F.C. Jobim, N.L. Xavier, D.M. Uchoa, D.B. Cruz, M. Saciloto, N. Chemello and G. Schwartsman. Prevalence of vascular-endothelial growth factor, matrix metalloproteinases and tissue inhibitors of metalloproteinases in primary breast cancer. Braz J Med Biol Res 2009; 42: 979-987.

Figure 1. Immunohistochemical expression of matrix metalloproteinases MMP-2 (A), MMP-9 (B) and tissue inhibitors of metalloproteases [TIMP-2 (C) and TIMP-1 (D)] in neoplastic cells of a breast tumor. The arrows show the immunoreaction in the cytoplasm of the neoplastic cells. Breast cancer cells are shown at 400X magnification (bar = 20 µm in all panels).