In vivo and in vitro anti-inflammatory and anti-nociceptive activities of lovastatin in rodents. D.O. Gonçalves, I.B.F. Calou, R.P. Siqueira, A.A. Lopes, L.K.A. Leal, G.A.C. Brito, A.R. Tomé and G.S.B. Viana. Braz J Med Biol Res 2011; 44: 173-181.

Figure 3. A, Effects of lovastatin (LOV) and morphine on the formalin test in mice. Mice (8 per group) were treated with LOV (2, 5, and 10 mg/kg, po) or morphine (10 mg/kg, sc), and 15 min later with naloxone (3 mg/kg, sc). Thirty minutes later, each animal received a subcutaneous injection of 20 µL 1% formalin in the right hind paw. The period of time (s) each mouse spent licking the injected paw was recorded. Data are reported as means ± SEM. aP < 0.01; bP < 0.001 vs controls (ANOVA followed by the Student Newman-Keuls post hoc test). B, Effects of naloxone (NAL) on the anti-nociceptive activity of lovastatin (LOV) and morphine, in the formalin test in mice. Data are reported as means ± SEM for 8 animals. aP < 0.001 vs controls; bP < 0.01 vs control; cP < 0.001 vs morphine; dP < 0.001 vs LOV 5 (ANOVA followed by the Student Newman-Keuls post hoc test).