SUMMARY OBJECTIVE: This study aimed to investigate the sex-specific association between hyperuricemia and the risk of hypertension and whether obesity mediates this association. METHODS: This study included 31,395 (47.0% women) adults without hypertension, cardiovascular disease, or cancer at baseline who completed at least one follow-up annual examination between 2009 and 2016. Cox regression models were performed to calculate hazard ratios and 95% confidence intervals. Mediation analysis was conducted to estimate the effect of body mass index on the association between hyperuricemia and hypertension. RESULTS: During a median 2.9-year follow-up, hyperuricemia was significantly associated with a higher risk of hypertension (HR 1.15, 95%CI 1.07-1.24 for all participants; HR 1.12, 95%CI 1.03-1.22 for men; and HR 1.23, 95%CI 1.02-1.48 for women) after adjustment for potential confounders. Additional adjustment for body mass index attenuated this association (HR 1.09, 95%CI 1.08-1.10 for all participants; HR 1.07; 95%CI 0.98-1.16 for men; HR 1.18; 95%CI 0.96-1.44 for women). Mediation analysis showed that BMI partially mediated the relationship between hyperuricemia and incident hypertension (indirect effect HR 1.09, 95%CI 1.08-1.10; direct effect: HR 1.08, 95%CI 1.02-1.15). The percentage of the mediation effect was 53.2% (95%CI 37.9-84.5). CONCLUSION: Hyperuricemia is associated with a risk of hypertension in both sexes, and BMI partially mediates hyperuricemia-related incident hypertension.

Objectives: To explore the effects of computer radiation on weight and oxidant-antioxidant status of rats, and further to confirm that whether vitamin C has protective effects on computer radiation. Methods: Sixty Male adult ICR mice were randomly divided into six groups. each group give different treatment as follows: group A was control, group B given vitamin C intake, group C given 8 h/day computer radiation exposure, group D given vitamin C intake and 8 h/day computer radiation group E given 16 h/day computer radiation exposure, group F given vitamin C intake plus exposure to 16 h/day computer radiation. After seven weeks, mice was executed to collect the blood samples, for detecting total antioxidant capacity (T-AOC) and alkaline phosphates (ALP)content in serum or liver tissue were determined by ELIASA. Results: No difference was found for the change of weight among six groups at different week. In the group C, D and F, the liver tissue T-AOC level were higher than the group A. In the group B, C and E, the serum ALP level were lower than the group A (P<0.05). Conclusions: The study indicate that computer radiation may have an adverse effect on T-AOC and ALP level of mice, and vitamin C have protective effect against computer radiation.

Objetivos: Explorar los efectos de la radiación de ordenador sobre el peso y el estado oxidativo-antioxidativo de los ratones, y además para confirmar si la vitamina C tiene efectos protectores contra la radiación de ordenador. Métodos: Sesenta ratones machos adultos ICR fueron aleatoriamente divididos en seis grupos. Cada grupo recibió un tratamiento diferente del modo siguiente: el grupo A fue el grupo de control, el grupo B recibió vitamina C, el grupo C fue sometido a una exposicion a la radiacion de ordenador de 8 h/día, el Grupo D recibió vitamina C y fue sometido a una exposicion a la radiacion de ordenador de 8 h/día, el Grupo E fue sometido a una radiación de ordenador de 16 h/día, el grupo F recibió vitamina C y fue sometido a una exposicion a la radiacion de ordenador de 16 h/día. Al cabo de siete semanas, los ratones fueron ejecutados para extraer las muestras de sangre, para detectar la capacidad antioxidante total (T-AOC) y el contenido de fosfatasa alcalina (ALP) en suero o en tejido hepático fue determinado mediante ELISA. Resultados: No se encontraron diferencias en cuanto a cambio de peso entre los seis grupos diferentes. En los grupos C, D y F, el nivel en de T-AOC en tejido hepático fue más alto que en el grupo A. En los grupos B, C y E, el nivel de ALP en suero fue más bajo que en el Grupo A (P < 0,05). Conclusiones: El estudio indican que la radiación de ordenador puede tener un efecto adverso en los niveles de T-AOC y ALP de ratones, y que la vitamina C tendría un efecto protector contra la radiación del ordenador.

The electron paramagnetic resonance (EPR) parameters (g factors and the hyperfine structure constants) for Ni2+ and Co+ in MgO are theoretically studied from the perturbation formulas of these parameters for a 3d8 ion in octahedral crystal-fields. In the computations, the ligand orbital and spin-orbit coupling contributions are taken into account using the cluster approach. The calculated EPR parameters are in good agreement with the experimental data. The larger g factor and the smaller magnitude of the hyperfine structure constant for Ni2+ as compared with those for Co+ can be attributed to the higher spin-orbit coupling coefficient and the lower dipolar hyperfine structure parameter of the former, respectively.