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au:CAVALHEIRO, ANA MARIA

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Assessment of websites on cleft lip and palate in Brazilian Portuguese
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Corrêa, Camila de Castro

; Lobo, Fernanda Souza

; Benito, Ana Luiza Vieira

; Silva, Maria Clara Luciano

; Pirola-Picinato, Melissa

; Maximino, Luciana Paula

; Cavalheiro, Maria Gabriela

Revista CEFAC

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2023, Volume 25 N. 4 elocation e1723

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: this study aimed at assessing the legibility, reliability, usability and coverage of websites on cleft lip and/or palate (CL/P) in Brazilian Portuguese and providing a global comparison. Methods: in order to evaluate the obtained data, four protocols were used, i.e., the Website Coverage Protocol, the legibility (by means of the COH METRIX PORT), the reliability (Discern Protocol), and the usability (by means of the System Usability Scale). Results: 98 websites were included with average legibility scoring of 31.6±11.7, rated as a hard readability level. Coverage average scoring was 19.9±3.79 from a total of 35 points. As for reliability, average scoring was 43.2±6.51 points, rated as acceptable. The usability scoring was 24.8±2.18 points, rated as the worst imaginable one. Conclusion: therefore, the assessed Brazilian websites on CL/P were rated difficult for legibility, requiring high-school level of education, restricted coverage and acceptable reliability, in addition to the low usability. The results were similar to those of websites from other countries, except for the legibility aspect, which was lower for Brazilian websites.

https://doi.org/10.1590/1982-0216/20232541723

Chronic use of hydroxychloroquine did not protect against COVID-19 in a large cohort of patients with rheumatic diseases in Brazil
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Pileggi, Gecilmara Salviato

; Ferreira, Gilda Aparecida

; Gomides Reis, Ana Paula Monteiro

; Reis Neto, Edgard Torres

; Abreu, Mirhelen Mendes

; Albuquerque, Cleandro Pires

; Araújo, Nafice Costa

; Bacchiega, Ana Beatriz

; Bianchi, Dante Valdetaro

; Bica, Blanca

; Bonfa, Eloisa Duarte

; Borba, Eduardo Ferreira

; Brito, Danielle Christinne Soares Egypto

; Duarte, Ângela Luzia Branco Pinto

; Santo, Rafaela Cavalheiro Espírito

; Fernandes, Paula Reale

; Guimarães, Mariana Peixoto

; Gomes, Kirla Wagner Poti

; Kakehasi, Adriana Maria

; Klumb, Evandro Mendes

; Lanna, Cristina Costa Duarte

; Marques, Claudia Diniz Lopes

; Monticielo, Odirlei André

; Mota, Licia Maria Henrique

; Munhoz, Gabriela Araújo

; Paiva, Eduardo Santos

; Pereira, Helena Lucia Alves

; Provenza, José Roberto

; Ribeiro, Sandra Lucia Euzébio

; Rocha Junior, Laurindo Ferreira

; Sampaio, Camila Santana Justo Cintra

; Sampaio, Vanderson Souza

; Sato, Emília Inoue

; Skare, Thelma

; de Souza, Viviane Angelina

; Valim, Valeria

; Lacerda, Marcus Vinícius Guimarães

; Xavier, Ricardo Machado

; Pinheiro, Marcelo Medeiros

Advances in Rheumatology

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2021, Volume 61 elocation 60

