Effect of the GABAB agonist baclofen on dipyrone-induced delayed gastric emptying in rats. E.F. Collares and A.M. Vinagre. Brazilian Journal of Medical and Biological Research, 38 (1): 99, 2005.
Figure 1. Gastric retention of a saline test meal 10 min after orogastric administration to rats. Eight days before the experiment, all animals were implanted with a stainless steel cannula into the right lateral ventricle. The animals were injected iv with vehicle (C) or 80 mg/kg (240 µmol/kg) dipyrone (Dp), followed by icv injection through an internal cannula of 10 µl vehicle (bac0) or an equal volume of solution containing 0.5, 1 or 2 µg baclofen (bac0.5, bac1 and bac2, respectively). Gastric retention, reported as mean ± SEM in percent, was determined 10 min after removal of the internal cannula. The number of animals in each group is given in parentheses. *P < 0.05 (Tukey test).