Rhein induces apoptosis of human gastric cancer SGC-7901 cells via an intrinsic mitochondrial pathway. Yiwen Li, Yuqing Xu, Bo Lei, Wenxiu Wang, Xin Ge and Jingrui Li. Braz J Med Biol Res 2012; 45: 1052-1059

Figure 2. Cell apoptosis observed using TUNEL staining. SGC-7901 cells were treated with rhein (0, 100, 200, or 300 µM) for 48 h. Apoptotic cells exhibited morphological changes in the nuclei typical of apoptosis. Photographs were taken under an inverted microscope (scale bar, 50 μm). Arrows indicate apoptotic cells.