Pesquisa | SciELO

ABSTRACT Four treatments were established to evaluate the effect of delayed first exogenous feeding and subsequent feeding periods on the development of goldfish larvae. The fasting and feeding periods were arranged as follows: T1 (0DFA:30DF), T2 (4DFA:26DF), T3 (8DFA:22DF), and T4 (12DFA:18DF), where DFA are the days of fasting and DF are the days of feeding. The larvae were kept in community tanks for each repetition, with 75 larvae per tank (3.75 larvae L−1). There was no significant difference in total length or final weight between larvae submitted to 0, 4, and 8 days of feed deprivation. However, larvae submitted to 12 DFA had higher values of the same variables than the other treatments. No significant difference in larval survival was observed between T1, T2, and T3, but T4 negatively influenced survival. Under the conditions evaluated, the point of no return was 4 DFA. Dead larvae were partly eaten in the fasting treatments. The delayed first feeding should be avoided in large-scale productions since it significantly reduces survival during cultivation. This article results from research funded by the Pescarte Environmental Education Project (PEA/IBAMA).

https://doi.org/10.3856/vol51-issue2-fulltext-2993

Vitamin A deficiency as a cause of blindness in feedlot calves
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Pupin, Rayane C.

; Souza, Larissa L.

; Silva, Thaisa X.

; Fonseca, Helena Carolina F.

; Silva, Eduarda A.S.

; Gomes, Danilo C.

; Araújo, Marcelo Augusto de

; Lemos, Ricardo Antônio A.

Pesquisa Veterinária Brasileira

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2023, Volume 43 elocation e07249

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT: Vitamin A is an essential micronutrient to reproduction, development, normal growth, and function of the nervous system and vision, especially in growing animals. Hypovitaminosis A can affect any of these functions. The aim of this study was to describe the epidemiology, clinical signs, pathological aspects, and diagnostic approach in an outbreak of blindness in feedlot calves fed only grain. Five of 57 ten-month-old calves became blind after eight months at the feedlot. Clinical signs were mydriasis, absent pupillary and menace reflexes, bilaterally. Hypovitaminosis A was suspected and subsequently confirmed by low serum levels of vitamin A. One calf was euthanized and necropsied, and no gross findings were present. Histopathological lesions were restricted to the retina and characterized by degeneration and atrophy of the photoreceptor layer and some retinal scars. The calves were treated with intramuscular vitamin A injection at a dose of 5,000 international units (IU) per kilogram of body weight (kg BW) every 60 days until slaughter. Affected calves did not recover visual capacity, but no other cases occurred.

RESUMO: Vitamina A é um micronutriente essencial para reprodução, desenvolvimento, crescimento normal, além de participar do funcionamento do sistema nervoso central e visão, especialmente em animais em crescimento. Hipovitaminose A pode afetar qualquer uma dessas funções. O objetivo desse artigo é descrever a epidemiologia, sinais clínicos, aspectos patológicos e abordagem diagnóstica em um surto de cegueira em bezerros confinados alimentados apenas com grãos. De 57 bezerros de dez meses de idade, cinco ficaram cegos após oito meses no confinamento. Os sinais clínicos eram midríase, ausência de reflexo pupilar a luz e de ameaça, bilateralmente. Suspeitou-se de hipovitaminose A, que foi subsequentemente confirmada pelos baixos níveis séricos de vitamina A. Um bezerro foi eutanasiado e necropsiado, e alterações macroscópicas não foram encontradas. Lesões histopatológicas estavam restritas a retina e caracterizavam-se por degeneração e atrofia da camada de fotorreceptores, além de cicatrizes na retina. Os bezerros foram tratados com injeção intramuscular de vitamina A, na dose de 5.000 unidades internacionais (UI) por quilograma de peso vivo (Kg PV) a cada 60 dias, até o dia do abate. Os bezerros afetados não recuperaram a capacidade visual, mas novos casos não ocorreram.

https://doi.org/10.1590/1678-5150-pvb-7249

Posicionamento sobre Doença Isquêmica do Coração – A Mulher no Centro do Cuidado – 2023
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Oliveira, Gláucia Maria Moraes de