Abstract: En | Text: En | PDF: En

Abstract Background: There is a lack of information on the role of chronic use of hydroxychloroquine during the SARS-CoV-2 outbreak. Our aim was to compare the occurrence of COVID-19 between rheumatic disease patients on hydroxychloroquine with individuals from the same household not taking the drug during the first 8 weeks of community viral transmission in Brazil. Methods: This baseline cross-sectional analysis is part of a 24-week observational multi-center study involving 22 Brazilian academic outpatient centers. All information regarding COVID-19 symptoms, epidemiological, clinical, and demographic data were recorded on a specific web-based platform using telephone calls from physicians and medical students. COVID-19 was defined according to the Brazilian Ministry of Health (BMH) criteria. Mann-Whitney, Chi-square and Exact Fisher tests were used for statistical analysis and two binary Final Logistic Regression Model by Wald test were developed using a backward-stepwise method for the presence of COVID-19. Results: From March 29th to May 17st, 2020, a total of 10,443 participants were enrolled, including 5166 (53.9%) rheumatic disease patients, of whom 82.5% had systemic erythematosus lupus, 7.8% rheumatoid arthritis, 3.7% Sjögren’s syndrome and 0.8% systemic sclerosis. In total, 1822 (19.1%) participants reported flu symptoms within the 30 days prior to enrollment, of which 3.1% fulfilled the BMH criteria, but with no significant difference between rheumatic disease patients (4.03%) and controls (3.25%). After adjustments for multiple confounders, the main risk factor significantly associated with a COVID-19 diagnosis was lung disease (OR 1.63; 95% CI 1.03-2.58); and for rheumatic disease patients were diagnosis of systemic sclerosis (OR 2.8; 95% CI 1.19-6.63) and glucocorticoids above 10 mg/ day (OR 2.05; 95% CI 1.31-3.19). In addition, a recent influenza vaccination had a protective effect (OR 0.674; 95% CI 0.46-0.98). Conclusion: Patients with rheumatic disease on hydroxychloroquine presented a similar occurrence of COVID-19 to household cohabitants, suggesting a lack of any protective role against SARS-CoV-2 infection. Trial registration Brazilian Registry of Clinical Trials (ReBEC; RBR - 9KTWX6).

https://doi.org/10.1186/s42358-021-00217-0 22 downloads

Guidance on diagnosis, prevention and treatment of thromboembolic complications in COVID-19: a position paper of the Brazilian Society of Thrombosis and Hemostasis and the Thrombosis and Hemostasis Committee of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy
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Orsi, Fernanda Andrade

; De Paula, Erich V.

; Santos, Fernanda de Oliveira

; Teruchkin, Marcelo Melzer

; Campêlo, Dirceu Hamilton Cordeiro

; Mello, Tayana Teixeira

; Chindamo, Maria Chiara

; Macedo, Ariane Vieira Scarlatelli

; Rocha, Ana Thereza

; Ramacciotti, Eduardo

; Nascimento, Ana Clara Kneese

; Annichino-Bizzacchi, Joyce

; Lourenco, Dayse Maria

; Guerra, João Carlos de Campos

; Rezende, Suely Meireles

; Cavalheiro Filho, Cyrillo

Hematology, Transfusion and Cell Therapy

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oct 2020, Volume 42 N. 4 Pages 300 - 308

Abstract: En | Text: En | PDF: En

ABSTRACT Hemostatic abnormalities and thrombotic risk associated with coronavirus disease 2019 (COVID-19) are among the most discussed topics in the management of this disease. The aim of this position paper is to provide the opinion of Brazilian experts on the thromboprophylaxis and management of thrombotic events in patients with suspected COVID-19, in the sphere of healthcare in Brazil. To do so, the Brazilian Society of Thrombosis and Hemostasis (BSTH) and the Thrombosis and Hemostasis Committee of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy (ABHH) have constituted a panel of experts to carefully review and discuss the available evidence about this topic. The data discussed in this document was reviewed by May 9, 2020. Recommendations and suggestions reflect the opinion of the panel and should be reviewed periodically as new evidence emerges.

https://doi.org/10.1016/j.htct.2020.06.001 840 downloads

Quality of life and clinical and demographic characteristics of patients with cutaneous squamous cell carcinoma submitted to tumor resection by double-bladed scalpel
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Barazzetti, Daniel Ongaratto

; Barazzetti, Pedro Henrique Ongaratto

; Cavalheiro, Bárbara Thomé

; Ely, Jorge Bins

; Nunes, Daniel Holthausen

; Stamm, Ana Maria Nunes de Faria

Anais Brasileiros de Dermatologia

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may 2019, Volume 94 N. 3 Pages 304 - 312

