The relationship of FricTest® responses with an urticaria activity score, urticaria control test and quality of life scales in patients with symptomatic dermographism

Kıraç, Ömer Faruk; Tosun, Mustafa; Güner, Rukiye Yasak; Akyol, Melih

doi:10.1016/j.abd.2025.501147

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Original Article • An. Bras. Dermatol. 100 (05) • 2025 • https://doi.org/10.1016/j.abd.2025.501147 linkcopy

The relationship of FricTest® responses with an urticaria activity score, urticaria control test and quality of life scales in patients with symptomatic dermographism

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Background The FricTest is used as a valuable tool for diagnosing and conducting threshold testing for Symptomatic Dermographism (SD).

Objective In this study, the authors aimed to make a comparison between the Urticaria Activity Score (UAS), Urticaria Control Test (UCT), Visual Analog Scale (VAS), Dermatology Life Quality Index (DLQI), and Chronic Urticaria-Specific Quality of Life (CU-QoL) used to evaluate disease activity and control in the follow-up of urticaria patients and the Fric Test responses used in the diagnosis of dermographism.

Methods 71 patients with SD were included in the study. Fric test 4.0 was performed in all patients at baseline and at month 1. The correlations of Fric test scores with UCT, UAS, VAS, DLQI, and CU-QoL at baseline as well as the changes in responses of treatment in the mean scores at month 1 were performed.

Results In the correlation analyses, positive correlations were observed between UAS, DLQI, and CU-QoL scores and changes in Fric test 4.5 mm and 4 mm responses from baseline to the first month of treatment (p< 0.05). No significant correlations were found between Fric test 3.5 mm and 3 mm responses and CU-QoL, UAS, DLQI, and VAS scores (p> 0.05).

Study limitations This study includes results from a small sample size, and larger-scale clinical trials are needed.

Conclusion Changes in the Fric test 4.5 mm and 4 mm responses of treatment were found to be more sensitive in detecting UCT, UAS, CU-QoL, and DLQI changes than the responses of the Fric test 3.5 mm and 3 mm.

Keywords
Dermographism; Urticaria; Quality of Life

	Min‒max (Median)	p a
	Mean ± SD
Baseline of CU-QoL	25‒74 (38)	<0.001
Baseline of CU-QoL	38.2 ± 10.4
Month 1 of CU-QoL	12‒42 (27)
Month 1 of CU-QoL	29.4 ± 7.1
Baseline of UCT	0‒16 (8)	<0.001
Baseline of UCT	8.6 ± 4.0
Month 1 of UCT	4‒16 (12)
Month 1 of UCT	11.9 ± 2.7
Baseline of UAS	3‒39 (21)	<0.001
Baseline of UAS	20.2 ± 8.8
Month 1 of UAS	0‒28 (9)
Month 1 of UAS	9.6 ± 6.8
Baseline of DLQI	0‒21 (3)	<0.001
Baseline of DLQI	3.9 ± 3.4
Month 1 of DLQI	0‒9 (1)
Month 1 of DLQI	1.5 ± 1.2
Baseline of Fric test 4.5 mm	1.6‒6.3 (3.2)	<0.001
Baseline of Fric test 4.5 mm	3.4 ± 1.0
Month 1 of Fric test 4.5 mm	0‒4.6 (2.2)
Month 1 of Fric test 4.5 mm	2.2 ± 0.9
Baseline of Fric test 4 mm	1.2‒5.6 (2.9)	<0.001
Baseline of Fric test 4 mm	3.0 ± 1.0
Month 1 of Fric test 4 mm	0‒4.2 (2)
Month 1 of Fric test 4 mm	1.7 ± 1.1
Baseline of Fric test 3.5 mm	0‒4.7 (2.4)	<0.001
Baseline of Fric test 3.5 mm	2.3 ± 1.3
Month 1 of Fric test 3.5 mm	0‒4 (1.5)
Month 1 of Fric test 3.5 mm	1.2 ± 1.2
Baseline of Fric test 3 mm	0‒4.2 (1.5)	<0.001
Baseline of Fric test 3 mm	1.4 ± 1.5
Month 1 of Fric test 3 mm	0‒3.7 (0)
Month 1 of Fric test 3 mm	0.6 ± 1.1
Baseline of VAS mm	0‒10 (4)	<0.001
Baseline of VAS mm	3.8 ± 2.8
Month 1 of VAS	0‒10 (1)
Month 1 of VAS	2.1 ± 2.5

Baseline to month 1 differences	R	pa
Fric test 4.5 mm response baseline to month 1
CU-QoL	0.352	0.003
UCT	-0.398	0.001
UAS	0.402	0.001
DLQI	0.369	0.002
VAS	0.180	0.142
Fric test 4 mm response baseline to month 1
CU-QoL	0.312	0.009
UCT	.397	0.001
UAS	0.341	0.004
DLQI	0.424	<0.001
VAS	0.187	0.130

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Sociedade Brasileira de Dermatologia Av. Rio Branco, 39 18. and., 20090-003 Rio de Janeiro RJ, Tel./Fax: +55 21 2253-6747 - Rio de Janeiro - RJ - Brazil
E-mail: revista@sbd.org.br

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[1] CU-QoL, Chronic Urticaria Quality of Life Questionnaire; UAS, Urticaria Activity Score; UCT, Urticaria Control Test; DLQI, Dermatology Life Quality Index; VAS, Visual Analog Scale.

[TFN1] ^a
The level of significance (p-value) was accepted as 0.05.

Age, years
Min‒max (Median)	18‒75 (41)
Mean ± SD	41.5 ± 15.0
BMI, kg/m²
Min‒max (Median)	14.2‒57.8 (26.4)
Mean ± SD	27.4 ± 6.6
Time of urticaria diagnosis (year)
Min‒max (Median)	0.15‒21.0 (4)
Mean ± SD	5.8 ± 5.6
Gender
Male	18 (25.4%)
Female	53 (74.6%)
Working status
Not working	42 (59.16%)
Working	29 (40.84%)
Marital status
Married	52 (73.24%)
Single	19 (26.76%)
Education level
Primary Education	32 (45.07%)
Secondary Education	18 (25.35%)
Higher Education	21 (29.57%)
Smoking status
No	54 (76.05%)
Yes	17 (23.9%)
Drinking status
No	64 (90.14%)
Yes	7 (9.85%)