Long-term melatonin treatment reduces ovarian mass and enhances tissue antioxidant defenses during ovulation in the rat. L.G.A. Chuffa, J.P.A. Amorim, G.R. Teixeira, L.O. Mendes, B.A. Fioruci, P.F.F. Pinheiro, F.R.F. Seiva, E.L.B. Novelli, W. Mello Júnior, M. Martinez and F.E. Martinez.
Figure 1. A, Protocol for melatonin treatment based on Zeitgeber time (ZT) corresponding to the environmental circadian time. B, Rats received 100 µg melatonin·100 g body weight-1·day-1, ip, for 60 days.