Abstract: En | Text: En | PDF: En

Abstract: Background: Non-melanoma skin cancer accounts for a third of all malignancies registered in Brazil, with squamous cell carcinoma (SCC) being one of its subtypes. It develops in photo-exposed areas, affecting social habits and causing negative influence on quality of life (QoL). Objectives: To evaluate QoL in patients with primary cutaneous SCC. Methods: A cross-sectional study was performed in patients with clinical diagnosis of SCC, corroborated by dermoscopy and confirmed by histopathology; prior to resection of the tumor using the double-blade scalpel technique, a questionnaire on the Dermatology Life Quality Index (DLQI) was applied. Results: Among the 46 evaluated patients, mean age was 67.1 ± 16.0 years, with a predominance of males, low educational level and socioeconomic status, Fitzpatrick II phototype, history of outdoor work, and tumor location in exposed photo areas. Mean DLQI was 4.02 ± 0.63, and in the categorization, 11 (23.9%) had a moderate to severe negative effect on QoL. The skin tumor had a negative impact on daily activities (33% of cases), treatment effects (30%), and symptoms and feelings (29%). Study limitations: There is no gold standard instrument for assessing QoL in dermatological patients. Conclusion: In the study sample, one-fourth of patients with SCC had a moderate to severe negative effect on quality of life.

https://doi.org/10.1590/abd1806-4841.20197842 801 downloads

Genetic and biological characterisation of Zika virus isolates from different Brazilian regions
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Strottmann, Daisy Maria

; Zanluca, Camila

; Mosimann, Ana Luiza Pamplona

; Koishi, Andrea C

; Auwerter, Nathalia Cavalheiro

; Faoro, Helisson

; Cataneo, Allan Henrique Depieri

; Kuczera, Diogo

; Wowk, Pryscilla Fanini

; Bordignon, Juliano

; Duarte dos Santos, Claudia Nunes

Memórias do Instituto Oswaldo Cruz

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2019, Volume 114 elocation e190150

Abstract: En | Text: En | PDF: En

BACKGROUND Zika virus (ZIKV) infections reported in recent epidemics have been linked to clinical complications that had never been associated with ZIKV before. Adaptive mutations could have contributed to the successful emergence of ZIKV as a global health threat to a nonimmune population. However, the causal relationships between the ZIKV genetic determinants, the pathogenesis and the rapid spread in Latin America and in the Caribbean remain widely unknown. OBJECTIVES The aim of this study was to characterise three ZIKV isolates obtained from patient samples during the 2015/2016 Brazilian epidemics. METHODS The ZIKV genomes of these strains were completely sequenced and in vitro infection kinetics experiments were carried out in cell lines and human primary cells. FINDINGS Eight nonsynonymous substitutions throughout the viral genome of the three Brazilian isolates were identified. Infection kinetics experiments were carried out with mammalian cell lines A549, Huh7.5, Vero E6 and human monocyte-derived dendritic cells (mdDCs) and insect cells (Aag2, C6/36 and AP61) and suggest that some of these mutations might be associated with distinct viral fitness. The clinical isolates also presented differences in their infectivity rates when compared to the well-established ZIKV strains (MR766 and PE243), especially in their abilities to infect mammalian cells. MAIN CONCLUSIONS Genomic analysis of three recent ZIKV isolates revealed some nonsynonymous substitutions, which could have an impact on the viral fitness in mammalian and insect cells.

https://doi.org/10.1590/0074-02760190150 2111 downloads

Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil
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Kauffmann, Carla

; Giacomin, Ana Caroline

; Arossi, Kelen

; Pacheco, Leandra Andressa

; Hoehne, Lucélia

; Freitas, Elisete Maria de

; Machado, Gérzia Maria de Carvalho

; Cavalheiro, Marilene Marcuzzo do Canto

; Gnoatto, Simone Cristina Baggio

; Ethur, Eduardo Miranda

Brazilian Journal of Pharmaceutical Sciences

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2019, Volume 55 elocation e17584