; Almeida, Maria Cristina Costa de

; Rassi, Daniela do Carmo

; Bragança, Érika Olivier Vilela

; Moura, Lidia Zytynski

; Arrais, Magaly

; Campos, Milena dos Santos Barros

; Lemke, Viviana Guzzo

; Avila, Walkiria Samuel

; Lucena, Alexandre Jorge Gomes de

; Almeida, André Luiz Cerqueira de

; Brandão, Andréa Araujo

; Ferreira, Andrea Dumsch de Aragon

; Biolo, Andreia

; Macedo, Ariane Vieira Scarlatelli

; Falcão, Breno de Alencar Araripe

; Polanczyk, Carisi Anne

; Lantieri, Carla Janice Baister

; Marques-Santos, Celi

; Freire, Claudia Maria Vilas

; Pellegrini, Denise

; Alexandre, Elizabeth Regina Giunco

; Braga, Fabiana Goulart Marcondes

; Oliveira, Fabiana Michelle Feitosa de

; Cintra, Fatima Dumas

; Costa, Isabela Bispo Santos da Silva

; Silva, José Sérgio Nascimento

; Carreira, Lara Terra F.

; Magalhães, Lucelia Batista Neves Cunha

; Matos, Luciana Diniz Nagem Janot de

; Assad, Marcelo Heitor Vieira

; Barbosa, Marcia M.

; Silva, Marconi Gomes da

; Rivera, Maria Alayde Mendonça

; Izar, Maria Cristina de Oliveira

; Costa, Maria Elizabeth Navegantes Caetano

; Paiva, Maria Sanali Moura de Oliveira

; Castro, Marildes Luiza de

; Uellendahl, Marly

; Oliveira Junior, Mucio Tavares de

; Souza, Olga Ferreira de

; Costa, Ricardo Alves da

; Coutinho, Ricardo Quental

; Silva, Sheyla Cristina Tonheiro Ferro da

; Martins, Sílvia Marinho

; Brandão, Simone Cristina Soares

; Buglia, Susimeire

; Barbosa, Tatiana Maia Jorge de Ulhôa

; Nascimento, Thais Aguiar do

; Vieira, Thais

; Campagnucci, Valquíria Pelisser

; Chagas, Antonio Carlos Palandri

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 Nº 7 elocation e20230303

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20230303

WATER DEMAND AND WATER USE EFFICIENCY IN ‘PALMER’ MANGO CULTIVATION IN THE LOW-MIDDLE SÃO FRANCISCO VALLEY
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Silva Junior, Francisco B. da

; Silva, Marcelo J. da

; Carvalho, Herica F. de S.

; Santos, Cloves Vilas Boas dos

; Silva, Thieres G. F. da

; Souza, Luciana S. B. de

; Leitão, Mario de M. Vilas Boas R.

; Moura, Magna S. B. de

Engenharia Agrícola

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2023, Volume 43 Nº 3 elocation e20220189

Resumo: En | Texto: En | PDF: En

ABSTRACT The study aimed to determine the evapotranspiration (ETc) of the mango cv. ‘Palmer’ over two productive cycles, analyzing water-use efficiency (WUE) and crop water productivity (CWP) to propose average crop coefficient (Kc) values for improving irrigation management under cultivation conditions in the Low-Middle São Francisco Valley. The study was conducted from July 2019 to May 2021 in a commercial ‘Palmer’ mango orchard in Petrolina, State of Pernambuco, Brazil. Micrometeorological data was collected throughout the experimental period. The crop evapotranspiration (ETc) was determined using Bowen ratio energy balance (BREB), and then the Kc, WUE, and CWP were determined. The highest ETc values occurred during the floral induction phase (5.14 ± 0.85 mm day-1), with a Kc of 0.85; however, the lowest values were observed during the fruit maturation phase (3.60 ± 0.73 mm day-1), with a Kc of 0.91. Average water consumption per cycle was 1445 mm, with a daily average of 4.39 mm day-1. WUE and CWP were 16.9 and 24.5 kg ha-1 mm-1, respectively. Average Kc values of 0.81, 0.76, 0.85, 0.90, 0.95, and 0.91 are recommended for the vegetative growth, rest period and shoot maturation, floral induction, flowering, fruit development, and fruit maturation phases, respectively.

https://doi.org/10.1590/1809-4430-eng.agric.v43n3e20220189/2023

Impact of sprayer drone flight height on droplet spectrum in mountainous coffee plantation
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Souza, Felipe G.

; Portes, Marcelo F.

; Silva, Marcus V.

; Teixeira, Mauri M.

; Furtado Júnior, Marconi R.

