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ABSTRACT Purpose Our objective was to investigate the prevalence of SWA, associated factors, relationship with STIs, and behavioral aspects in men attended at Referral Centers for STIs and acquired immunodeficiency syndrome (AIDS)/CR-STI/AIDS in northeast Brazil. Materials and Methods In this cross-sectional study, a questionnaire with sociodemographic, clinical, sexual and SWA practices information was applied to 400 men attended at two CR-STI/AIDS in Northeast Brazil on the years of 2018 and 2019. Clinical and laboratory diagnoses of STIs were confirmed in medical records. Logistic regression models were performed to identify the independent predictors for SWA. Results The prevalence of SWA over total samples was 15.00%. Of the participants, 239 (59.75%) of the participants were diagnosed with STIs, and of these 37 (15.48%) reported SWA. Most men practiced SWA in adolescence, being the last episode more than 20 years ago, usually with asinine and mules, in vaginal route and without a condom. SWA practitioners have higher percentages of occurrence of some viral STIs. SWA was associated with increasing age, history of residence in a rural area with remained over 12 years, married or widowed/separated, heterosexuals, with less than 7 years of study, Catholics, with hepatitis B, former user of alcoholic beverages and smokers, with a history of STI and intercourse with sex workers. Conclusion SWA practices increase STIs vulnerability. The association between hepatitis B and SWA highlights the importance of educational campaigns and conclusive studies on the topic.

https://doi.org/10.1590/s1677-5538.ibju.2022.0395

Rapidly progressive Kaposi’s sarcoma associated with human immunodeficiency syndrome Kaposis Kaposi s
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Pinheiro, Camila Gonçalves

; Paiva, Francisco de Assis Silva

; Ferreira, Isabelle Sousa Medeiros Torres

; Meira, Gabriela Teixeira Viana Suppa

; Bonfim, Antônio Carlos Evangelista de Araújo

; Trindade, Luciana Cavalcante

Anais Brasileiros de Dermatologia

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Abr 2023, Volume 98 Nº 2 Páginas 272 - 275

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1016/j.abd.2021.12.008

Soybean extracts can improve plant development
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May, André

; Silva, Evandro Henrique Figueiredo Moura da

; Vieira Junior, Nilson Aparecido

; Vilela, Elke Simoni Dias

; Santos, Michelli de Souza dos

; Coelho, Luciana Fontes

; Pedrinho, Alexandre

; Batista, Bruna Durante

; Viana, Ronaldo da Silva

Scientia Agricola

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2023, Volume 80 elocation e20210102

Resumo: En | Texto: En | PDF: En

ABSTRACT: Microbial biodiversity of an environment can contribute to plant growth and increase crop yield. Plant extracts from soybean (Glycine max (L.) Merrill) were investigated on soybean plants grown after inoculation with these extracts. Soil samples were collected from two important Brazilian soybean-growing regions to produce the extracts used in the experiments. The extracts were produced with material collected from aboveground biomass and rhizosphere of soybean plants cultivated in a controlled greenhouse (phase 1). The extracts produced in phase 1 were applied in a sequential experiment (phase 2). Phase 2 was conducted to examine the plant microbiome after the microbial alteration process in the greenhouse through seed inoculation with the extracts produced previously. Samples of aboveground biomass were collected to determine root dry matter and crop yield. Bacterial 16S rRNA sequences were processed to determine the final microbial content of soybean. The inoculated treatments had lower species diversity; however, the phyla Firmicutes and Bacteroidetes were more abundant in the treatments than in the non-inoculated treatment. The soybean plant stem in the inoculated treatment also had a positive response to enrichment of the bacterial classes Betaproteobacteria, Bacilli and Flavobacteria. Inoculation affected the microbial composition of soybean plants. The alteration of microbiome changes revealed differences for crop yield between the inoculated and non-inoculated treatments, with up to 93.5 % higher crop yields per plant according to the extract applied.

https://doi.org/10.1590/1678-992x-2021-0102

Genetic parameters considering traits of importance for cassava biofortification
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Santos, Vanderlei da Silva

; Fukuda, Wânia Maria Gonçalves

; Oliveira, Luciana Alves de

; Pereira, Marcio Eduardo Canto

; Nuti, Marilia Regini

; Carvalho, José Luiz Viana de

; Pereira, Helcio Duarte

Crop Breeding and Applied Biotechnology

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2023, Volume 23 Nº 2 elocation e447923211

Resumo: En | Texto: En | PDF: En

Abstract Twenty six sweet cassava clones were evaluated in two agricultural years, in randomized block design, with 3 replications and plots with 25 plants. The harvests were at 12 months after planting, in both years. The traits evaluated were root yield (RY), dry matter content (DMC), total carotenoids content (TC), β-carotene content (BC), trans-β-carotene content (TrBC) and total cyanide content (TCy). Genotype was significant (P<0.05) in all traits. Broad-sense heritability estimates at the plot level ( h m g 2 ) ranged from 77% (RY) to 93% (TC and TrBC), while the accuracy ranged from 0.88 (RY) to 0.96 (BC and TrBC). The genetic correlations among TC, BC and TrBC were high (0.96 to 0.99) and significant, and the genetic correlations involving these traits and TCy were negative. These results demonstrate the existence of great genetic variability in characteristics important to cassava biofortification and, consequently, great perspectives in the breeding for this purpose.