Abstract: En | Text: En | PDF: En

In South American folk medicine members of the genus Myrciaria are used for the treatment of malaria, diarrhoea, asthma, inflammation and post-partum uterine cleansing. The aim of this work was to evaluate its antileishmanial properties (in vitro) of essential oil derived from leaves of Myrciaria plinioides D. Legrand, a plant species that is native in South of Brazil. The essential oil was obtained by hydro-distillation using fresh leaves of M. plinioides. The chemical composition of this essential oil (MPEO, M. plinioides essential oil) was determined by gas chromatography coupled to mass spectrometry (GC-MS). MPEO was assayed in vitro for antileishmanial properties against promastigotes of Leishmania amazonensis and Leishmania infantum, and for cytotoxicity against murine peritoneal macrophages. The MPEO comprised 66 components and was rich in oxygenated sesquiterpenes (82.66%) containing spathulenol (21.12%) as its major constituent. The MPEO was effective against L. amazonensis with IC50 value of 14.16 ± 7.40 µg/mL, while against L. infantum the IC50 value was higher with 101.50 ± 5.78 µg/mL. The MPEO showed significant activity against L. amazonensis, and presented a selectivity index (SI) of 6.60. The results suggest that the essential oil from leaves of M. plinioides is a promising source for new antileishmanial agents against L. amazonensis.

https://doi.org/10.1590/s2175-97902019000217584 732 downloads

Eficiência de um sistema piloto utilizando áreas alagadas no pós-tratamento do lixiviado gerado no Aterro Sanitário de Curitiba, Curitiba, Paraná, Brasil
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Amorim, Ana Maria Pereira Barreto

; Cavalheiro, Thaís Lopes

; Preussler, Karla Heloise

; Mielke, Erica Costa

; Cubas, Selma Aparecida

; Maranho, Leila Teresinha

Engenharia Sanitaria e Ambiental

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jun 2018, Volume 23 N. 3 Pages 535 - 542

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO No Aterro Sanitário de Curitiba ocorre o pós-tratamento do lixiviado em áreas alagadas naturais. Para avaliar o papel das macrófitas nesse pós-tratamento, foi desenvolvido um sistema piloto. Dessa forma, o objetivo do presente estudo foi avaliar a eficiência do sistema piloto utilizado para o pós-tratamento do lixiviado desse aterro sanitário. O sistema foi construído com duas caixas d’água: na primeira foi colocada a macrófita Echinochloa polystachya e na segunda, Eichhornia crassipes. O sistema operou em batelada e foi realizado um ciclo de sete dias. Para o monitoramento do sistema foram efetuadas coletas e análises do lixiviado, do substrato e das macrófitas. A eficiência do sistema no pós-tratamento do lixiviado foi de 72% para demanda bioquímica de oxigênio, 30% para demanda química de oxigênio, 76% para fósforo total e fósforo inorgânico, 38% para nitrato, 33% para nitrito, 58% para nitrogênio amonical, 44% para nitrogênio orgânico e 13% para zinco.

ABSTRACT In the Curitiba Landfill the post-treatment of the leachate occurs in natural wetlands. In order to evaluate the role of macrophytes in this post-treatment, it was developed a pilot system. Thus, the objective of this study was to evaluate the effectiveness of the pilot system in the post-treatment of the leachate in this landfill. The system was built with two water tanks: the macrophyte Echinochloa polystachya was placed in the first one; and the Eichhornia crassipes was placed in the second one. The system operated in batch in a seven-day cycle. For monitoring the system, samples were collected, and analyses of the leachate, the substrate, and the macrophytes were performed. The efficiency of the system in the post-treatment of the leachate was 72% for biochemical oxygen demand, 30% for chemical oxygen demand, 76% for total phosphorus and inorganic phosphorus, 38% for nitrate, 33% for nitrite, 58% for ammoniacal nitrogen, 44% for organic nitrogen, and 13% for zinc.

https://doi.org/10.1590/s1413-4152201894495 1217 downloads

Perfil das pessoas com deficiência física e Políticas Públicas: a distância entre intenções e gestos
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Nogueira, Giovani Cavalheiro

; Schoeller, Soraia Dornelles

; Ramos, Flávia Regina de Souza

; Padilha, Maria Itayra

; Brehmer, Laura Cavalcanti de Farias

; Marques, Ana Maria Fernandes Borges

Ciência & Saúde Coletiva

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oct 2016, Volume 21 N. 10 Pages 3131 - 3142