Revista Brasileira de Engenharia Agrícola e Ambiental

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Dez 2022, Volume 26 Nº 12 Páginas 901 - 906

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Condições climáticas e parâmetros operacionais dos pulverizadores influenciam a qualidade da pulverização. Os veículos aéreos não tripulados são considerados uma ferramenta tecnológica moderna, útil e bastante eficiente na aplicação de defensivos agrícolas, uma vez que realizam pulverizações pontuais, reduzindo problemas ambientais e de saúde pública. O objetivo deste estudo foi caracterizar a qualidade da pulverização realizada com um veículo aéreo não tripulado em função da altura de voo e a posição do alvo em lavoura de café de região montanhosa. Utilizou-se três alturas de voo (2,5; 3,0; e 4,0 m) e os alvos foram colocados na parte inferior e superior da planta. Em cada planta utilizou-se 12 etiquetas de papel hidrossensível no total, seis para a parte inferior e seis para a parte superior. O software CIR 1.5 foi aplicado para determinar a porcentagem de cobertura, densidade de gotas, diâmetro da mediana volumétrica, diâmetro correspondente a 10 e 90% do volume, diâmetro mediano numérico e amplitude relativa. Os resultados mostraram que a altura de voo apenas influenciou os parâmetros diâmetro volumétrico que corresponde a 10% do volume, diâmetro mediano numérico e porcentagem de cobertura. A posição do alvo no dossel influenciou todos os parâmetros de pulverização estudados. No café de montanha, o sistema de pulverização por veículo aéreo não tripulado é mais eficiente para a parte inferior da planta.

ABSTRACT Weather conditions and sprayer operating parameters influence spray quality. Unmanned aerial vehicles are considered a modern, useful, and very efficient technological tool in the application of pesticides, as they carry out punctual spraying, and reduce environmental and public health problems. The objective of this study was to characterize the spraying quality carried out with an unmanned aerial vehicle as a function of flight height and target position in a coffee plantation in a mountainous region. Three flight heights (2.5, 3.0, and 4.0 m) were used, and the targets were placed at the top and bottom of the plant. For each plant, six water sensitive papers were placed on top of the plant and six were placed at the bottom. CIR 1.5 software was applied to determine the coverage percentage, drop density, volume median diameter, volumetric diameter corresponding to 10 and 90%, numerical median diameter, and relative amplitude. The results showed that the flight height only influenced the parameters of the volumetric diameter corresponding to 10% of the volume, numerical median diameter, and coverage percentage. The target position on the canopy influenced all the evaluated spraying parameters. In mountainous coffee plantations, the spraying system using unmanned aerial vehicle spraying is more efficient for the lower part of the plant.

https://doi.org/10.1590/1807-1929/agriambi.v26n12p901-906

Benzophenone Derivatives Showed Dual Anti-Inflammatory and Antiproliferative Activities by Inhibiting COX Enzymes and Promote Cyclin E Downregulation
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Folquitto, Laís R. S.

; Souza, Thiago B. de

; Januario, Jaqueline P.

; Nascimento, Isadora M.

; Brandão, Brenda T. V.

; Moreira, Maria E. C.

; Horvath, Renato O.

; Santos, Marcelo H.

; Coelho, Luiz F. L.

; Veloso, Marcia P.

; Soares, Marisi G.

; Carvalho, Diogo T.

; Ionta, Marisa

; Chagas-Paula, Daniela A.

; Dias, Danielle F.

Journal of the Brazilian Chemical Society

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Abr 2022, Volume 33 Nº 4 Páginas 348 - 360

Resumo: En | Texto: En | PDF: En

Considering the promising antitumor effects of compounds with dual anti-inflammatory and antiproliferative activities, thus benzophenones analogs (2-7) were evaluated on in vivo anti-inflammatory assay and molecular docking analysis. Those with the best molecular docking results were in vitro evaluated on cyclooxygenase (COX) enzymes and tested regarding antiproliferative activity. All derivatives displayed in vivo anti-inflammatory activity. Among them, the substances 2’-hydroxy-4’-benzoylphenyl-β-D-glucopyranoside (4), 4-hydroxy-4’-methoxybenzophenone (5) and 4’-(4’’-methoxybenzoyl)phenyl-β-D-glucopyranoside (7) showed the best values of Glide Score in COX-2 docking evaluation and 4 and 5 selectively inhibited COX-2 and COX-1 in vitro enzymatic assay, respectively. Thus, 4 and 5 were tested against breast cancer (MCF-7, MDA MB-231, Hs578T) and non-small-cell-lung cancer (A549) cell lines. The estrogen-positive MCF-7 cell line was more responsive compared to other tested cell lines. They induced cell cycle arrest at G1/S transition in MCF-7 cell line once there was an increase in G0/G1 population with concomitant reduction of S population. The antiproliferative activity of these substances on MCF-7 was associated with their ability to inhibit cyclin E expression, a critical regulator of G1/S transition. Taken together, the data indicate that 4 and 5 have dual anti-inflammatory and antiproliferative activities and support further studies to evaluate their antitumor potential.

https://doi.org/10.21577/0103-5053.20210154

Growth curve in elephant grass genotypes based on morpho-agronomic traits for energy production
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Vidal, Ana-Kesia F.