https://doi.org/10.1590/1984-70332023v23n2a23

Autonomic response of older women to the submaximal effort in the six-minute walk test: a cross-sectional study
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Lourenço, Ana Letícia dos Santos

; Barbosa, João Victor Pereira

; Pessoa, Marcilene Glay Viana

; Pereira, Marylia Santos

; Oliveira, Adrielle Silva de

; Melo, Luciana Costa

Fisioterapia e Pesquisa

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Out 2022, Volume 29 Nº 4 Páginas 342 - 349

Resumo: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT This cross-sectional study aimed to evaluate the autonomic response of older women in the six-minute walk test. In total, 32 women aged 60 years or older without a diagnosed health problem were evaluated during the six-minute walk test. To monitor the autonomic response, the following variables were considered: heart rate, systolic and diastolic blood pressure, respiratory rate, and perceived exertion. These variables were compared during rest, effort, and recovery. This study also sought a correlation between autonomic function variables and performance in the test and perceived exertion. Results showed that the effort made by older women in the six-minute walk test induces an autonomic response resulting in increased heart rate and systolic and diastolic blood pressure; however, the respiratory rate remained unchanged during the test. Diastolic blood pressure remained high during recovery. No correlation was found neither between perceived exertion and cardiovascular physiological response nor between distance covered and variation of the autonomic response or level of physical conditioning. Therefore, the effort spent in the six-minute walk test promotes an autonomic response in older women, increasing cardiovascular stress without increasing ventilation. In this context, the Borg scale was not representative of cardiovascular stress during the test.

RESUMEN El objetivo de este estudio fue investigar la respuesta autonómica de ancianas al esfuerzo en la prueba de paso de 6 minutos (6MWT). Se realizó un estudio transversal con la participación de 32 ancianas, de 60 años o más, sin problemas de salud diagnosticados durante la 6MWT. Para monitorear la respuesta autonómica, se consideraron las siguientes variables: frecuencia cardíaca, presión arterial sistólica y diastólica, frecuencia respiratoria y esfuerzo percibido. Se compararon estas variables durante el período de reposo, esfuerzo y recuperación. También se buscó una correlación entre las variables de función autonómica y rendimiento en la prueba y el esfuerzo percibido. Los resultados mostraron que el esfuerzo producido en la 6MWT genera una respuesta autonómica que conduce a un aumento de la frecuencia cardíaca y de la presión arterial sistólica y diastólica en las mujeres, pero la frecuencia respiratoria se mantuvo sin cambios durante la prueba. La presión arterial diastólica se mantuvo alta durante el período de recuperación. No hubo correlación entre el esfuerzo percibido y la respuesta fisiológica cardiovascular presentada, tampoco entre la distancia recorrida y la variación de la respuesta autonómica o el nivel de condicionamiento físico. Se concluyó que el esfuerzo realizado en la 6MWT generó una respuesta autonómica en las ancianas al intensificar el estrés cardiovascular pero sin aumentar la ventilación. En este contexto, la escala de Borg no fue significativa para el estrés cardiovascular durante la prueba.

RESUMO O objetivo deste estudo foi investigar a resposta autonômica de idosas ao esforço do teste de caminhada de 6 minutos (TC6M). Realizou-se um estudo transversal a partir da avaliação de 32 idosas, sem problemas de saúde diagnosticados, com 60 anos ou mais, durante o TC6M. Para o monitoramento da resposta autonômica, foram consideradas as seguintes variáveis: frequência cardíaca, pressão arterial sistólica e diastólica, frequência respiratória e percepção de esforço. Essas variáveis foram comparadas durante o período de repouso, esforço e recuperação. Buscou-se também correlação entre as variáveis da função autonômica e o desempenho no teste e a percepção de esforço. Os resultados demonstraram que o esforço gerado no TC6M induz uma resposta autonômica que leva ao aumento da frequência cardíaca e da pressão arterial sistólica e diastólica em mulheres, porém a frequência respiratória permaneceu inalterada durante o teste. A pressão arterial diastólica permaneceu elevada durante a recuperação. Não houve correlação entre a percepção de esforço e a resposta fisiológica cardiovascular apresentada, nem entre a distância percorrida e a variação da resposta autonômica ou o nível de condicionamento físico. Concluiu-se que o esforço despendido no TC6M promove uma resposta autonômica em idosas, intensificando o estresse cardiovascular sem aumentar a ventilação. Nesse contexto, a escala de Borg não foi representativa do estresse cardiovascular durante o teste.

https://doi.org/10.1590/1809-2950/20026529042022en

Orofacial antinociceptive effects of perillyl alcohol associated with codeine and its possible modes of action
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LIMEIRA, Rebecca Rhuanny Tolentino

; DANTAS, Natália Viana

; TOMAZ-MORAIS, James Felipe

; COSTA, Tereza Karla Vieira Lopes da

; BRAGA, Renan Marinho

; SOUSA, Frederico Barbosa

; SCOTTI, Luciana

; SALVADORI, Mirian Graciela da Silva Stiebbe

; ALMEIDA, Reinaldo Nóbrega de

; CASTRO, Ricardo Dias

Brazilian Oral Research

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2022, Volume 36 elocation e109

