Rhein induces apoptosis of human gastric cancer SGC-7901 cells via an intrinsic mitochondrial pathway. Yiwen Li, Yuqing Xu, Bo Lei, Wenxiu Wang, Xin Ge and Jingrui Li. Braz J Med Biol Res 2012; 45: 1052-1059

Figure 1. Rhein-induced anti-proliferation of SGC-7901 cells. SGC-7901 cells were treated with rhein at doses of 0, 50, 100, 150, or 200 µM for 24, 48, and 72 h. Cell viability was evaluated with the MTT assay and results are reported as relative cell viability (%). All data were normalized to the control group, which was considered to be 100%. The results showed that rhein inhibited proliferation of SGC-7901 cells in a dose- and time-dependent manner. *P < 0.05 versus control group (0 µM) (two-way ANOVA followed by the Tukey post hoc test).