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What is your diagnosis? • An. Bras. Dermatol. 96 (2) • Mar-Apr 2021 • https://doi.org/10.1016/j.abd.2020.08.009   copy

Case for diagnosis. Dorsal nodule in a 10-year-old male☆ ☆ How to cite this article: Xu G, Fu X, Fang J, Huang C. Case for diagnosis. Dorsal nodule in a 10-year-old male. An Bras Dermatol. 2021;96:237-9. ,☆☆ ☆☆ Study conducted at the Department of Dermatology, Jinhua Fifth Hospital, Jinhua, China.

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Granular cell tumors (GCTs) are rare soft-tissue neoplasms. GCT immunohistochemistry is positive for S-100, NSE, and CD68. This report describes the case of a 10-year-old male who presented with a dorsal nodule. A biopsy revealed aggregates and sheets of large epithelioid and spindle cells. The cells had abundant eosinophilic granular cytoplasm. Immunohistochemical analysis was positive for CD68, NKI/C3, and synaptophysin; weakly positive for NSE; and negative for S-100, SOX10, HMB45, Melan A, cytokeratin, SMA, EMA, and CD163. The Ki-67 index was less than 1%. A diagnosis of an S-100 negative, cutaneous, benign GCT was determined.

KEYWORDS
Benign; Cutaneous; Granular cell tumor; S-100 negative

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