; Daher, Rogério F.

; Freitas, Rafael S.

; Stida, Wanessa F.

; Lédo, Francisco-José da S.

; Silva, Verônica B. da

; Entringer, Geovana C.

; Tardin, Flávio D.

; Gravina, Geraldo de A.

; Vivas, Marcelo

; Souza, Alexandre G. de

; Ambrósio, Moisés

; Santana, Josefa-Grasiela da S.

; Farias, João E.C.

Chilean journal of agricultural research

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Mar 2022, Volume 82 Nº 1 Páginas 78 - 87

Resumo: En | Texto: En | PDF: En

ABSTRACT The elephant grass (Cenchrus purpureus (Schumach.) Morrone) is one of the species with great prominence for energy production because of its favorable traits, such as high yield and short cycle, combined with several biomass quality characteristics. Therefore, this study intended to evaluate the morpho-agronomic traits of eight elephant grass genotypes under different cutting ages. A randomized block design with three replicates was applied to the experiment, and plots were composed of a 12 m long line divided into six subplots for each of the bimonthly cuts. Eight genotypes were evaluated in the plots, and the cutting ages (2, 4, 6, 8, 10, and 12-mo) were analyzed in the subplots. The following traits were assessed: DM yield, (DMY) percentage of DM, and average plant height (HEI). All genetic-statistical analyses were conducted using the Genes Program. The evaluated genotypes showed nonsignificant differences, indicating that, for the evaluated traits, these genotypes are genetically similar. Most genotypes presented linear effect of 2nd degree in the two assessment cuts, pointing they did not reach their maximum capacity of DMY in the time interval of the evaluated cuts. The maximum %DM achieved for the most genotypes occurred at about 9-mo age, while genotypes Vruckwona and BAG-86 at about 10-mo age. The maximum points for HEI trait were between 8 and 10-mo age. Increasing the cutting interval leads to increases in DM yield, with the 10-mo cutting age being the most efficient, resulting in higher yields.

7 downloads

Guidelines for Parkinson’s disease treatment: consensus from the Movement Disorders Scientific Department of the Brazilian Academy of Neurology - motor symptoms
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Saba, Roberta Arb

; Maia, Débora Palma

; Cardoso, Francisco Eduardo Costa

; Borges, Vanderci

; F. Andrade, Luiz Augusto

; Ferraz, Henrique Ballalai

; Barbosa, Egberto Reis

; Rieder, Carlos Roberto de Mello

; da Silva, Delson José

; Chien, Hsin Fen

; Capato, Tamine

; Rosso, Ana Lúcia

; Souza Lima, Carlos Frederico

; Bezerra, José Marcelo Ferreia

; Nicaretta, Denise

; Povoas Barsottini, Orlando Graziani

; Godeiro-Júnior, Clécio

; Broseghini Barcelos, Lorena

; Cury, Rubens Gisbert

; Spitz, Mariana

; Azevedo Silva, Sônia Maria César

; Della Colletta, Marcus Vinicius

Arquivos de Neuro-Psiquiatria

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Mar 2022, Volume 80 Nº 3 Páginas 316 - 329

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O tratamento da doença de Parkinson (DP) constitui um desafio, especialmente por ser considerado muito individualizado. A Academia Brasileira de Neurologia (ABN) identificou a necessidade de disseminar o conhecimento sobre o manejo do tratamento da DP, adaptando as melhores evidências à realidade brasileira. Assim, foi realizada uma revisão sobre as principais orientações de tratamento publicadas, baseada nas recomendações elaboradas por um grupo de especialistas em transtornos do movimento do departamento científico da ABN.

ABSTRACT The treatment of Parkinson's disease (PD) is challenging, especially since it is considered highly individualized. The Brazilian Academy of Neurology has recognized the need to disseminate knowledge about the management of PD treatment, adapting the best evidence to the Brazilian reality. Thus, the main published treatment guidelines were reviewed based on the recommendations of group from the Movement Disorders Scientific Department of the Brazilian Academy of Neurology.

https://doi.org/10.1590/0004-282x-anp-2021-0219

Correlations between Web Searches and COVID-19 Epidemiological Indicators in Brazil
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Locatelli, Marcelo Sartori

