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Case for diagnosis. Hyperpigmented and excoriated papules and nodules in a diabetic patient How to cite this article: Hasbún C., Sandoval M, González-Bombardiere S. Case for diagnosis. Hyperpigmented and excoriated papules and nodules in a diabetic patient. An Bras Dermatol. 2020;95:756-759. ,☆☆ ☆☆ This study was conducted at the Department of Dermatology, Faculty of Medicine, Pontificia Universidad Católica de Chile. Santiago, Chile.

Abstract

Reactive perforating collagenosis is a rare perforating dermatosis clinically characterized by intensely pruritic hyperpigmented papules, plaques, and nodules with a central keratotic plug. Histopathology reveals transepidermal elimination of collagen fibers. Its pathophysiology is still under investigation, but the acquired form has been linked to systemic conditions such as diabetes mellitus and chronic kidney disease. However, it has also been described as a paraneoplastic syndrome. The authors present the case of a 65-year-old diabetic patient in which a myeloproliferative neoplasm was suspected.

KEYWORDS
Collagen diseases; Diabetes mellitus; Kidney failure, chronic; Paraneoplastic endocrine syndromes

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