Resumo: En | Texto: En | PDF: En

Abstract This study evaluated the orofacial antinociceptive effect of (S)-(-)-perillyl alcohol (PA) associated with codeine (C) and investigated the possible molecular anchorage mechanisms of PA. Mice (n = 5 per group) were treated with PA alone and associated with codeine and assigned to the following groups: 75.0 mg/kg PA; 75.0 mg/kg PA + C 30 mg/kg; PA 37.5 mg/kg + C 15.0 mg/kg; C 30.0 mg/kg; and control. Nociception was induced by formalin, capsaicin, and glutamate, and was quantified based on the duration (in seconds) of face grooming. The possible mechanisms of action were evaluated by molecular docking study. In the formalin test, PA75/C30 presented an effect in the neurogenic (p < 0.0001) and inflammatory (p < 0.005) phases. Mice treated with PA75 (p < 0.0001) and PA75/C30 (p < 0.0005) showed a reduced nociceptive behavior in the capsaicin test. Glutamate-induced nociception also was blocked by PA75 (p < 0.0005) and C30 (p < 0.0005). The molecular anchorage analysis indicated high negative binding energy values for the evaluated receptors, especially glutamate receptors (AMPA -79.57 Kcal/mol, mGLUR6 -71.25, and NMDA -66.33 Kcal/mol). PA associated with codeine showed orofacial antinociceptive activity, with theoretical evidence of interaction with glutamate receptors.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0109

Repercussões da infodemia associada ao COVID-19 na saúde mental do idoso no Brasil
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Bezerra Cavalcante, Ricardo

; da Costa Carbogim, Fabio

; Fávero Bulgarelli, Alexandre

; Mello dos Santos, Camila

; Queiroz Ribeiro, Andréia

; Carvalho Pinto, Ione

; Machado Zacharias, Fabiana Costa

; Aparecida Fabriz, Luciana

; Moura de Oliveira, Deíse

; Toledo de Mendonça, Erica

; Ricardo Moreira, Tiago

; Miranda Machado, Richardson

; Ribeiro Bitencourt, Graziele

; Alfradique de Souza, Priscilla

; Fereira Santana, Rosimere

; Cabreira Panitz Cruz, Gylce Eloisa

; Rezende Freitas, Eduarda

; Salmazo da Silva, Henrique

; Viana Cruz, Fabiana

; Silva Fhon, Jack Roberto

; Shizuê Kitamura, Elisa

; Gonçalves Leite, Isabel Cristina

; Rodrigues Braz, Patricia

; Consolação dos Santos, Regina

; Prado Rocha, Flávia

; Aparecida Silva, Eveline

; Barreiros Tavares, Thais

; Duarte Martins, Jerusa Gonçalves

; Alves de Araújo Püschel, Vilanice

Revista Cubana de Información en Ciencias de la Salud

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2022, Volume 33 elocation e1871

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO: O fenômeno denominado infodemia refere-se ao aumento do volume informacional sobre um tema em específico, que se multiplica rapidamente em um curto período de tempo, e tem-se destacado frente ao contexto da crise sanitária desencadeada pela pandemia de COVID-19. O excesso de informações pode suscitar sentimentos de medo, ansiedade, estresse e outras condições de sofrimento mental. O estudo tem como objetivo descrever o perfil de exposição a informações sobre COVID-19 e suas repercussões na saúde mental de idosos brasileiros. Trata-se de um estudo transversal realizado com 1924 idosos brasileiros. Coletaram-se dados por meio de web-based survey enviada aos idosos por redes sociais e e-mail, no período de julho a outubro de 2020. Os resultados da análise descritiva dos dados demonstram que a maioria dos idosos apresentou idade entre 60 e 69 anos (69,02%), é do sexo feminino (71,26%), casados (53,79%) e de cor branca (75,57%). Cerca de 21,67% (n = 417) concluíram a graduação, 19,75% (380) concluíram especialização e 16,63% (320) concluíram mestrado ou doutorado. Foram reportados como fontes frequentes de exposição às notícias ou informações sobre a COVID-19, a televisão 862 (44,80%) e as redes sociais 651 (33,84%). Os participantes assinalaram que a televisão (46,47%; n = 872), as redes sociais (30,81%; n = 575) e o rádio (14,48%; 251) os afetavam psicológica e/ou fisicamente. Receber notícias falsas sobre a COVID-19 pela televisão (n = 482; 19,8%) e pelas redes sociais (n = 415; 21,5%) repercutiu, principalmente, estresse e medo. As informações disseminadas contribuem para conscientização, mas, também, afetam física e/ou psicologicamente muitos idosos, principalmente gerando medo e estresse.

