In vivo and in vitro anti-inflammatory and anti-nociceptive activities of lovastatin in rodents. D.O. Gonçalves, I.B.F. Calou, R.P. Siqueira, A.A. Lopes, L.K.A. Leal, G.A.C. Brito, A.R. Tomé and G.S.B. Viana.
Figure 1. Effects of lovastatin (LOV) and indomethacin on paw edema induced by carrageenan in rats. The animals (8 per group) were treated with LOV (2, 5, and 10 mg/kg, po), indomethacin (20 mg/kg, po), or vehicle (distilled water, po). One hour after receiving these drugs, each animal was injected sc with 0.1 mL 1% carrageenan in the right hind paw. The edema was measured immediately prior to the carrageenan injection and 1, 2, 3, 4, and 24 h later. Its volume in mL was determined with a plethysmometer as the difference between the final and initial volumes. Data are reported as means ± SEM. aP < 0.05; bP < 0.01; cP < 0.001 vs controls (ANOVA followed by the Student Newman-Keuls post hoc test).