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What is your diagnosis? • An. Bras. Dermatol. 96 (1) • Jan-Feb 2021 • https://doi.org/10.1016/j.abd.2020.06.004   copy

Case for diagnosis. A pruritic eruption of keratotic papules over the face and neck☆ ☆ How to cite this article: Relvas M, Calvão J, Coutinho I, Cardoso JC. Case for diagnosis A pruritic eruption of keratotic papules over the face and neck. An Bras Dermatol. 2021;96:100-2. ,☆☆ ☆☆ Study conducted at the Department of Dermatology, Coimbra University Hospital Center, Coimbra, Portugal.

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Abstract

Generalized eruptive keratoacanthoma of Grzybowski is a rare variant of multiple keratoacanthomas counting with about 40 cases reported. It is a chronic and progressive disease for which none of the described therapeutic options has been entirely satisfactory. We report a case of an 83-year-old female who presented with a 3-month history of extremely pruritic, multiple, skin-coloured to erythematous to brownish, millimetric papules, with a keratotic centre. Histological examination of an incisional biopsy was consistent with the diagnosis of keratoacanthoma. The patient started acitretin 25 milligrams daily with a complete resolution of pruritus and regression of numerous lesions.

KEYWORDS
Acitretin; Grzybowski; Keratoacanthoma

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