Figure 1. Effects of lovastatin (LOV) and indomethacin on paw edema induced by carrageenan in rats. The animals (8 per group) were treated with LOV (2, 5, and 10 mg/kg, po), indomethacin (20 mg/kg, po), or vehicle (distilled water, po). One hour after receiving these drugs, each animal was injected sc with 0.1 mL 1% carrageenan in the right hind paw. The edema was measured immediately prior to the carrageenan injection and 1, 2, 3, 4, and 24 h later. Its volume in mL was determined with a plethysmometer as the difference between the final and initial volumes. Data are reported as means ± SEM. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001 vs controls (ANOVA followed by the Student Newman-Keuls post hoc test).