Does Mean Platelet Volume Decrease in the presence of Coronary Artery Fistula?

Sincer, Isa; Çekici, Yusuf; Cosgun, Mehmet; Aktas, Gulali; Gunes, Yilmaz; Erdal, Emrah; Mansiroglu, Asli Kurtar; Inanır, Mehmet

doi:10.5935/abc.20190088

Isa Sincer Mailing Address: Isa Sincer Abant Izzet Baysal University Hospital - Department of Cardiology - Alpagut mah. 223 sok.no:20 Camlıbel apt. BOLU, Bolu 14280 - Turkey E-mail: isasincer@yahoo.com

Abant Izzet Baysal University Hospital, Bolu - Turkey

https://orcid.org/0000-0003-2399-9585

Yusuf Çekici

Gaziantep Dr. Ersin Arslan Education and Research Hospital, Gaziantep - Turkey

https://orcid.org/0000-0002-4585-3707

Mehmet Cosgun

Abant Izzet Baysal University Hospital, Bolu - Turkey

https://orcid.org/0000-0002-6965-7444

Gulali Aktas

Abant Izzet Baysal University Hospital, Bolu - Turkey

https://orcid.org/0000-0001-7306-5233

Yilmaz Gunes

Abant Izzet Baysal University Hospital, Bolu - Turkey

https://orcid.org/0000-0003-3817-851X

Emrah Erdal

Abant Izzet Baysal University Hospital, Bolu - Turkey

https://orcid.org/0000-0002-3893-5376

Asli Kurtar Mansiroglu

Abant Izzet Baysal University Hospital, Bolu - Turkey

https://orcid.org/0000-0002-1495-1697

Mehmet Inanır

Abant Izzet Baysal University Hospital, Bolu - Turkey

https://orcid.org/0000-0003-1784-3584

Mailing Address: Isa Sincer Abant Izzet Baysal University Hospital - Department of Cardiology - Alpagut mah. 223 sok.no:20 Camlıbel apt. BOLU, Bolu 14280 - Turkey E-mail: isasincer@yahoo.com

Author contributions

Conception and design of the research: Sincer I, Cosgun M, Gunes Y, Mansiroglu AK, Inanır M; Acquisition of data: Sincer I, Çekici Y, Cosgun M, Erdal E, Mansiroglu AK, Inanır M; Analysis and interpretation of the data: Sincer I, Çekici Y, Aktas G, Gunes Y; Statistical analysis: Sincer I, Cosgun M, Aktas G, Erdal E; Writing of the manuscript: Aktas G, Gunes Y, Erdal E, Mansiroglu AK, Inanır M; Critical revision of the manuscript for intellectual content: Sincer I, Çekici Y, Aktas G, Gunes Y.

Potential Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Baseline characteristics	Fistula (n = 50)	Control (n = 70)	p
Age (mean ±SD) (years))	58 ± 12	55 ± 8	0.123^a
Male/female	32/18	24/46	0.001^b
Hypertension (%)	14 (28%)	13 (19%)	0.223 ^b
Smoking	24 (48%)	35 (50%)	0.829 ^b
Family history	10 (20%)	12 (17%)	0.115 ^b
Diabetes mellitus	12 (24%)	9 (13%)	0.113 ^b
Acetyl salicylic acid	17 (34%)	21(30%)	0.119 ^b
Statin	15 (30%)	18 (26%)	0.143 ^b
ACE inhibitor	2 (4%)	3 (4%)	0.938 ^b
B-blocker	17 (34%)	20 (29%)	0.26 ^b

	Fistula (n = 50)	Control (n = 70)	p
Creatinine(mg/dL)	0.80 (0.30)	0.80 (0.22)	0.50^a a Data without normal distribution shown as median (interquartile range), acomparison with Mann Whitney U test,
Fasting plasma glucose (mg/dL)	98 (57)	101(17)	0.90 ^a a Data without normal distribution shown as median (interquartile range), acomparison with Mann Whitney U test,
LDL-cholesterol (mg/dL)	111 (48)	101(56)	0.47 ^a a Data without normal distribution shown as median (interquartile range), acomparison with Mann Whitney U test,
HDL-cholesterol (mg/dL)	42 (16)	44(24)	0.04 ^a a Data without normal distribution shown as median (interquartile range), acomparison with Mann Whitney U test,
Triglycerides (mg/dL)	150 (115)	157(107)	0.49 ^a a Data without normal distribution shown as median (interquartile range), acomparison with Mann Whitney U test,
Total cholesterol (mg/dL)	190 (54	187(54)	0.56 ^a a Data without normal distribution shown as median (interquartile range), acomparison with Mann Whitney U test,
Hematocrit (%)	42 (7)	41(6)	0.45 ^a a Data without normal distribution shown as median (interquartile range), acomparison with Mann Whitney U test,
Monocytes (x10³ µL)	0.61(0.36)	0.62(0.24)	0.42 ^a a Data without normal distribution shown as median (interquartile range), acomparison with Mann Whitney U test,
Hemoglobin (gr/dL)	13.9 ± 1.8	13.3 ± 1.9	0.12 ^b b comparison with t-test. MPV: mean platelet volume; WBC: White blood cells; LDL: low-density lipoprotein cholesterol; HDL: high-density lipoprotein cholesterol.
MPV(fL)	8.84 ± 1.71	10.43 ± 1.34	< 0.001 ^b b comparison with t-test. MPV: mean platelet volume; WBC: White blood cells; LDL: low-density lipoprotein cholesterol; HDL: high-density lipoprotein cholesterol.
Platelet count (k/mm³)	271 ± 82.72	268 ± 78	0.85 ^b b comparison with t-test. MPV: mean platelet volume; WBC: White blood cells; LDL: low-density lipoprotein cholesterol; HDL: high-density lipoprotein cholesterol.
Lymphocytes (x10³ µL)	2.37 ± 0.751	2.46 ± 1.01	0.60 ^b b comparison with t-test. MPV: mean platelet volume; WBC: White blood cells; LDL: low-density lipoprotein cholesterol; HDL: high-density lipoprotein cholesterol.
WBC (x10³ µL)	8.2 ± 3.1	6.35 ± 2.01	0.18 ^b b comparison with t-test. MPV: mean platelet volume; WBC: White blood cells; LDL: low-density lipoprotein cholesterol; HDL: high-density lipoprotein cholesterol.

Variables	Fistula	Control	p
Left ventricle end-diastolic diameter(cm)	4.7 ± 0.65	4.6 ± 0.53	0.22
Left ventricle end-systolic diameter(cm)	3.4 ± 0.86	3.3 ± 0.72	0.123
Ejection Fraction (%)	61.4 ± 8.9	63.1 ± 0.76	0.11
Right ventricle end-diastolic diameter(cm)	2.87 ± 0.81	2.46 ± 0.4	0.04
Left atrium diameter(cm)	3.3 ± 0.64	3.4 ± 0.71	0.19

Variables	N (%)
Origin of fistulae
RCA	16(32%)
ADA	15(30%)
CX	15(30%)
LMCA	4(8%)
Drainage site of the fistulae
Pulmonary artery	15(%30)
Right ventricle	17(%34)
Right atrium	5(%10)
Left ventricle	13(%26)
Shape of the fistulae
Straight	4(%8)
Single tortuous	21(%42)
Multiple tortuous	25(%50)

[TFN1] ACE: angiotensin-converting enzyme; SD: Standard deviation, data were compared with Student's t-test (^a) and Chi-square test (^b).