Cytotoxicity and antitumoral activity of dichloromethane extract and its fractions from Pothomorphe umbellata
Sacoman, J.L.; Monteiro, K.M.; Possenti, A.; Figueira, G.M.; Foglio, M.A.; Carvalho, J.E.
Braz J Med Biol Res 2008; 41: 411-415.
Figure 1. Kaplan-Meier survival curves of mice (8 animals per group) treated with Pothomorphe umbellata dichloromethane crude extract. Doses (A) 300 mg/kg (P = 0.0002) and (B) 100 (P < 0.0001), 200 (P < 0.0001), and 400 mg/kg (P < 0.0001). Controls: saline (negative) and doxorubicin (positive, 5 mg/kg). Day 0 is the day of cell inoculation and days 4, 11 (A) and 4, 11 and 18 (B) are the days of treatment. The survival curves were analyzed by the rank-log test, which indicates the statistical difference between the number of deaths in the negative control group (saline) and the treated ones.