Sulfated proteoglycans as modulators of neuronal migration and axonal decussation in the developing midbrain. L.A. Cavalcante, J. Garcia-Abreu, F.A. Mendes, V. Moura Neto, L.C.F. Silva, G. Onofre, G. Weissmüller and S.L. Carvalho. Brazilian Journal of Medical and Biological Research, 36 (8): 993, 2003.

Figure 1. Effect of glycosaminoglycan lyase treatment on total length of neurites cultured on lateral (L) or medial (M) astrocytes (see also Figure 3). A, Control co-culture (L) and co-cultures treated with chondroitinase ABC (L + chase ABC) or heparitinase 1 (L + hept). B, Control co-culture (M) and co-cultures treated with chondroitinase ABC (M + chase ABC) or heparitinase 1 (M + hept). Box-and-whisker plots show the total length of neurites. The boxes enclose the 25th and 75th percentiles and are bisected by the median; whiskers indicate the 5th and 95th percentiles, i.e., conservative estimates for the shortest and the longest set of neurites. L + chase ABC and M + hept are significantly different from the respective controls L (P < 0.05) and M (P < 0.0001). Modified from Ref. 40, courtesy of Wiley-Liss.