of Rsv on protein metabolism and intracellular signaling in innervated (sham-operated; Sham) and 3-day sciatic denervated (Den) rat skeletal muscles. Rsv (10-4 M) reduced total proteolysis (40%) in sham muscles. Den increased total proteolysis (~40%) in muscle, which was accompanied by an increase in the activities of ubiquitin-proteasome (~3-fold) and lysosomal (100%) proteolytic systems. Rsv reduced total proteolysis (59%) in Den muscles by inhibiting the hyperactivation of ubiquitin-proteasome (50%) and lysosomal (~70%) systems. Neither Rsv nor Den altered calcium-dependent proteolysis in muscles. Mechanistically, Rsv stimulated PKA/CREB signaling in Den muscles, and PKA blockage by H89 (50μM) abolished the antiproteolytic action of the polyphenol. Rsv reduced FoxO4 phosphorylation (~60%) in both Sham and Den muscles and Akt phosphorylation (36%) in Den muscles. Rsv also caused a homeostatic effect in Den muscles by returning their protein synthesis rates to levels similar to Sham muscles. These data indicate that Rsv directly inhibits the proteolytic activity of lysosomal and ubiquitin-proteasome systems, mainly in Den muscles through, at least in part, the activation of PKA/CREB signaling.

https://doi.org/10.1590/0001-3765202320220877

15.

Tolerance of tomato seedling cultivars to different values of irrigation water salinity
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Oliveira, Carlos E. da S.

; Zoz, Tiago

; Jalal, Arshad

; Seron, Cassio de C.

; Silva, Rafael A. da

; Teixeira Filho, Marcelo C. M.

Revista Brasileira de Engenharia Agrícola e Ambiental

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Out 2022, Volume 26 Nº 10 Páginas 697 - 705

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O uso de água salina na produção de mudas de hortaliças é uma questão de preocupação mundial, portanto, selecionar cultivares de tomate com tolerância à água salina é essencial para uma melhor qualidade e produção dos frutos. Este trabalho teve como objetivo estimar o nível máximo de salinidade da água de irrigação que não prejudique a produção de mudas de tomateiro e encontrar cultivares com tolerância aos efeitos da salinidade nesta fase. No primeiro experimento os tratamentos foram dispostos em esquema fatorial 3 × 8 (três cultivares de tomateiro foram cultivadas sob oito valores de condutividade elétrica da água de irrigação) e no segundo experimento em esquema fatorial 10 × 3 (com 10 cultivares e três valores de condutividade elétrica da água de irrigação). A redução de 50% no acúmulo de matéria seca radicular ocorreu com a condutividade elétrica da água de irrigação (CEa) de 2,31 dS m-1. A redução de mais de 50% do índice de qualidade de Dickson foi observada com CEa de 6,38 dS m-1. A irrigação com 3,0 dS m-1 prejudica a emergência e o crescimento de todas as plântulas das dez cultivares de tomateiro, sendo as cultivares Coração de Boi, Dominador, Maestrina, Sheena e Shanty as mais tolerantes a condições de irrigação salina com 3.0 dS m-1. A condutividade elétrica da água de irrigação superior a 2,31 dS m-1 prejudica o crescimento radicular de mudas de tomateiro.

ABSTRACT The use of water with different salinity values in the production of vegetable seedlings is an issue of global concern; therefore, selecting tomato cultivars with tolerance to saline water is essential to improve the fruit quality and production. This study aimed to estimate the maximum electrical conductivity of irrigation water that does not harm the production of tomato seedlings and find cultivars with tolerance to the effects of salinity in this phase. In the first experiment, the treatments were arranged in a 3 × 8 factorial scheme (three tomato cultivars and eight values of electrical conductivity of irrigation water). The second experiment was arranged in a 10 × 3 factorial scheme (10 cultivars and three values of electrical conductivity of irrigation water). The 50% reduction in the root dry matter accumulation occurred with the electrical conductivity of irrigation water (ECw) of 2.31 dS m-1. The reduction of more than 50% of the Dickson quality index was observed with an ECw of 6.38 dS m-1. Irrigation with 3.0 dS m-1 impairs the complete emergence and growth of seedlings of all tomato cultivars. Coração de Boi, Dominador, Maestrina, Sheena, and Shanty were the tomato cultivars most tolerant to the irrigation water with 3.0 dS m-1 of ECw. The electrical conductivity of irrigation water higher than 2.31 dS m-1 impairs the root growth of tomato seedlings.

https://doi.org/10.1590/1807-1929/agriambi.v26n10p697-705

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