Abstract:
Background:
Recent studies that investigated the effect of vitamin D on skin cancer risk have exhibited inconsistent results.
Objective:
The aim of the study was to evaluate vitamin D status in patients with actinic keratosis.
Methods:
A cross-sectional study was conducted on 31 patients with actinic keratosis and 29 healthy controls. Serum vitamin D levels in the study group were determined by liquid chromatography/tandem mass spectrometry.
Results:
Serum 25(OH)D levels in patients with actinic keratosis were significantly higher than those of the healthy controls (P=0.04). Prevalence of 25(OH)D deficiency was significantly higher in the healthy controls (75.9%) compared to the patients with actinic keratosis (54.8%), but the difference was not statistically significant (P= 0.09).
Study limitations:
The cross-sectional design of the study, data on smoking based on patient self-report, and subjects’ different dietary habits, which can influence 25(OH)D levels, are the study’s limitations.
Conclusion:
Serum vitamin D level can be used as a marker for ultraviolet B radiation from sun exposure; therefore, it can be used in individuals at risk of actinic keratosis. Oral intake of vitamin D through diet or supplements is proposed instead of prolonged ultraviolet exposure to maintain adequate vitamin D serum levels. Further research is needed to elucidate the role of vitamin D in skin carcinogenesis.
Keywords:
Keratosis, actinic; Skin neoplasms; Vitamin D