R.R. Guerra, M.R. Trotta, O.M. Parra, J.L. Avanzo, A. Bateman, T.P.A. Aloia, M.L.Z. Dagli and F.J. Hernandez-Blazquez. Modulation of extracellular matrix by nutritional hepatotrophic factors in thioacetamide-induced liver cirrhosis in the rat. Braz J Med Biol Res 2009; 42: 1027-1034.

Figure 1. Effect of hepatotrophic factors on thioacetamide-induced liver cirrhosis in rat. a, Liver section of a rat receiving physiologic saline. Extensive deposition of collagen is seen (arrows) among the regenerative nodules (star). b, Liver section of a rat from the group treated with hepatotrophic factors showing a reduction of inter- and intranodular collagen and thinning of fibrous septa (arrows) and regenerative nodules (star), and the reappearence of a centrolobular vein (arrowheads). c, Liver section of a control rat showing the normal parenchymal structure and a central vein (arrowhead). Picrosirius staining. Bar: 200 μm.