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Trata-se de um estudo transversal, com abordagem quantitativa cujo objetivo principal foi descrever o perfil epidemiológico das pessoas com deficiência física residentes no município de Florianópolis, Santa Catarina e analisá-lo frente às políticas públicas voltadas a esta população. A amostra mínima foi determinada por cálculo estatístico, considerando a população do município com deficiência física, conforme dados do Censo Populacional de 2010. Os dados foram coletados via formulário eletrônico instalado em dispositivos móveis e armazenados em um provedor virtual. A análise e tratamento dos dados foram realizados no programa Statistical Package for the Social Sciences. Foram considerados 139 questionários. Os resultados foram divididos em Atributos individuais; Atributos sociais e Características relacionadas à deficiência. Além do perfil descritivo das pessoas com deficiência física o estudo analisa e discute o distanciamento entre a proposta das políticas públicas mundiais e brasileiras e as ações efetivas de atenção aos direitos destas pessoas. Assim, é fundamental agir frente às reais necessidades da população e consolidar as propostas de promoção, proteção e reabilitação da saúde.

Abstract This is a cross-sectional study with a quantitative approach, establishing the epidemiological profile of people with physical disabilities resident in the municipality of Florianópolis, in the Southern Brazilian state of Santa Catarina, and analyzing it in relation to the public policies related to that population. The minimum sample was determined by a statistical calculation, considering the population of the municipality with disabilities, according to data from the 2010 Population Census. The data were collected using an electronic form installed in mobile devices and stored at an online provider. The data were analyzed and handled with the software Statistical Package for the Social Sciences. A total of 139 questionnaires were processed. A separation of the results was made using these categories: Individual attributes; Social attributes; and Characteristics related to disability. As well as the descriptive profile of the disabled people, the study analyses and discusses the distance, worldwide and in Brazil, between the proposals for public policies and the actual actions of care directed towards the rights of these people. The conclusion is that there is a fundamental need to act in relation to the real needs of this population and consolidate proposals for health promotion, health protection and health rehabilitation for them.

https://doi.org/10.1590/1413-812320152110.17622016 6672 downloads

Perfil das pessoas com deficiência física e Políticas Públicas: a distância entre intenções e gestos
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Nogueira, Giovani Cavalheiro

; Schoeller, Soraia Dornelles

; Ramos, Flávia Regina de Souza

; Padilha, Maria Itayra

; Brehmer, Laura Cavalcanti de Farias

; Marques, Ana Maria Fernandes Borges

Ciência & Saúde Coletiva

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oct 2016, Volume 21 N. 10 Pages 3131 - 3142

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-812320152110.17622016 995 downloads

10.

Thermographic analysis and autonomic response in the hands of patients with leprosy
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Cavalheiro, Aretusa Lopes

; Costa, Debora Tacon da

; Menezes, Ana Luiza Ferro de

; Pereira, Janser Moura

; Carvalho, Eliane Maria de

Anais Brasileiros de Dermatologia

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jun 2016, Volume 91 N. 3 Pages 274 - 283

Abstract: En | Text: En | PDF: En

Abstract: Background: Low temperatures and slow blood flow may result from peripheral neuropathy caused by leprosy, and the simple detection of cold fingers could already be a preliminary classification for these patients. Objective: To investigate whether infrared thermography would be able to measure this change in temperature in the hands of people with leprosy. Method: The study assessed 17 leprosy patients who were under treatment at the National Reference Center for Sanitary Dermatology and Leprosy, Uberlândia/MG, and 15 people without leprosy for the control group. The infrared camera FLIR A325 and Therma CAM Researcher Professional 2.9 software were used to measure the temperature. The room was air-conditioned, maintaining the temperature at 25°C; the distance between the camera and the limb was 70 cm. The vasomotor reflex of patients was tested by a cold stress on the palm. Results: The study showed a significant interaction between the clinical form of leprosy and temperature, where the control group and the borderline-borderline form revealed a higher initial temperature, while borderline-lepromatous and lepromatous leprosy showed a lower temperature. Regarding vasomotor reflex, lepromatous leprosy patients were unable to recover the initial temperature after cold stress, while those with the borderline-tuberculoid form not only recovered but exceeded the initial temperature. Conclusion: Thermography proved a potential tool to assist in the early detection of neuropathies, helping in the prevention of major nerve damage and the installation of deformities and disabilities that are characteristic of leprosy.

https://doi.org/10.1590/abd1806-4841.20164612 1613 downloads

11.

