Protection against neurotoxicity by an autophagic mechanism. Kangyong Liu, Jiankang Huang, Rongfu Chen, Ting Zhang, Liwei Shen, Jiajun Yang and Xiaojiang Sun. Braz J Med Biol Res 2012; 45: 401-407
Figure 2. Morphological changes in PC12 cells with different treatments. Cell morphology was examined under a phase contrast microscope 24 h after incubation with phosphate-buffered saline (A), 1-methyl-4-phenylpyridinium (MPP+) (B) and MPP+ plus 3-n-butylphthalide (NBP) (C). Twenty-four hours after MPP+ treatment, some of the PC12 cells died (arrows), leaving cells that appeared shrunken and with short processes (B). In contrast, in the NBP-treated groups the dendritic processes surrounding the cells were largely preserved (C), suggesting that NBP protected neuronal cells from MPP+-induced death.