; Cunha, Evandro L. T. P

; Guiginski, Janaína

; Franco, Ramon A. S

; Bernardes, Tereza

; Alzamora, Pedro Loures

; Silva, Daniel Victor F. da

; Ganem, Marcelo Augusto S

; Santos, Thiago H. M

; Carvalho, Anne I. R

; Souza, Leandro M. V

; Paixão, Gabriela P. F

; Chaves, Elisa França

; Santos, Guilherme Bezerra dos

; Santos, Rafael Vinícius dos

; Freitas, Amanda Cupertino de

; Flores, Matheus G

; Biezuner, Rachel F

; Cardoso, Rodolfo Lins

; Fonseca, Rodrigo Machado

; Silva, Ana Paula Couto da

; Meira Jr, Wagner

Brazilian Archives of Biology and Technology

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2022, Volume 65 elocation e22210648

Resumo: En | Texto: En | PDF: En

Abstract: COVID-19 rapidly spread across the world in an unprecedented outbreak with a massive number of infected and fatalities. The pandemic was heavily discussed and searched on the internet, which generated big amounts of data related to it. This led to the possibility of attempting to forecast coronavirus indicators using the internet data. For this study, Google Trends statistics for 124 selected search terms related to pandemic were used in an attempt to find which keywords had the best Spearman correlations with a lag, as well as a forecasting model. It was found that keywords related to coronavirus testing among some others, such as “I have contracted covid”, had high correlations (≥0.7) with few weeks of lag (≤4 weeks). Besides that, the ARIMAX model using those keywords had promising results in predicting the increase or decrease of epidemiological indicators, although it was not able to predict their exact values. Thus, we found that Google Trends data may be useful for predicting outbreaks of coronavirus a few weeks before they happen, and may be used as an auxiliary tool in monitoring and forecasting the disease in Brazil.

https://doi.org/10.1590/1678-4324-2022210648

10.

Addition of açai oil during the close-up dry period of Holstein cows improves colostrum quality and immune responses of their calves
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SANTOS, DAIANE S. DOS

; KLAUCK, VANDERLEI

; THEISEN, CLEITON

; BORDIGON, BRUNA

; FARINA, RENAN

; PEREIRA, WANDERSON A.B.

; SOUZA, CARINE F.

; BALDISSERA, MATHEUS D.

; SCHOGOR, ANA LUIZA B.

; VEDOVATTO, MARCELO

; PALMER, ELIZABETH A.

; SILVA, ALEKSANDRO S. DA

Anais da Academia Brasileira de Ciências

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2022, Volume 94 Nº 4 elocation e20201592

Resumo: En | Texto: En | PDF: En

Abstract This study evaluated of the effects of açai oil during the close-up dry period of Holstein cows on colostrum quality, as well as on the immune and antioxidant responses of their calves. Sixteen multiparous cows were assigned randomly to two treatments: 1) CONTROL (n = 8) - 4.48% of soybean oil/concentrate; 2) AÇAI (n =8) - 4.48% of açai oil/concentrate. Cows fed with açai oil had greater (P≤0.04) colostrum concentrations of immunoglobulins (Ig) G (1st and 2nd milking), IgG heavy chains, IgA (only at 1st milking), alpha-lactalbumin (1st milking), total protein, and antioxidant capacity against peroxyl radicals (only at 1st milking). Cows fed with açai oil had greater serum concentrations of globulin (only on the day of calving) and total protein (only on the day of calving) (P = 0.03). Calves born of cows fed with açai oil had greater serum concentrations of total protein (only 24 and 48 h after calving) and serum concentration of IgG heavy chain (only 24 h after calving) and globulin (only 24 and 48 h after calving) (P = 0.01). These data suggest that the addition of açai oil in the cow feed during the close-up dry period boosted immunity in their calves by altering the composition of colostrum.

https://doi.org/10.1590/0001-3765202220201592

11.

Diretriz de Miocardites da Sociedade Brasileira de Cardiologia – 2022
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Montera, Marcelo Westerlund

; Marcondes-Braga, Fabiana G.

; Simões, Marcus Vinícius

; Moura, Lídia Ana Zytynski

; Fernandes, Fabio

; Mangine, Sandrigo

; Oliveira Júnior, Amarino Carvalho de

; Souza, Aurea Lucia Alves de Azevedo Grippa de

; Ianni, Bárbara Maria

; Rochitte, Carlos Eduardo

; Mesquita, Claudio Tinoco

; de Azevedo Filho, Clerio F.

; Freitas, Dhayn Cassi de Almeida

; Melo, Dirceu Thiago Pessoa de

; Bocchi, Edimar Alcides

; Horowitz, Estela Suzana Kleiman

; Mesquita, Evandro Tinoco

; Oliveira, Guilherme H.