Relação entre necessidade de adornos com satisfação com imagem corporal e autoconceito profissional da equipe de enfermagem
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Puggina, Ana Cláudia

; Cavalheiro, Ana Carolina

; Trentino, Jéssica Pereira

; Castro, Paulo Francisco de

; Silva, Maria Júlia Paes da

Escola Anna Nery

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dec 2015, Volume 19 N. 4 Pages 563 - 570

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract Objective: To explore the relationship between the feeling of missing not wearing adornments and body image satisfaction and the professional self-concept of the members of the nursing team. Methods: Quantitative analytical study. Professionals from a nursing team (n = 46) responded to a Professional Self-Concept Scale, Body Image Satisfaction Assessment Scale and a characterization questionnaire. Results: The total mean score for the Professional Self-Concept Scale was 111.6 (± 13.3) and for the Body Image Satisfaction Assessment Scale it was 81.6 (± 14.1). There were statistically significant differences in the comparison of the feeling of missing not wearing adornments in the dimensions of Realization (p-value = 0.0074), Self-confidence (p-value = 0.0386) and Health (p-value = 0.0109) of the Professional Self-Concept Scale. Conclusion: Individuals who are more realized, more self-confident, more perceive the influence of work on own health and more satisfied with their appearance do not miss wearing adornments in the hospital environment.

Resumen Objetivo: Relacionar la sensación de falta de adorno con la satisfacción de la imagen corporal y el autoconcepto profesional de miembros de un equipo de enfermería. Métodos: Estudio analítico cuantitativo. Participaron enfermeros (n = 46) que respondieron la Escala de Autoconcepto Professional, la Escala de Evaluación de la Satisfacción con la Imagen Corporal y un cuestionario de caracterización. Resultados: La media de puntos totales de la Escala de Autoconcepto Professional fue 111,6 (± 13,3), y la Escala de Evaluación de la Satisfacción con la Imagen Corporal, 81,6 (± 14,1). Hubo diferencias estadísticamente significativas en comparación con la percepción de la falta de adorno en las dimensiones Realización (valor de p = 0,0074), Autoconfianza (valor de p = 0,0386) y Salud (valor de p = 0,0109), en la Escala de Autoconcepto Professional. Conclusión: Los individuos más realizados, seguros, que mejor comprenden la influencia del trabajo en la propia salud y más satisfechos con la apariencia no sintieron falta de los adornos en el ambiente hospitalario.

Resumo Objetivo: Relacionar a sensação de falta de adornos com a satisfação da imagem corporal e o autoconceito profissional dos membros da equipe de enfermagem. Métodos: Estudo analítico quantitativo. Profissionais da equipe de enfermagem (n = 46) responderam a Escala de Autoconceito Profissional, a Escala de Avaliação da Satisfação da Imagem Corporal e um questionário de caracterização. Resultados: O escore médio total da Escala de Autoconceito Profissional foi de 111,6 (± 13,3) e da Escala Avaliação da Satisfação com a Imagem Corporal foi de 81,6 (± 14,1). Houve diferenças estatisticamente significativas na comparação da sensação de falta de adornos nas dimensões Realização (valor de p = 0,0074), Autoconfiança (valor de p = 0,0386) e Saúde (valor de p = 0,0109) da Escala Autoconceito Profissional. Conclusão: Indivíduos mais realizados, mais autoconfiantes, que mais percebem a influencia do trabalho na própria saúde e mais satisfeitos com a aparência não sentiram falta de adornos no ambiente hospitalar.

https://doi.org/10.5935/1414-8145.20150075 7 downloads

12.

Relação entre necessidade de adornos com satisfação com imagem corporal e autoconceito profissional da equipe de enfermagem
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Puggina, Ana Cláudia

; Cavalheiro, Ana Carolina

; Trentino, Jéssica Pereira

; Castro, Paulo Francisco de

; Silva, Maria Júlia Paes da

Escola Anna Nery

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dec 2015, Volume 19 N. 4 Pages 563 - 570

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.5935/1414-8145.20150075 4163 downloads

13.