ABSTRACT The phenomenon called infodemia refers to the increase in the volume of information on a specific topic, which multiplies rapidly in a short period of time, and has stood out in the context of the health crisis triggered by the COVID-19 pandemic. Too much information can trigger feelings of fear, anxiety, stress, and other conditions of mental distress. The study aims to describe the profile of exposure to information about COVID-19 and its repercussions on the mental health of elderly Brazilians. This is a cross-sectional study carried out with 1924 elderly Brazilians. Data were collected through a web-based survey sent to the elderly via social networks and email, from July to October 2020. The results of the descriptive analysis of the data show that most of the elderly were aged between 60 and 69 years (69.02%), female (71.26%), married (53.79%) and white (75.57%). About 21.67% (n = 417) concluded their graduation, 19.75% (380) concluded their specialization and 16.63% (320) concluded their master's or doctoral degrees. Television 862 (44.80%) and social networks 651 (33.84%) were reported as frequent sources of exposure to news or information about COVID-19. Participants indicated that television (46.47%; n = 872), social networks (30.81%; n = 575) and radio (14.48%; 251) affected them psychologically and/or physically. Receiving fake news about COVID-19 on television (n = 482; 19.8%) and on social media (n = 415; 21.5%) mainly resulted in stress and fear. The disseminated information contributes to awareness, but also affects physically and/or psychologically many elderly people, mainly generating fear and stress.

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Association of insufficient practice of physical activity with demographic, anthropometric and biochemical factors in hypertensive patients
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Cantanhede, Nayra Anielly Cabral

; Ribeiro, Valdinar Sousa

; França, Ana Karina Teixeira da Cunha

; Hortegal, Elane Viana

; Santos, Alcione Miranda dos

; Carvalho, Wellington Roberto Gomes de

; Martins, Isabelle Christine Vieira da Silva

; Dias, Luciana Pereira Pinto

; Salgado Filho, Natalino

Cadernos Saúde Coletiva

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Dez 2021, Volume 29 Nº 4 Páginas 474 - 484

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Abstract Background Considering the magnitude of systemic hypertension (SH) and its complications, as well as the importance of regular physical activity in its prevention and/or treatment, there is a necessity to identify the factors associated with insufficient practice of physical activity. Objective To analyze factors associated with insufficient physical activity in hypertensive patients treated at Primary Health Care (PHC). Method This cross-sectional study was performed with a random sample of 305 hypertensive patients in three PHC units in São Luis, state of Maranhão, Brazil. A bivariate analysis was performed with estimates of prevalence ratios and confidence intervals, and multivariate analysis using Poisson regression. Results Insufficient physical activity was observed in 38.7% of the sample. Insufficient physical activity was associated with having <8 years of formal education (prevalence ratio–PR=1.58; 95% confidence interval-CI=1.04–2.39), total cholesterol ≥200 mg/dL (PR=0.78; 95% CI=0.58–1.04), low-density lipoprotein cholesterol-LDL ≥100 mg/dL (PR=0.79; 95% CI=0.53–0.95), and high-density lipoprotein cholesterol-HDL <40 mg/dL among men and <50 mg/dL among women (PR=1.21; 95% CI=0.90–1.64). Length of education <8 years (PR=1.50; 95% CI=0.99–2.29) and LDL ≥100 mg/dL (PR=0.72;95% CI=0.54–0.96) were also associated in the multivariate regression. Conclusion High prevalence of insufficient physical activity and its association with low education level and altered LDL serum levels were observed in hypertensive patients.

Resumo Introdução Considerando-se a magnitude da hipertensão arterial sistêmica e suas complicações, assim como a importância da atividade física regular na sua prevenção e/ou tratamento, é necessário identificar os fatores associados à prática de atividade física insuficiente. Objetivo Analisar os fatores associados à atividade física insuficiente em hipertensos atendidos na atenção primária à saúde. Método Estudo transversal realizado com amostra aleatória de 305 hipertensos em três unidades de saúde de São Luís (MA). Foi realizada análise bivariada, com estimativas de razões de prevalência, intervalos de confiança e análise multivariada por regressão de Poisson. Resultados A atividade física insuficiente foi observada em 38,7% da amostra. Atividade física insuficiente foi associada a menos de 8 anos de educação formal (razão de prevalência - RP = 1,58; intervalo de confiança de 95% - IC = 1,04–2,39), colesterol total ≥200 mg/dL (RP = 0,78; IC 95% = 0,58 -1,04), lipoproteína de baixa densidade colesterol-LDLc ≥100 mg/dL (RP = 0,79; IC 95% = 0,53-0,95) e lipoproteína de alta densidade colesterol-HDLc <40 mg / dL entre homens e <50 mg/dL entre mulheres (RP = 1,21; IC 95% = 0,90-1,64). A escolaridade <8 anos (RP = 1,50; IC 95% = 0,99–2,29) e LDLc ≥100 mg/dL (RP = 0,72; IC 95% = 0,54–0,96) também estiveram associados na regressão multivariada. Conclusão Observou-se alta prevalência de atividade física insuficiente e sua associação com baixa escolaridade e LDLc alterado em hipertensos.

https://doi.org/10.1590/1414-462x202129040161

Effect of the storage period on physical-chemical characteristics, microbiological composition and sensory acceptance of two varieties of frozen sweet cassava
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Oliveira, Luciana Alves de

