In vivo and in vitro anti-inflammatory and anti-nociceptive activities of lovastatin in rodents. D.O. Gonçalves, I.B.F. Calou, R.P. Siqueira, A.A. Lopes, L.K.A. Leal, G.A.C. Brito, A.R. Tomé and G.S.B. Viana.
Figure 3. A, Effects of lovastatin (LOV) and morphine on the formalin test in mice. Mice (8 per group) were treated with LOV (2, 5, and 10 mg/kg, po) or morphine (10 mg/kg, sc), and 15 min later with naloxone (3 mg/kg, sc). Thirty minutes later, each animal received a subcutaneous injection of 20 µL 1% formalin in the right hind paw. The period of time (s) each mouse spent licking the injected paw was recorded. Data are reported as means ± SEM. aP < 0.01; bP < 0.001 vs controls (ANOVA followed by the Student Newman-Keuls post hoc test). B, Effects of naloxone (NAL) on the anti-nociceptive activity of lovastatin (LOV) and morphine, in the formalin test in mice. Data are reported as means ± SEM for 8 animals. aP < 0.001 vs controls; bP < 0.01 vs control; cP < 0.001 vs morphine; dP < 0.001 vs LOV 5 (ANOVA followed by the Student Newman-Keuls post hoc test).