Counteracting effects on free radicals and histological alterations induced by a fraction with casearins
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ARAÚJO, ÉVERTON JOSÉ FERREIRA DE

; OLIVEIRA, GUILHERME ANTÔNIO LOPES DE

; SOUSA, LÍVIA QUEIROZ DE

; BOLZANI, VANDERLAN DA SILVA

; CAVALHEIRO, ALBERTO JOSÉ

; TOME, ADRIANA DA ROCHA

; PERON, ANA PAULA

; SANTOS, ANDRÉ GONZAGA DOS

; CITÓ, ANTONIA MARIA DAS GRAÇAS LOPES

; PESSOA, CLÁUDIA

; FREITAS, RIVELILSON MENDES DE

; FERREIRA, PAULO MICHEL PINHEIRO

Anais da Academia Brasileira de Ciências

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sep 2015, Volume 87 N. 3 Pages 1791 - 1807

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMOCasearia sylvestris Swartz é uma planta medicinal amplamente distribuída no Brasil. Ela possui atividade anti-inflamatória, antiulcerogênica e antitumoral e é popularmente utilizada para tratar envenenamentos ofídicos, ferimentos, diarreia, gripes e resfriados. Suas folhas são ricas em diterpenos clerodânicos tricíclicos oxigenados, particularmente casearinas. Aqui, nós avaliamos as atividades antioxidantes de um fração com casearinas (FC) isolada de C. sylvestrise as alterações histológicas no sistema nervoso central e fígados de camundongos Mus musculus. Primeiramente, estudos in vitro(0,9, 1,8, 3,6, 5,4 e 7,2 μg/mL) revelaram valores de CE50 de 3,7, 6,4 e 0,16 µg/mL para nitrito, radical hidroxila e níveis de TBARS, respectivamente. Em seguida, a FC (2,5, 5, 10 e 25 mg/kg/dia) foi administrada intraperitonealmente por 7 dias consecutivos em camundongos Swiss. Os níveis de nitrito no hipocampo (26,2, 27,3, 30,2 e 26,6 µM) e no corpo estriado (26,3, 25,4, 34,3 e 27,5 µM) aumentaram em todos os animais tratados com a FC (P < 0.05). As menores doses reduziram os níveis de glutationa reduzida, de catalase e de TBARS no hipocampo e no corpo estriado. Com exceção da redução na formação de TBARS, a FC demonstrou atividade antioxidante apenas in vitro. Os animais exibiram alterações histológicas que sugerem neurotoxicidade e hepatotoxicidade, indicando a necessidade de cuidados em relação ao consumo de preparações medicinais à base de Casearia sylvestris.

ABSTRACTCasearia sylvestris Swartz is a medicinal plant widely distributed in Brazil. It has anti-inflammatory, antiulcer and antitumor activities and is popularly used to treat snakebites, wounds, diarrhea, flu and chest colds. Its leaves are rich in oxygenated tricyclic cis-clerodane diterpenes, particulary casearins. Herein, we evaluated the antioxidant activities of a fraction with casearins (FC) isolated from C. sylvestrisand histological changes on the central nervous system and livers of Mus musculus mice. Firstly, in vitro studies (0.9, 1.8, 3.6, 5.4 and 7.2 μg/mL) revealed EC50 values of 3.7, 6.4 and 0.16 µg/mL for nitrite, hydroxyl radical and TBARS levels, respectively. Secondly, FC (2.5, 5, 10 and 25 mg/kg/day) was intraperitoneally administered to Swiss mice for 7 consecutive days. Nitrite levels in the hippocampus (26.2, 27.3, 30.2 and 26.6 µM) and striatum (26.3, 25.4, 34.3 and 27.5 µM) increased in all treated animals (P < 0.05). Lower doses dropped reduced glutathione, catalase and TBARS levels in the hippocampus and striatum. With the exception of this reduction in TBARS formation, FC displayed only in vitro antioxidant activity. Animals exhibited histological alterations suggestive of neurotoxicity and hepatotoxicity, indicating the need for precaution regarding the consumption of medicinal formulations based on Casearia sylvestris.

https://doi.org/10.1590/0001-3765201520150149 2424 downloads

14.

