When strength turns into disease: acne fulminans in a bodybuilder^*

To the Editor:

A 31-year-old male visited our hospital seeking dermatological care. He had been bodybuilding for a long time and had recently initiated a strict preparation program for a contest. To this end, he took intramuscular testosterone injections on three occasions, developing severe acneiform lesions. The course was gradual but progressive, leading to limitations in his daily activities, with arthralgia of the shoulders and ankles, as well as difficulty to work, move, change clothes and even sleep at night. No fever was reported. Initial testing revealed: a white blood count of 12.570/ mm³; an erythrocyte sedimentation rate of 50mm/h; a platelet count of 278.000/mm³, without liver abnormalities. Upon physical examination, multiple, nodulocystic, erythematous papules and pustules were found on his face, chest, back and arms. Extensive ulcerations with brown-yellowish thick crusts were scattered mainly over his shoulders, the proximal areas of both arms and the upper back (Figure 1). The diagnosis of acne fulminans was made and treatment was initiated with prednisone 45mg/daily, doxycycline 100mg twice daily and antihistamines. He was told to definitively discontinue hormonal treatment. Four weeks later, isotretinoin was started at an initial dose of 30mg/daily and corticosteroids were gradually tapered. A good clinical response was achieved, with progressive healing. Acne fulminans is a rare condition, considered the most severe form of acne.¹ It usually affects young individuals aged 13-22 years, predominantly males with a prior history of mild or moderate acne². It is characterized by the sudden onset of highly inflammatory, ulcerative, painful lesions covered with haemorrhagic crusts, most often located on the upper chest and back.² Constitutional symptoms and laboratory abnormalities are frequently seen, as in this case. The etiology of acne fulminans remains unclear but it appears to be multifactorial. Doping acne is a variant, induced by exogenous hormones (EHs) such as testosterone or derivatives, provoking hypertrophy of the sebaceous glands, increased production of skin surface lipids and sebum, in addition to increased density of the Propionibacterium acnes population.^3,4 The prevalence of EH usage is increasing dramatically, especially among amateur bodybuilders (reaching up to 80%) and weightlifters (38-58%). This is favored by the non-therapeutic prescription of EH by some physicians who are unaware of its side effects. It has been estimated that up to 50% of users could develop doping acne.³ Certainly, the most important indication in these cases is the immediate cessation of EH. Due to severe, systemic symptoms, supportive care, along with a 4-6 week course of systemic corticosteroids, must be considered as first-line therapy. Subsequent addition of systemic retinoids is recommended, starting with 0.5 mg/kg daily, with a gradual dose increase to achieve early control of constitutional features as well as clearance of lesions.⁵ It is imperative nowadays to pay special attention to society's growing interest in having a perfectly sculpted body. Acne is a condition commonly associated with the use of hormonal therapies and its severe forms represent one of the risks that must be diagnosed and treated promptly.

Figure 1
Multiple erythematous nodules, papules, pustules and ulcerations with brown-yellowish thick crusts on the chest, shoulders and arms

• Financial Support: None
• *
  Work performed at the Department of Dermatology. Facultad de Medicina. Pontificia Universidad Católica de Chile – Santiago, Chile.

REFERENCES

• ¹
  Giavedoni P, Mascaró-Galy JM, Aguilera P, Estrach-Panella T. Acne fulminans successfully treated with cyclosporine and isotretinoin. J Am Acad Dermatol. 2014;70:e38-9.
• ²
  Zaba R, Schwartz R, Jarmuda S, Czarnecka-Operacz M, Silny W.. Acne fulminans: explosive systemic form of acne. J Eur Acad Dermatol Venereol. 2011;25:501-7.
• ³
  Walker J, Adams B. Cutaneous manifestations of anabolic-androgenic steroid use in athletes. Int J Dermatol. 2009;48:1044-8.
• ⁴
  Kraus SL, Emmert S, Schön MP, Haenssle HA. The dark side of beauty: acne fulminans induced by anabolic steroids in a male bodybuilder. Arch Dermatol. 2012;148:1210-2.
• ⁵
  Lages RB, Bona SH, Silva FV, Gomes AK, Campelo V. Acne fulminans successfully treated with prednisone and dapsone. An Bras Dermatol. 2012;87:612-4.

Publication Dates

• Publication in this collection
  Sep-Oct 2016

History

• Received
  07 Nov 2015
• Accepted
  16 Dec 2015