; Villacorta, Humberto

; Rossi Neto, João Manoel

; Barbosa, João Marcos Bemfica

; Figueiredo Neto, José Albuquerque de

; Luiz, Louise Freire

; Hajjar, Ludhmila Abrahão

; Beck-da-Silva, Luis

; Campos, Luiz Antonio de Almeida

; Danzmann, Luiz Cláudio

; Bittencourt, Marcelo Imbroinise

; Garcia, Marcelo Iorio

; Avila, Monica Samuel

; Clausell, Nadine Oliveira

; Oliveira Jr, Nilson Araujo de

; Silvestre, Odilson Marcos

; Souza, Olga Ferreira de

; Mourilhe-Rocha, Ricardo

; Kalil Filho, Roberto

; Al-Kindi, Sadeer G.

; Rassi, Salvador

; Alves, Silvia Marinho Martins

; Ferreira, Silvia Moreira Ayub

; Rizk, Stéphanie Itala

; Mattos, Tiago Azevedo Costa

; Barzilai, Vitor

; Martins, Wolney de Andrade

; Schultheiss, Heinz-Peter

Arquivos Brasileiros de Cardiologia

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2022, Volume 119 Nº 1 Páginas 143 - 211

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20220412

12.

Atualização de Tópicos Emergentes da Diretriz Brasileira de Insuficiência Cardíaca – 2021
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Marcondes-Braga, Fabiana G.

; Moura, Lídia Ana Zytynski

; Issa, Victor Sarli

; Vieira, Jefferson Luis

; Rohde, Luis Eduardo

; Simões, Marcus Vinícius

; Fernandes-Silva, Miguel Morita

; Rassi, Salvador

; Alves, Silvia Marinho Martins

; Albuquerque, Denilson Campos de

; Almeida, Dirceu Rodrigues de

; Bocchi, Edimar Alcides

; Ramires, Felix José Alvarez

; Bacal, Fernando

; Rossi Neto, João Manoel

; Danzmann, Luiz Claudio

; Montera, Marcelo Westerlund

; Oliveira Junior, Mucio Tavares de

; Clausell, Nadine

; Silvestre, Odilson Marcos

; Bestetti, Reinaldo Bulgarelli

; Bernadez-Pereira, Sabrina

; Freitas Jr, Aguinaldo F.

; Biolo, Andréia

; Barretto, Antonio Carlos Pereira

; Jorge, Antônio José Lagoeiro

; Biselli, Bruno

; Montenegro, Carlos Eduardo Lucena

; Santos Júnior, Edval Gomes dos

; Figueiredo, Estêvão Lanna

; Fernandes, Fábio

; Silveira, Fabio Serra

; Atik, Fernando Antibas

; Brito, Flávio de Souza

; Souza, Germano Emílio Conceição

; Ribeiro, Gustavo Calado de Aguiar

; Villacorta, Humberto

; Souza Neto, João David de

; Goldraich, Livia Adams

; Beck-da-Silva, Luís

; Canesin, Manoel Fernandes

; Bittencourt, Marcelo Imbroinise

; Bonatto, Marcely Gimenes

; Moreira, Maria da Consolação Vieira

; Avila, Mônica Samuel

; Coelho Filho, Otavio Rizzi

; Schwartzmann, Pedro Vellosa

; Mourilhe-Rocha, Ricardo

; Mangini, Sandrigo

; Ferreira, Silvia Moreira Ayub

; Figueiredo Neto, José Albuquerque de

; Mesquita, Evandro Tinoco

Arquivos Brasileiros de Cardiologia

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Jun 2021, Volume 116 Nº 6 Páginas 1174 - 1212

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210367 3168 downloads

13.

Caracterização Histológica das Lesões da Valva Mitral de Pacientes com Cardiopatia Reumática
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Gomes, Nayana F. A.

; Pascoal-Xavier, Marcelo A.

; Passos, Livia S. A.

; Paula, Thiago Mendonça Nunes

; Aguiar, João Marcelo de Souza

; Guarçoni, Felipe Vieira

; Nassif, Maria Cecília Landim

; Gelape, Claudio Leo

; Braulio, Renato

; Costa, Paulo Henrique N.

; Passaglia, Luiz Guilherme

; Martins, Raquel Braga

; Dutra, Walderez O.

; Nunes, Maria Carmo P.