; Reis, Ronielli Cardoso

; Viana, Eliseth de Souza

; Santos, Josemara Ferreira dos

; Souza, Vivian dos Santos

; Assis, Jaciene Lopes de Jesus

; Sasaki, Fabiana Fumi Cerqueira

; Santos, Vanderlei da Silva

Brazilian Journal of Food Technology

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2021, Volume 24 elocation e2020215

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo A mandioca de mesa pode ser comercializada congelada para facilitar o preparo e o consumo. Este trabalho teve como objetivo avaliar as características físico-químicas, o tempo de cozimento, a qualidade microbiológica e os atributos sensoriais das variedades BRS Aipim Brasil e Eucalipto, durante o armazenamento sob congelamento. As raízes foram lavadas em água, sanitizadas, cortadas em cilindros, descascadas, sanitizadas, drenadas, acondicionadas em embalagens de nylon/ polietileno de baixa densidade e armazenadas a -18 °C, sendo avaliadas a cada 30 dias, aproximadamente. A variedade Eucalipto apresentou a menor umidade (61,98%) e os maiores rendimentos de polpa (71,41%) e teor de amido (33,45%). A variedade BRS Aipim Brasil apresentou menor intensidade de cor (11,48) e maior ângulo de cor (97,45°). Os dois genótipos de mandioca não apresentaram diferenças em termos de acidez, luminosidade, sólidos solúveis, teor de açúcar total e pH. A variedade Eucalipto apresentou o menor tempo de cozimento (25 minutos) e umidade (62,92%), para os cinco tempos de armazenamento avaliados. Essa variedade também apresentou o maior teor de amido durante o armazenamento, exceto aos 31 dias. A variedade Eucalipto foi mais aceita para os atributos cor, aroma e impressão global. Em relação ao sabor e à textura, as duas variedades foram consideradas semelhantes e foram classificadas entre os termos hedônicos “gostei ligeiramente” e “gostei moderadamente”. A aceitação sensorial das raízes não foi alterada ao longo do armazenamento e as notas atribuídas foram acima de 6,0, o que representa o limite mínimo de aceitação, para todos os atributos avaliados. A mandioca congelada a -18 °C pode ser comercializada por 120 dias com segurança microbiológica, sem que ocorram alterações significativas das suas características físico-químicas e sensoriais.

Abstract Sweet cassava can be sold frozen, i.e., frozen food, to facilitate preparation and consumption. This study aimed to evaluate physical-chemical characteristics, cooking time, microbiological quality and sensory attributes regarding the varieties BRS Aipim Brasil and Eucalipto in frozen storage. The roots were washed in water, sanitized, cut into cylinders, peeled, sanitized, drained, packed in nylon/ low density polyethylene packages and stored at -18 °C, being evaluated every 30 days, approximately. The Eucalipto variety showed the lowest moisture (61.98%) and the highest pulp yield (71.41%) and starch content (33.45%). However, the BRS Aipim Brasil variety had lower color intensity (11.48) and greater color angle (97.45°) than Eucalipto. The two cassava genotypes showed no difference in terms of acidity, luminosity, soluble solids, total sugar content and pH. The Eucalipto variety showed the shortest cooking time (25 minutes) and moisture (62.92%) concerning the five storage times that were evaluated. This variety also had the highest starch content during storage, except at 31 days. The Eucalipto variety was more accepted for the color, aroma and overall impression attributes. Regarding flavor and texture, the two varieties were considered similar and were classified between the hedonic terms “like slightly” and “like moderately”. The sensory acceptance of the roots was not altered during storage and the grades attributed were above 6.0, which represents the minimum acceptance limit, for all evaluated attributes. Cassava frozen at -18 °C can be marketed for 120 days without microbiological risk, and without significant changes in its physical-chemical and sensory characteristics.

https://doi.org/10.1590/1981-6723.21520 148 downloads

10.

Determination of phenolic and triterpenic compounds in Jatropha gossypiifolia L by Ultra-high performance liquid chromatography-tandem mass spectrometric (UHPLC-MS/MS)
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Silveira, Rudinei da Silva

; Leal, Gabriela Camera

; Molin, Thais Ramos Dal

; Faccin, Henrique

; Gobo, Luciana Assis

; Silveira, Géssica Domingos da

; Souza, Mariana Tatsch da Silva

; Lameira, Osmar Alves

; Carvalho, Leandro Machado de

; Viana, Carine

Brazilian Journal of Pharmaceutical Sciences

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2020, Volume 56 elocation e17262

Resumo: En | Texto: En | PDF: En

This work describes the chemical characterization of extracts of Jatropha gossypiifolia (from Amazonia region) concerning the presence of phenolic and triterpenic compounds using Ultra High Perfomance Liquid chromatography coupled to Mass Spectrometry in Tandem (UHPLC-MS/MS) methods. The studied compounds belong to the most frequently found classes in medicinal plants (triterpenes, flavonoids, flavones, hydroxycinnamic acids, coumarins, catechins and stilbenes), which have been analyzed as chemical and bioactive markers in hydroethanolic and aqueous extracts. Several polyphenolic compounds identified herein are unprecedented in the scientific literature for this species. The chemical markers identified and quantified in the studied extracts of J. gossypiifolia were gallic acid, chlorogenic acid, catechin, caffeic acid, vanillic acid, p-coumaric acid, ferullic acid, rutin, quercitrin, 3-acetylcoumarin, trans-cinnamic acid, quercetin, luteolin, apigenin, kaempferol, chrysin. α-amyrin, β-amyrin and lupeol. As the majority compounds, (+)-catechin, p-coumaric acid, ferulic acid, luteolin, α-amyrin and β-amyrin were found to be present at mg kg-1 levels. J. gossypiifolia extracts presented a high in vitro activity against different reactive oxygen species (hydroxyl, peroxyl, and superoxide anion radicals). Several polyphenolic compound data presented herein are unprecedented in the scientific literature for this plant species. As a result, this plant can be a new source of bioactive molecules for therapeutic purposes.

https://doi.org/10.1590/s2175-97902019000417262 1426 downloads

11.

Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol
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COSTA, Tereza Karla Vieira Lopes da

; BARROS, Mariana Silva

; BRAGA, Renan Marrinho

; VIANA, Jéssika de Oliveira

; SOUSA, Frederico Barbosa de

; SCOTTI, Luciana

; SCOTTI, Marcus Tullius

; BATISTA, André Ulisses Dantas

; ALMEIDA, Reinaldo Nóbrega de

; CASTRO, Ricardo Dias de

Brazilian Oral Research

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2020, Volume 34 elocation e094

Resumo: En | Texto: En | PDF: En

Abstract We aimed to evaluate the orofacial antinociceptive effect of geraniol in mice and its molecular anchorage mechanism. Seven mice per group (probabilistic sample) were treated with geraniol (12.5, 25 and 50 mg/kg, i.p.), morphine (6 mg/kg, i.p.) and vehicle (saline + Tween 80 at 0.2%, i.p.) 30 minutes prior to the beginning of the experiment. Injecting glutamate (25 μM), capsaicin (2.5 μg) and formalin (2%) into the right upper lip (perinasal) of the mouse induced nociception. Behavioral analysis of the animals considered the friction time (in seconds) of the mentioned region using hind or front paws by a researcher blinded to the treatment groups. The statistical analysis was performed blindly, considering α = 5%. The results showed that in the glutamate and capsaicin tests, concentrations of 25 mg/kg and 50 mg/kg presented antinociceptive activity (p < 0.005, power> 80%). In the formalin test, geraniol was able to reduce nociception at a concentration of 50 mg/kg (p < 0.005, power> 80%). In the molecular anchorage study, high values of binding between the evaluated substance and receptors of glutamate were observed (metabotropic glutamate receptor, -87.8501 Kcal/mol; N-methyl-D-aspartate, -86.4451 Kcal/mol; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid, -85.6755 Kcal/mol). Geraniol presented orofacial antinociceptive activity, probably by interacting with glutamate-related receptors.

https://doi.org/10.1590/1807-3107bor-2020.vol34.0094 467 downloads

12.

Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Adults
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Barban, Juliana Bernardo

; Simões, Belinda Pinto

; Moraes, Bruna Del Guerra de Carvalho

; Anunciação, Cássia Rehem da

; Rocha, Cristiane Santos da

; Pintor, Daniela Cristina Querino

; Guerra, Daiane Cristina

; Silva, Deise Andrade

; Brandão, Edith de Castro Martins

; Kerbauy, Fábio

; Pires, Fernanda Ramos de Oliveira

; Morais, Graciele Lima

; Schmidt Filho, Jayr

; Sicchieri, Juliana Maria Faccioli

; Barroso, Karine Sampaio Nunes

; Viana, Luciana Verçoza

; Rocha, Mariana Hollanda Martins da

; Guimarães, Maysa Penteado

; Lazzari, Natalia Leonetti Couto

; Hamerschlak, Nelson

; Ramos, Patricia

; Gomes, Plinio Nascimento

; Mendonça, Priscila da Silva

; Oliveira, Raquel Candido de

; Scomparim, Renata Corrêa

; Chiattone, Ricardo

; Diez-Garcia, Rosa Wanda

; Cardenas, Thaís de Campos

; Miola, Thais Manfrinato

; Costa, Thalita Cristina de Mello

; Rocha, Vanderson

; Pereira, Andrea Z

einstein (São Paulo)

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2020, Volume 18 elocation AE4530

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O estado nutricional do paciente submetido ao transplante de células-tronco hematopoéticas é considerado fator de risco independente, podendo influenciar na qualidade de vida e na tolerância ao tratamento proposto. O comprometimento do estado nutricional durante o transplante de células-tronco hematopoéticas ocorre principalmente devido aos efeitos adversos decorrentes do condicionamento ao qual o paciente é submetido. Desta forma, a adequada avaliação nutricional e o acompanhamento durante o transplante de células-tronco hematopoéticas tornam-se imprescindíveis. Com o objetivo de salientar a importância do estado nutricional e da composição corporal durante o tratamento, bem como as principais características relacionadas à avaliação nutricional do paciente, o Consenso Brasileiro de Nutrição em Transplante de Células-Tronco Hematopoiéticas: Adulto foi elaborado visando uniformizar e atualizar a Terapia Nutricional nesta área. Com a participação de nutricionistas, nutrólogos e hematologistas de 15 centros brasileiros referências em transplante de células-tronco hematopoéticas

