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TROPICAL/INFECTOPARASITARY DERMATOLOGY • An. Bras. Dermatol. 96 (05) • 2021 • https://doi.org/10.1016/j.abd.2021.03.003   copy

Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis☆ ☆ How to cite this article: Sampaio RNR, Ferreira MF, Martins SS, Motta JOC. Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis. An Bras Dermatol. 2021;96:602-4. ,☆☆ ☆☆ Study conducted at the Hospital Universitário de Brasília and Dermatomycology Laboratory, Faculty of Medicine, Universidade de Brasília, DF, Brazil.

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Diffuse cutaneous leishmaniasis is a rare universal disease associated with an inadequate host cell immune response, caused by different species: infantum, aethiopica, major, mexicana, and others, which presents the challenge of a poor therapeutic response. In Brazil, it is caused by L. amazonensis. A case confirmed by histopathology with an abundance of vacuolated macrophages full of amastigotes and lymphocyte scarcity, identified by RFLP-ITS1PCR and in vitro decrease and exhaustion of the host cell immune response to L. amazonensis antigen, was treated early (3 months after the onset) with Glucantime (2 months) and allopurinol (29 months) with clinical cure, after a follow-up for 30 months after treatment.

KEYWORDS
Allopurinol; Antimony; Recurrence; Therapy; Diffuse cutaneous leishmaniasis

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