Comparative proteomics analysis of chronic atrophic gastritis: changes of protein expression in chronic atrophic gastritis without Helicobacter pylori infection. Lin Zhang, Yanhong Hou, Kai Wu and Dan Li.
Figure 4. Biological interaction networking of PSME1 and RPS12 in chronic atrophic gastritis (CAG). PSME1 and RPS12 were imported into Pathway Studio (USA) and an interaction map was generated with information from the Ensembl database, the Pfam protein families database, Prosite database, GNF GeneAtlas database, and PDB database. Each node represents either a protein or a control mechanism of the interaction. The NF-κB and PBP-RAF/MAPK signaling pathways could be major molecular interaction pathways. The compendious molecular interaction pathway, which linked PSME1, RPS12 and PBP, could impact on some cell functions such as cell proliferation and apoptosis, and the cell cycle could then promote the formation of CAG.