Abstract Objective Not only white blood cells but also platelets are being considered in inflammatory reactions from now on. Mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) have been shown to change in inflammatory diseases like myocardial infarction, stroke and implicated in psychiatric disorders nowadays. Our first aim is to investigate the relation of MPV and NLR with depression and secondly to assess if they change with the treatment of depression. Methods Forty-nine patients diagnosed with major depressive disorder (MDD) and hospitalized in a university hospital psychiatry inpatient unit retrospectively included in the study. Control group consisted of 48 hospital workers with no known disease. Complete blood count, Hamilton Depression Rating Scale (HAM-D) and Clinical Global Impression-Severity Scale (CGI-S) scores at admission and at discharge were noted and compared for the patient group. Discussion MPV of depressed patients was higher than controls. When we look at admission and discharge scores of clinical scales, decrement is statistically significant for both HAM-D and CGI-S. There was decline both in MPV and NLR which were both statistically significant. Conclusion Decreasing MPV and NLR values with the treatment of depression confirm the involvement of inflammatory processes in the pathophysiology of depression.

ResumoFundamento:A investigação da relação entre doença psiquiátrica e doença cardíaca sempre foi um tema de interesse na literatura médica.Objetivo:Investigar a relação entre ansiedade, depressão e distúrbios psicológicos gerais e fluxo coronariano lento (FCL).Métodos:Quarenta e quatro pacientes com FCL e 50 pacientes com fluxo coronariano normal (FCN) foram recrutados prospectivamente. Foram registrados: dados clínicos, parâmetros laboratoriais à admissão e características ecocardiográficas e angiográficas. Escalas de avaliação da Lista de Verificação de Sintomas-90 Revisada (SCL-90-R), do Inventário Beck de Depressão (IBD) e do Inventário Beck de Ansiedade (IBA) foram determinadas para cada paciente.Resultados:O grupo FCL incluiu 44 indivíduos e o grupo controle 50 indivíduos. Os grupos foram comparados quanto à idade, sexo e fatores de risco para aterosclerose. No grupo FCL, os escores do IBA, do IBD e do índice geral de sintomas foram significativamente mais altos que no grupo controle (13 [18,7] vs. 7,5 [7], p = 0,01; 11 [14,7] vs. 6,5 [7], p = 0,01; 1,76 [0,81] vs. 1,1[0,24], p = 0,01; respectivamente). Pacientes com FCL em mais de um vaso apresentaram os escores mais elevados. Na análise de correlação univariada, a média das contagens de quadros TIMI foi correlacionada positivamente com o IBA (r = 0,56, p = 0,01), com o IBD (r = 0,47, p = 0,01) e com o Índice Geral de Sintomas (r = 0,65, p = 0,01). Os testes psiquiátricos não tiveram correlação com fatores de risco para aterosclerose.Conclusão:Nosso estudo revelou taxas de depressão, ansiedade e distúrbios psicológicos gerais mais elevadas em pacientes com FCL. Esta conclusão justifica novos estudos.

AbstractBackground:The relationship between psychiatric illness and heart disease has been frequently discussed in the literature. The aim of the present study was to investigate the relationship between anxiety, depression and overall psychological distress, and coronary slow flow (CSF).Methods:In total, 44 patients with CSF and a control group of 50 patients with normal coronary arteries (NCA) were prospectively recruited. Clinical data, admission laboratory parameters, and echocardiographic and angiographic characteristics were recorded. Symptom Checklist 90 Revised (SCL-90-R), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) scales were administered to each patient.Results:The groups were comparable with respect to age, sex, and atherosclerotic risk factors. In the CSF group, BAI score, BDI score, and general symptom index were significantly higher than controls (13 [18.7] vs. 7.5 [7], p = 0.01; 11 [14.7] vs. 6.5 [7], p = 0.01; 1.76 [0.81] vs. 1.1[0.24], p = 0.01; respectively). Patients with CSF in more than one vessel had the highest test scores. In univariate correlation analysis, mean thrombolysis in myocardial infarction (TIMI) frame counts were positively correlated with BAI (r = 0.56, p = 0.01), BDI (r = 0.47, p = 0.01), and general symptom index (r = 0.65, p = 0.01). The psychiatric tests were not correlated with risk factors for atherosclerosis.Conclusion:Our study revealed higher rates of depression, anxiety, and overall psychological distress in patients with CSF. This conclusion warrants further studies.