ABSTRACT The nutritional status of patients submitted to hematopoietic stem cell transplant is considered an independent risk factor, which may influence on quality of life and tolerance to the proposed treatment. The impairment of nutritional status during hematopoietic stem cell transplant occurs mainly due to the adverse effects resulting from conditioning to which the patient is subjected. Therefore, adequate nutritional evaluation and follow-up during hematopoietic stem cell transplant are essential. To emphasize the importance of nutritional status and body composition during treatment, as well as the main characteristics related to the nutritional assessment of the patient, the Brazilian Consensus on Nutrition in Hematopoietic Stem Cell Transplant: Adults was prepared, aiming to standardize and update Nutritional Therapy in this area. Dietitians, nutrition physicians and hematologists from 15 Brazilian centers thar are references in hematopoietic stem cell transplant took part.

https://doi.org/10.31744/einstein_journal/2020ae4530 3888 downloads

13.

Study of brainstem auditory evoked potentials in early diagnosis of congenital toxoplasmosis,
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Fontes, Aline Almeida

; Carvalho, Sirley Alves da Silva

; Andrade, Gláucia Manzan Queiroz de

; Carellos, Ericka Viana

; Romanelli, Roberta Castro

; Resende, Luciana Macedo de

Brazilian Journal of Otorhinolaryngology

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Ago 2019, Volume 85 Nº 4 Páginas 447 - 455

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Introdução: A toxoplasmose congênita é uma doença infecciosa com grande prevalência nos países tropicais. Caracteriza-se por sequelas neurológicas, oftalmológicas e auditivas. Objetivo: O objetivo desse estudo foi avaliar e descrever o potencial evocado auditivo de tronco encefálico em bebês de 1 a 3 meses diagnosticados com toxoplasmose congênita e comparar com bebês de mesma faixa etária sem a infecção. Metódo: Trata-se de um estudo observacional, analítico e transversal, no qual foi realizada a pesquisa do potencial evocado auditivo de tronco cerebral em lactentes com toxoplasmose congênita. Foram realizados os exames audiológicos: emissões otoacústicas evocadas por estímulo transiente, potencial auditivo de tronco encefálico clínico e automático. Resultados: Participaram do estudo 100 crianças, porém a amostra final foi constituída por 76. Das 37 crianças com toxoplasmose incluídas no estudo, 28 completaram a avaliação neurológica de imagem e, dessas, três (10,7%) apresentaram exame neurológico alterado. Na avaliação do potencial evocado auditivo de tronco encefálico, duas crianças sem toxoplasmose e 10 com toxoplasmose congênita apresentaram resultado sugestivo de alteração no processo maturacional da via auditiva de tronco encefálico. Conclusão: Foram identificadas 10 (27%) crianças com possível alteração unilateral na avaliação eletrofisiológica e um risco cinco vezes maior de uma criança entre um e três meses com toxoplasmose apresentar alteração no potencial evocado auditivo de tronco encefálico quando comparada com uma criança da mesma faixa de idade sem a infecção.

Abstract Introduction: Congenital toxoplasmosis is an infectious disease with high prevalence in tropical countries. It is characterized by neurological, ophthalmological and auditory sequelae. Objective: The aim of this study was to evaluate and describe the brainstem auditory evoked potential in infants aged 1-3 months diagnosed with congenital toxoplasmosis and to compare them with infants of the same age group without the infection. Methods: This is an observational, analytical and cross-sectional study in which brainstem auditory evoked potential was investigated in infants with congenital toxoplasmosis. The following audiological exams were performed: transient-evoked otoacoustic emissions, clinical and automatic brainstem auditory evoked potential. Results: 100 children participated in the study, but the final sample consisted of 76 children. Of the 37 children with toxoplasmosis included in the study, 28 completed the neurological imaging evaluation, and of these, 3 (10.7%) showed an altered neurological examination. At the brainstem auditory evoked potential assessment, two children without toxoplasmosis and 10 children with congenital toxoplasmosis had results suggestive of alterations in the brainstem auditory pathway maturation. Conclusion: 10 (27%) children were identified with a possible unilateral alteration in the electrophysiological assessment. There was a 5-fold higher risk for a child between 1 and 3 months of age with toxoplasmosis to have an altered brainstem auditory evoked potential compared to a child of the same age range without the infection.

https://doi.org/10.1016/j.bjorl.2018.03.012 1810 downloads

14.

Accidental enteral feeding tube dislodgement with the use of a dedicated feeding tube attachment device versus adhesive tape as the securing method: a randomized clinical trial
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Assis, Michelli Cristina Silva de

; Macedo, Andreia Barcellos Teixeira

; Gazal, Cláudia Hallal Alves

; Martins, Célia Mariana Barbosa de Souza

; Viana, Luciana Verçoza

Nutrición Hospitalaria

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Jun 2019, Volume 36 Nº 3 Páginas 504 - 509