Arquivos Brasileiros de Cardiologia

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Mar 2021, Volume 116 Nº 3 Páginas 404 - 412

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamentos: Os mecanismos subjacentes pelos quais a doença cardíaca reumática (DCR) levam à disfunção valvar grave não são totalmente compreendidos. Objetivo: O presente estudo avaliou as alterações histopatológicas nas valvas mitrais (VM) buscando uma associação entre o padrão de disfunção valvar predominante e os achados histopatológicos. Métodos: Em 40 pacientes submetidos à troca da VM devido a DCR e em 20 controles submetidos a transplante cardíaco, foram analisados os aspectos histológicos da VM excisada. Dados clínicos e ecocardiográficos também foram coletados. As análises histológicas foram realizadas usando coloração com hematoxilina-eosina. Determinou-se inflamação, fibrose, neoangiogênese, calcificação e metaplasia adiposa. Valores de p<0,05 foram considerados estatisticamente significativos. Resultados: A idade média dos pacientes com DCR foi de 53±13 anos, sendo 36 (90%) do sexo feminino, enquanto a idade média dos controles foi de 50±12 anos, semelhante aos casos, sendo a maioria do sexo masculino (70%). O endocárdio valvar reumático apresentou espessura maior que os controles (1,3±0,5 mm versus 0,90±0,4 mm, p=0,003, respectivamente), e infiltrado inflamatório mais intenso no endocárdio (78% versus 36%; p=0,004), com predominância de células mononucleares. Ocorreu fibrose moderada a acentuada mais frequentemente em válvulas reumáticas do que em válvulas controle (100% vs. 29%; p<0,001). Ocorreu calcificação em 35% das valvas reumáticas, principalmente entre as valvas estenóticas, associada à área valvar mitral (p=0,003). Conclusões: Apesar do intenso grau de fibrose, o processo inflamatório permanece ativo na valva mitral reumática, mesmo em doença tardia com disfunção valvar. A calcificação predominou em valvas estenóticas e em pacientes com disfunção ventricular direita.

Abstract Background: The underlying mechanisms by which rheumatic heart disease (RHD) lead to severe valve dysfunction are not completely understood. Objective: The present study evaluated the histopathological changes in mitral valves (MV) seeking an association between the pattern of predominant valvular dysfunction and histopathological findings. Methods: In 40 patients who underwent MV replacement due to RHD, and in 20 controls that underwent heart transplant, histological aspects of the excised MV were analyzed. Clinical and echocardiographic data were also collected. Histological analyses were performed using hematoxylin-eosin staining. Inflammation, fibrosis, neoangiogenesis, calcification and adipose metaplasia were determined. A p value<0.05 was considered to be statistically significant. Results: The mean age of RHD patients was 53±13 years, 36 (90%) were female, whereas the mean age of controls was 50±12 years, similar to the cases, with the majority of males (70%). The rheumatic valve endocardium presented greater thickness than the controls (1.3±0.5 mm versus 0.90±0.4 mm, p=0.003, respectively), and a more intense inflammatory infiltrate in the endocardium (78% versus 36%; p=0.004), with predominance of mononuclear cells. Moderate to marked fibrosis occurred more frequently in rheumatic valves than in control valves (100% vs. 29%; p<0.001). Calcification occurred in 35% of rheumatic valves, especially among stenotic valves, which was associated with the mitral valve area (p=0.003). Conclusions: Despite intense degree of fibrosis, the inflammatory process remains active in the rheumatic mitral valve, even at late disease with valve dysfunction. Calcification predominated in stenotic valves and in patients with right ventricular dysfunction.

https://doi.org/10.36660/abc.20200154 542 downloads

14.

New Law of Brazilian Biodiversity: Legal Aspects and Impact in the Field of Biotechnology
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FOLGOSI, MARCELO

; VALVERDE, ALESSANDRA L.

; FIAUX, SORELE B.

; MOURÃO, SAMANTHA C.

; LEAL, RICARDO H.

; CERQUEIRA, ALOYSIO M.F.

; BRUNO, SÁVIO F.

; WEID, OLIVIA V.D.

; ANGELI, RENATA

; NETO, JOSÉ C.D.

; SOUZA, MIRIAM A. DE

; PAIXÃO, RITA L.

; ALVES, GUTEMBERG G.

; GONZALEZ, MARCELO S.

