Participation of the NO/cGMP/K+ATP pathway in the antinociception induced by Walker tumor bearing in rats. A.L.R. Barbosa, C.A. Pinheiro, G.J. Oliveira, J.N.L. Torres, M.O. Moraes, R.A. Ribeiro, M.L. Vale and M.H.L.P. Souza. Braz J Med Biol Res 2012; 45: 531-536
Figure 3. Involvement of cGMP in the antinociceptive effect induced by Walker tumor implantation. 1H-[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) (8 µg/paw; 50 µL) was administered 30 min before carrageenan (500 µg/paw; 100 µL) or prostaglandin E2 (PGE2; 400 ng/paw; 50 µL) administration in the right paws of rats with (4th day after tumor implantation) or without tumor. The analgesic activity of Walker tumors in the right hind-paw was measured 3 or 4 h after carrageenan (Panel A) or PGE2-induced hypernociception (Panel B). #P < 0.05 compared to Walker tumor group. *P < 0.05 compared to saline group (ANOVA/Bonferroni test).