Figure 1. Immunohistochemical expression of matrix metalloproteinases MMP-2 (A), MMP-9 (B) and tissue inhibitors of metalloproteases [TIMP-2 (C) and TIMP-1 (D)] in neoplastic cells of a breast tumor. The arrows show the immunoreaction in the cytoplasm of the neoplastic cells. Breast cancer cells are shown at 400X magnification (bar = 20 µm in all panels).