In vivo and in vitro anti-inflammatory and anti-nociceptive activities of lovastatin in rodents. D.O. Gonçalves, I.B.F. Calou, R.P. Siqueira, A.A. Lopes, L.K.A. Leal, G.A.C. Brito, A.R. Tomé and G.S.B. Viana.
Figure 2. Effects of lovastatin (LOV) and indomethacin (INDO) on neutrophil migration induced by the intraperitoneal injection of carrageenan in mice. The animais (8 per group) were treated with LOV (0.5, 1, and 5 mg/kg, po), INDO (20 mg/kg, po) or vehicle (distilled water, po), and received 1% carrageenan (0.25 mL, ip) 1 h after the treatments. Four hours later, the animals were sacrificed, the peritoneal cavity washed with 2 mL phosphate-buffered saline containing heparin, and the exudate collected for neutrophil counting. Data are reported as means ± SEM. aP < 0.001 vs controls (ANOVA followed by the Student Newman-Keuls post hoc test).