; PAIVA, SELMA R. DE

Anais da Academia Brasileira de Ciências

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2021, Volume 93 elocation e20210413

Resumo: En | Texto: En | PDF: En

Abstract Access to genetic resources (GR) and/or traditional knowledge associated with genetic resources (ATK) has been regulated in Brazil since 2001. The law 13,123 / 2015 determined a significant change in the theme, mainly on the rules of distribution of benefits obtained for conservation and sustainable use of biodiversity, the access to technology and technology transfer, the exploitation of products or reproductive material from the GR or ATK and consignment to the outside of part or all the living or dead organism shipped for GR. The implementation of international treaties on GR and ATK for research, biotechnological development and bioprospecting have been causing difficulties for Brazilian researchers, mainly due to the lack of information and dissemination available for compliance with the legislation. In this work, the members of the Committee for Access to Genetic Resources and Associated Traditional Knowledge of the Federal Fluminense University (UFFGEN) - Brazil, and collaborators performed a critical reflection on the new law, helping Brazilian researchers with information necessary to understand the changes made by the new legislation, especially in the field of Biotechnology associated with Brazilian Biodiversity.

https://doi.org/10.1590/0001-3765202120210413 1 downloads

15.

Use and misuse of biomarkers and the role of D-dimer and C-reactive protein in the management of COVID-19: A post-hoc analysis of a prospective cohort study
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Gonçalves, Fabio Augusto Rodrigues

; Besen, Bruno Adler Maccagnan Pinheiro

; Lima, Clarice Antunes de

; Corá, Aline Pivetta

; Pereira, Antônio José Rodrigues

; Perazzio, Sandro Félix

; Gouvea, Christiane Pereira

; Fonseca, Luiz Augusto Marcondes

; Trindade, Evelinda Marramon

; Sumita, Nairo Massakazu

; Duarte, Alberto José da Silva

; Lichtenstein, Arnaldo

; Bonfa, Eloisa

; Utiyama, Edivaldo M.

; Segurado, Aluisio C.

; Perondi, Beatriz

; Miethke-Morais, Anna

; Montal, Amanda C.

; Harima, Leila

; Fusco, Solange R. G.

; Silva, Marjorie F.

; Rocha, Marcelo C.

; Marcilio, Izabel

; Rios, Izabel Cristina

; Kawano, Fabiane Yumi Ogihara

; Jesus, Maria Amélia de

; Kallas, Ésper George

; Carmo, Carolina

; Tanaka, Clarice

; Souza, Heraldo Possolo de

; Marchini, Julio F. M.

; Carvalho, Carlos

; Ferreira, Juliana C.

; Levin, Anna Sara Shafferman

; Oliveira, Maura Salaroli

; Guimarães, Thaís

; Lázari, Carolina dos Santos

; Sabino, Ester

; Magri, Marcello M. C.

; Barros-Filho, Tarcisio E. P.

; Francisco, Maria Cristina Peres Braido

; Costa, Silvia F.

Clinics

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2021, Volume 76 elocation e3547

Resumo: En | Texto: En | PDF: En

OBJECTIVE: Coronavirus disease 2019 (COVID-19) is associated with high mortality among hospitalized patients and incurs high costs. Severe acute respiratory syndrome coronavirus 2 infection can trigger both inflammatory and thrombotic processes, and these complications can lead to a poorer prognosis. This study aimed to evaluate the association and temporal trends of D-dimer and C-reactive protein (CRP) levels with the incidence of venous thromboembolism (VTE), hospital mortality, and costs among inpatients with COVID-19. METHODS: Data were extracted from electronic patient records and laboratory databases. Crude and adjusted associations for age, sex, number of comorbidities, Sequential Organ Failure Assessment score at admission, and D-dimer or CRP logistic regression models were used to evaluate associations. RESULTS: Between March and June 2020, COVID-19 was documented in 3,254 inpatients. The D-dimer level ≥4,000 ng/mL fibrinogen equivalent unit (FEU) mortality odds ratio (OR) was 4.48 (adjusted OR: 1.97). The CRP level ≥220 mg/dL OR for death was 7.73 (adjusted OR: 3.93). The D-dimer level ≥4,000 ng/mL FEU VTE OR was 3.96 (adjusted OR: 3.26). The CRP level ≥220 mg/dL OR for VTE was 2.71 (adjusted OR: 1.92). All these analyses were statistically significant (p<0.001). Stratified hospital costs demonstrated a dose-response pattern. Adjusted D-dimer and CRP levels were associated with higher mortality and doubled hospital costs. In the first week, elevated D-dimer levels predicted VTE occurrence and systemic inflammatory harm, while CRP was a hospital mortality predictor. CONCLUSION: D-dimer and CRP levels were associated with higher hospital mortality and a higher incidence of VTE. D-dimer was more strongly associated with VTE, although its discriminative ability was poor, while CRP was a stronger predictor of hospital mortality. Their use outside the usual indications should not be modified and should be discouraged.

https://doi.org/10.6061/clinics/2021/e3547

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