Hemodialysis services: are public policies turned to guaranteeing the access?
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Barbieri, Ana Rita

; Gonçalves, Crhistinne Cavalheiro Maymone

; Cheade, Maria de Fátima Meinberg

; Souza, Cristina

; Tsuha, Daniel Henrique

; Ferreira, Kássio Costa

; Rasi, Lucas

; Paranhos Filho, Antonio Conceição

Cadernos de Saúde Pública

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jul 2015, Volume 31 N. 7 Pages 1505 - 1516

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

A expansão da hemodiálise como escolha para o tratamento da insuficiência renal crônica em seu estágio final precisa ser organizada com garantia de acesso aos que dela necessitam. O estudo ecológico realizado no Mato Grosso do Sul, Brasil, em 2012, mapeou geograficamente pacientes que realizam hemodiálise, as distâncias percorridas, o número estimado de doentes com base em bancos de dados do Departamento de Informática do Sistema Único de Saúde (DATASUS) e análise dos prontuários nas 12 clínicas. A prevalência de pacientes em hemodiálise no estado assemelha-se à média nacional, com aproximadamente 55 pacientes para cada 100 mil habitantes. As análises indicam concentração de pacientes em municípios que possuem as clínicas e vazios geográficos que geram deslocamentos superiores a 100km para mais de 16% dos pacientes. Os resultados sugerem a necessidade de fortalecer políticas públicas que considerem para a tomada de decisão: a desconcentração da oferta de serviços, a ampliação da oferta de procedimentos domiciliares e a educação permanente de profissionais.

The increasing incidence of chronic renal failure in Brazil and the consequential expansion of hemodialysis as a choice for treatment in final stage have to be taken into account to guarantee access to those in need. The ecological study conducted in Mato Grosso do Sul State, Brazil, in 2012, using data from the Brazilian Health Informatics Department (DATASUS) and from the analysis of medical records in 12 clinics, identified and mapped patients on hemodialysis, the distance they travelled and the estimated number of patients. The prevalence of hemodialysis patients in Mato Grosso do Sul State, about 55 per 100,000 inhabitants, is similar to the national average. The analyses indicated concentration of patients in counties with clinics and also geographical gaps that generate displacement of over 100km for more than 16% of patients. The results point to the necessity of strengthening public policies that consider, for decision-making, the decentralization of service, the expansion of home care and the follow-up education for professionals.

Este trabajo trata sobre la expansión de la hemodiálisis, como una opción para el tratamiento de la insuficiencia renal crónica en su fase final, así como la necesidad de organizarse para garantizar el acceso a las personas necesitadas. Se realizó un estudio ecológico en Mato Grosso do Sul, Brasil, en 2012 con pacientes asignados geográficamente, en tratamiento de hemodiálisis; analizando distancias, número estimado de pacientes, a partir de bases de datos del Departamiento de Informática del Sistema Único de Salud (DATASUS), y análisis de los registros de pacientes en 12 clínicas. La prevalencia de pacientes en hemodiálisis en el estado se asemeja a la media nacional, con aproximadamente 55 pacientes por cada 100.000 habitantes. El análisis indica la concentración de los pacientes en los municipios que tienen deficiencias clínicas y geográficas, que generan desplazamientos a más de 100km a un 16% de los pacientes. Los resultados sugieren la necesidad de fortalecer las políticas públicas, con el fin de que tengan en cuenta para la toma de decisiones, la descentralización de la prestación de servicios, la ampliación de la oferta de los procedimientos de la vivienda y la educación continua de los profesionales.

https://doi.org/10.1590/0102-311X00073514 2335 downloads

15.

Hemodialysis services: are public policies turned to guaranteeing the access?
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Barbieri, Ana Rita

; Gonçalves, Crhistinne Cavalheiro Maymone

; Cheade, Maria de Fátima Meinberg

; Souza, Cristina

; Tsuha, Daniel Henrique

; Ferreira, Kássio Costa

; Rasi, Lucas

; Paranhos Filho, Antonio Conceição

Cadernos de Saúde Pública

Journal Metrics
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jul 2015, Volume 31 N. 7 Pages 1505 - 1516

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0102-311X00073514 1171 downloads

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