Rhein induces apoptosis of human gastric cancer SGC-7901 cells via an intrinsic mitochondrial pathway. Yiwen Li, Yuqing Xu, Bo Lei, Wenxiu Wang, Xin Ge and Jingrui Li. Braz J Med Biol Res 2012; 45: 1052-1059

Figure 6. Treatment with rhein increased the expression of cytochrome c and Apaf-1 in SGC-7901 cells. SGC-7901 cells were treated with rhein (0, 100, 200, or 300 µM) for 48 h and protein levels of cytochrome c (A) and Apaf-1 (B) were determined by Western blot. Data are reported as the means ± SEM of at least three experiments. *P < 0.05 versus control group (0 µM) (one-way ANOVA followed by the Tukey post hoc test).