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Introduction: accidental dislodgement of enteral feeding tubes has been considered as an important quality indicator of the efficacy of enteral nutrition therapy. However, in clinical practice, the use of feeding tube attachment devices (FTADs), as an alternative to the traditional method of adhesive tape alone, has not yet been evaluated for its effectiveness in reducing inadvertent tube dislodgement. Objective: to evaluate the impact of using a dedicated FTAD compared with the traditional securing method with adhesive tape on the occurrence of accidental enteral feeding tube removal. Methods: a randomized clinical trial comparing two strategies for enteral feeding tube securement: use of traditional adhesive tape vs FTAD. The primary endpoint was the percentage of accidental enteral feeding tube dislodgement after randomization. Results: a total of 104 inpatients (mean age: 61.4 ± 17.5 years) were included (52 patients per group). Most were women with cerebrovascular disease (35.6%), diabetes (28.8%) and neoplasia (27.9%). There were 39 (37.5%) cases of accidental tube removal, 30.8% in the FTAD group and 44.2% in the adhesive tape group (p = 0.22). During follow-up, patients in the FTAD group received a mean of 60.0% of the volume of enteral nutrition prescribed, while patients in the adhesive tape group received 57.0% (p = 0.61). There was no difference in skin lesions between the groups. Conclusion: the strategy of using a dedicated FTAD as the method for securing enteral feeding tubes did not reduce the risk of accidental tube dislodgement compared with the traditional securing method with adhesive tape.

Resumen Introducción: la expulsión accidental de sondas de alimentación enteral se ha considerado un indicador importante de la calidad de la eficacia de la terapia de nutrición enteral. Sin embargo, en la práctica clínica, el uso de dispositivos de fijación de tubos de alimentación (FTAD, por sus siglas en inglés), como una alternativa al método tradicional de cinta adhesiva exclusivamente, aún no se ha evaluado por su eficacia para reducir el desprendimiento accidental de sondas. Objetivo: evaluar el impacto de usar un FTAD dedicado en comparación con el método tradicional de aseguramiento con cinta adhesiva en caso de que se produzca una extracción accidental de la sonda de alimentación enteral. Métodos: se realizó un ensayo clínico aleatorizado que comparó dos estrategias para asegurar la sonda de alimentación enteral: el uso de cinta adhesiva tradicional frente a FTAD. El punto final primario fue el porcentaje de desplazamiento accidental del tubo de alimentación enteral después de la aleatorización. Resultados: se incluyó un total de 104 pacientes hospitalizados (edad media 61,4 ± 17,5 años) (52 pacientes por grupo). La mayoría eran mujeres con enfermedad cerebrovascular (35,6%), diabetes (28,8%) y neoplasia (27,9%). Hubo 39 casos (37.5%) de extracción accidental de tubos, 30,8% en el grupo FTAD y 44,2% en el grupo de cinta adhesiva (p = 0,22). Durante el seguimiento, los pacientes del grupo FTAD recibieron una media del 60,0% del volumen de nutrición enteral prescrito, mientras que los pacientes del grupo de cinta adhesiva recibieron el 57,0% (p = 0,61). No hubo diferencia en las lesiones de la piel entre los grupos. Conclusión: la estrategia de utilizar un FTAD dedicado como método para asegurar las sondas de alimentación enteral no redujo el riesgo de retiradas accidentales en comparación con el método tradicional de sujeción con cinta adhesiva.

https://doi.org/10.20960/nh.02440 201 downloads

15.

Zika virus: - a review of the main aspects of this type of arbovirosis
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Dias, Ítala Keane Rodrigues

; Sobreira, Cicera Luciana da Silva

; Martins, Rosa Maria Grangeiro

; Santana, Kelly Fernanda Silva

; Lopes, Maria do Socorro Vieira

; Joventino, Emanuella Silva

; Viana, Maria Corina Amaral

Revista da Sociedade Brasileira de Medicina Tropical

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Jun 2018, Volume 51 Nº 3 Páginas 261 - 269

Resumo: En | Texto: En | PDF: En

Abstract The objective of this study was to integrate findings related to Zika virus from the scientific literature. An integrative review of Medline was conducted, and data search was performed using the Health Sciences Descriptor Zika virus and the following filters: full texts available; studies in humans; full articles; and publications in Portuguese, French, English, and Spanish. After application of the filters, followed by reading of the titles, abstracts, and full texts, 44 studies were included in the review, for which content analysis was performed. A large part of the literature comprised review articles (84%; N=37); the majority was in English (95%, N=42). In 2016, 84% (N=37) of our sample articles was published, while in 2017, 16% (N=7) was published. The main form of viral transmission was thorough the mosquito Aedes aegypti (N=30). In addition, sexual transmission (N=09), transmission through blood transfusion (N=16), vertical transmission (N=21) and transmission from occupational activities (N=03) occurred. It was possible to diagnose the disease by testing blood (N=22), urine (N=14), saliva (N=06), semen/sperm (N=03), cerebrospinal and amniotic fluid, and other tissues (N=02). Symptomatology occurred in 1-5 people (N=10) between 3 and 7 days after a mosquito bite (N=09). Complications observed were Guillain Barré syndrome (N=27); neurological Zika syndrome (N=27); meningitis, meningoencephalitis, and myelitis (N=07); deaths and/or newborns (N=03). The review provides scientific evidence that contributes to the care, planning and implementation of public policies.

https://doi.org/10.1590/0037-8682-0130-2018 3783 downloads

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