Contribution of CD4+ T cells to the early mechanisms of ischemia-reperfusion injury in a mouse model of acute renal failure. H.S. Pinheiro, N.O.S. Camara, I.L. Noronha, I.L. Maugeri, M.F. Franco, J.O.A.P. Medina and A. Pacheco-Silva. Braz J Med Biol Res, April 2007, Volume 40(4) 557-568.
Figure 2. Effect of CD4+ cell depletion on renal function (urea) after ischemia-reperfusion (IR). Animals of the CD4+-depleted groups treated with GK1.5 (filled triangles, N = 8 on day 1, N = 9 on day 2 and N = 11 on day 5), and MHC class II knock-out (MHC II KO) animals (open triangles, N = 6 on day 2 and N = 4 on day 5) produced less urea than the ischemic group (filled squares, N = 9 on day 1, N = 8 on day 2 and N = 8 on day 5) after the same IR injury 1 and 2 days after reperfusion. Sham group (open squares, N = 3 on each point). Blood samples were obtained at sacrifice and each point represents a separate group of mice. *P < 0.05 for the GK1.5 group vs the ischemic group on day 1. **P < 0.05 for the GK1.5 and MHC II KO groups vs the ischemic group on day 2 (ANOVA test with Student-Newman-Keuls correction).