Paraoxonase-1 Genotype and Angiogram Positive Coronary Artery Disease

Keywords
Coronary Artery Disease/genetics; Mortality; Polymorphism, Genetic; Genetic Predisposition to Disease; Risk Factors

Dear Editor,

We would like to share ideas on the publication “Association of Paraoxonase-1 Genotype and Phenotype with Angiogram Positive Coronary Artery Disease”. ¹ Soflaei et al.¹ noted that The presence of the G allele of the rs662 single nucleotide polymorphism is independently associated with an increased risk of coronary artery disease (CAD).¹ The effect of polymorphism is investigated in this study. CAD might or might not be impacted by the hereditary component studied in this report. We both concur that CAD may be related to the underlying genetic component under research. However, CAD has been linked to numerous genetic variations. Examples of gene polymorphisms include the effect of polymorphisms (M235T and T174M) on the angiotensinogen gene (AGT), TGFB1 rs1800469, and BCMO1 rs6564851.²-³ Future research should examine the implications of unexpected, possibly perplexing genetic variants.

Referências

• ¹
  Soflaei SS, Baktashian M, Moghaddam KH, Saberi-Karimian M, Kosari N, Hashemi SM, et al. Association of Paraoxonase-1 Genotype and Phenotype with Angiogram Positive Coronary Artery Disease. Arq Bras Cardiol. 2022;119(4):593-601. doi: 10.36660/abc.20210422.
  » https://doi.org/10.36660/abc.20210422
• ²
  Zhang Q, Huang Q, Wang X, Wang Y, Hua X. The effect of polymorphisms (M235T and T174M) on the angiotensinogen gene (AGT) in coronary artery disease in the Eastern Asian population: A systematic review and meta-analysis. Medicine. (Baltimore). 2022 Aug 26;101(34):e29911. DOI: 10.1097/MD.0000000000029911
  » https://doi.org/10.1097/MD.0000000000029911
• ³
  Mooney RE, Linden GJ, Winning L, Linden K, Kee F, McKeown PP, et al. Association of TGFB1 rs1800469 and BCMO1 rs6564851 with coronary heart disease and IL1B rs16944 with all-cause mortality in men from the Northern Ireland PRIME study. PLoS One. 2022 Aug 22;17(8):e0273333. DOI: 10.1371/journal.pone.0273333
  » https://doi.org/10.1371/journal.pone.0273333

Publication Dates

• Publication in this collection
  07 Apr 2023
• Date of issue
  2023